Bjog-An International Journal of Obstetrics and Gynaecology最新文献

{"title":"Predicting Adverse Perinatal Outcomes in Dichorionic Twin Pregnancies: A Multicentre Cohort Study","authors":"Veronica Giorgione,&nbsp;Mariarita Trapani,&nbsp;Miriam Lopian,&nbsp;Mariafrancesca Brutto,&nbsp;Maria Giulia Ferrante,&nbsp;Amarnath Bhide,&nbsp;Jacques C. Jani,&nbsp;Dominique A. Badr,&nbsp;Tullio Ghi,&nbsp;Basky Thilaganathan,&nbsp;Alessandra Familiari,&nbsp;Elisa Bevilacqua","doi":"10.1111/1471-0528.18125","DOIUrl":"10.1111/1471-0528.18125","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Dichorionic twin pregnancies are associated with increased risks of stillbirth or medically indicated early preterm birth (ePTB) to avoid stillbirths. This study evaluated the predictive value of fetal estimated weight (EFW) and Doppler indices before adverse perinatal outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Retrospective multicentre cohort study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Three tertiary centres in the UK, Italy and Belgium.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Population</h3>\u0000 \u0000 <p>The study included 1294 dichorionic twin pregnancies managed between 2013 and 2023.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Univariable and multivariable analyses assessed the association and the predictive accuracy between EFW and Doppler indices taken within 2 weeks of birth or adverse perinatal outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Stillbirths (of one or both twins) or medically indicated ePTB before 34 weeks' gestation for fetal indications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study identified 58 pregnancies (4.5%) complicated by adverse perinatal outcomes. There were significant differences (all <i>p</i> &lt; 0.001) between twins with adverse perinatal outcomes and liveborn twins for small for gestational age foetuses (89.5% vs. 59.3%), EFW discordance (31.8% vs. 8.4%), umbilical artery (UA) pulsatility index (PI) discordance (39.7% vs. 12.6%) and middle cerebral artery PI discordance (27.6% vs. 13.3%). These associations remained significant after adjusting for maternal characteristics and gestational age. The best predictive model included EFW discordance and UA PI discordance, with an area under the curve of 0.90.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The integration of intertwin EFW and UA PI discordance can effectively predict stillbirths or the need for medically indicated ePTB. After external validation in larger populations, this model could provide effective risk stratification of dichorionic pregnancies to enable targeted interventions to improve clinical outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 7","pages":"983-990"},"PeriodicalIF":4.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphenols for the Prevention or Management of Preeclampsia: A Systematic Review and Meta-Analysis","authors":"Phi-Yen Nguyen,&nbsp;Ben Sanderson,&nbsp;Maureen Makama,&nbsp;Kate Mills,&nbsp;Anne Ammerdorffer,&nbsp;A. Metin Gülmezoglu,&nbsp;Joshua P. Vogel,&nbsp;Annie R. A. McDougall","doi":"10.1111/1471-0528.18106","DOIUrl":"10.1111/1471-0528.18106","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To evaluate the effects of polyphenol-containing products during pregnancy on preeclampsia-related maternal and neonatal outcomes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Design&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Systematic review and meta-analysis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Setting&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Nine databases and one trial registry, from inception to August 11th, 2023.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Population/Sample&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Randomised controlled trials where women received polyphenolic-containing products (as standardised extracts or dietary supplements) compared to placebo or standard care.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;All review stages were conducted by two independent reviewers. Random-effects meta-analysis with the Hartung–Knapp–Sidik–Jonkman method using a framework for studies with few events.