Bjog-An International Journal of Obstetrics and Gynaecology最新文献

{"title":"Timing of Term Births and Associated Mortality Risks: Ecological Analysis Across 28 European Countries","authors":"Jóhanna Gunnarsdóttir,&nbsp;Marianne Philibert,&nbsp;Mika Gissler,&nbsp;Karin Källén,&nbsp;Kari Klungsøyr,&nbsp;Marzia Loghi,&nbsp;Alison Macfarlane,&nbsp;Luule Sakkeus,&nbsp;Vlad Tica,&nbsp;Jennifer Zeitlin","doi":"10.1111/1471-0528.18292","DOIUrl":"10.1111/1471-0528.18292","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To explore term mortality rates in relation to rates of early-term birth (gestational ages 37 + 0 to 38 + 6 weeks), regarded as a proxy indicator of practices of elective birth by induction or caesarean.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Ecological study using national birth data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>28 European countries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Population</h3>\u0000 \u0000 <p>Births ≥ 37 weeks between 2015 and 2020.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Aggregated data on live and stillbirths by completed week of gestation was compiled from routine sources in the Euro-Peristat network. Countries were divided into three groups based on their percentages of early-term births using terciles (high, medium and low) and mortality rates were compared between groups with random-effects meta-analysis of proportions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Stillbirths (antepartum or intrapartum fetal death) and perinatal death (stillbirth or early neonatal death) per 1000 total births ≥ 37 weeks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Early-term birth rates ranged from 17.8% (Iceland) to 49.1% (Cyprus), with terciles being &lt; 21%, 21%–27%, and &gt; 27%. Post-term birth rates were low in countries with higher early-term birth rates. The pooled stillbirth rate ≥ 37 weeks was 1.28 per 1000 total births (95% CI: 1.13–1.46) in the lowest tercile and 1.05 (95% CI: 0.95–1.16) in the highest (<i>p</i> = 0.05), but prediction intervals were wide reflecting heterogeneity within groups. No evidence of difference was seen between perinatal mortality rates by tercile (<i>p</i> = 0.71).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>On average, the stillbirth rate was lower in countries where early-term birth rates were highest, but no difference was found in perinatal mortality rates. Heterogeneity was high within groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 11","pages":"1655-1663"},"PeriodicalIF":4.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18292","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired Fertility and Sexual Function in Women With Hirschsprung Disease: Results From an International Multi-Centre Cross-Sectional Study","authors":"Joseph R. Davidson,&nbsp;Annika Mutanen,&nbsp;Anna Löf Granström,&nbsp;Anders Telle Hoel,&nbsp;Stavros P. Loukogeorgakis,&nbsp;Paolo De Coppi,&nbsp;Kristin Bjørnland,&nbsp;Tomas Wester,&nbsp;Simon Eaton,&nbsp;Mikko P. Pakarinen,&nbsp;Joe Curry","doi":"10.1111/1471-0528.18294","DOIUrl":"10.1111/1471-0528.18294","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Hirschsprung is a congenital disorder affecting the gastrointestinal tract. However, pelvic colorectal surgery in infancy has been hypothesised to impact gynaecological outcomes in later life. Describe sexual function and fertility outcomes in women with Hirschsprung disease compared to population controls. Assess factors associated with poor outcomes (sexual dysfunction and subfertility).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>International multicentre cross-sectional cohort study with comparison to controls from the general population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Status post-discharge from paediatric services.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Population</h3>\u0000 \u0000 <p>Female patients aged &gt; 20 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Validated questionnaire-based survey with linkage to patient medical records. Comparison with controls using univariate analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Sexual dysfunction (Female Sexual Function Index; FSFI ≤ 26), Subfertility at 1 and 2 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sexual dysfunction as per the FSFI was more common in patients and associated with poor functional outcomes; sexual abstinence seemed to associate even more so with poor bowel outcomes. Subfertility was higher in patients compared to controls (1 year: 21/45 (47%) vs. 38/178 (21%), <i>p</i> = 0.0008; 2 years: 12/45 (27%) vs. 17/178 (10%), <i>p</i> = 0.004). There was an increased proportion of patients who had accessed fertility services (20/45 (44%) vs. 43/178 (24%); <i>p</i> = 0.009), the proportion of successful pregnancies in patients attempting to conceive with IVF (11/17 (65%) vs. 27/43 (63%); <i>p</i> = 1.0) was similar.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These novel data suggest that women with Hirschsprung disease who have undergone reconstructive surgery may be at risk for adverse sexual function and fertility outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 11","pages":"1673-1680"},"PeriodicalIF":4.