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From RNA to DNA: Emergence of reverse transcriptases from an ancestral RNA-dependent RNA polymerase 从 RNA 到 DNA:从依赖 RNA 的原始 RNA 聚合酶到逆转录酶的出现。
IF 2 4区 生物学
Biosystems Pub Date : 2024-09-28 DOI: 10.1016/j.biosystems.2024.105345
Sávio Torres de Farias , Ana Karoline Nunes-Alves , Marco José
{"title":"From RNA to DNA: Emergence of reverse transcriptases from an ancestral RNA-dependent RNA polymerase","authors":"Sávio Torres de Farias ,&nbsp;Ana Karoline Nunes-Alves ,&nbsp;Marco José","doi":"10.1016/j.biosystems.2024.105345","DOIUrl":"10.1016/j.biosystems.2024.105345","url":null,"abstract":"<div><div>The transition from RNA as the informational molecule of primordial biological systems to the DNA genomes of modern organisms represents one of the greatest evolutionary transitions in the history of life. One way to understand this transition is to comprehend the origin of the enzymes responsible for the metabolism of nucleic acid polymers. In the present work, we reconstructed the ancestral sequence of RNA-dependent DNA polymerase (RdDp) and modeled its structure. The data demonstrate that, in terms of primary sequence, the ancestral sequences exhibit characteristic elements of RdDp; however, structurally, they are more similar to RNA-dependent RNA polymerase (RdRp). The presented data suggest that RdDp may have originated through modifications and neofunctionalization from an RdRp-like ancestor.</div></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":"246 ","pages":"Article 105345"},"PeriodicalIF":2.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reflexive neural circuits and the origin of language and music codes 反射神经回路与语言和音乐代码的起源。
IF 2 4区 生物学
Biosystems Pub Date : 2024-09-28 DOI: 10.1016/j.biosystems.2024.105346
Abir U. Igamberdiev
{"title":"Reflexive neural circuits and the origin of language and music codes","authors":"Abir U. Igamberdiev","doi":"10.1016/j.biosystems.2024.105346","DOIUrl":"10.1016/j.biosystems.2024.105346","url":null,"abstract":"<div><div>Conscious activity is grounded in the reflexive self-awareness in sense perception, through which the codes signifying sensual perceptive events operate and constrain human behavior. These codes grow via the creative generation of hypertextual statements. We apply the model of Vladimir Lefebvre (Lefebvre, V.A., 1987, J. Soc. Biol. Struct. 10, 129–175) to reveal the underlying structures on which the perception and creative development of language and music codes are based. According to this model, the reflexive structure of conscious subject is grounded in three thermodynamic cycles united by the control of the basic functional cycle by the second one, and resulting in the internal action that it turn is perceived by the third cycle evaluating this action. In this arrangement, the generative language structures are formed and the frequencies of sounds that form musical phrases and patterns are selected. We discuss the participation of certain neural brain structures and the establishment of reflexive neural circuits in the <em>ad hoc</em> transformation of perceptive signals, and show the similarities between the processes of perception and of biological self-maintenance and morphogenesis. We trace the peculiarities of the temporal encoding of emotions in music and musical creativity, as well as the principles of sharing musical information between the performing and the perceiving individuals.</div></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":"246 ","pages":"Article 105346"},"PeriodicalIF":2.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
William Bateson, black slavery, eugenics and speciation: The relative roles of politics and science 威廉-贝特森、黑人奴隶制、优生学和物种繁衍:政治与科学的相对作用。
IF 2 4区 生物学
Biosystems Pub Date : 2024-09-28 DOI: 10.1016/j.biosystems.2024.105348
Donald R. Forsdyke
{"title":"William Bateson, black slavery, eugenics and speciation: The relative roles of politics and science","authors":"Donald R. Forsdyke","doi":"10.1016/j.biosystems.2024.105348","DOIUrl":"10.1016/j.biosystems.2024.105348","url":null,"abstract":"<div><div>The peace of the world is challenged by societal confrontations that can often be labeled “racial” or “ethnic.” Emblematic of this is discrimination based on skin colour. William Bateson's background suggests sympathy with the black emancipation movement. Yet the movement's success is attributed more to battles between political figures than between scientists with contending views on the biology of racial differences. However, in the long term, Bateson's contributions to slavery and eugenic issues may be seen as no less important than those of politicians. Mendel's discovery of what we now know as “genes” languished until seized upon by Bateson in 1900. For six