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Sex-Specific Association Between Calcium-Channel Blocker Use and B-Type Natriuretic Peptide Levels in Elderly Hypertensive Patients With Heart Failure With Preserved Ejection Fraction. 老年高血压心力衰竭患者射血分数保留患者钙通道阻滞剂使用与b型利钠肽水平的性别特异性关联
IF 3.7 3区 医学
Circulation Journal Pub Date : 2025-09-25 Epub Date: 2025-07-03 DOI: 10.1253/circj.CJ-25-0404
Eisaku Harada, Toshihiro Yamada, Yuji Mizuno, Yuichiro Arima, Koichi Kikuta, Hirofumi Yasue
{"title":"Sex-Specific Association Between Calcium-Channel Blocker Use and B-Type Natriuretic Peptide Levels in Elderly Hypertensive Patients With Heart Failure With Preserved Ejection Fraction.","authors":"Eisaku Harada, Toshihiro Yamada, Yuji Mizuno, Yuichiro Arima, Koichi Kikuta, Hirofumi Yasue","doi":"10.1253/circj.CJ-25-0404","DOIUrl":"10.1253/circj.CJ-25-0404","url":null,"abstract":"<p><strong>Background: </strong>The effects of calcium-channel blockers (CCBs) in heart failure with preserved ejection fraction (HFpEF), particularly by sex, remain unclear.</p><p><strong>Methods and results: </strong>We retrospectively analyzed 412 elderly hypertensive patients with HFpEF (308 women, 104 men). Female CCB users had significantly lower B-type natriuretic peptide (BNP) levels. Multivariable regression showed that CCB use was independently associated with lower BNP, higher EF, and lower tricuspid regurgitation pressure gradient in women, but not in men.</p><p><strong>Conclusions: </strong>CCB use, particularly amlodipine, may be associated with sex-specific hemodynamic benefits in hypertensive elderly women with HFpEF, independent of blood pressure control.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1719-1721"},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of the Right Ventricle Overhaul Procedure in Comprehensive Management for Pulmonary Atresia With Intact Ventricular Septum - A Magnetic Resonance Imaging-Based Study. 右心室检查在完整室间隔肺闭锁综合治疗中的作用——基于磁共振成像的研究。
IF 3.7 3区 医学
Circulation Journal Pub Date : 2025-09-25 Epub Date: 2025-09-03 DOI: 10.1253/circj.CJ-25-0177
Jae Hong Lee, Woong-Han Kim, Seung Min Baek, Yoon Seong Lee, Hye Won Kwon, Sungkyu Cho, Jae Gun Kwak, Mi Kyoung Song, Sang-Yun Lee, Gi Beom Kim, Eun Jung Bae
{"title":"Role of the Right Ventricle Overhaul Procedure in Comprehensive Management for Pulmonary Atresia With Intact Ventricular Septum - A Magnetic Resonance Imaging-Based Study.","authors":"Jae Hong Lee, Woong-Han Kim, Seung Min Baek, Yoon Seong Lee, Hye Won Kwon, Sungkyu Cho, Jae Gun Kwak, Mi Kyoung Song, Sang-Yun Lee, Gi Beom Kim, Eun Jung Bae","doi":"10.1253/circj.CJ-25-0177","DOIUrl":"10.1253/circj.CJ-25-0177","url":null,"abstract":"<p><strong>Background: </strong>We evaluated the surgical outcomes of modified right ventricle (RV) overhaul (mRVOh), implemented as part of comprehensive management for pulmonary atresia with intact ventricular septum (PA-IVS).</p><p><strong>Methods and results: </strong>Twenty-five mRVOh procedures were performed in 23 patients with PA-IVS without RV-dependent coronary circulation. The procedure involved RV sinus myectomy, infundibular muscle resection, and tricuspid valve (TV) and pulmonary valve (PV) repair. In addition, in neonates and young infants, Blalock-Taussig shunt or patent ductus arteriosus banding was performed simultaneously. TV and PV annulus sizes were measured using echocardiography; RV function and volume were assessed using magnetic resonance imaging (MRI) in 18 patients. The median age and body weight at the time of mRVOh were 7.0 months and 7.1 kg, respectively. Biventricular repair was performed in 19 patients, and 6 required reoperations, including 2 with redo mRVOh. After mRVOh, the mean TV and PV annulus z-scores showed a significant increase towards the normal range, from -1.91 to -1.40 (P=0.031), and from -2.23 to -1.11 (P=0.014), respectively. Serial postoperative MRI showed significant increases in RV end-diastolic and end-systolic volume indices, stroke volume index, and cardiac index (P<0.001 for all), with preserved RV function.