Evan J Giangrande, Ramona S Weber, Eric Turkheimer
{"title":"What Do We Know About the Genetic Architecture of Psychopathology?","authors":"Evan J Giangrande, Ramona S Weber, Eric Turkheimer","doi":"10.1146/annurev-clinpsy-081219-091234","DOIUrl":"https://doi.org/10.1146/annurev-clinpsy-081219-091234","url":null,"abstract":"<p><p>In the second half of the twentieth century, twin and family studies established beyond a reasonable doubt that all forms of psychopathology are substantially heritable and highly polygenic. These conclusions were simultaneously an important theoretical advance and a difficult methodological obstacle, as it became clear that heritability is universal and undifferentiated across forms of psychopathology, and the radical polygenicity of genetic effects limits the biological insight provided by genetically informed studies at the phenotypic level. The paradigm-shifting revolution brought on by the Human Genome Project has recapitulated the great methodological promise and the profound theoretical difficulties of the twin study era. We review these issues using the rubric of genetic architecture, which we define as a search for specific genetic insight that adds to the general conclusion that psychopathology is heritable and polygenic. Although significant problems remain, we see many promising avenues for progress.</p>","PeriodicalId":50755,"journal":{"name":"Annual Review of Clinical Psychology","volume":null,"pages":null},"PeriodicalIF":18.4,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39660842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Differences/Disorders of Sex Development: Medical Conditions at the Intersection of Sex and Gender.","authors":"David E Sandberg, Melissa Gardner","doi":"10.1146/annurev-clinpsy-081219-101412","DOIUrl":"https://doi.org/10.1146/annurev-clinpsy-081219-101412","url":null,"abstract":"<p><p>Defined as congenital conditions in which development of chromosomal, gonadal, or anatomic sex is atypical, differences or disorders of sex development (DSDs) comprise many discrete diagnoses ranging from those associated with few phenotypic differences between affected and unaffected individuals to those where questions arise regarding gender of rearing, gonadal tumor risk, genital surgery, and fertility. Controversies exist in numerous areas including how DSDs are conceptualized, how to refer to the set of conditions and those affected by them, and aspects of clinical management that extend from social media to legislative bodies, courts of law, medicine, clinical practice, and scholarly research in psychology and sociology. In addition to these aspects, this review covers biological and social influences on psychosocial development and adjustment, the psychosocial and psychosexual adaptation of people born with DSDs, and roles for clinical psychologists in the clinical management of DSDs.</p>","PeriodicalId":50755,"journal":{"name":"Annual Review of Clinical Psychology","volume":null,"pages":null},"PeriodicalIF":18.4,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170864/pdf/nihms-1893840.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9432859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincent Taschereau-Dumouchel, Cody A Cushing, Hakwan Lau
{"title":"Real-Time Functional MRI in the Treatment of Mental Health Disorders.","authors":"Vincent Taschereau-Dumouchel, Cody A Cushing, Hakwan Lau","doi":"10.1146/annurev-clinpsy-072220-014550","DOIUrl":"https://doi.org/10.1146/annurev-clinpsy-072220-014550","url":null,"abstract":"<p><p>Multiple mental disorders have been associated with dysregulation of precise brain processes. However, few therapeutic approaches can correct such specific patterns of brain activity. Since the late 1960s and early 1970s, many researchers have hoped that this feat could be achieved by closed-loop brain imaging approaches, such as neurofeedback, that aim to modulate brain activity directly. However, neurofeedback never gained mainstream acceptance in mental health, in part due to methodological considerations. In this review, we argue that, when contemporary methodological guidelines are followed, neurofeedback is one of the few intervention methods in psychology that can be assessed in double-blind placebo-controlled trials. Furthermore, using new advances in machine learning and statistics, it is now possible to target very precise patterns of brain activity for therapeutic purposes. We review the recent literature in functional magnetic resonance imaging neurofeedback and discuss current and future applications to mental health.</p>","PeriodicalId":50755,"journal":{"name":"Annual Review of Clinical Psychology","volume":null,"pages":null},"PeriodicalIF":18.4,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39847353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amanda L Baker, Erin Forbes, Sonja Pohlman, Kristen McCarter
