Annals of Human Biology最新文献_第7页

Identification of mitophagy and ferroptosis-related hub genes associated with intracerebral haemorrhage through bioinformatics analysis. 通过生物信息学分析鉴定与脑内出血相关的有丝分裂和铁突变相关的枢纽基因。

IF 1.7 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-06-12 DOI: 10.1080/03014460.2024.2334719

Yan Wang, Rufeng Wang, Jianzhong Zhu, Ling Chen

{"title":"Identification of mitophagy and ferroptosis-related hub genes associated with intracerebral haemorrhage through bioinformatics analysis.","authors":"Yan Wang, Rufeng Wang, Jianzhong Zhu, Ling Chen","doi":"10.1080/03014460.2024.2334719","DOIUrl":"https://doi.org/10.1080/03014460.2024.2334719","url":null,"abstract":"Background: Mitophagy and ferroptosis occur in intracerebral haemorrhage (ICH) but our understanding of mitophagy and ferroptosis-related genes remains incomplete.Aim: This study aims to identify shared ICH genes for both processes.Methods: ICH differentially expressed mitophagy and ferroptosis-related genes (DEMFRGs) were sourced from the GEO database and literature. Enrichment analysis elucidated functions. Hub genes were selected via STRING, MCODE, and MCC algorithms in Cytoscape. miRNAs targeting hubs were predicted using miRWalk 3.0, forming a miRNA-hub gene network. Immune microenvironment variances were assessed with MCP and TIMER. Potential small molecules for ICH were forecasted via CMap database.Results: 64 DEMFRGs and ten hub genes potentially involved in various processes like ferroptosis, TNF signalling pathway, MAPK signalling pathway, and NF-kappa B signalling pathway were discovered. Several miRNAs were identified as shared targets of hub genes. The ICH group showed increased infiltration of monocytic lineage and myeloid dendritic cells compared to the Healthy group. Ten potential small molecule drugs (e.g. Zebularine, TWS-119, CG-930) were predicted via CMap.Conclusion: Several shared genes between mitophagy and ferroptosis potentially drive ICH progression via TNF, MAPK, and NF-kappa B pathways. These results offer valuable insights for further exploring the connection between mitophagy, ferroptosis, and ICH.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"51 1","pages":"2334719"},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characterisation of sickle cell disease and classification of major haplotypes associated with the β-globin cluster (HBB gene) by means of SNP marker sequencing in a group of samples from Bolívar, Colombia. 通过对哥伦比亚玻利瓦尔的一组样本进行 SNP 标记测序，确定镰状细胞病的分子特征，并对与β-球蛋白簇（HBB 基因）相关的主要单倍型进行分类。

IF 1.7 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-02-20 DOI: 10.1080/03014460.2024.2308714

Marcela Díaz-Matallana, Ignacio Briceño, Escilda Benavides-Benítez, Jaime E Bernal, Julio C Martínez-Lozano

{"title":"Molecular characterisation of sickle cell disease and classification of major haplotypes associated with the β-globin cluster (HBB gene) by means of SNP marker sequencing in a group of samples from Bolívar, Colombia.","authors":"Marcela Díaz-Matallana, Ignacio Briceño, Escilda Benavides-Benítez, Jaime E Bernal, Julio C Martínez-Lozano","doi":"10.1080/03014460.2024.2308714","DOIUrl":"10.1080/03014460.2024.2308714","url":null,"abstract":"Background: Colombia has a mestizo population and the prevalence of haemoglobin variants varies according to each region, but heterozygous carriers can be found in all of them.Aim: To characterise sickle cell disease (SCD) haematologically, biochemically, and molecularly, and detect classic haplotypes by DNA sequencing in a group of samples from Bolívar, Colombia.Subjects and methods: Blood samples were collected after informed consent from volunteers from eight communities in the Bolívar department, plus samples from the Pacific region, Providencia Island, and Bogotá were included. Data were obtained from: (1) haematological analyses; (2) biochemical tests: dHPLC was used to determine haemoglobin (Hb); and (3) DNA sequencing data through five SNPs.Results: 101 samples were identified by rs334 through Sanger's Sequencing, structural haemoglobinopathies HbAS (34.65%), HbSS (2.97%) and HbAC (1.98%) were found. When contrasting the Hb identification results between SNP rs334 Vs. dHPLC/Isoelectric Focusing (IEF), a coincidence was found in 39/43 samples analysed, therefore, when comparing these techniques, a significant correlation was found (Pearson's correlation coefficient r = 0.998). 26 samples previously analysed by rs334 were classified into classical haplotypes CAR (50.0%), BEN (30.76%), CAM (7.69%), SEN (3.84%), and ATP-I (7.69%).Conclusions: SCD characterisation and SNPs-based classification through Sanger's DNA sequencing have not been performed before in Colombia. The results of this work will make it possible to expand the data or records of carriers and those affected, which will benefit patients and their families.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"51 1","pages":"2308714"},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139914007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Professor Donald A. Bailey Jan 5^th 1934 to June 3^rd 2023. 唐纳德-贝利（Donald A. Bailey）教授，1934 年 1 月 5 日至 2023 年 6 月 3 日。