exhausting years he struggled to win scientific acceptance of these biological character-determining units. Later, he pressed the Mendelian message home to the general public, opposing simplistic applications of Mendelian principles to human affairs, and arguing that minor genic differences that distinguished “races” – e.g. skin colour – do not initiate new species. Bateson praised the “physiological selection” speciation hypothesis of Darwin's young research associate, George Romanes. This enthusiasm was rekindled by Robert Lock and formulated in modern terms with C. R. Crowther. Thus, the spark that initiates a divergence into two species can be non-genic. This normal form of hybrid sterility, based on genome-wide DNA sequence differences, operates on, but has not succeeded in dividing, the human species. It should not be labeled “idiopathic,” and be clearly distinguished both from pathological sterility and undiagnosed sterilities that may prove to be pathological. We are one reproductively isolated population, the human species.</div></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":"246 ","pages":"Article 105348"},"PeriodicalIF":2.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Avian influenza A H5N1 hemagglutinin protein models have distinct structural patterns re-occurring across the 1959–2023 strains 禽流感甲型 H5N1 血凝素蛋白模型在 1959-2023 株中重复出现不同的结构模式。
IF 2 4区 生物学
Biosystems Pub Date : 2024-09-28 DOI: 10.1016/j.biosystems.2024.105347
Marni E. Cueno, Noriaki Kamio, Kenichi Imai
{"title":"Avian influenza A H5N1 hemagglutinin protein models have distinct structural patterns re-occurring across the 1959–2023 strains","authors":"Marni E. Cueno,&nbsp;Noriaki Kamio,&nbsp;Kenichi Imai","doi":"10.1016/j.biosystems.2024.105347","DOIUrl":"10.1016/j.biosystems.2024.105347","url":null,"abstract":"<div><div>Influenza A H5N1 hemagglutinin (HA) plays a crucial role in viral pathogenesis and changes in the HA receptor binding domain (RBD) have been attributed to alterations in viral pathogenesis. Mutations often occur within the HA which in-turn results in HA structural changes that consequently contribute to protein evolution. However, the possible occurrence of mutations that results to reversion of the HA protein (going back to an ancestral protein conformation) which in-turn creates distinct HA structural patterns across the 1959–2023 H5N1 viral evolution has never been investigated. Here, we generated and verified the quality of the HA models, identified similar HA structural patterns, and elucidated the possible variations in HA RBD structural dynamics. Our results show that there are 7 distinct structural patterns occurring among the 1959–2023 H5N1 HA models which suggests that reversion of the HA protein putatively occurs during viral evolution. Similarly, we found that the HA RBD structural dynamics vary among the 7 distinct structural patterns possibly affecting viral pathogenesis.</div></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":"246 ","pages":"Article 105347"},"PeriodicalIF":2.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel hypothesis about mechanism of thalidomide action on pattern formation 沙利度胺对模式形成作用机制的新假设
IF 2 4区 生物学
Biosystems Pub Date : 2024-09-26 DOI: 10.1016/j.biosystems.2024.105344
Denis Touroutine , Nadya Morozova
{"title":"A novel hypothesis about mechanism of thalidomide action on pattern formation","authors":"Denis Touroutine ,&nbsp;Nadya Morozova","doi":"10.1016/j.biosystems.2024.105344","DOIUrl":"10.1016/j.biosystems.2024.105344","url":null,"abstract":"<div><div>Morphogenesis, the complex process governing the formation of functional living structures, is regulated by a multitude of molecular mechanisms at various levels. While research in recent decades has shed light on many pathways involved in morphogenesis, none singularly accounts for the precise geometric shapes of organisms and their components in space. To bridge this conceptual gap between specific molecular mechanisms and the creation of definitive morphological forms, we have proposed the \"epigenetic code hypothesis\" in our previous work. In this framework, \"epigenetic\" means any inheritable cellular information beyond the genetic code that regulates cell fate alongside genetic information. In this study, we conduct a comprehensive analysis of thalidomide's teratogenic effects through the lens of our proposed \"epigenetic code\" theory, revealing significant indirect support for our hypothesis. We also explore the structural and functional parallels between thalidomide and auxin.</div></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":"246 ","pages":"Article 105344"},"PeriodicalIF":2.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intelligence: Natural, artificial, or what? 智能:自然智能、人工智能还是什么?
