Circulation Journal最新文献

The Hidden Burden of Cancer-Associated Venous Thromboembolism　- An Emerging Challenge in Cardio-Oncology. 癌症相关静脉血栓栓塞的隐性负担——心脏肿瘤学的新挑战。

IF 5.8 3区医学

Circulation Journal Pub Date : 2026-09-03 DOI: 10.1253/circj.CJ-26-0701

Jiro Sakamoto

引用次数: 0

Development and Validation of Risk Models for Outcomes of Isolated Coronary Artery Bypass Grafting　- A Nationwide Analysis in Japan. 孤立冠状动脉旁路移植术结果风险模型的开发和验证——日本全国范围内的分析。

IF 5.8 3区医学

Circulation Journal Pub Date : 2026-09-02 DOI: 10.1253/circj.CJ-26-0160

Sachiko Hayashi, Hiraku Kumamaru, Shiori Nishimura, Aya Saito, Hideyuki Shimizu, Noboru Motomura

{"title":"Development and Validation of Risk Models for Outcomes of Isolated Coronary Artery Bypass Grafting　- A Nationwide Analysis in Japan.","authors":"Sachiko Hayashi, Hiraku Kumamaru, Shiori Nishimura, Aya Saito, Hideyuki Shimizu, Noboru Motomura","doi":"10.1253/circj.CJ-26-0160","DOIUrl":"https://doi.org/10.1253/circj.CJ-26-0160","url":null,"abstract":"Background: Reliable preoperative risk assessment is essential in cardiac surgery. In Japan, coronary artery bypass grafting (CABG) risk models have been developed from the Japan Cardiovascular Surgery Database - Adult section (JCVSD-A), with JapanSCORE I and II released previously. To reflect contemporary practice, we developed and validated JapanSCORE III, an updated risk model for isolated CABG, using JCVSD-A.Methods and results: We identified patients undergoing isolated CABG between 2018 and 2023 in the JCVSD-A. The dataset was temporally split into development (2018-2022) and validation (2023) cohorts. A least absolute shrinkage and selection operator model was developed to predict operative mortality, incorporating imaging-based predictors and clinically relevant factors. Secondary outcome models were constructed for stroke, reoperation, prolonged ventilation, renal failure, deep sternal wound infection (DSWI), gastrointestinal complications, and intensive care unit stay >7 days. Model performance was assessed by areas under the curve (AUC) and calibration plots. Among 70,180 patients (mean age 69.3 years; 20% women), operative mortality was 2.7%. The incidence of stroke, reoperation, prolonged ventilation, renal failure, DSWI, gastrointestinal complications, and prolonged ICU stay was 1.8%, 1.5%, 3.7%, 2.0%, 1.1%, 1.3%, and 13.2%, respectively. Operative mortality and renal failure models demonstrated good discrimination (AUC >0.8) and calibration in validation.Conclusions: Operative outcomes remained stable despite increasing predicted risk. The JapanSCORE III models showed good predictive performance, providing valid tools for preoperative risk stratification.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Changes in Serum N-Terminal Pro B-Type Natriuretic Peptide Levels and All-Cause and Cause-Specific Mortality　- The Hisayama Study. 血清n端前b型利钠肽水平变化与全因死亡率和病因特异性死亡率之间的关系——Hisayama研究

IF 5.8 3区医学

Circulation Journal Pub Date : 2026-09-02 DOI: 10.1253/circj.CJ-25-1168

Asahi Kato, Emi Oishi, Akihiro Maezono, Satoko Sakata, Yoshihiko Furuta, Mao Shibata, Jun Hata, Tetsuro Ago, Kohtaro Abe, Toshiharu Ninomiya

{"title":"Association Between Changes in Serum N-Terminal Pro B-Type Natriuretic Peptide Levels and All-Cause and Cause-Specific Mortality　- The Hisayama Study.","authors":"Asahi Kato, Emi Oishi, Akihiro Maezono, Satoko Sakata, Yoshihiko Furuta, Mao Shibata, Jun Hata, Tetsuro Ago, Kohtaro Abe, Toshiharu Ninomiya","doi":"10.1253/circj.CJ-25-1168","DOIUrl":"https://doi.org/10.1253/circj.CJ-25-1168","url":null,"abstract":"Background: Few epidemiological studies have investigated the association between changes in serum N-terminal pro B-type natriuretic peptide (NT-proBNP) and mortality in the general Asian population.Methods and results: We followed 2,703 community-dwelling Japanese residents aged ≥40 years who had serum NT-proBNP concentrations measured in both 2002-2003 and 2007-2008 over a median period of 10.3 years. Changes in NT-proBNP were categorized as decreasing (change ≤-25%), no change (-25%<change<+25%), or increasing (change ≥+25%). Mortality hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. During the follow-up period, 497 deaths occurred (108 cardiovascular, 389 non-cardiovascular). Compared with the no-change group, multivariable-adjusted HRs in the increasing group were 1.73 (95% CI 1.37-2.17), 1.76 (95% CI 1.08-2.87), and 1.71 (95% CI 1.32-2.22) for all-cause, cardiovascular, and non-cardiovascular mortality, respectively. Subgroup analyses by baseline serum NT-proBNP concentration (2002-2003) showed consistent associations with all-cause mortality in both lower (<125 pg/mL) and higher (≥125 pg/mL) NT-proBNP groups, with a tendency towards stronger associations in the higher NT-proBNP group.Conclusions: Changes in serum NT-proBNP concentrations may indicate mortality risk in a community-dwelling Asian population.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining Sarcopenic Obesity in the Asian Working Group for Sarcopenia 2025 Era: Diagnostic Precision Matters. 在2025年亚洲肌少症工作组中定义肌少性肥胖：诊断精度问题。