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Main Outcome Measures&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Clinical outcomes combining the core outcome set for preeclampsia and WHO's priority outcomes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Fourteen trials investigating six candidates were included. In women with preeclampsia, the addition of epigallocatechin gallate (EGCG) to nifedipine may reduce the time needed to achieve blood pressure control (mean difference (MD) = −14.10 min, 95% CI −18.46 to −9.74) and increase the time to the next hypertensive crisis (MD = 3.10 h, 95% CI 2.35 to 3.85) compared to nifedipine alone (1 trial, 349 women; low certainty). Similarly, the addition of resveratrol to nifedipine may reduce the time needed to achieve blood pressure control (MD = −15.50 min, 95% CI −19.83 to −11.17) and increase the time to the next hypertensive crisis (MD = 2.50 h, 95% CI 2.09 to 2.91) (1 trial, 349 women; low certainty). No differences were observed for other outcomes or candidates (&lt;i&gt;Salvia miltiorrhiza, Bryophyllum pinnatum&lt;/i&gt; , raspberry and cranberry extracts).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;ECGC and resveratrol supplements have been investigated for potential effects in managing clinical signs and symptoms of preeclampsia; however, evidence on the clinical and adverse effects of polyphenols is limited and uncertain.&lt;/p&gt;\u0000 ","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 7","pages":"867-879"},"PeriodicalIF":4.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publishers' Response to Post-Publication Concerns About Clinical Research in Women's Health","authors":"Siddharth Shivantha,&nbsp;Nicole Ling Shan Au,&nbsp;Lyle Gurrin,&nbsp;Jim Thornton,&nbsp;Jeremy Nielsen,&nbsp;Ben W. Mol","doi":"10.1111/1471-0528.18100","DOIUrl":"10.1111/1471-0528.18100","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Potentially untrustworthy medical research is often identified after publication. We evaluated the effectiveness and efficiency of post-publication review of such studies in women's health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Cohort study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Sample</h3>\u0000 \u0000 <p>Potentially untrustworthy papers published in women's health journals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We wrote to the editors and publishers about potentially untrustworthy papers in women's health and requested an investigation according to the procedure established by the Committee of Publication Ethics (COPE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measure</h3>\u0000 \u0000 <p>Study characteristics, investigation outcome classed as retraction, expression of concern (EoC), correction or no wrongdoing found, and time to decision. We also report the case completion rate per journal and publisher.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between 7th November 2017 and 30th April 2024, we wrote to editors and publishers of 891 potentially untrustworthy papers published in 206 different journals. At present, 263 (30%) of 891 papers received an outcome, with 227 (86%) labelled as problematic [152 (58%) retracted; 75 (29%) EoC]. For articles with a decision, it took a median time of 38 months for editors and publishers to decide, with 13% of the flagged cases reaching a decision within 12 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The current PPR process is inefficient and ineffective in assessing and removing untrustworthy data from the medical literature.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 7","pages":"892-901"},"PeriodicalIF":4.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, Regional and National Burden of Infertility due to Endometriosis: Results From the Global Burden of Disease Study 2021 and Forecast to 2044","authors":"Yue Chen,&nbsp;Cheng Liu,&nbsp;Xiuping Wang,&nbsp;Yi Liu,&nbsp;Hengwei Liu","doi":"10.1111/1471-0528.18108","DOIUrl":"10.1111/1471-0528.18108","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To analyse global prevalence data for infertility due to endometriosis from 1990 to 2021, emphasising health inequalities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Population-based study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Data from the Global Burden of Disease (GBD) database.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Population</h3>\u0000 \u0000 <p>Individuals diagnosed with infertility due to endometriosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A statistical method was employed to evaluate changes in disease prevalence over time. We also analysed how disease prevalence varies by age, time period and birth cohort. A model was used to predict future trends. Additionally, we examined the relationship between prevalence and the socio-demographic index (SDI) levels across countries. Finally, we conducted a decomposition analysis to identify key factors driving changes and assessed health inequality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>The burden of infertility due to endometriosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The global burden of infertility due to endometriosis in 2021 showed a downward trend, and the low SDI region had a notably higher burden. High risk was observed in the 25–29 age group in the age effects analysis. Period risks almost kept decreasing over these years, and for cohort effects, the later born individuals showed an overall lower risk than the earlier born individuals. Cross-country inequality analysis revealed significant disparities, with countries in lower SDI categories bearing a higher burden.