American Journal of Medicine最新文献_第8页

Trust and Value in AI-Driven Medicine. 人工智能医学中的信任与价值。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-06-05 DOI: 10.1016/j.amjmed.2025.06.001

Ruchi Bhatia

引用次数: 0

A Call for Health Care Providers to Address Faith, Religiosity, and Spirituality among Older Adults. 呼吁医疗保健提供者解决老年人的信仰、宗教信仰和灵性问题。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-06-04 DOI: 10.1016/j.amjmed.2025.05.048

Hawa O Abu

引用次数: 0

Physician Mental Health: Understanding Physician Burnout and Solutions for Well-Being. 医生心理健康：了解医生的倦怠和健康的解决方案。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-06-04 DOI: 10.1016/j.amjmed.2025.05.039

Diana Hsiao, Adithi A Tirumalai, Justina John, Sohum Sheth, Beth Frates, Dean Ornish, Monica Aggarwal

引用次数: 0

The Performance of Biomarkers for the Diagnosis of Parkinson Disease: A Systematic Review. 生物标志物在帕金森病诊断中的作用：系统综述。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-06-03 DOI: 10.1016/j.amjmed.2025.05.047

Jaden Lim, Yeonglong Ay

{"title":"The Performance of Biomarkers for the Diagnosis of Parkinson Disease: A Systematic Review.","authors":"Jaden Lim, Yeonglong Ay","doi":"10.1016/j.amjmed.2025.05.047","DOIUrl":"10.1016/j.amjmed.2025.05.047","url":null,"abstract":"Background: Early diagnosis of Parkinson disease remains challenging due to the current clinical diagnostic approach. With machine learning emerging as a powerful tool for biomarker discovery, we aimed to determine whether biomarkers processed by machine learning models can enable earlier detection of Parkinson disease.Methods: We conducted a literature search with a 10-year limit that yielded 161 biomarkers derived from serum, cerebrospinal fluid, and genes. Initially, biomarkers were classified into 4 groups according to the biological timeline of Parkinson disease pathogenesis. Subsequently, we further organized the biomarkers into 2 categories: pre-motor phase and motor phase biomarkers. Two analyses were then conducted according to the aforementioned classifications, with the performance of biomarkers evaluated via their area under the curve values as derived from machine learning models.Results: No significant differences were found in either analysis, suggesting that all biomarkers, regardless of their role in the biological sequences underpinning Parkinson disease pathogenesis, and their association with the pre-motor or motor phases of Parkinson disease, have the potential to serve as equally valid diagnostic predictors. Additionally, we identified 26 top-performing biomarkers with high area under the curve values (>0.8).Conclusions: The main finding in our analyses was that pre-motor phase biomarkers, which offer the advantage of enabling an earlier diagnosis compared with clinical methods, can achieve a comparably high level of diagnostic accuracy as motor phase biomarkers. Therefore, our foremost suggestion is further research into the clinical viability of pre-motor phase biomarkers that compose part of the aforementioned 26 top-performing biomarkers.","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dexterity and Bimanual Coordination, Cognitive Function, and Mental and Cognitive Well-Being in People with Young Onset Dementia: A Case-Control Study. 灵巧性和双手协调、认知功能、精神和认知健康与年轻痴呆患者：一项病例对照研究。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-06-03 DOI: 10.1016/j.amjmed.2025.05.034

Ethan C J Berry, Nilihan E M Sanal-Hayes, Nicholas F Sculthorpe, Sowmya Munishankar, Debbie Tolson, Lawrence D Hayes