IF 5.8 3区医学

Circulation Journal Pub Date : 2026-09-01 DOI: 10.1253/circj.CJ-26-0902

Yoshihiro Yoshimura, Ayaka Matsumoto

引用次数: 0

Defining Sarcopenic Obesity in the Asian Working Group for Sarcopenia 2025 Era: Diagnostic Precision Matters　- Reply. 在2025年肌少症亚洲工作组中定义肌少症性肥胖：诊断精度问题-答复。

IF 5.8 3区医学

Circulation Journal Pub Date : 2026-09-01 DOI: 10.1253/circj.CJ-26-0925

Yuta Ozaki

引用次数: 0

The Tell-Tale Heart　- Persistent Immune Activation in Histologically Rejection-Free Heart Transplant Recipients. 无组织学排斥的心脏移植受者的心脏持续免疫激活。

IF 5.8 3区医学

Circulation Journal Pub Date : 2026-08-29 DOI: 10.1253/circj.CJ-26-0642

Toshiyuki Ko, Hiroyuki Morita

引用次数: 0

Changes in Remote Monitoring for Patients With Cardiac Implantable Electronic Devices After a Reimbursement Revision　- An Interrupted Time-Series Analysis. 报销修订后心脏植入式电子装置患者远程监测的变化——中断时间序列分析。

IF 5.8 3区医学

Circulation Journal Pub Date : 2026-08-29 DOI: 10.1253/circj.CJ-26-0548

Koki Takegawa, Koshiro Kanaoka, Haruka Matsuura, Shoko Chishaki-Kawabata, Yoshitaka Iwanaga, Tetsuo Sasano, Yoshihiro Miyamoto

引用次数: 0

Cardiovascular-Kidney-Metabolic Syndrome Age Derived From Routine Health Checkup and Claims Data　- Large-Scale Epidemiological Study. 心血管-肾-代谢综合征年龄来自常规健康检查和索赔数据-大规模流行病学研究。

IF 5.8 3区医学

Circulation Journal Pub Date : 2026-08-28 DOI: 10.1253/circj.CJ-26-0498

Yuta Suzuki, Hidehiro Kaneko, Masachika Nishikawa, Akira Okada, Toshiyuki Ko, Takahiro Jimba, Atsushi Mizuno, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Tatsuhiko Azegami, Kaori Hayashi, Koichi Node, Hideo Yasunaga, Norihiko Takeda

{"title":"Cardiovascular-Kidney-Metabolic Syndrome Age Derived From Routine Health Checkup and Claims Data　- Large-Scale Epidemiological Study.","authors":"Yuta Suzuki, Hidehiro Kaneko, Masachika Nishikawa, Akira Okada, Toshiyuki Ko, Takahiro Jimba, Atsushi Mizuno, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Tatsuhiko Azegami, Kaori Hayashi, Koichi Node, Hideo Yasunaga, Norihiko Takeda","doi":"10.1253/circj.CJ-26-0498","DOIUrl":"https://doi.org/10.1253/circj.CJ-26-0498","url":null,"abstract":"Background: The cardiovascular-kidney-metabolic (CKM) framework emphasizes the interplay of metabolic, renal, and cardiovascular abnormalities in cardiovascular disease risk. We aimed to develop a CKM syndrome age algorithm using routinely collected health checkup and claims data in Japan.Methods and results: We conducted a cohort study of 376,612 men and 478,853 women aged 20-79 years in the DeSC database. Flexible parametric survival models were developed for 5 incident cardiovascular outcomes corresponding to CKM syndrome stage 4 (i.e., heart failure, myocardial infarction, atrial fibrillation, stroke, and peripheral arterial disease) and a composite outcome comprising these 5 outcomes. The models used available CKM-related variables obtained from health checkups and administrative claims data. Model performance was assessed using bootstrap internal validation. CKM syndrome age was defined as the age at which a hypothetical same-sex individual with an optimal CKM risk profile would have the same predicted 5-year risk as the participant. The developed prediction models showed acceptable discrimination across the 6 outcomes, with optimism-corrected Harrell's C-index ranging from 0.694 to 0.724 in men and from 0.653 to 0.716 in women. CKM syndrome age showed higher discrimination than chronological age alone across all outcomes and both sexes.Conclusions: CKM syndrome age may serve as an intuitive tool for communicating integrated cardiovascular risk beyond chronological age in health checkup settings.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimated Small Dense Low-Density Lipoprotein Cholesterol Is Independently Associated With Arterial Stiffness　- Large Japanese Screening Study. 估计小密度低密度脂蛋白胆固醇与动脉硬化独立相关-大型日本筛选研究。