</p><p><strong>Conclusions: </strong>Both RV size and TV annulus showed proportionate growth after mRVOh. mRVOh may be a viable option for facilitating sustainable RV and TV growth in selected patients with PA-IVS.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1672-1683"},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heart Transplant Waiting List Mortality - Impact of HeartMate 3 and the Need for Prioritized Organ Allocation. 心脏移植等候名单死亡率-心脏伴侣3的影响和优先器官分配的需要。
IF 3.7 3区 医学
Circulation Journal Pub Date : 2025-09-25 Epub Date: 2025-06-28 DOI: 10.1253/circj.CJ-25-0088
Shunsuke Saito, Daisuke Yoshioka, Takuji Kawamura, Ai Kawamura, Shin Yajima, Yusuke Misumi, Takashi Kido, Takashi Yamauchi, Shigeru Miyagawa
{"title":"Heart Transplant Waiting List Mortality - Impact of HeartMate 3 and the Need for Prioritized Organ Allocation.","authors":"Shunsuke Saito, Daisuke Yoshioka, Takuji Kawamura, Ai Kawamura, Shin Yajima, Yusuke Misumi, Takashi Kido, Takashi Yamauchi, Shigeru Miyagawa","doi":"10.1253/circj.CJ-25-0088","DOIUrl":"10.1253/circj.CJ-25-0088","url":null,"abstract":"<p><strong>Background: </strong>Japan's heart transplantation system is characterized by an extremely long waiting period, which contributes to significant mortality on the waiting list. The current allocation system may maintain favorable post-transplant outcomes at the expense of high-risk patients, particularly those with severe heart failure or complications following left ventricular assist device (LVAD) implantation. To explore an optimal allocation system for Japan, we investigated risk factors for waiting list mortality.</p><p><strong>Methods and results: </strong>We analyzed 300 patients registered on the heart transplant waiting list at Osaka University between 2014 and 2024. Cox hazard analysis identified age at registration (hazard ratio [HR] 1.023) and congenital heart disease (HR 4.531) as independent risk factors for mortality. In the LVAD cohort (n=244), right heart failure (HR 4.582), stroke associated with systemic infection (HR 5.175), and sudden stroke without preceding infection (HR 3.158) were significant risk factors. Although the HeartMate 3 significantly reduced sudden stroke (P<0.001), it did not improve right heart failure or infection-related stroke. Patients with these complications had significantly lower proportions of time at home with an LVAD (P<0.001).</p><p><strong>Conclusions: </strong>Prioritized organ allocation for patients with congenital heart disease, right heart failure, or LVAD-related infections may improve waiting list survival. Reducing hospitalizations in high-risk LVAD patients could also be beneficial from a healthcare economics perspective.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1600-1607"},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation Between the J-MACS, HeartMate3, and J-HeartMate Risk Scores and Their Prognostic Impact in Japanese Patients With Heart Failure - A Retrospective Study. 日本心力衰竭患者J-MACS、HeartMate3和J-HeartMate风险评分的相关性及其对预后的影响——一项回顾性研究
IF 3.7 3区 医学
Circulation Journal Pub Date : 2025-09-25 Epub Date: 2025-06-13 DOI: 10.1253/circj.CJ-24-0956
Kaoruko Aoki, Togo Iwahana, Ryohei Ono, Hirotoshi Kato, Yuichi Saito, Yoshio Kobayashi