{"title":"Behavioral Interventions to Reduce Cardiovascular Risk Among People with Severe Mental Disorder.","authors":"Amanda L Baker, Erin Forbes, Sonja Pohlman, Kristen McCarter","doi":"10.1146/annurev-clinpsy-072720-012042","DOIUrl":"https://doi.org/10.1146/annurev-clinpsy-072720-012042","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) is the leading cause of death among people with severe mental disorder (SMD). CVD risk factors occur at the individual, health system, and socio-environmental levels and contribute not only to high rates of CVD but also to worsening mental health. While acknowledging this wider context, this review focuses on behavioral interventions for seven CVD risk behaviors-smoking, physical inactivity, excessive alcohol consumption, low fruit and vegetable intake, inadequate sleep, poor social participation, and poor medication adherence-that are common among people with SMD. We survey recent meta-reviews of the literature and then review additional key studies to provide clinical recommendations for behavioral interventions to reduce CVD risk among people with SMD. A transdiagnostic psychological approach from the start of mental health treatment, drawing upon multidisciplinary expertise to address multiple risk behaviors, is recommended.</p>","PeriodicalId":50755,"journal":{"name":"Annual Review of Clinical Psychology","volume":null,"pages":null},"PeriodicalIF":18.4,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39931698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Measurement-Based and Data-Informed Psychological Therapy.","authors":"Wolfgang Lutz, Brian Schwartz, Jaime Delgadillo","doi":"10.1146/annurev-clinpsy-071720-014821","DOIUrl":"https://doi.org/10.1146/annurev-clinpsy-071720-014821","url":null,"abstract":"<p><p>Outcome measurement in the field of psychotherapy has developed considerably in the last decade. This review discusses key issues related to outcome measurement, modeling, and implementation of data-informed and measurement-based psychological therapy. First, an overview is provided, covering the rationale of outcome measurement by acknowledging some of the limitations of clinical judgment. Second, different models of outcome measurement are discussed, including pre-post, session-by-session, and higher-resolution intensive outcome assessments. Third, important concepts related to modeling patterns of change are addressed, including early response, dose-response, and nonlinear change. Furthermore, rational and empirical decision tools are discussed as the foundation for measurement-based therapy. Fourth, examples of clinical applications are presented, which show great promise to support the personalization of therapy and to prevent treatment failure. Finally, we build on continuous outcome measurement as the basis for a broader understanding of clinical concepts and data-driven clinical practice in the future.</p>","PeriodicalId":50755,"journal":{"name":"Annual Review of Clinical Psychology","volume":null,"pages":null},"PeriodicalIF":18.4,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39727556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kirk I Erickson, Shannon D Donofry, Kelsey R Sewell, Belinda M Brown, Chelsea M Stillman
{"title":"Cognitive Aging and the Promise of Physical Activity.","authors":"Kirk I Erickson, Shannon D Donofry, Kelsey R Sewell, Belinda M Brown, Chelsea M Stillman","doi":"10.1146/annurev-clinpsy-072720-014213","DOIUrl":"https://doi.org/10.1146/annurev-clinpsy-072720-014213","url":null,"abstract":"<p><p>Is the field of cognitive aging irretrievably concerned with decline and deficits, or is it shifting to emphasize the hope of preservation and enhancement of cognitive function in late life? A fragment of an answer comes from research attempting to understand the reasons for individual variability in the extent and rate of cognitive decline. This body of work has created a sense of optimism based on evidence that there are some health behaviors that amplify cognitive performance or mitigate the rate of age-related cognitive decline. In this context, we discuss the role of physical activity on neurocognitive function in late adulthood and summarize how it can be conceptualized as a constructive approach both for the maintenance of cognitive function and as a therapeutic for enhancing or optimizing cognitive function in late life. In this way, physical activity research can be used to shape perceptions of cognitive aging.</p>","PeriodicalId":50755,"journal":{"name":"Annual Review of Clinical Psychology","volume":null,"pages":null},"PeriodicalIF":18.4,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9219462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dylan G Gee, Kathryn A DeYoung, Katie A McLaughlin, Rachael M Tillman, Deanna M Barch, Erika E Forbes, Robert F Krueger, Timothy J Strauman, Mariann R Weierich, Alexander J Shackman
{"title":"Training the Next Generation of Clinical Psychological Scientists: A Data-Driven Call to Action.","authors":"Dylan G Gee, Kathryn A DeYoung, Katie A McLaughlin, Rachael M Tillman, Deanna M Barch, Erika E Forbes, Robert F Krueger, Timothy J Strauman, Mariann R Weierich, Alexander J Shackman","doi":"10.1146/annurev-clinpsy-081219-092500","DOIUrl":"https://doi.org/10.1146/annurev-clinpsy-081219-092500","url":null,"abstract":"<p><p>The central goal of clinical psychology is to reduce the suffering caused by mental health conditions. Anxiety, mood, psychosis, substance use, personality, and other mental disorders impose an immense burden on global public health and the economy. Tackling this burden will require the development and dissemination of intervention strategies that are more effective, sustainable, and equitable. Clinical psychology is uniquely poised to serve as a transdisciplinary hub for this work. But rising to this challengerequires an honest reckoning with the strengths and weaknesses of current training practices. Building on new data, we identify the most important challenges to training the next generation of clinical scientists. We provide specific recommendations for the full spectrum of stakeholders-from funders, accreditors, and universities to program directors, faculty, and students-with an emphasis on sustainable solutions that promote scientific rigor and discovery and enhance the mental health of clinical scientists and the public alike.</p>","PeriodicalId":50755,"journal":{"name":"Annual Review of Clinical Psychology","volume":null,"pages":null},"PeriodicalIF":18.4,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086080/pdf/nihms-1746982.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10247436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clare Shaffer, Christiana Westlin, Karen S Quigley, Susan Whitfield-Gabrieli, Lisa Feldman Barrett