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18294","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Mechanisms of Dysmenorrhea: Novel Insights From Menstrual Effluent in an Adolescent Cohort","authors":"Chandrashekara N. Kyathanahalli,&nbsp;Frank F. Tu,&nbsp;Kevin M. Hellman","doi":"10.1111/1471-0528.18275","DOIUrl":"10.1111/1471-0528.18275","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To examine how eicosanoid levels in menstrual effluent of adolescents within 3 years of menarche relate to the severity of menstrual pain.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Design&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Prospective cohort study.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Setting&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Community teaching hospital.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Population or Sample&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Adolescents within 3 years after menarche.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Participants provided a menstrual effluent sample between 4 and 30 months after menarche. Eicosanoid and oxylipin concentrations were measured in the menstrual effluent. We compared effluent concentrations of participants with menstrual pain (&lt;i&gt;n&lt;/i&gt; = 33) to age-matched pain-free controls (&lt;i&gt;n&lt;/i&gt; = 18).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Main Outcome Measures&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Eicosanoid and oxylipin concentrations in menstrual effluent.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Participants with dysmenorrhea had higher PGF2α (4.5 [1.6, 8.9] ng/mL, &lt;i&gt;p&lt;/i&gt; = 0.014) than controls (1.1 [0.07, 4.4] ng/mL). However, differences in PGE2 (7.1 [2.6, 10.1] vs. 3.5 [1.0, 5.1], &lt;i&gt;p&lt;/i&gt; = 0.053) and 12-HETE (36.3 [23.7, 60.7] vs. 29.6 [13.4, 51.5], &lt;i&gt;p&lt;/i&gt; = 0.305) were not significant. The correlations between PGF2α (&lt;i&gt;r&lt;/i&gt; = 0.37, &lt;i&gt;p&lt;/i&gt; = 0.004) or PGE2 concentration (&lt;i&gt;r&lt;/i&gt; = 0.28, &lt;i&gt;p&lt;/i&gt; = 0.046) and menstrual pain intensity were moderate to small. Overall, there were positive correlations between menstrual volume and eicosanoid concentrations (&lt;i&gt;r&lt;/i&gt;'s &gt; 0.4, &lt;i&gt;p&lt;/i&gt;'s &lt; 0.001). Participants with dysmenorrhea taking analgesics had more PGF2α (66.2 [43.0, 164.7]) than controls (19.1 [6.0, 47.5], &lt;i&gt;p&lt;/i&gt; = 0.04). LC-MS/MS revealed higher concentrations of 12-HETE, 14,15-EET, 15-HETE, 18cdLTB4, LTB4 and PGF2α—and lower 6-kPGF1α—in the effluent of participants with dysmenorrhea compared to controls.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Elevated PGF2α in adolescents with dysmenorrhea, modest correlations between prostaglandin concentrations and menstrual pain, and the identification of additional oxylipins suggest that inflammatory processes beyond the prostaglandin pa","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 11","pages":"1626-1634"},"PeriodicalIF":4.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Contraceptive Initiation and Use Among Women Who Have Given Birth in the Last Year: Findings From the 2023 Women's Reproductive Health Survey","authors":"Catherine Stewart,&nbsp;Amy Hough,&nbsp;Melissa J. Palmer,&nbsp;Ona McCarthy,&nbsp;Rebecca S. French,&nbsp;Neha Pathak","doi":"10.1111/1471-0528.18264","DOIUrl":"10.1111/1471-0528.18264","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study investigates contraceptive use among individuals who have recently given birth. It aims to identify factors associated with contraceptive use at two months and one-year of giving birth. Additionally, it assesses whether receiving and being satisfied with contraceptive counselling influences contraceptive use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Cross-sectional analysis of data from the 2023 Women's Reproductive Health Survey.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>England.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Population</h3>\u0000 \u0000 <p>Participants who had given birth in the last year (<i>n</i> = 2044).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Bivariate and multivariable logistic regressions examined factors associated with contraceptive use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Contraceptive initiation within two months of giving birth. Contraceptive use within one year of giving birth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 73% (<i>n</i> = 1489/2044) of participants were using contraception, however 58% (<i>n</i> = 1154/1998) had not initiated use within two months of giving birth. Bivariate analyses indicated that younger participants, those who received counselling, and those satisfied with it had higher odds of initiating contraception within two months. Similarly, younger individuals, those not desiring more children, and those who received counselling had higher odds of using contraception within one year. Multivariable analysis showed that receiving counselling and being satisfied with it were significantly associated with early initiation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights the need for high-quality contraceptive counselling as part of maternity care. Counselling during or immediately after pregnancy was shown to impact contraceptive initiation and use. Policy improvements and further research on achieving universal high-quality counselling are important to ensure equitable access to contraception.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 11","pages":"1615-1625"},"PeriodicalIF":4.