{"title":"Real-world weight loss with injectable semaglutide vs dulaglutide for diabetes.","authors":"Allison Spitery, Alison Lobkovich, Emily Thomas","doi":"10.37765/ajmc.2026.89952","DOIUrl":"10.37765/ajmc.2026.89952","url":null,"abstract":"<p><strong>Objective: </strong>To compare the real-world effects of weekly injectable semaglutide (Ozempic) vs dulaglutide (Trulicity) on weight loss in an urban, predominantly African American patient sample with type 2 diabetes (T2D).</p><p><strong>Study design: </strong>This retrospective cohort study included adult patients with T2D at an academic internal medicine clinic who were initiated on semaglutide or dulaglutide.</p><p><strong>Methods: </strong>The primary outcome was the percentage change in actual body weight (ABW) from baseline at 52 weeks. Secondary outcomes included mean weight loss in kg, weight loss of at least 5% and at least 10% at 52 weeks, percentage change in hemoglobin A1c (HbA1c) at 52 weeks, and HbA1c levels of less than 7% and less than 8% at 52 weeks.</p><p><strong>Results: </strong>The percentage change in ABW from baseline at 52 weeks was greater with semaglutide (n = 60) than with dulaglutide (n = 60) (-6.51% vs -1.14%; P = .001). The absolute change in ABW at 52 weeks was greater with semaglutide than with dulaglutide (-15.98 kg vs -4.93 kg; P = .001). More patients using semaglutide achieved weight loss of at least 5% and at least 10% at 52 weeks than those using dulaglutide (≥ 5%: 51.7% vs 25.0%; P = .003; ≥ 10%: 31.7% vs 8.3%; P = .001). A higher percentage of patients using semaglutide than those using dulaglutide achieved an HbA1c less than 7% and less than 8% at 52 weeks (< 7%: 53.3% vs 38.3%; P = .100; < 8%: 78.3% vs 68.3%; P = .220). The absolute change in HbA1c was greater with semaglutide than dulaglutide (-2.15% vs -1.36%; P = .033).</p><p><strong>Conclusions: </strong>Treatment with semaglutide resulted in a greater reduction in body weight and HbA1c than with dulaglutide in a real-world study of patients with T2D.</p>","PeriodicalId":50808,"journal":{"name":"American Journal of Managed Care","volume":"32 6","pages":"328-333"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Employers can now save by comparing health care prices.","authors":"David Schleifer, Raymond Tsai","doi":"10.37765/ajmc.2026.89929","DOIUrl":"10.37765/ajmc.2026.89929","url":null,"abstract":"<p><p>Employers can use price transparency data to reconsider their choice of carriers or plans, negotiate prices with their carriers, and steer employees toward high-quality, reasonably priced providers.</p>","PeriodicalId":50808,"journal":{"name":"American Journal of Managed Care","volume":"32 Spec. No. 6","pages":"eSP4-eSP6"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of Medicaid reimbursement for psychiatrists on the health care burden of serious mental illness.","authors":"Onur Baser, Heidi C Waters, Nehir Yapar, Gabriela Samayoa, Xue Han, Deborah Freedman, Lauren Isenman, Rashmi Patel","doi":"10.37765/ajmc.2026.89961","DOIUrl":"https://doi.org/10.37765/ajmc.2026.89961","url":null,"abstract":"<p><strong>Objective: </strong>Health care resource utilization (HCRU) and cost among Medicaid patients with serious mental illness (SMI) were compared in states with high and low reimbursement for psychiatric services.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Methods: </strong>Using 2021-2023 Kythera Labs Medicaid data, the 20 most frequently billed procedures by psychiatrists were identified. We selected states with the top 20% and bottom 20% mean reimbursement. The SMI population had 1 or more medical claims for SMI during the identification period and continuous enrollment for 1 year pre- and post diagnosis. The effect of reimbursement rates on health outcomes was estimated, controlling for patient-level and fixed-state characteristics.</p><p><strong>Results: </strong>The high-reimbursement-rate cohort (n = 99,024) was 5% less likely to have psychiatric-specific inpatient and outpatient visits and 23% less likely to have psychiatric-specific emergency department (ED) visits than the low-reimbursement cohort (n = 154,437). The high-reimbursement cohort was less likely to have inpatient and ED visits and demonstrated 24% lower overall costs and 19% lower psychiatric-specific costs annually.</p><p><strong>Conclusions: </strong>Higher Medicaid reimbursement rates for psychiatric services were associated with reduced HCRU and costs. Although this observed association may not imply causality, it could reflect beneficial behavioral changes (eg, improved provider participation and care continuity) or unintended mechanisms such as increased utilization review that may restrict access.</p>","PeriodicalId":50808,"journal":{"name":"American Journal of Managed Care","volume":"32 6","pages":"e198-e204"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Razanne Oueini, Ben Shirley, Christie Teigland, Melissa Castora-Binkley, Scott Bilder, Kiran Sunkari, Lynn Pezzullo