{"title":"Allostasis, Action, and Affect in Depression: Insights from the Theory of Constructed Emotion.","authors":"Clare Shaffer, Christiana Westlin, Karen S Quigley, Susan Whitfield-Gabrieli, Lisa Feldman Barrett","doi":"10.1146/annurev-clinpsy-081219-115627","DOIUrl":"https://doi.org/10.1146/annurev-clinpsy-081219-115627","url":null,"abstract":"<p><p>The theory of constructed emotion is a systems neuroscience approach to understanding the nature of emotion. It is also a general theoretical framework to guide hypothesis generation for how actions and experiences are constructed as the brain continually anticipates metabolic needs and attempts to meet those needs before they arise (termed allostasis). In this review, we introduce this framework and hypothesize that allostatic dysregulation is a trans-disorder vulnerability for mental and physical illness. We then review published findings consistent with the hypothesis that several symptoms in major depressive disorder (MDD), such as fatigue, distress, context insensitivity, reward insensitivity, and motor retardation, are associated with persistent problems in energy regulation. Our approach transforms the current understanding of MDD as resulting from enhanced emotional reactivity combined with reduced cognitive control and, in doing so, offers novel hypotheses regarding the development, progression, treatment, and prevention of MDD.</p>","PeriodicalId":50755,"journal":{"name":"Annual Review of Clinical Psychology","volume":null,"pages":null},"PeriodicalIF":18.4,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247744/pdf/nihms-1818495.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10249361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richard E Zinbarg, Alexander L Williams, Susan Mineka
{"title":"A Current Learning Theory Approach to the Etiology and Course of Anxiety and Related Disorders.","authors":"Richard E Zinbarg, Alexander L Williams, Susan Mineka","doi":"10.1146/annurev-clinpsy-072220-021010","DOIUrl":"https://doi.org/10.1146/annurev-clinpsy-072220-021010","url":null,"abstract":"<p><p>The authors describe how contemporary learning theory and research provide the basis for models of the etiology and maintenance of anxiety and related disorders. They argue that contemporary learning theory accounts for much of the complexity associated with individual differences in the development and course of these disorders. These insights from modern research on learning overcome the limitations of earlier behavioral approaches, which were overly simplistic and have been justifiably criticized. The authors show how considerations of early learning histories and temperamental vulnerabilities affect the short- and long-term likelihood that experiences with stressful events will lead to the development of anxiety disorders. They also discuss how contextual variables during and after stressful learning experiences influence the maintenance of anxiety disorder symptoms. Thus, contemporary learning models provide a rich and nuanced understanding of the etiology and course of anxiety and related disorders.</p>","PeriodicalId":50755,"journal":{"name":"Annual Review of Clinical Psychology","volume":null,"pages":null},"PeriodicalIF":18.4,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39899554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Lynn, Craig P. Polizzi, H. Merckelbach, C. Chiu, Reed Maxwell, Dalena van Heugten, S. Lilienfeld
{"title":"Dissociation and Dissociative Disorders Reconsidered: Beyond Sociocognitive and Trauma Models Toward a Transtheoretical Framework.","authors":"S. Lynn, Craig P. Polizzi, H. Merckelbach, C. Chiu, Reed Maxwell, Dalena van Heugten, S. Lilienfeld","doi":"10.1146/annurev-clinpsy-081219-102424","DOIUrl":"https://doi.org/10.1146/annurev-clinpsy-081219-102424","url":null,"abstract":"For more than 30 years, the posttraumatic model (PTM) and the sociocognitive model (SCM) of dissociation have vied for attention and empirical support. We contend that neither perspective provides a satisfactory account and that dissociation and dissociative disorders (e.g., depersonalization/derealization disorder, dissociative identity disorder) can be understood as failures of normally adaptive systems and functions. We argue for a more encompassing transdiagnostic and transtheoretical perspective that considers potentially interactive variables including sleep disturbances; impaired self-regulation and inhibition of negative cognitions and affects; hyperassociation and set shifts; and deficits in reality testing, source attributions, and metacognition. We present an overview of the field of dissociation, delineate uncontested and converging claims across perspectives, summarize key multivariable studies in support of our framework, and identify empirical pathways for future research to advance our understanding of dissociation, including studies of highly adverse events and dissociation. Expected final online publication date for the Annual Review of Clinical Psychology, Volume 18 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":50755,"journal":{"name":"Annual Review of Clinical Psychology","volume":null,"pages":null},"PeriodicalIF":18.4,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44427219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}