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The global burden of infertility due to endometriosis has become a significant public health concern over recent decades. Governments should adapt prevention strategies to fit their specific national contexts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 7","pages":"944-960"},"PeriodicalIF":4.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-Trimester Prediction of Gestational Diabetes Mellitus Based on Maternal Risk Factors","authors":"Argyro Syngelaki,&nbsp;Alan Wright,&nbsp;Cristina Gomez Fernandez,&nbsp;Rea Mitsigiorgi,&nbsp;Kypros H. Nicolaides","doi":"10.1111/1471-0528.18110","DOIUrl":"10.1111/1471-0528.18110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To develop and validate a new first-trimester model for the prediction of gestational diabetes mellitus (GDM) based on maternal demographic characteristics and elements of medical history.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Prospective cohort study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Inner-city hospital.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Population</h3>\u0000 \u0000 <p>41 587 women with singleton pregnancies at 11⁺⁰–13⁺⁶ weeks' gestation, including 4231 (10.2%) who subsequently developed GDM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Logistic regression model for GDM was developed and fivefold cross-validation was performed to assess the calibration and predictive performance of the model, assessed by the area under the receiver operating characteristic curve (AUROC) and detection rates (DRs) at different screen positive rates (SPRs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measure</h3>\u0000 \u0000 <p>GDM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In both parous women with a previous history of GDM and nulliparous women or parous women with no history of GDM, significant contributors to the prediction of GDM were maternal age, weight, height, ethnicity and family history of diabetes mellitus. In parous women with no previous history of GDM, there was a contribution from the birthweight z-score of the previous pregnancy. There was good agreement between the predicted risk and observed incidence of GDM (intercept 0.000, 95% CI: −0.034, 0.034; slope 1.000, 95% CI: 0.967, 1.033). The AUROC curve was 0.757 (95% CI: 0.749, 0.765). The performance was higher for GDM treated with insulin versus metformin or diet alone. At SPR of 40%, the DR of the insulin, metformin and diet alone group was 87.2% (95% CI: 84.9, 89.3), 80.0% (77.8, 82.0) and 61.5% (59.2, 63.7), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Assessment of risk for GDM can be achieved in the first trimester based on maternal risk factors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 7","pages":"972-982"},"PeriodicalIF":4.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Impacting Live Birth Probability After In Vitro Fertilisation and Embryo Transfer in Women With Endometrial Cancer Following Conservative Therapy: A Retrospective Cohort Study","authors":"Ningning Pan,&nbsp;Hongyi Wei,&nbsp;Yang Wang,&nbsp;Rong Li,&nbsp;Caihong Ma","doi":"10.1111/1471-0528.18063","DOIUrl":"10.1111/1471-0528.18063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to elucidate the factors influencing live birth outcomes following in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) after conservative therapy in women with early-stage endometrioid endometrial cancer (EEC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Single-centre retrospective cohort study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Reproductive Center, Peking University Third Hospital.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Population</h3>\u0000 \u0000 <p>One hundred and seventeen women with Stage IA EEC who received conservative treatment and achieved complete remission.