{"title":"Changes in persistence to basal insulin following the Medicare out-of-pocket cost cap.","authors":"Razanne Oueini, Ben Shirley, Christie Teigland, Melissa Castora-Binkley, Scott Bilder, Kiran Sunkari, Lynn Pezzullo","doi":"10.37765/ajmc.2026.89963","DOIUrl":"https://doi.org/10.37765/ajmc.2026.89963","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate changes in persistence to basal insulin following the implementation of the $35 monthly out-of-pocket cost cap for insulin for Medicare beneficiaries.</p><p><strong>Study design: </strong>We completed a retrospective cohort analysis of a nationally representative Medicare Advantage sample from 2022 to 2023.</p><p><strong>Methods: </strong>We compared precap rates of persistence to basal insulin in 2022 with postcap rates in 2023 using Persistence to Basal Insulin, a health plan performance measure used in Medicare Part D quality programs, among the study population and multiple subgroups.</p><p><strong>Results: </strong>A statistically significant increase (+1.3 percentage points; P < .001) was seen in overall patient persistence to basal insulin in the first year of the implementation of the insulin cost cap. Subgroup analyses showed greater increases in persistence in several subpopulations, including patients aged 45 to 54 and 65 to 74 years, male patients, non-Hispanic Black patients, and patients residing in certain census divisions, especially those with a high prevalence of type 2 diabetes.</p><p><strong>Conclusions: </strong>In addition to providing financial relief to Medicare patients, the implementation of the insulin cost cap was associated with an improvement in patients' treatment persistence to basal insulin therapy, a measure associated with positive health and economic outcomes. These results lend useful insight into future policy evaluations and proposals that seek to improve treatment access and address disparities in appropriate medication use.</p>","PeriodicalId":50808,"journal":{"name":"American Journal of Managed Care","volume":"32 6","pages":"e212-e216"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Associations between socioeconomic status, healthy lifestyle, and multimorbidity in the US.","authors":"Shifeng Wu","doi":"10.37765/ajmc.2026.89967","DOIUrl":"10.37765/ajmc.2026.89967","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationships between socioeconomic status (SES) and multimorbidity, which can inform public health strategies.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Methods: </strong>Data from participants in the National Health and Nutrition Examination Survey 2007-2018 were analyzed. Weighted multivariate logistic regression assessed associations between multimorbidity, SES, and healthy lifestyles. Subgroup analyses stratified by key covariates evaluated stratified risks. Sensitivity analyses verified result robustness.</p><p><strong>Results: </strong>After adjustment, compared with low-SES individuals, medium-SES individuals showed a significantly increased OR of multimorbidity (1.267; 95% CI, 1.079-1.489), whereas high-SES individuals exhibited a significantly decreased OR (0.723; 95% CI, 0.647-0.807). Healthy lifestyles exerted a protective effect, particularly within the medium-SES subgroup. Middle-aged non-Hispanic White women in the medium-SES group demonstrated elevated risk.</p><p><strong>Conclusions: </strong>Moderate SES is a critical risk factor for multimorbidity. Lifestyle interventions effectively reduce disease burden, particularly in middle-SES populations, with targeted protection needed for middle-aged non-Hispanic White women. Additionally, heightened vigilance is warranted regarding the expanding disease risks among young and middle-aged populations, alongside advocating for robust research initiatives to optimize evidence-based public health interventions.</p>","PeriodicalId":50808,"journal":{"name":"American Journal of Managed Care","volume":"32 Spec. No. 6","pages":"eSP22-eSP32"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Local implementation of the national opioid settlements: challenges and opportunities.","authors":"Alyssa Altstaedter, Amy Yeung, Dennis P Scanlon","doi":"10.37765/ajmc.2026.89943","DOIUrl":"10.37765/ajmc.2026.89943","url":null,"abstract":"<p><p>The opioid epidemic is a significant public health crisis in the US. The recent national opioid settlements have provided financial resources to abate the crisis; however, several questions have emerged regarding the administrative process of fund use, how Pennsylvania and external stakeholders are allocating the funds, what motivates them, what challenges they face, and what the future of the opioid crisis holds. To understand the firsthand experiences of various stakeholders involved in the national opioid settlement, 15 semistructured interviews were conducted via Zoom between July 2024 and October 2024. Interviews addressed comparisons to the tobacco settlement, administration and use of funds, barriers to program evaluation and implementation, and future directions for the opioid crisis. Key emergent themes included tensions between county and administrative stakeholder groups, challenges in applying the guidelines created by the national opioid settlement to community-level programs, and uncertainty about the future of opioid abatement. It is critical for administrative stakeholders to understand substance use disorder (SUD) treatment, prevention, and programming and to translate legal documents into applicable guidelines for public health professionals and community stakeholders. All stakeholders should continue education efforts to destigmatize people impacted by SUD. Providing local autonomy over spending funds is beneficial; however, the current administrative systems are not equipped to address the challenges that have arisen, underscoring the need for long-term, data-driven strategies to measure the impact of national opioid settlement dollars and ensure accountability.</p>","PeriodicalId":50808,"journal":{"name":"American Journal of Managed Care","volume":"32 Spec. No. 6","pages":"SP248-SP257"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manijeh Berenji, Michele Kowalski-McGraw, Larry Ozeran, Richard Schreiber