{"title":"Dexterity and Bimanual Coordination, Cognitive Function, and Mental and Cognitive Well-Being in People with Young Onset Dementia: A Case-Control Study.","authors":"Ethan C J Berry, Nilihan E M Sanal-Hayes, Nicholas F Sculthorpe, Sowmya Munishankar, Debbie Tolson, Lawrence D Hayes","doi":"10.1016/j.amjmed.2025.05.034","DOIUrl":"10.1016/j.amjmed.2025.05.034","url":null,"abstract":"Background: Dexterity and bimanual coordination, cognitive function, and mental and cognitive well-being have not been previously examined in people with young onset dementia. Therefore, this study examined dexterity and bimanual coordination, cognitive function, and mental and cognitive well-being in people with young onset dementia (n = 16), and age-matched healthy controls (n = 17).Methods: Both groups completed the Purdue Pegboard Test (dexterity and bimanual coordination), Addenbrooke's Cognitive Examination III (cognitive function), General Anxiety Disorder-7 (general anxiety), Generic health-related quality of life measures (overall health), General Self-Efficacy Scale (self-efficacy), Patient Health Questionnaire (depression), and The Pittsburgh Sleep Quality Index (sleep quality).Results: The main findings of the present investigation were that people with young onset dementia displayed poorer dexterity and bimanual coordination, generic health-related quality of life analogue, and generic self-efficacy compared with age-matched healthy controls. However, people with young onset dementia and age-matched healthy controls were comparable for anxiety, depression, generic health-related quality of life index, and sleep quality index.Conclusions: This study highlights differences in dexterity and bimanual coordination, quality of life, and self-efficacy between people with young onset dementia and controls. People with young onset dementia exhibited poorer dexterity, generic health-related quality of life analogue, and self-efficacy. The study highlights the potential impacts of young onset dementia on dexterity, health-related quality of life, and self-efficacy. More longitudinal research is needed to assess the time course of this impact and explore support strategies.","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep Quality and Outcomes in Preclinical Heart Failure: A Prospective UK Biobank Cohort Study. 临床前心力衰竭的睡眠质量和预后：一项前瞻性英国生物银行队列研究。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-06-02 DOI: 10.1016/j.amjmed.2025.05.037

Fang Zhu, Joseph J Shearer, Jungnam Joo, Rui Miao, Jason Y Y Wong, Gabriel Goodney, Jungeun Lim, Maryam Hashemian, Gretell Henríquez-Santos, Ji-Eun Kim, Sadiya S Khan, Philip Greenland, Véronique L Roger

{"title":"Sleep Quality and Outcomes in Preclinical Heart Failure: A Prospective UK Biobank Cohort Study.","authors":"Fang Zhu, Joseph J Shearer, Jungnam Joo, Rui Miao, Jason Y Y Wong, Gabriel Goodney, Jungeun Lim, Maryam Hashemian, Gretell Henríquez-Santos, Ji-Eun Kim, Sadiya S Khan, Philip Greenland, Véronique L Roger","doi":"10.1016/j.amjmed.2025.05.037","DOIUrl":"10.1016/j.amjmed.2025.05.037","url":null,"abstract":"Background: Prevention is crucial in reducing heart failure (HF) morbidity and mortality. The American Heart Association guideline emphasizes the progression from preclinical to clinical HF, yet the association between sleep and outcomes in preclinical HF remains unexplored. Our objective was to examine sleep quality in a large cohort of preclinical HF, and assess its association with clinical HF and mortality risk.Methods: Using UK Biobank data from 2006-2010, we identified individuals with preclinical HF (Stage A/B). We examined self-reported sleep characteristics (duration, chronotype, insomnia, snoring, daytime sleepiness) individually and combined into a sleep quality score. Participants were followed until 2021 for clinical HF (Stage C/D) or death. Cox proportional hazard models assessed the relationship between sleep quality and clinical HF or mortality, accounting for competing risks. Interaction effects among sleep, sex, and deprivation were explored.Results: Among 311,446 preclinical HF participants (mean age 57.5 years, 49% men), sleep quality was categorized as healthy (35%), intermediate (60%), and poor (5%). Over a median 12-year follow-up, 10,780 clinical HF events and 24,996 deaths occurred. Poor sleep quality was associated with a higher risk of clinical HF (hazard ratio 2.03; 95% confidence interval, 1.79-2.31 in women; hazard ratio 1.55; 95% confidence interval, 1.41-1.71 in men). Deprivation was associated with higher HF risk across all sleep categories (P < .01).Conclusions: Low-quality sleep was prevalent and associated with a higher risk of clinical HF and death, especially in women. Deprivation was linked to worse outcomes in both sexes. These findings highlight an opportunity to improve preclinical HF outcomes by addressing sleep quality.","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Cancer and Anti-Synthetase Syndrome: A Retrospective Multicenter Study. 癌症与抗合成酶综合征的关系：一项回顾性多中心研究。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-06-01 DOI: 10.1016/j.amjmed.2025.05.042

