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Journal of Case Reports and Medical History最新文献

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Primary Biliary Cholangitis and Rheumatoid Arthritis: An Emerging Association 原发性胆管炎与类风湿关节炎：新出现的关联
Journal of Case Reports and Medical History Pub Date : 2024-02-13 DOI: 10.54289/jcrmh2400113
{"title":"Primary Biliary Cholangitis and Rheumatoid Arthritis: An Emerging Association","authors":"","doi":"10.54289/jcrmh2400113","DOIUrl":"https://doi.org/10.54289/jcrmh2400113","url":null,"abstract":"Primary Biliary Cholangitis (PBC), formerly known as primary biliary cirrhosis, is an autoimmune-related cholestatic hepatopathy, representing a common cause of intrahepatic cholestasis due to progressive bile duct destruction. Often, PBC is linked with other autoimmune disorders such as Sjogren’s syndrome, thyroid dysfunction, scleroderma, and systemic lupus erythematosus. However, the association of PBC with rheumatoid arthritis (RA) is rare, estimated at 1.8 to 5.6%. We present a clinical case of PBC discovered in a patient with deforming rheumatoid arthritis.","PeriodicalId":507376,"journal":{"name":"Journal of Case Reports and Medical History","volume":"88 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139840315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Biliary Cholangitis and Rheumatoid Arthritis: An Emerging Association 原发性胆管炎与类风湿关节炎：新出现的关联
Journal of Case Reports and Medical History Pub Date : 2024-02-13 DOI: 10.54289/jcrmh2400113
{"title":"Primary Biliary Cholangitis and Rheumatoid Arthritis: An Emerging Association","authors":"","doi":"10.54289/jcrmh2400113","DOIUrl":"https://doi.org/10.54289/jcrmh2400113","url":null,"abstract":"Primary Biliary Cholangitis (PBC), formerly known as primary biliary cirrhosis, is an autoimmune-related cholestatic hepatopathy, representing a common cause of intrahepatic cholestasis due to progressive bile duct destruction. Often, PBC is linked with other autoimmune disorders such as Sjogren’s syndrome, thyroid dysfunction, scleroderma, and systemic lupus erythematosus. However, the association of PBC with rheumatoid arthritis (RA) is rare, estimated at 1.8 to 5.6%. We present a clinical case of PBC discovered in a patient with deforming rheumatoid arthritis.","PeriodicalId":507376,"journal":{"name":"Journal of Case Reports and Medical History","volume":"10 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139780558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dengue Fever with Hemolysis: Unmasking Beta-Thalassemia 登革热伴溶血：揭开β-地中海贫血的面纱
Journal of Case Reports and Medical History Pub Date : 2024-02-12 DOI: 10.54289/jcrmh2400115
{"title":"Dengue Fever with Hemolysis: Unmasking Beta-Thalassemia","authors":"","doi":"10.54289/jcrmh2400115","DOIUrl":"https://doi.org/10.54289/jcrmh2400115","url":null,"abstract":"Intravascular hemolysis is a rare but known complication of Dengue infection. Following is the description of a patient who presented with features of intravascular hemolysis with other sequelae of Dengue infection. Clinical stigmata of chronic iron overload led to a search for the aetiology of chronic hemolysis, which resulted in a diagnosis of non-transfusion-dependent beta-thalassemia.","PeriodicalId":507376,"journal":{"name":"Journal of Case Reports and Medical History","volume":"172 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139842027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dengue Fever with Hemolysis: Unmasking Beta-Thalassemia 登革热伴溶血：揭开β-地中海贫血的面纱
Journal of Case Reports and Medical History Pub Date : 2024-02-12 DOI: 10.54289/jcrmh2400115
{"title":"Dengue Fever with Hemolysis: Unmasking Beta-Thalassemia","authors":"","doi":"10.54289/jcrmh2400115","DOIUrl":"https://doi.org/10.54289/jcrmh2400115","url":null,"abstract":"Intravascular hemolysis is a rare but known complication of Dengue infection. Following is the description of a patient who presented with features of intravascular hemolysis with other sequelae of Dengue infection. Clinical stigmata of chronic iron overload led to a search for the aetiology of chronic hemolysis, which resulted in a diagnosis of non-transfusion-dependent beta-thalassemia.","PeriodicalId":507376,"journal":{"name":"Journal of Case Reports and Medical History","volume":"19 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive Candidiasis Causing Diabetic Ketoacidosis 侵袭性念珠菌病引发糖尿病酮症酸中毒
Journal of Case Reports and Medical History Pub Date : 2024-02-10 DOI: 10.54289/jcrmh2400114
{"title":"Invasive Candidiasis Causing Diabetic Ketoacidosis","authors":"","doi":"10.54289/jcrmh2400114","DOIUrl":"https://doi.org/10.54289/jcrmh2400114","url":null,"abstract":"Diabetic ketoacidosis (DKA) is a common yet fatal complication of diabetes mellitus which is characterised by uncontrolled hyperglycaemia, metabolic acidosis, and increased body ketone concentration. This preventable hyperglycaemic emergency accounts for more than 50,000 hospital days per year [1]. Infections, non-compliance to medication are the main precipitating factors for DKA, although myocardial infarction, stroke, trauma, and substance abuse may result in DKA. Clinical features of the same include nausea, vomiting, dehydration, pain abdomen, Kussmaul breathing pattern or even altered mental sensorium. Different types of infections can precipitate DKA, commonly of which are pneumonia, urinary tract infection, Oro-mucosal and aural infections. Careful evaluation and identification of precipitating factor should be made earlier for prompt treatment The aim of this case report is to review knowledge gaps in precipitating factors of DKA.","PeriodicalId":507376,"journal":{"name":"Journal of Case Reports and Medical History","volume":" August","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139787442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive Candidiasis Causing Diabetic Ketoacidosis 侵袭性念珠菌病引发糖尿病酮症酸中毒