{"title":"Correlation Between the J-MACS, HeartMate3, and J-HeartMate Risk Scores and Their Prognostic Impact in Japanese Patients With Heart Failure - A Retrospective Study.","authors":"Kaoruko Aoki, Togo Iwahana, Ryohei Ono, Hirotoshi Kato, Yuichi Saito, Yoshio Kobayashi","doi":"10.1253/circj.CJ-24-0956","DOIUrl":"10.1253/circj.CJ-24-0956","url":null,"abstract":"<p><strong>Background: </strong>In addition to the J-HeartMate Risk Score (J-HMRS) and HeartMate 3 Risk Score (HM3RS), the J-MACS Risk Score (J-MACS-RS) was developed to predict death after left ventricular assist device (LVAD) implantation in Japanese patients with heart failure (HF). However, the correlation between these scores, the characteristics of high-risk patients as per these scores, and the mortality stratification of these scores in HF patients regardless of LVAD implantation are still not fully understood.</p><p><strong>Methods and results: </strong>Hospitalized patients with HF who underwent echocardiography and right heart catheterization were included (n=269). Patients at low or medium risk per the J-HMRS or HM3RS and at high risk per the J-MACS-RS (LM<sub>J-HM</sub>H<sub>J-MACS</sub> and LM<sub>HM3</sub>H<sub>J-MACS</sub>, respectively) were compared with those at low or medium risk per both scores (LM<sub>J-HM</sub>LM<sub>J-MACS</sub>and LM<sub>HM3</sub>LM<sub>J-MACS</sub>, respectively). The J-MACS-RS was well associated with the J-HMRS (r=0.66) and HM3RS (r=0.65). Patients with LM<sub>J-HM</sub>H<sub>J-MACS</sub> were older and showed a higher prevalence of ischemic etiology and history of cardiac surgery than those with LM<sub>J-HM</sub>LM<sub>J-MACS</sub>. LM<sub>J-HM</sub>H<sub>J-MACS</sub> and LM<sub>HM3</sub>H<sub>J-MACS</sub>showed higher serum creatinine levels and central venous pressure-to-pulmonary artery wedge pressure ratios than LM<sub>J-HM</sub>LM<sub>J-MACS</sub>and LM<sub>HM3</sub>LM<sub>J-MACS</sub>, respectively. All scores stratified the 3-year mortality in patients with HF.</p><p><strong>Conclusions: </strong>The J-MACS-RS correlated well with the J-HMRS and HM3RS. These scores may predict 3-year mortality, even in Japanese HF patients, regardless of LVAD implantation.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1591-1599"},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revisiting the Barthel Index - A Common Language for Activities of Daily Living With Timeless Value in the Digital Era. 重新审视Barthel指数——数字时代具有永恒价值的日常生活活动的共同语言。
IF 3.7 3区 医学
Circulation Journal Pub Date : 2025-09-25 Epub Date: 2025-08-30 DOI: 10.1253/circj.CJ-25-0443
Hiroaki Obata, Tohru Izumi, Takayuki Inomata, Shigeru Makita, Shigeru Fujimoto
{"title":"Revisiting the Barthel Index - A Common Language for Activities of Daily Living With Timeless Value in the Digital Era.","authors":"Hiroaki Obata, Tohru Izumi, Takayuki Inomata, Shigeru Makita, Shigeru Fujimoto","doi":"10.1253/circj.CJ-25-0443","DOIUrl":"10.1253/circj.CJ-25-0443","url":null,"abstract":"<p><strong>Background: </strong>In aging societies, shared tools are needed to assess and communicate activities of daily living (ADL). The Barthel Index (BI) is widely used in administrative data but remains underutilized in discharge planning.</p><p><strong>Methods and results: </strong>We analyzed 605 older cardiovascular patients discharged from a regional hospital, classifying functional levels by BI ambulation, total score, and 6-minute walk distance. Higher levels corresponded with greater ADL independence across BI items.</p><p><strong>Conclusions: </strong>The BI reflects structured functional tiers and serves as a common language in care coordination.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1722-1723"},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Go to the Emergency Department - Early Cardiologist Engagement in Acute Myocardial Infarction Complicated by Cardiogenic Shock. 去急诊科-早期心脏病专家参与急性心肌梗死合并心源性休克。
IF 3.7 3区 医学
Circulation Journal Pub Date : 2025-09-23 DOI: 10.1253/circj.CJ-25-0668
Shoji Kawakami, Takahiro Nakashima
{"title":"Go to the Emergency Department - Early Cardiologist Engagement in Acute Myocardial Infarction Complicated by Cardiogenic Shock.","authors":"Shoji Kawakami, Takahiro Nakashima","doi":"10.1253/circj.CJ-25-0668","DOIUrl":"https://doi.org/10.1253/circj.CJ-25-0668","url":null,"abstract":"","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Characteristics and Outcomes of Infective Endocarditis in Patients Undergoing Maintenance Hemodialysis - A Retrospective Nationwide Database Analysis. 维持性血液透析患者感染性心内膜炎的临床特征和结局——回顾性全国数据库分析。