IF 1.7 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-06-07 DOI: 10.1080/03014460.2024.2356950

Adam D G Baxter-Jones

引用次数: 0

Cross-sectional associations between patterns of cultural engagement and indicators of biological dysregulation. 文化参与模式与生物失调指标之间的横截面关联。

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-09-25 DOI: 10.1080/03014460.2024.2399276

Emma S Walker, Daisy Fancourt, Meena Kumari, Anne McMunn

{"title":"Cross-sectional associations between patterns of cultural engagement and indicators of biological dysregulation.","authors":"Emma S Walker, Daisy Fancourt, Meena Kumari, Anne McMunn","doi":"10.1080/03014460.2024.2399276","DOIUrl":"https://doi.org/10.1080/03014460.2024.2399276","url":null,"abstract":"Background: Research has shown that cultural activities may bring about improved health. However, large-scale quantitative analyses on cultural engagement and biomarkers are lacking to date. As a result, the mechanisms through which cultural activities may be associated with health are unclear.Aim: Test quantitative associations between cultural engagement pattern (including active and passive engagement in arts, sports, and heritage activities) and indicators of biological dysregulation in a large dataset.Subjects and methods: Understanding Society data were used to conduct cross-sectional linear regression analyses between a data-driven latent class model of cultural engagement and indicators of anthropometric, cardiovascular, metabolic, immune, and neuroendocrine function. Analyses were adjusted for age, gender, ethnicity, childcare responsibility, urbanicity, leisure time satisfaction, capacity-related factors, socioeconomic position, social and economic capital indicators, physical activity, and medication use.Results: More culturally participants had better indicators of biological health, such as lower waist circumference and fibrinogen blood concentration. Specific associations between cultural engagement pattern and the different biological outcomes were also observed. The associations were explained in part by correlated factors (accounting for around half of the association).Conclusions: Cultural engagement is cross-sectionally associated with biomarkers, although the characteristics of people who engage with culture are an important consideration when interpreting these findings.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"51 1","pages":"2399276"},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "new systems for dental maturity based on seven and four teeth" Demirjian and Goldstein, Annals of Human Biology, 1976,3,411-421. 对 "基于七齿和四齿的牙齿成熟新系统 "的评论，Demirjian 和 Goldstein，《人类生物学年鉴》，1976 年，3,411-421。

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-10-08 DOI: 10.1080/03014460.2024.2401026

Helen M Liversidge

引用次数: 0

Exploring biomarkers of Alzheimer's disease based on multi-omics and Mendelian randomisation analysis. 基于多组学和孟德尔随机分析探索阿尔茨海默病的生物标志物。

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-11-07 DOI: 10.1080/03014460.2024.2415035

Kun Tu, Wenhui Zhou, Shubing Kong

{"title":"Exploring biomarkers of Alzheimer's disease based on multi-omics and Mendelian randomisation analysis.","authors":"Kun Tu, Wenhui Zhou, Shubing Kong","doi":"10.1080/03014460.2024.2415035","DOIUrl":"https://doi.org/10.1080/03014460.2024.2415035","url":null,"abstract":"Background: Alzheimer's disease (AD) is an irreversible neurodegenerative disorder with no fully curative treatment.Aim: This study aims to identify effective biomarkers for AD diagnosis and treatment by combining multi-omics and Mendelian randomisation (MR) analyses.Subjects and methods: Positron emission tomography (PET), single nucleotide polymorphism (SNP), and gene expression data of AD patients using advanced correlation analysis methods (AdaSMCCA, rAdaSMCCA, and unAdaSMCCA algorithms) are integrated.Results: Several regions of interest, risk SNP sites, and risk genes associated with AD are identified. Expression quantitative trait loci (eQTL) for the top 100 risk genes are retrieved from public datasets. A two-sample MR analysis using genome-wide association study (GWAS) data reveals two genes (FAM117A and ACSL1) causally related to AD. Additionally, single-cell transcriptome (scRNA-seq) data from AD samples are analysed to identify high-scoring cell clusters and their interactions.Conclusions: The identified multi-omics biomarkers and genes causally related to AD could inform clinical diagnosis and treatment.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"51 1","pages":"2415035"},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paediatric dominant and non-dominant handgrip reference curves and the association with body composition 儿科优势和非优势手握参考曲线以及与身体成分的关系

IF 1.7 4区医学

Annals of Human Biology Pub Date : 2024-01-22 DOI: 10.1080/03014460.2023.2298474

Catherine M. Avitabile, David R. Weber, Babette S. Zemel

引用次数: 0

Linking infant size and early growth with maternal lifestyle and breastfeeding - the first year of life in the CRIBS cohort. 将婴儿的大小和早期成长与母亲的生活方式和母乳喂养联系起来——在CRIBS队列中第一年的生活。