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Preterm Birth After a Caesarean Section at Full Dilatation","authors":"Joanne Ludlow","doi":"10.1111/1471-0528.18287","DOIUrl":"10.1111/1471-0528.18287","url":null,"abstract":"<p><b>Linked article:</b> This is a mini commentary on Acker et al., pp. 1585–1593 in this issue. To view this article visit https://doi.org/10.1111/1471-0528.18225.</p>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 11","pages":"1594-1595"},"PeriodicalIF":4.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premenstrual Dysphoric Disorder Prevalence and Symptoms Across Age Groups: A Cross-Sectional Study","authors":"Adriana Orcesi Pedro,&nbsp;Roberto Carmignani Verdade,&nbsp;Maura Gonzaga Lapa,&nbsp;Juliana Dinéia Perez Brandão,&nbsp;Vivienne Carduz Castilho","doi":"10.1111/1471-0528.18261","DOIUrl":"10.1111/1471-0528.18261","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To estimate the prevalence and symptom severity of premenstrual dysphoric disorder (PMDD) in Brazilian women according to age groups, and to conduct an association analysis between psychoemotional and somatic symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Cross-sectional study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>303 private clinics across Brazil.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Population</h3>\u0000 \u0000 <p>45 160 women aged 20–49 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Self-report questionnaire regarding the prevalence and intensity of premenstrual symptoms. Statistical analysis performed using Pearson's chi-square test and Poisson regression and multiple logistic regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Prevalence and intensity of somatic and psychoemotional premenstrual symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Prevalence of PMDD was 3.57% (95% CI: 3.40–3.75). Psychoemotional symptoms were more prevalent than somatic symptoms, with anxiety/tension (99.9%) and irritability/anger (99.8%) being the most frequently reported symptoms. Weight gain (92.5%) and edema (92.1%) were the most prevalent somatic symptoms. Anxiety/tension and headache occurred independently of other symptoms. Binge eating was associated with weight gain (OR = 2.77, 95% CI [2.11, 3.62]), acne (OR = 2.37, 95% CI [1.79, 3.10]), immunoallergic exacerbations (OR = 1.81, 95% CI [1.26, 2;60]) and edema (OR—0.74, 95% CI [0.55, 0.97]). Affective lability was associated with immunoallergic exacerbations (OR = 1.49, 95% CI [1.16, 1.91]) and mastalgia (OR = 1.29, 95% CI [1.02, 1.63]). Depression was associated with acne (OR = 0.72, 95% CI [0.57, 0.89]) and weight gain (OR = 0.77, 95% CI [0.61, 0.96]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The prevalence of PMDD was consistent with other population studies. Psychoemotional symptoms were more prevalent. Association analysis provided new insights into premenstrual symptomatology.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 11","pages":"1596-1605"},"PeriodicalIF":4.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregestational Diabetes and Duration of Active Labour Compared With Non-Diabetic Women: A Population-Based Cohort Study","authors":"Sofia Nevander,&nbsp;Sara Carlhäll,&nbsp;Karin Källén,&nbsp;Caroline Lilliecreutz,&nbsp;Marie Blomberg","doi":"10.1111/1471-0528.18276","DOIUrl":"10.1111/1471-0528.18276","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To evaluate the impact of pregestational diabetes on duration of active labour (DAL) in induced and spontaneous labour and to compare caesarean section (CS) rates and indications between women with and without diabetes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Design&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A population-based cohort study.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Setting&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Sweden.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Population&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;243 537 nulliparous women, registered in the Swedish Pregnancy Register, who delivered a singleton fetus at ≥ 34&lt;sup&gt;+0&lt;/sup&gt; gestational weeks + days between 2014 and 2020. Women with gestational diabetes mellitus were excluded.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;DAL was compared between women with pregestational diabetes and those without diabetes using Kaplan-Meier survival analysis and Cox regression analysis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Main Outcome Measures&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;DAL. Rates and indications for CS.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Women with pregestational diabetes had longer active labour and a reduced chance of vaginal delivery at a given time-point compared to women without diabetes, adjusted hazard ratio 0.65 (95% CI: 0.60–0.70, &lt;i&gt;p&lt;/i&gt; &lt; 0.001). Among those with spontaneous labour, median DAL in diabetic vs. non-diabetic women was 9.60 h versus 8.75 h, difference 0.85 h (95% CI 0.20–1.50), &lt;i&gt;p&lt;/i&gt; &lt; 0.001. Corresponding numbers for induced labours were 8.92 h versus 7.20 h, difference 1.72 h (95% CI 0.94–2.49), &lt;i&gt;p&lt;/i&gt; &lt; 0.001.