IF 3.7 3区 医学
Circulation Journal Pub Date : 2025-09-23 DOI: 10.1253/circj.CJ-25-0646
Kyo Kamisaka, Hiroshi Okamoto, Takeshi Nishi, Yoshitaka Sasahira, Koshiro Kanaoka, Yoko Sumita, Chisato Izumi, Shiro Uemura
{"title":"Clinical Characteristics and Outcomes of Infective Endocarditis in Patients Undergoing Maintenance Hemodialysis - A Retrospective Nationwide Database Analysis.","authors":"Kyo Kamisaka, Hiroshi Okamoto, Takeshi Nishi, Yoshitaka Sasahira, Koshiro Kanaoka, Yoko Sumita, Chisato Izumi, Shiro Uemura","doi":"10.1253/circj.CJ-25-0646","DOIUrl":"https://doi.org/10.1253/circj.CJ-25-0646","url":null,"abstract":"<p><strong>Background: </strong>Patients with infective endocarditis (IE) on maintenance hemodialysis (HD) have poor outcomes, but contemporary data remain limited.</p><p><strong>Methods and results: </strong>We conducted a retrospective analysis using a nationwide Japanese administrative database and identified 12,158 patients hospitalized with IE between 2018 and 2021, including 806 (6.6%) on maintenance HD. The inhospital mortality rate was significantly higher in HD patients (30.0% vs. 13.5%, P<0.05).</p><p><strong>Conclusions: </strong>Maintenance HD patients with IE had worse outcomes, underscoring the need for early recognition and tailored management in this highrisk group.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contribution of First Contact With a Cardiologist to the Door-to-Cardiac Catheterization Laboratory Time in Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock - Data From K-ACTIVE. 首次接触心脏病专家对急性心肌梗死合并心源性休克患者从门到心导管实验室时间的贡献——来自K-ACTIVE的数据。
IF 3.7 3区 医学
Circulation Journal Pub Date : 2025-09-20 DOI: 10.1253/circj.CJ-25-0130
Toshinori Ko, Yusuke Hosokawa, Kuniya Asai, Atsuo Maeda, Yoshihiro Akashi, Junya Ako, Yuji Ikari, Toshiaki Ebina, Kouichi Tamura, Atsuo Namiki, Kiyoshi Hibi, Kazuki Fukui, Ichiro Michishita, Kazuo Kimura, Hiroshi Suzuki
{"title":"Contribution of First Contact With a Cardiologist to the Door-to-Cardiac Catheterization Laboratory Time in Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock - Data From K-ACTIVE.","authors":"Toshinori Ko, Yusuke Hosokawa, Kuniya Asai, Atsuo Maeda, Yoshihiro Akashi, Junya Ako, Yuji Ikari, Toshiaki Ebina, Kouichi Tamura, Atsuo Namiki, Kiyoshi Hibi, Kazuki Fukui, Ichiro Michishita, Kazuo Kimura, Hiroshi Suzuki","doi":"10.1253/circj.CJ-25-0130","DOIUrl":"https://doi.org/10.1253/circj.CJ-25-0130","url":null,"abstract":"<p><strong>Background: </strong>Current guidelines recommend early revascularization in patients with cardiogenic shock (CS) following acute myocardial infarction (AMI). However, guideline-recommended first medical contact-to-device times is reportedly achieved in only 40% of patients.</p><p><strong>Methods and results: </strong>We retrospectively analyzed 369 patients with AMI complicated by CS from the Kanagawa-Acute Cardiovascular Registry to evaluate factors influencing delays in treatment and their effect on in-hospital mortality. Patients were stratified into 2 groups based on the median door-to-cardiac catheterization laboratory (D2C) time (≤39 or >39 min). In the group with D2C time ≤39 min, the first-contact physician was more frequently a cardiologist (71.9% vs. 47.0%; P<0.001) and significantly more patients had chest pain as the chief complaint (70.3% vs. 47.4%; P<0.001). Although pre- and post-percutaneous coronary intervention Thrombolysis in Myocardial Infarction flow was similar between the 2 groups, in-hospital mortality was significantly lower in the D2C time ≤39 min group (18.8% vs. 37.6%; P<0.001). Multivariate logistic regression analysis revealed that D2C time >39 min was independently associated with a non-cardiologist being the first-contact physician, the absence of chest pain, a higher heart rate, and elevated creatinine levels.