IF 1.7 4区医学

Annals of Human Biology Pub Date : 2023-02-01 DOI: 10.1080/03014460.2023.2224058

Jelena Šarac, Dubravka Havaš Auguštin, Iva Šunić, Mario Lovrić, Natalija Novokmet, Sanja Musić Milanović, Lawrence M Schell, Saša Missoni

{"title":"Linking infant size and early growth with maternal lifestyle and breastfeeding - the first year of life in the CRIBS cohort.","authors":"Jelena Šarac, Dubravka Havaš Auguštin, Iva Šunić, Mario Lovrić, Natalija Novokmet, Sanja Musić Milanović, Lawrence M Schell, Saša Missoni","doi":"10.1080/03014460.2023.2224058","DOIUrl":"https://doi.org/10.1080/03014460.2023.2224058","url":null,"abstract":"Background: Every third child in Croatia is classed as overweight or obese. Infant growth can represent early warning signs for obesity.Aim: To detect early risk factors for obesity by investigating infant size and early growth trajectories and their association with maternal lifestyle and breastfeeding.Subjects and methods: Ninety-eight mother-child pairs from the Croatian Islands' Birth Cohort Study (CRIBS) cohort were included in the study. Data were collected from questionnaires and medical records. Growth data were converted to Z-scores using World Health Organisation (WHO) standards and used as the primary outcome.Results: Z-score trajectories in the first year of life were in line with WHO standards. A direct link between infant size and maternal socioeconomic status (SES) or breastfeeding was not detected. However, child weight gain in the first 6 months was associated with maternal body mass index (BMI) before pregnancy (p < 0.01). A positive association was also established between breastfeeding and maternal SES and mothers that report an unhealthy diet have heavier children (p < 0.05, respectively).Conclusion: Infant size and early growth in Croatia is in line with WHO standards and risk factors for obesity development were detectable in the first year of life, but not highly pronounced. However, more effective BMI monitoring and promotion of a healthy diet and lifestyle of women before and during pregnancy is needed.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"50 1","pages":"332-340"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10192746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Time to treat the climate and nature crisis as one indivisible global health emergency. 是时候将气候和自然危机视为一个不可分割的全球卫生紧急事件了。

IF 1.7 4区医学

Annals of Human Biology Pub Date : 2023-02-01 Epub Date: 2023-11-07 DOI: 10.1080/03014460.2023.2276516

Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Gregory E Erhabor, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski

引用次数: 0

Bioarchaeological study of ancient Teotihuacans based on complete mitochondrial genome sequences and diet isotopes. 基于线粒体全基因组序列和饮食同位素的古代特奥替华Can的生物考古学研究。

IF 1.7 4区医学

Annals of Human Biology Pub Date : 2023-02-01 Epub Date: 2023-10-09 DOI: 10.1080/03014460.2023.2261844

Fuzuki Mizuno, Fuyuki Tokanai, Masahiko Kumagai, Koji Ishiya, Saburo Sugiyama, Michiko Hayashi, Kunihiko Kurosaki, Shintaroh Ueda

{"title":"Bioarchaeological study of ancient Teotihuacans based on complete mitochondrial genome sequences and diet isotopes.","authors":"Fuzuki Mizuno, Fuyuki Tokanai, Masahiko Kumagai, Koji Ishiya, Saburo Sugiyama, Michiko Hayashi, Kunihiko Kurosaki, Shintaroh Ueda","doi":"10.1080/03014460.2023.2261844","DOIUrl":"10.1080/03014460.2023.2261844","url":null,"abstract":"Background: The Teotihuacan civilisation was the largest one in ancient Mesoamerica. The Teotihuacan city was born in the north-eastern Basin of Mexico around the second century BC, reached its peak in the fourth century AD, and had cultural influence throughout Mesoamerica. At its peak, the size of the city reached more than 20 km2, and the total population is estimated to have increased from 100,000 to 200,000. However, knowledge of the genetic background of the Teotihuacan people is still limited.Aim: We aimed to determine the mitogenome sequences of the Teotihuacan human remains and compare the ancient and present Mesoamericans. In addition, we aimed to identify the food habits of ancient Teotihuacans.Subjects and methods: We determined the mitogenome sequences of human remains dated to 250-636 cal AD using target enrichment-coupled next generation sequencing. We also performed stable isotope analysis.Results: We successfully obtained nearly full-length sequences newly unearthed from a civilian dwelling in the Teotihuacan site. Teotihuacan mitochondrial DNA was classified into the haplogroups in present and ancient Mesoamericans. In addition, Teotihuacan individuals had a diet dependent on C4 plants such as maize.Conclusion: Genetic diversity varied among the Teotihuacans.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"50 1","pages":"390-398"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0