IF 2 4区 生物学
Biosystems Pub Date : 2024-09-26 DOI: 10.1016/j.biosystems.2024.105343
Ron Cottam, Roger Vounckx
{"title":"Intelligence: Natural, artificial, or what?","authors":"Ron Cottam,&nbsp;Roger Vounckx","doi":"10.1016/j.biosystems.2024.105343","DOIUrl":"10.1016/j.biosystems.2024.105343","url":null,"abstract":"<div><div>We consider the competing attributes of natural intelligence (NI) and artificial intelligence (AI). Attention is paid to conceptual, theoretical, stylistic and structural aspects of both, and non-human intelligence. Intelligence is related to information processing and current views of physical structuring. Means of distinguishing between NI and AI are noted, and neural and digital structures are described. Pribram's bi-computational neural networks are introduced, and high-level Pribram computation is discussed. We describe the hierarchical Aquarium scheme, along with an AI implementation, and conclude with a proposition for future quantum-based artificial intelligence.</div></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":"246 ","pages":"Article 105343"},"PeriodicalIF":2.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A control measure for epidemic spread based on the susceptible–infectious–susceptible (SIS) model 基于易感-传染-易感(SIS)模型的流行病传播控制措施。
IF 2 4区 生物学
Biosystems Pub Date : 2024-09-25 DOI: 10.1016/j.biosystems.2024.105341
Jin-Xuan Yang, Haiyan Wang, Xin Li, Ying Tan, Yongjuan Ma, Min Zeng
{"title":"A control measure for epidemic spread based on the susceptible–infectious–susceptible (SIS) model","authors":"Jin-Xuan Yang,&nbsp;Haiyan Wang,&nbsp;Xin Li,&nbsp;Ying Tan,&nbsp;Yongjuan Ma,&nbsp;Min Zeng","doi":"10.1016/j.biosystems.2024.105341","DOIUrl":"10.1016/j.biosystems.2024.105341","url":null,"abstract":"<div><div>When an epidemic occurs in a network, finding the important links and cutting them off is an effective measure for preventing the spread of the epidemic. Traditional methods that remove important links easily lead to a disconnected network, inevitably incurring high costs arising from quarantining individuals or communities in a real-world network. In this study, we combine the clustering coefficient and the eigenvector to identify the important links using the susceptible–infectious–susceptible (SIS) model. The results show that our approach can improve the epidemic threshold while maintaining the connectivity of the network to control the spread of the epidemic. Experiments on multiple real-world and synthetic networks of varying sizes, demonstrate the effectiveness and scalability of our approach.</div></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":"246 ","pages":"Article 105341"},"PeriodicalIF":2.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The indispensable role of time in autonomous development 时间在自主发展中不可或缺的作用。
IF 2 4区 生物学
Biosystems Pub Date : 2024-09-21 DOI: 10.1016/j.biosystems.2024.105340
William Letsou
{"title":"The indispensable role of time in autonomous development","authors":"William Letsou","doi":"10.1016/j.biosystems.2024.105340","DOIUrl":"10.1016/j.biosystems.2024.105340","url":null,"abstract":"<div><div>Advances in single-cell analysis have led to a picture of development largely in agreement with Waddington’s eponymous epigenetic landscape, in which a cell’s fate is determined by its basin of attraction in a high-dimensional gene-expression space. Yet conceptual gaps remain as to how a single progenitor can simultaneously generate multiple endpoints, and why time should be required of the process at all. We propose a theoretical model based on the Hamiltonian mechanics of <span><math><mi>n</mi></math></span>-dimensional rotational motion, which resolves these paradoxes. We derive the result that systems which become different from themselves over time must initially move in a direction <em>not</em> towards their ultimate endpoints, and propose that this process of resolving ambiguity can be quantified (in an information-theoretic sense) by the volume subtended in gene-expression space by the trajectories taken by the system towards its endpoints. We discuss the implications of this theory for the analysis of single-cell gene-expression data in studies of development.</div></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":"246 ","pages":"Article 105340"},"PeriodicalIF":2.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Causal Modeling and Thermodynamics: Towards a new convergence of the two fields 因果建模与热力学:实现两个领域的新融合。