</p><p><strong>Conclusions: </strong>D2C time ≤39 min is correlated with reduced mortality in AMI patients with CS. Implementing systems to ensure cardiologists are the initial responders and optimizing in-hospital workflows could reduce the D2C time and improve outcomes.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Implications of Non-Sustained Ventricular Tachycardia in the Indication for Primary Prevention With an Implantable Cardioverter Defibrillator - Subanalysis From the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE). 非持续性室性心动过速在植入式心律转复除颤器一级预防适应症中的临床意义——来自日本心力衰竭和心源性猝死预防试验(HINODE)的亚分析。
IF 3.7 3区 医学
Circulation Journal Pub Date : 2025-09-20 DOI: 10.1253/circj.CJ-24-0888
Kohei Ishibashi, Satoshi Oka, Toshihiro Nakamura, Yuichiro Miyazaki, Akinori Wakamiya, Nobuhiko Ueda, Kenzaburo Nakajima, Tsukasa Kamakura, Mitsuru Wada, Yuko Inoue, Koji Miyamoto, Satoshi Nagase, Takeshi Aiba, Kengo Kusano, Kazutaka Aonuma
{"title":"Clinical Implications of Non-Sustained Ventricular Tachycardia in the Indication for Primary Prevention With an Implantable Cardioverter Defibrillator - Subanalysis From the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE).","authors":"Kohei Ishibashi, Satoshi Oka, Toshihiro Nakamura, Yuichiro Miyazaki, Akinori Wakamiya, Nobuhiko Ueda, Kenzaburo Nakajima, Tsukasa Kamakura, Mitsuru Wada, Yuko Inoue, Koji Miyamoto, Satoshi Nagase, Takeshi Aiba, Kengo Kusano, Kazutaka Aonuma","doi":"10.1253/circj.CJ-24-0888","DOIUrl":"https://doi.org/10.1253/circj.CJ-24-0888","url":null,"abstract":"<p><strong>Background: </strong>The usefulness of non-sustained ventricular tachycardia (NSVT) in predicting sudden cardiac death is not clear. The Heart Failure Indication and Sudden Cardiac Death Prevention Trial Japan (HINODE) investigated the effectiveness of implantable cardioverter defibrillator (ICD) treatment for primary prevention in Japanese patients. This subanalysis examined associations between NSVT and clinical outcomes.</p><p><strong>Methods and results: </strong>Patients with ICD/cardiac resynchronization therapy defibrillator (CRT-D) for primary prevention (n=164) were divided into NSVT (n=25) and no NSVT (n=139) groups. NSVT was defined as ventricular tachycardia of <30 s duration regardless of pulse rate. The median follow-up period was 19 months, mean patient age was 67 years, and 21% of patients were female. There were no significant differences between the 2 groups in the frequency ischemic cardiomyopathy, mean left ventricular ejection fraction, or (in Kaplan-Meier analysis) in all-cause mortality (log-rank P=0.613), ventricular arrhythmia (VA; log-rank P=0.282), or the composite endpoint of all-cause death and VA events (log-rank P=0.352). Cox proportional hazards analysis indicated that NSVT was not a prognostic factor.</p><p><strong>Conclusions: </strong>Prognosis was similar between the NSVT and no NSVT groups. NSVT, although recommended in guidelines for risk stratification, was not associated with appropriate ICD therapy in patients with ICD/CRT-D for primary prevention. The utility of NSVT in guiding ICD indication may depend on its definition and the characteristics of the studied population, and requires further investigation.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Relevance of Atriogenic Tethering in Atrial Functional Mitral Regurgitation. 房源性栓系在心房功能性二尖瓣反流中的临床意义。
IF 3.7 3区 医学
Circulation Journal Pub Date : 2025-09-19 DOI: 10.1253/circj.CJ-25-0651
Kenya Kusunose
{"title":"Clinical Relevance of Atriogenic Tethering in Atrial Functional Mitral Regurgitation.","authors":"Kenya Kusunose","doi":"10.1253/circj.CJ-25-0651","DOIUrl":"https://doi.org/10.1253/circj.CJ-25-0651","url":null,"abstract":"","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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