Bjog-An International Journal of Obstetrics and Gynaecology最新文献

{"title":"Assisted Reproductive Technology in China: A Commentary","authors":"Fang Gu, Yao Lu, Yanwen Xu, Yun Sun","doi":"10.1111/1471-0528.18157","DOIUrl":"https://doi.org/10.1111/1471-0528.18157","url":null,"abstract":"<p>Over the past few decades, assisted reproductive technology (ART) has rapidly developed in mainland China. The number of ART centers increased dramatically from 85 in 2006 to 375 in 2018. In total, 1.08 million ART cycles were performed in 2018 [<span>1</span>]. Based on the large volume of ART data in China, Chinese researchers have conducted studies on various aspects to improve clinical practice and seek innovations and breakthroughs in the field of ART.</p><p>However, the popularity of ART raises concerns regarding the safety of ART offspring [<span>2</span>]. Wang et al. [<span>3</span>] conducted a prospective cohort study to assess the comprehensive health status of school-age children conceived through ART compared to that of children conceived naturally. They found that ART- and naturally conceived children had a similar overall health status, but ART-conceived children had at an increased risk of latent exotropia. Liu et al. [<span>4</span>] performed a matched cohort study to examine the effect of laser-assisted hatching (LAH) on the physical, metabolic, cognitive, and behavioural profiles of singletons conceived through frozen–thawed embryo transfer (FET) at preschool age. The results showed that at 4–6 years of age, the cognitive, metabolic, and physical developmental outcomes of pre-school children born after LAH treatment were comparable to those of pre-school children born without LAH treatment, indicating that LAH is possibly a safe assisted reproductive technology method. This study by Liu et al. is the first follow-up study to assess the health of offspring born after LAH up to the preschool age. Wu et al. [<span>5</span>] investigated the relationship between prolonged ovarian stimulation and neonatal outcomes after autologous fresh embryo transfer (fET) and found that prolonged ovarian stimulation did not increase adverse neonatal outcomes in singleton newborns after autologous fET. This retrospective cohort study by Wu et al. is the first to investigate the effects of prolonged ovarian stimulation on neonatal outcomes after autologous fET. Hu et al. [<span>6</span>] found that the overall risk of perinatal and neonatal complications in singleton live births was higher in patients with poor ovarian response (POR) than in those with normal ovarian response (NOR); however, the risks were similar after logistic regression adjustment. Taken together, these studies indicate that ART does not increase the risk of adverse events in offspring.</p><p>Robust evidence of effectiveness and safety is a prerequisite for the introduction of new technologies in reproductive medicine [<span>7</span>]. Chinese researchers are making great efforts to investigate whether each ART intervention improves clinical outcomes. Xu et al. [<span>8</span>] found that higher luteinizing hormone (LH) levels on trigger day were associated with improved pregnancy outcomes in gonadotropin-releasing hormone (GnRH) antagonist protocols. Maintaining an optimal","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 S2","pages":"5-7"},"PeriodicalIF":4.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Reply.","authors":"Hitomi Okubo, Shoji F Nakayama, Asako Mito, Naoko Arata, Yukihiro Ohya","doi":"10.1111/1471-0528.18130","DOIUrl":"https://doi.org/10.1111/1471-0528.18130","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Reply.","authors":"Yuhang Liang, Jie Ou, Jing Fu, Yijing Wang, Yanping Li, Jinchen Li, Yan Yi","doi":"10.1111/1471-0528.18131","DOIUrl":"https://doi.org/10.1111/1471-0528.18131","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Impacting Live Birth Probability After In Vitro Fertilisation and Embryo Transfer in Women With Endometrial Cancer Following Conservative Therapy: A Retrospective Cohort Study","authors":"Ningning Pan,&nbsp;Hongyi Wei,&nbsp;Yang Wang,&nbsp;Rong Li,&nbsp;Caihong Ma","doi":"10.1111/1471-0528.18063","DOIUrl":"10.1111/1471-0528.18063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to elucidate the factors influencing live birth outcomes following in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) after conservative therapy in women with early-stage endometrioid endometrial cancer (EEC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Single-centre retrospective cohort study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Reproductive Center, Peking University Third Hospital.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Population</h3>\u0000 \u0000 <p>One hundred and seventeen women with Stage IA EEC who received conservative treatment and achieved complete remission.