Laura Bucy, Hervé Devilliers, Paul Decker, Florian Manneville, Bernard Bonnotte, Bruno Ribeiro Baptista, Anne Guillaumot, Philippe Bonniaud, Jean Francis Maillefert, Alain Meyer, Amelie Servettaz, Julien Campagne, Nadine Magy-Bertrand, Roland Jaussaud, Thomas Moulinet

{"title":"Association of Cancer and Anti-Synthetase Syndrome: A Retrospective Multicenter Study.","authors":"Laura Bucy, Hervé Devilliers, Paul Decker, Florian Manneville, Bernard Bonnotte, Bruno Ribeiro Baptista, Anne Guillaumot, Philippe Bonniaud, Jean Francis Maillefert, Alain Meyer, Amelie Servettaz, Julien Campagne, Nadine Magy-Bertrand, Roland Jaussaud, Thomas Moulinet","doi":"10.1016/j.amjmed.2025.05.042","DOIUrl":"10.1016/j.amjmed.2025.05.042","url":null,"abstract":"Objectives: We aimed to assess the incidence of cancer-associated myositis among patients with anti-synthetase syndrome, identify factors associated with cancer-associated myositis, and assess its impact on prognosis.Methods: We conducted a retrospective multicenter study, including adult patients with anti-synthetase syndrome. Factors associated with cancer were assessed using a multivariable logistic regression model. Unsupervised analysis was used to identify a cluster of patients associated with cancer. Cox proportional hazard ratio model was used to assess impact of cancer-associated myositis on mortality.Results: Among the 122 patients included, 14 (11.4%) met cancer-associated myositis criteria. Standardized incidence ratio was 5.4 (5.14 to 5.65, P < .0001). Patients with cancer-associated myositis were older, more often had a history of cancer, and had lower creatine kinase level and less muscular weakness. They had a significantly worse overall survival compared with those without (log-rank test χ2 = 16.2, P < .0001). Age and history of cancer were independently associated with cancer-associated myositis. Patients with cancer-associated myositis segregated within a cluster characterized by an older age, a milder muscular involvement, and less Jo-1 antibodies. Finally, cancer-associated myositis was an independent predictor of death.Conclusion: Cancer-associated myositis is not rare in anti-synthetase syndrome, with higher incidence compared with the general population. Due to its higher mortality, cancer should be carefully screened, especially in older patients with history of cancer.","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin Deep: A Narrative Case Series and Review of Cutaneous Vasculitis and Possible Doppelgängers. 皮肤深层：皮肤血管炎和可能的叙述性病例系列和回顾Doppelgängers。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-05-31 DOI: 10.1016/j.amjmed.2025.05.043

Gabriel Kirsch, Cristine Arcilla, Maya Khasho, Gurjit S Kaeley

引用次数: 0

Malignant Pleural Effusion as a Presentation of Recurrent Penile Squamous Cell Carcinoma. 恶性胸腔积液是复发性阴茎鳞状细胞癌的表现。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-05-30 DOI: 10.1016/j.amjmed.2025.05.041

Eamon P McCarron, Joanne Jooste, Aisling Fegan, Jenson Daniel, Darren Brady, Jason Wieboldt

引用次数: 0

Isolated Diabetic Third Cranial Palsy with MRI Enhancement. 孤立性糖尿病第三脑瘫的MRI增强。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-05-30 DOI: 10.1016/j.amjmed.2025.05.040

Amlan Kusum Datta, Anirban Majhi

引用次数: 0