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Medical records from our database were retrospectively analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Cumulative live births and endometrial cancer recurrence rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cumulative live birth rate of women who underwent controlled ovarian stimulation (COS) was significantly higher than in those who did not (43.7% vs. 20.0%; <i>p</i> = 0.021), whereas the endometrial cancer recurrence rate was similar (26.1% vs. 30%; <i>p</i> = 0.812). Of 87 patients who received COS cycles, 71 underwent embryo transfer, of which 38 resulted in live birth and 33 did not. There was a significant association between live births and both endometrial thickness (odds ratio [OR] 1.753, 95% confidence interval [CI] 1.174–2.616, <i>p</i> = 0.006) and the number of transferable embryos (OR 1.270, 95% CI 1.017–1.587, <i>p</i> = 0.035).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The chances of successful live births following IVF/ICSI-ET are encouraging for women diagnosed with EEC. Endometrial thickness and the number of transferable embryos are crucial factors associated with the success rate of live births in women with EEC undergoing IVF-ET.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 S2","pages":"100-106"},"PeriodicalIF":4.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Menstrual Disorders and Workforce Participation: A Prospective Longitudinal Study","authors":"Biresaw Wassihun Alemu,&nbsp;Michael Waller,&nbsp;Leigh R. Tooth","doi":"10.1111/1471-0528.18109","DOIUrl":"10.1111/1471-0528.18109","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the association between menstrual disorders and workforce participation among Australian women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Population-based cohort study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Secondary analysis of eight surveys collected between 2000 and 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Population</h3>\u0000 \u0000 <p>A total of 11 152 Australian women, born between 1973 and 1978.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Between 2000 and 2021, self-reported longitudinal survey data were collected. At each survey, menstrual disorders and workforce participation were measured. Data were analysed using generalised estimating equations for multinomial responses, with stratification by age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Workforce participation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Women who often experienced premenstrual tension reported lower odds of working part-time compared to full-time work (Adjusted Odds Ratio (AOR) = 0.74; 95% CI: 0.61, 0.90), with this finding strongest among women aged 31 to 40 (AOR = 0.68, 95% CI: 0.59, 0.78). While overall, women who often experienced irregular periods had higher odds of working part-time compared to full-time (AOR = 1.32, 95% CI: 1.08, 1.61), women aged 22 to 30 had lower odds of working part-time (AOR = 0.61, 95% CI: 0.39, 0.97). Women who experienced severe period pain had higher odds of being unemployed compared to working full-time (AOR = 1.18; 95% CI: 1.01, 1.36), with this association strongest in women aged 41 and older (AOR = 1.19, 95% CI: 1.01, 1.40).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There is substantial variation in the association between menstrual disorders and workforce participation, and the role of women's ages in these associations. Increased awareness of and further elucidation of these factors may improve women's engagement in the workforce.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 7","pages":"961-971"},"PeriodicalIF":4.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactive Hypoglycaemia at Glucose Tolerance Test—Another Presentation of Gestational Diabetes: A Multicentre Retrospective Study","authors":"Sana Rehman,&nbsp;Salsabeel Kazi,&nbsp;Haashim Shah,&nbsp;Nicola Wallis,&nbsp;Pradhiki Mahindra,&nbsp;Bassel H. Al Wattar,&nbsp;Melissa Whitten,&nbsp;Katherine Lattey,&nbsp;Molly Parrington,&nbsp;Rose Turner,&nbsp;Christy Burden,&nbsp;Dimitrios Siassakos","doi":"10.1111/1471-0528.18105","DOIUrl":"10.1111/1471-0528.18105","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To assess obstetric outcomes in pregnant women with ‘reactive hypoglycaemia’ (RH) during an oral glucose tolerance test (OGTT), defined as a 2-h blood glucose level lower than the fasting value.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Design&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Retrospective observational study.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Setting&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Two tertiary maternity units in the United Kingdom.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Population&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 1498 women with singleton pregnancies attending for an OGTT between April 2019 and July 2020.