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Medical records from our database were retrospectively analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Cumulative live births and endometrial cancer recurrence rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cumulative live birth rate of women who underwent controlled ovarian stimulation (COS) was significantly higher than in those who did not (43.7% vs. 20.0%; <i>p</i> = 0.021), whereas the endometrial cancer recurrence rate was similar (26.1% vs. 30%; <i>p</i> = 0.812). Of 87 patients who received COS cycles, 71 underwent embryo transfer, of which 38 resulted in live birth and 33 did not. There was a significant association between live births and both endometrial thickness (odds ratio [OR] 1.753, 95% confidence interval [CI] 1.174–2.616, <i>p</i> = 0.006) and the number of transferable embryos (OR 1.270, 95% CI 1.017–1.587, <i>p</i> = 0.035).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The chances of successful live births following IVF/ICSI-ET are encouraging for women diagnosed with EEC. Endometrial thickness and the number of transferable embryos are crucial factors associated with the success rate of live births in women with EEC undergoing IVF-ET.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 S2","pages":"100-106"},"PeriodicalIF":4.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sigma-1 Receptor-Mediated High Mobility Group A1 Silencing Alleviates Endoplasmic Reticulum Stress-Induced Ovarian Granulosa Cell Apoptosis: An In Vitro Cell Experimental Study","authors":"Lile Jiang,&nbsp;Shujun Yang,&nbsp;Cuilian Zhang","doi":"10.1111/1471-0528.18081","DOIUrl":"10.1111/1471-0528.18081","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the role and underlying mechanism of sigma-1 receptor (SigmaR1)/high mobility group A1 (HMGA1) in the pathogenesis of diminished ovarian reserve (DOR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>In vitro cell experimental study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>The Reproductive Medical Center, People's Hospital of Zhengzhou University.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Sample</h3>\u0000 \u0000 <p>Serum, follicular fluid (FF), ovarian granulosa cells (GCs) and KGN cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Samples were collected from DOR patients. Endoplasmic reticulum (ER) stress was induced in the GCs using thapsigargin (TG). mRNA and protein levels were determined using reverse transcription-quantitative polymerase chain reaction and western blotting. Cell apoptosis and viability were assessed using flow cytometry and cell counting kit-8. Protein colocalization was detected via immunofluorescence. Molecular interactions were validated using co-immunoprecipitation, luciferase reporter and chromatin immunoprecipitation assays.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Cell viability, cell apoptosis, SigmaR1, HMGA1 and ER stress-associated mRNA levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SigmaR1 expression decreased while HMGA1 expression increased in the serum, FF and GC samples of DOR patients and TG-treated GCs. TG induced ER stress and GC apoptosis; these effects were diminished by SigmaR1 overexpression or HMGA1 silencing. SigmaR1 expressed in the nuclear envelope forms a complex with gene repressor-specific protein 3 (SP3) and histone deacetylase (HDAC)1/2/3; however, TG reduced SigmaR1 in GCs and blocked the complex formation. HMGA1, a transcriptional target of SP3, was negatively modulated by the SigmaR1/SP3 complex. HMGA1 overexpression abolished the protective effect of SigmaR1 on TG-induced ER stress and GC apoptosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SigmaR1 formed a SmigaR1/SP3/HDAC complex to inhibit HMGA1 transcription, alleviating ER stress and GC apoptosis and providing new therapeutic targets for DOR.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 S2","pages":"120-131"},"PeriodicalIF":4.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further Considerations on Risk-Reducing Salpingectomy and Oophorectomy in BRCA1/2 Carriers.","authors":"Hui Zhang, Wanchen Zhao, Na Guo","doi":"10.1111/1471-0528.18116","DOIUrl":"https://doi.org/10.1111/1471-0528.18116","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Process of Consent for Planned Caesarean.","authors":"Maryam Abdelkarim, Siobhan Quenby, Joshua Odendaal","doi":"10.1111/1471-0528.18113","DOIUrl":"https://doi.org/10.1111/1471-0528.18113","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-evaluating the Preventive Role of Pre-Pregnancy Lifestyle Interventions on Adverse Pregnancy Outcomes.","authors":"XiaoPang Ren, Yuanyuan Guo","doi":"10.1111/1471-0528.18114","DOIUrl":"https://doi.org/10.1111/1471-0528.18114","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Reply.","authors":"Naomi O Riches","doi":"10.1111/1471-0528.18118","DOIUrl":"https://doi.org/10.1111/1471-0528.18118","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Reply.","authors":"C Obern, M Olovsson, T Tydén, I Sundström-Poromaa","doi":"10.1111/1471-0528.18120","DOIUrl":"https://doi.org/10.1111/1471-0528.18120","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}