Journal of Case Reports and Medical History Pub Date : 2024-02-10 DOI: 10.54289/jcrmh2400114
{"title":"Invasive Candidiasis Causing Diabetic Ketoacidosis","authors":"","doi":"10.54289/jcrmh2400114","DOIUrl":"https://doi.org/10.54289/jcrmh2400114","url":null,"abstract":"Diabetic ketoacidosis (DKA) is a common yet fatal complication of diabetes mellitus which is characterised by uncontrolled hyperglycaemia, metabolic acidosis, and increased body ketone concentration. This preventable hyperglycaemic emergency accounts for more than 50,000 hospital days per year [1]. Infections, non-compliance to medication are the main precipitating factors for DKA, although myocardial infarction, stroke, trauma, and substance abuse may result in DKA. Clinical features of the same include nausea, vomiting, dehydration, pain abdomen, Kussmaul breathing pattern or even altered mental sensorium. Different types of infections can precipitate DKA, commonly of which are pneumonia, urinary tract infection, Oro-mucosal and aural infections. Careful evaluation and identification of precipitating factor should be made earlier for prompt treatment The aim of this case report is to review knowledge gaps in precipitating factors of DKA.","PeriodicalId":507376,"journal":{"name":"Journal of Case Reports and Medical History","volume":"188 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139847338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular Challenges in Behçet's Disease: A Case Report Emphasizing Arterial Involvement 贝赫切特病的血管难题：强调动脉受累的病例报告
Journal of Case Reports and Medical History Pub Date : 2024-02-09 DOI: 10.54289/jcrmh2400112
{"title":"Vascular Challenges in Behçet's Disease: A Case Report Emphasizing Arterial Involvement","authors":"","doi":"10.54289/jcrmh2400112","DOIUrl":"https://doi.org/10.54289/jcrmh2400112","url":null,"abstract":"Behçet's disease, characterized by systemic manifestations primarily affecting the vascular system, presents unique challenges in diagnosis and management, particularly when arterial involvement occurs. This case report discusses a 50-year-old patient with Behçet's disease, highlighting the importance of recognizing and addressing arterial complications. The patient, diagnosed with bipolar aphthosis at 49, developed deep venous thrombosis and bilateral panuveitis, showing improvement with corticosteroids, azathioprine, and anticoagulation. A subsequent presentation a year later included deep vein thrombosis, loss of consciousness, and paraparesis, alongside mouth ulcers. Cerebral-medullary MRI revealed inflammatory arterial stenoses and tuberculous spondylodiscitis. A coincidental discovery of pulmonary embolism complicated therapeutic options, with satisfactory evolution following treatment. Discussion emphasizes the intricate nature of Behçet's disease, known for systemic and vascular involvement, especially in arteries. The rarity of cerebral arterial manifestations underscores the need for heightened awareness to diverse morphological presentations. Managing arterial complications requires a tailored therapeutic strategy, balancing immunosuppression and potential risks. Collaborative efforts among specialists are crucial for refining treatment approaches and improving outcomes. In conclusion, this case report underscores the importance of recognizing and addressing arterial complications in Behçet's disease for effective management. Continued research and multidisciplinary collaboration are essential to enhance our understanding and refine therapeutic interventions for this complex systemic disorder.","PeriodicalId":507376,"journal":{"name":"Journal of Case Reports and Medical History","volume":"179 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139849860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular Challenges in Behçet's Disease: A Case Report Emphasizing Arterial Involvement 贝赫切特病的血管难题：强调动脉受累的病例报告
Journal of Case Reports and Medical History Pub Date : 2024-02-09 DOI: 10.54289/jcrmh2400112
{"title":"Vascular Challenges in Behçet's Disease: A Case Report Emphasizing Arterial Involvement","authors":"","doi":"10.54289/jcrmh2400112","DOIUrl":"https://doi.org/10.54289/jcrmh2400112","url":null,"abstract":"Behçet's disease, characterized by systemic manifestations primarily affecting the vascular system, presents unique challenges in diagnosis and management, particularly when arterial involvement occurs. This case report discusses a 50-year-old patient with Behçet's disease, highlighting the importance of recognizing and addressing arterial complications. The patient, diagnosed with bipolar aphthosis at 49, developed deep venous thrombosis and bilateral panuveitis, showing improvement with corticosteroids, azathioprine, and anticoagulation. A subsequent presentation a year later included deep vein thrombosis, loss of consciousness, and paraparesis, alongside mouth ulcers. Cerebral-medullary MRI revealed inflammatory arterial stenoses and tuberculous spondylodiscitis. A coincidental