Janice Hoang, Kathryn Halliday, Deborah Allen, Wema Meranda Mtika, Eve Tranter, Grace Glover, Lynn Tatnell, Julia Hippisley-Cox, Carol Coupland, Sarah Hillman, Jennifer Hirst
{"title":"Factors Associated With Menopause Symptoms: A Systematic Review and Meta-Analysis.","authors":"Janice Hoang, Kathryn Halliday, Deborah Allen, Wema Meranda Mtika, Eve Tranter, Grace Glover, Lynn Tatnell, Julia Hippisley-Cox, Carol Coupland, Sarah Hillman, Jennifer Hirst","doi":"10.1111/1471-0528.70257","DOIUrl":"https://doi.org/10.1111/1471-0528.70257","url":null,"abstract":"<p><strong>Background: </strong>Menopause, marked by hormonal decline and menstrual cessation, is associated with various symptoms. Socio-demographic and behavioural factors may influence symptom type and severity. Understanding these associations can inform better symptom management.</p><p><strong>Objectives: </strong>To identify factors associated with the presence and severity of menopausal symptoms through systematic review and meta-analysis.</p><p><strong>Search strategy: </strong>We searched Medline, Embase, CINAHL and Cochrane for studies on demographic, behavioural, or health factors linked to vasomotor, vaginal dryness and joint symptoms in women aged 40-60.</p><p><strong>Selection criteria: </strong>Studies reporting odds ratios or raw numbers for symptom presence or severity were included.</p><p><strong>Data collection and analysis: </strong>Studies were combined for meta-analysis, reporting odds ratios and 95% confidence intervals. Quality assessment was performed to quantify the risk of bias.</p><p><strong>Results: </strong>Of 9228 screened articles, 61 were meta-analysed. Compared with White women, Black women had higher odds of vasomotor symptom presence (OR 1.65, 1.41-1.94) and severity (OR 1.91, 1.10-3.29), and vaginal dryness presence (OR 1.27, 1.10-1.47), while Asian had lower vasomotor symptom presence and severity (OR 0.40, 0.22-0.72; OR 0.55, 0.53-0.56). Higher education (OR 1.31, 1.09-1.56), high income (OR 1.41, 1.01-1.97) and depression (OR 2.36, 1.51-3.70) were associated with increased presence of vasomotor symptoms. Smoking and obesity were associated with both presence (OR 1.63, 1.30-2.04 and 1.35, 1.02-1.78) and severity (OR 1.56, 1.07-2.27 and 1.42, 1.11-1.83) of vasomotor symptoms.</p><p><strong>Conclusion: </strong>Socio-demographic and behavioural factors, including ethnicity, education, income, smoking, obesity and depression, influence menopausal symptoms, highlighting the need for personalised care.</p><p><strong>Trial registration: </strong>PROSPERO number: CRD42023459154.</p>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Author Reply.","authors":"Basky Thilaganathan, Monica Minopoli","doi":"10.1111/1471-0528.70132","DOIUrl":"10.1111/1471-0528.70132","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":"1317-1318"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving trustworthiness in research on women's health: Some suggestions from a reviewer's viewpoint.","authors":"Shigeki Matsubara","doi":"10.1111/1471-0528.17842","DOIUrl":"10.1111/1471-0528.17842","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":"1306-1307"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140877853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Janneke van 't Hooft, Bassel H Ai Wattar, Khalid S Khan
{"title":"Improving trustworthiness in research in women's health is a joint effort.","authors":"Janneke van 't Hooft, Bassel H Ai Wattar, Khalid S Khan","doi":"10.1111/1471-0528.17861","DOIUrl":"10.1111/1471-0528.17861","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":"1308-1309"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Maternal suicide up to 1 year postpartum: Evidence or emotion-based medicine?","authors":"Alain Braillon","doi":"10.1111/1471-0528.17841","DOIUrl":"10.1111/1471-0528.17841","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":"1305"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Su Mon Latt, Charles Opondo, Fiona Alderdice, Jennifer J Kurinczuk, Rachel Rowe
{"title":"Author Reply.","authors":"Su Mon Latt, Charles Opondo, Fiona Alderdice, Jennifer J Kurinczuk, Rachel Rowe","doi":"10.1111/1471-0528.70131","DOIUrl":"10.1111/1471-0528.70131","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":"1313-1314"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ChatGPT, Google and healthcare institution sources of postoperative patient instructions.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1111/1471-0528.17866","DOIUrl":"10.1111/1471-0528.17866","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":"1310"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Age at Menopause and Trajectories of Multimorbidity Progression to Mortality: A Multi-State Analysis of UK Biobank Data.","authors":"Min Li, Tianyu Liu, Haibo Zhou, Xinyue Yu, Hanhan Wang, Lixin Zheng, Zhongran Wang, Xu Han, Xiyun Ren, Xiangfeng Lu, Wenjing Tian","doi":"10.1111/1471-0528.70235","DOIUrl":"https://doi.org/10.1111/1471-0528.70235","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether age at menopause is associated with the trajectory of multimorbidity progression.</p><p><strong>Design: </strong>A retrospective cohort study.</p><p><strong>Setting: </strong>The UK Biobank.</p><p><strong>Population: </strong>121 017 postmenopausal women aged 40-69 years with complete baseline and menopausal data.</p><p><strong>Methods: </strong>Cox proportional hazards models were used to explore the associations between menopausal age and both multimorbidity and mortality. Multi-state models were further employed to evaluate the association of menopausal age with transitions from a health state to the first chronic disease (FCD), to multimorbidity, and to mortality from each state.</p><p><strong>Main outcome measures: </strong>Multimorbidity (defined as ≥ 2 of 35 chronic conditions) and mortality.</p><p><strong>Results: </strong>Over a median follow-up period of 8.6 years, 86 821 women developed the FCD, 42237 multimorbidity, and 10 527 participants died. In the multi-state models analysis, from health to FCD, compared with women who experienced menopause after age 50 years, the risks increased by 32%, 14%, and 3% among women with premature, early, and relatively early menopause, respectively (HR = 1.32, 95% CI: 1.28-1.36; HR = 1.14, 95% CI: 1.11-1.17; HR = 1.03, 95% CI: 1.01-1.05). Similarly, for the transition from FCD to multimorbidity, the risks increased by 22% (HR = 1.22, 95% CI: 1.17-1.27), 13% (HR = 1.13, 95% CI: 1.09-1.16), and 6% (HR = 1.06, 95% CI: 1.03-1.08), respectively.</p><p><strong>Conclusions: </strong>Earlier menopause was associated with an increased risk of multimorbidity and mortality, mainly affecting two trajectories, from health to FCD and FCD to multimorbidity.</p>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}