IF 2 4区 生物学
Biosystems Pub Date : 2024-09-19 DOI: 10.1016/j.biosystems.2024.105338
Dan Costa Baciu
{"title":"Causal Modeling and Thermodynamics: Towards a new convergence of the two fields","authors":"Dan Costa Baciu","doi":"10.1016/j.biosystems.2024.105338","DOIUrl":"10.1016/j.biosystems.2024.105338","url":null,"abstract":"<div><div>In 1824, Nicolas Léonard Sadi Carnot paid for the publication of his first book. Unfortunately it sparked little interest, and the young engineer never published another. In quick succession, Carnot served in the military, suffered from scarlet fever, mania, and cholera, and passed away in obscurity at age 36. Two centuries have elapsed since Carnot published his only book. Recognition came later. In particular, Carnot's reasoning inspired scientists to formulate the first and second laws of Thermodynamics. The new science that has emerged around these physical laws is nothing short of breathtaking. Yet, with success and growth, critical attention and skepticism have followed. In 1924, Louis de Broglie lauded the first law of Thermodynamics, while remaining more reserved to wards the second. The first law builds on a long history rooted in Causal Modeling, while the second does less so. Today, physicists such as Adrian Bejan continue praising Thermodynamics but contend that some formulations of the second law may have attracted broken science. The present article revisits this history in an attempt to cut through some of the fog. As an outcome of this re-evaluation, the article outlines a new convergence of Thermodynamics and Causal Modeling.</div></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":"246 ","pages":"Article 105338"},"PeriodicalIF":2.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantum logic automata generate class IV-like patterns and 1/f noise 量子逻辑自动机产生类 IV 模式和 1/f 噪声
IF 2 4区 生物学
Biosystems Pub Date : 2024-09-18 DOI: 10.1016/j.biosystems.2024.105339
Yuki Tokuyama , Yoshihiko Ohzawa , Yukio-Pegio Gunji
{"title":"Quantum logic automata generate class IV-like patterns and 1/f noise","authors":"Yuki Tokuyama ,&nbsp;Yoshihiko Ohzawa ,&nbsp;Yukio-Pegio Gunji","doi":"10.1016/j.biosystems.2024.105339","DOIUrl":"10.1016/j.biosystems.2024.105339","url":null,"abstract":"<div><p>Owing to recent advancements in brain science and AI, researchers tend to focus on the concept of self-organized criticality or the edge of chaos. On the other hand, quantum cognition, which is rooted in quantum mechanics, is promising for resolving various cognitive illusions. However, until recently, no connection between criticality and quantum mechanics was proposed. Gunji et al. (2024) recently introduced a linkage termed quantum logic automata, which encompasses not only quantum logic but also criticality characterized by power-law distributions. While quantum logic automata can be derived from various structures, only one of them has been proposed and discussed. Here, we define another type of quantum logic automata involving quantum logic and demonstrate that symmetric quantum logic automata lead to complex Class IV-like patterns and power-law distributions. Our findings support the association between criticality and quantum theory.</p></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":"246 ","pages":"Article 105339"},"PeriodicalIF":2.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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