discovery of pulmonary embolism complicated therapeutic options, with satisfactory evolution following treatment. Discussion emphasizes the intricate nature of Behçet's disease, known for systemic and vascular involvement, especially in arteries. The rarity of cerebral arterial manifestations underscores the need for heightened awareness to diverse morphological presentations. Managing arterial complications requires a tailored therapeutic strategy, balancing immunosuppression and potential risks. Collaborative efforts among specialists are crucial for refining treatment approaches and improving outcomes. In conclusion, this case report underscores the importance of recognizing and addressing arterial complications in Behçet's disease for effective management. Continued research and multidisciplinary collaboration are essential to enhance our understanding and refine therapeutic interventions for this complex systemic disorder.","PeriodicalId":507376,"journal":{"name":"Journal of Case Reports and Medical History","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidermodysplasia Verruciformis: Uncommon Skin Manifestation Unveiling Primary Immunodeficiency 疣状表皮增生症：揭示原发性免疫缺陷的不常见皮肤表现
Journal of Case Reports and Medical History Pub Date : 2024-02-08 DOI: 10.54289/jcrmh2400111
{"title":"Epidermodysplasia Verruciformis: Uncommon Skin Manifestation Unveiling Primary Immunodeficiency","authors":"","doi":"10.54289/jcrmh2400111","DOIUrl":"https://doi.org/10.54289/jcrmh2400111","url":null,"abstract":"Epidermodysplasia verruciformis (EV) is a rare genetic disorder marked by heightened susceptibility to persistent skin infections caused by human papillomaviruses (HPV). In some instances, EV is associated with immune deficiencies, especially those affecting cellular and humoral responses. Individuals with deficiencies in cellular immunity are more prone to developing EV. This clinical case presents an unusual form of combined immune deficiency, revealed through EV (Lutz-Lewandowsky syndrome). The patient's presentation with extensive verrucous lesions from a young age poses diagnostic challenges. Recurrent respiratory and digestive infections, without other systemic manifestations, complicate the diagnostic process. Decreased lymphocyte subpopulations, including global T, B, and NK lymphopenia, suggest combined immunodeficiency, reinforced by first-degree consanguinity. Negative results in viral serologies and investigations for systemic lupus erythematosus emphasize the importance of considering primary immunodeficiencies. Therapeutic interventions, such as immunoglobulin courses and local laser sessions, demonstrate a multidisciplinary strategy targeting both immune function and cutaneous manifestations. This case underscores the significance of early detection of combined immunodeficiencies for timely intervention and improved patient outcomes. Further research is crucial to explore the genetic complexities of combined immunodeficiencies and their implications in skin disorders like EV.","PeriodicalId":507376,"journal":{"name":"Journal of Case Reports and Medical History","volume":"73 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139850946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidermodysplasia Verruciformis: Uncommon Skin Manifestation Unveiling Primary Immunodeficiency 疣状表皮增生症：揭示原发性免疫缺陷的不常见皮肤表现
Journal of Case Reports and Medical History Pub Date : 2024-02-08 DOI: 10.54289/jcrmh2400111
{"title":"Epidermodysplasia Verruciformis: Uncommon Skin Manifestation Unveiling Primary Immunodeficiency","authors":"","doi":"10.54289/jcrmh2400111","DOIUrl":"https://doi.org/10.54289/jcrmh2400111","url":null,"abstract":"Epidermodysplasia verruciformis (EV) is a rare genetic disorder marked by heightened susceptibility to persistent skin infections caused by human papillomaviruses (HPV). In some instances, EV is associated with immune deficiencies, especially those affecting cellular and humoral responses. Individuals with deficiencies in cellular immunity are more prone to developing EV. This clinical case presents an unusual form of combined immune deficiency, revealed through EV (Lutz-Lewandowsky syndrome). The patient's presentation with extensive verrucous lesions from a young age poses diagnostic challenges. Recurrent respiratory and digestive infections, without other systemic manifestations, complicate the diagnostic process. Decreased lymphocyte subpopulations, including global T, B, and NK lymphopenia, suggest combined immunodeficiency, reinforced by first-degree consanguinity. Negative results in viral serologies and investigations for systemic lupus erythematosus emphasize the importance of considering primary immunodeficiencies. Therapeutic interventions, such as immunoglobulin courses and local laser sessions, demonstrate a multidisciplinary strategy targeting both immune function and cutaneous manifestations. This case underscores the significance of early detection of combined immunodeficiencies for timely intervention and improved patient outcomes. Further research is crucial to explore the genetic complexities of combined immunodeficiencies and their implications in skin disorders like EV.","PeriodicalId":507376,"journal":{"name":"Journal of Case Reports and Medical History","volume":" 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139790954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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