&lt;/p&gt;\u0000 \u0000 &lt;p&gt;Elective and emergency CS rates were higher in women with pregestational diabetes than non-diabetic women (7.4% and 29.4% vs. 2.6% and 7.1% respectively), with suspected macrosomia (50.4%) and fetal distress (31.9%) being the most common indications for CS among women with pregestational diabetes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The prolonged labour duration in women with pregestational diabetes highlights the importance of the labour ward staff's support and patience in managing diabetic parturients, potentially allowing more time before diagnosing labour dystocia. Extended labour duratio","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 11","pages":"1635-1643"},"PeriodicalIF":4.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"PARP Inhibitors Rechallenge in Patients With Recurrent Ovarian Cancer: A Multicentre Real-World Study in China\".","authors":"","doi":"10.1111/1471-0528.18285","DOIUrl":"https://doi.org/10.1111/1471-0528.18285","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin, Birthweight, and Large-For-Gestational-Age Neonates: A Secondary Analysis of the ASPRE Trial","authors":"Daniel L. Rolnik,&nbsp;Liona C. Poon,&nbsp;Argyro Syngelaki,&nbsp;David Wright,&nbsp;Neil O'Gorman,&nbsp;Catalina de Paco Matallana,&nbsp;Ranjit Akolekar,&nbsp;Deepa Janga,&nbsp;Mandeep Singh,&nbsp;Francisca S. Molina,&nbsp;Nicola Persico,&nbsp;Jacques C. Jani,&nbsp;Walter Plasencia,&nbsp;George Papaioannou,&nbsp;Kinneret Tenenbaum-Gavish,&nbsp;Hamutal Meiri,&nbsp;Kypros H. Nicolaides","doi":"10.1111/1471-0528.18263","DOIUrl":"10.1111/1471-0528.18263","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the effects of aspirin on the distribution of birthweight and its impact on the rates of large-for-gestational-age (LGA) neonates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Secondary analysis of the Combined Multimarker Screening and Randomised Patient Treatment with Aspirin for Evidence-based Preeclampsia Prevention (ASPRE) trial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Thirteen hospitals in England, Spain, Belgium, Greece, Italy and Israel.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Population</h3>\u0000 \u0000 <p>Participants of the ASPRE trial at increased risk of preterm pre-eclampsia (PE) who had a live birth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We compared the birthweight distributions and the rates of LGA neonates between the trial groups. Analyses were stratified according to the presence of pre-existing diabetes mellitus and the development of PE, and logistic regression was used to investigate independent predictors of LGA neonates with birthweight above the 90th percentile.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Birthweight distribution and rates of LGA neonates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 1571 singleton, live neonates (777 from the aspirin group and 794 from the placebo group), aspirin was associated with a shift in birthweight from &lt; 2500 to 2500–4000 g, and birthweight percentile from &lt; 25th to 25th—75th percentiles, with no significant increase in LGA neonates (5.5% vs. 6.2%, <i>p</i> = 0.667). Logistic regression demonstrated a significant interaction between treatment and pre-existing diabetes (<i>p</i>-value 0.034), and a positive association between maternal weight and LGA neonates (adjusted odds ratio 1.040, 95% confidence interval 1.030–1.051, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Aspirin use is associated with increased birthweight without increasing the rate of LGA neonates. Among women with pre-existing diabetes, aspirin may be associated with a higher rate of LGA neonates, warranting further investigation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 11","pages":"1606-1614"},"PeriodicalIF":4.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESSION OF CONCERN: The Relationship between Sonographic Fetal Thymus Size and the Components of the Systemic Fetal Inflammatory Response Syndrome in Women with Preterm Prelabour Rupture of Membranes","authors":"","doi":"10.1111/1471-0528.18272","DOIUrl":"10.1111/1471-0528.18272","url":null,"abstract":"<p><b>EXPRESSION OF CONCERN</b>: D. O. El-Haieg, A. A. Zidan, and M. M. El-Nemr, “The Relationship between Sonographic Fetal Thymus Size and the Components of the Systemic Fetal Inflammatory Response Syndrome in Women with Preterm Prelabour Rupture of Membranes,” <i>BJOG: An International Journal of Obstetrics &amp; Gynaecology</i> 115, no. 7 (2008): 836-841, https://doi.org/10.1111/j.1471-0528.2008.01715.x.</p><p>This Expression of Concern is for the above article, published online on 10 July 2008 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between journal Editor-in-Chief, Aris Papageorghiou; and John Wiley &amp; Sons Ltd. A third party reported that results and data included in this paper were statistically improbable. The authors did not respond to an inquiry and request for original data made by the publisher. Further review by an independent statistician confirmed that there were inconsistencies with respect to the gestational age values. The editors have further concluded that there are implausible clinical features in the study. All parties have determined that there are concerns regarding the data presented in this article, but that the veracity of the data and conclusions presented cannot be verified without the original data. Therefore, the journal has decided to issue an Expression of Concern to inform and alert readers. The authors did not respond to our notice regarding the Expression of Concern.</p>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 10","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}