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Maternal and neonatal outcomes were compared between three groups: gestational diabetes, reactive hypoglycaemia and normal OGTT. Both logistic and linear regression models were used, which adjusted for maternal age at booking, ethnicity, parity and BMI.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Main Outcome Measures&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Abdominal circumference &gt; 95th centile, polyhydramnios, gestational age at delivery, preterm birth, birthweight, neonatal hypoglycaemia, admission to neonatal unit, perinatal mortality.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Of the 1498 women, 26.7% (&lt;i&gt;n&lt;/i&gt; = 400) had reactive hypoglycaemia, 27.8% (&lt;i&gt;n&lt;/i&gt; = 417) GDM and 45.4% (&lt;i&gt;n&lt;/i&gt; = 681) normal GTT. The reactive hypoglycaemia group were twice as likely to develop polyhydramnios compared with both the GDM (OR 2.77, 95% CI 1.40–5.50) and control groups (OR 2.47, 95% CI 1.31–4.65). Relative to those with GDM, women with reactive hypoglycaemia had a similar mean birthweight (mean difference 59.4 g, &lt;i&gt;p&lt;/i&gt; = 0.06) but were less likely to experience neonatal hypoglycaemia (OR 0.30, 95% CI 0.001–0.15) or preterm birth (OR 0.33, 95% CI 0.18–0.60). No differences were found in maternal hypertensive disorders, abdominal circumference &gt; 95th centile, shoulder dystocia, Apgar &lt; 7, cord pH, admission to neonatal unit or perinatal mortality.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Women with reactive hypoglycaemia in this sample were at risk of adverse outcomes frequently associated with diabetes, including polyhydramnios.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 &lt;/di","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 7","pages":"927-934"},"PeriodicalIF":4.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sigma-1 Receptor-Mediated High Mobility Group A1 Silencing Alleviates Endoplasmic Reticulum Stress-Induced Ovarian Granulosa Cell Apoptosis: An In Vitro Cell Experimental Study","authors":"Lile Jiang,&nbsp;Shujun Yang,&nbsp;Cuilian Zhang","doi":"10.1111/1471-0528.18081","DOIUrl":"10.1111/1471-0528.18081","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the role and underlying mechanism of sigma-1 receptor (SigmaR1)/high mobility group A1 (HMGA1) in the pathogenesis of diminished ovarian reserve (DOR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>In vitro cell experimental study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>The Reproductive Medical Center, People's Hospital of Zhengzhou University.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Sample</h3>\u0000 \u0000 <p>Serum, follicular fluid (FF), ovarian granulosa cells (GCs) and KGN cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Samples were collected from DOR patients. Endoplasmic reticulum (ER) stress was induced in the GCs using thapsigargin (TG). mRNA and protein levels were determined using reverse transcription-quantitative polymerase chain reaction and western blotting. Cell apoptosis and viability were assessed using flow cytometry and cell counting kit-8. Protein colocalization was detected via immunofluorescence. Molecular interactions were validated using co-immunoprecipitation, luciferase reporter and chromatin immunoprecipitation assays.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Cell viability, cell apoptosis, SigmaR1, HMGA1 and ER stress-associated mRNA levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SigmaR1 expression decreased while HMGA1 expression increased in the serum, FF and GC samples of DOR patients and TG-treated GCs. TG induced ER stress and GC apoptosis; these effects were diminished by SigmaR1 overexpression or HMGA1 silencing. SigmaR1 expressed in the nuclear envelope forms a complex with gene repressor-specific protein 3 (SP3) and histone deacetylase (HDAC)1/2/3; however, TG reduced SigmaR1 in GCs and blocked the complex formation. HMGA1, a transcriptional target of SP3, was negatively modulated by the SigmaR1/SP3 complex. HMGA1 overexpression abolished the protective effect of SigmaR1 on TG-induced ER stress and GC apoptosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SigmaR1 formed a SmigaR1/SP3/HDAC complex to inhibit HMGA1 transcription, alleviating ER stress and GC apoptosis and providing new therapeutic targets for DOR.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 S2","pages":"120-131"},"PeriodicalIF":4.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further Considerations on Risk-Reducing Salpingectomy and Oophorectomy in BRCA1/2 Carriers.","authors":"Hui Zhang, Wanchen Zhao, Na Guo","doi":"10.1111/1471-0528.18116","DOIUrl":"https://doi.org/10.1111/1471-0528.18116","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}