{"title":"AI cannot fix a broken claims paradigm.","authors":"Manijeh Berenji, Michele Kowalski-McGraw, Larry Ozeran, Richard Schreiber","doi":"10.37765/ajmc.2026.89958","DOIUrl":"https://doi.org/10.37765/ajmc.2026.89958","url":null,"abstract":"<p><p>We read with interest a feature article on AJMC.com, titled \"AI Seen as Key to Reducing Health Care Claim Denials, Survey Finds,\" that highlighted the anticipated impact of artificial intelligence (AI) on the claims process. According to Steinzor et al, claim denials are climbing due to data inaccuracies, staffing shortages, fragmented eligibility systems, and outdated technology, pushing providers to prioritize denial reduction. The authors asserted that economic pressures and declining collections are intensifying the demand for faster, cleaner claims processing. Although most providers believe AI can strengthen the claims life cycle, adoption generally remains low. The main concerns center around accuracy, compliance, and training. As policies and payer rules change, providers are forced to adjust, with some turning to AI-driven solutions in the hopes of stabilizing financial performance and streamlining operations. We assert that AI on its own cannot fix a broken claims paradigm.</p>","PeriodicalId":50808,"journal":{"name":"American Journal of Managed Care","volume":"32 6","pages":"e183-e184"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jason Bartock, Adam Green, Raquel Nahra, Amy Bordogna, Amir Davoodi, Jean-Sebastien Rachoin
{"title":"Association of travel nursing with quality outcomes in hospitalized patients.","authors":"Jason Bartock, Adam Green, Raquel Nahra, Amy Bordogna, Amir Davoodi, Jean-Sebastien Rachoin","doi":"10.37765/ajmc.2026.89960","DOIUrl":"https://doi.org/10.37765/ajmc.2026.89960","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of increased travel nursing on patient safety and infection outcomes.</p><p><strong>Study design: </strong>Retrospective analysis of staffing data from a large tertiary center (2019-2023).</p><p><strong>Methods: </strong>We examined associations between nurse staffing ratios, agency nurse use, hospital-acquired infections, and patient safety indicators (PSIs) using Spearman correlations, analysis of variance, and regression analyses.</p><p><strong>Results: </strong>Agency nursing shifts rose sharply from 70.9 per month (0.9% of shifts) in 2019 to 1206 per month (12.7%) in 2023 across inpatient units and the emergency department. Over that same period, PSI events increased from 7.1 to 9.3 per month, and total infections rose from 15.8 to 20.5 per month. Hospital-wide, greater reliance on agency nurses correlated with more pressure ulcers (PSI 03), postoperative acute kidney injury requiring dialysis (PSI 10), ventilator-associated pneumonia (VAP), total PSIs, and total infections. In critical care units, higher agency staffing was specifically linked to increased VAP, Clostridioides difficile infections, and overall infections. When agency nurses accounted for more than 10% of the workforce, there was an independent association with a higher number of PSIs, although not with infections.</p><p><strong>Conclusions: </strong>Rising dependence on agency nurses coincided with increased patient safety events and selected infections. Although confounding factors may contribute to this association, these findings emphasize the need for structured integration, orientation, and monitoring of temporary staff to ensure patient safety while addressing workforce shortages.</p>","PeriodicalId":50808,"journal":{"name":"American Journal of Managed Care","volume":"32 6","pages":"e192-e197"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reducing GLP-1 prior authorization friction: a managed care playbook.","authors":"Aayush Sisodia","doi":"10.37765/ajmc.2026.89957","DOIUrl":"https://doi.org/10.37765/ajmc.2026.89957","url":null,"abstract":"<p><p>High-cost glucagon-like peptide-1 therapies force payers to balance access and affordability, but many delays and abandonment events are driven less by coverage policy than by avoidable utilization management (UM) friction inside the prior authorization (PA) workflow. This article proposes a practical, reproducible PA Friction Index that payers and pharmacy benefit managers can calculate from existing UM and claims metadata to identify where friction concentrates, monitor equity-sensitive effects, and prioritize fixes that improve time-to-start metrics without loosening clinical safeguards. This commentary outlines the index's domains and measurable signals, describes where automation helps vs harms (and the guardrails needed), and provides a 90-day implementation checklist focused on standardizing criteria, expanding electronic PA, reducing rework, and continuously monitoring outcomes such as time to decision, abandonment, and appeals.</p>","PeriodicalId":50808,"journal":{"name":"American Journal of Managed Care","volume":"32 6","pages":"e179-e182"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What do we do with these prices? ushering in the next phase of price transparency innovation in Medicare Advantage.","authors":"Pooja Chandrashekar, Sachin H Jain","doi":"10.37765/ajmc.2026.89973","DOIUrl":"10.37765/ajmc.2026.89973","url":null,"abstract":"<p><p>The problem is not that price transparency itself has failed, but rather that policy makers have focused their efforts on the wrong place.</p>","PeriodicalId":50808,"journal":{"name":"American Journal of Managed Care","volume":"32 Spec. No. 6","pages":"eSP9-eSP11"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}