IF 5.8 3区医学

Circulation Journal Pub Date : 2026-08-28 DOI: 10.1253/circj.CJ-26-0093

Shuya Shinchi, Yuichi Akasaki, Daisuke Tokutake, Shin Kawasoe, Shota Uebo, Takuro Kubozono, Hironori Miyahara, Koichi Tokusige, Mitsuru Ohishi

{"title":"Estimated Small Dense Low-Density Lipoprotein Cholesterol Is Independently Associated With Arterial Stiffness　- Large Japanese Screening Study.","authors":"Shuya Shinchi, Yuichi Akasaki, Daisuke Tokutake, Shin Kawasoe, Shota Uebo, Takuro Kubozono, Hironori Miyahara, Koichi Tokusige, Mitsuru Ohishi","doi":"10.1253/circj.CJ-26-0093","DOIUrl":"https://doi.org/10.1253/circj.CJ-26-0093","url":null,"abstract":"Background: Small dense low-density lipoprotein cholesterol (sdLDL-C) is an established atherogenic marker; however, the association between estimated sdLDL-C (EsdLDL-C) and arterial stiffness remains unclear.Methods and results: We analyzed 23,623 participants (13,518 men, 10,105 women). EsdLDL-C was calculated using the Sampson equation, and arterial stiffness was defined as a brachial-ankle pulse wave velocity (baPWV) ≥1,400 cm/s. After adjustment for cardiovascular risk factors, higher EsdLDL-C levels were significantly associated with arterial stiffness in the overall population and in men, whereas the association in women did not reach statistical significance in the continuous analysis. Nevertheless, the risk of arterial stiffness increased in a stepwise manner across EsdLDL-C quartiles; the highest EsdLDL-C quartile had a significantly higher risk than the lowest in both men (odds ratio [OR] 1.91; 95% confidence interval [CI] 1.59-2.29) and women (OR 1.54; 95% CI 1.22-1.95). In a 4-group analysis, high EsdLDL-C significantly increased risk, regardless of whether estimated low-density lipoprotein cholesterol levels were below or above the median. Stratified analysis by systolic blood pressure (SBP; <120, 120-129, 130-139, and ≥140 mmHg) revealed that the association was significant across all categories in men, but was less consistent in women and was significant only in the strict normotensive group (SBP <120 mmHg).Conclusions: EsdLDL-C calculated from standard lipid parameters is significantly associated with arterial stiffness. This association is robust in men and evident in normotensive women, suggesting that EsdLDL-C is a useful indicator for arteriosclerotic risk assessment.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updated 2026 Japanese Diagnostic Criteria for Takayasu Arteritis. 更新2026年日本高须动脉炎诊断标准。

IF 5.8 3区医学

Circulation Journal Pub Date : 2026-08-27 DOI: 10.1253/circj.CJ-26-0679

Hajime Yoshifuji, Haruhito A Uchida, Yasuhiro Onishi, Yoshia Miyawaki, Eisuke Amiya, Ryotaro Asano, Takuya Hashimoto, Tomonori Ishii, Jun Ishizaki, Shuichi Ito, Toru Iwahashi, Naomi Iwata, Takatoyo Kiko, Yasuhiro Maejima, Takako Miyamae, Hiroko Nagafuchi, Kunihiro Shigematsu, Tsuyoshi Shirai, Natsuka Umezawa, Takahiko Sugihara, Yoshiko Watanabe, Naoto Tamura, Yoshikazu Nakaoka

{"title":"Updated 2026 Japanese Diagnostic Criteria for Takayasu Arteritis.","authors":"Hajime Yoshifuji, Haruhito A Uchida, Yasuhiro Onishi, Yoshia Miyawaki, Eisuke Amiya, Ryotaro Asano, Takuya Hashimoto, Tomonori Ishii, Jun Ishizaki, Shuichi Ito, Toru Iwahashi, Naomi Iwata, Takatoyo Kiko, Yasuhiro Maejima, Takako Miyamae, Hiroko Nagafuchi, Kunihiro Shigematsu, Tsuyoshi Shirai, Natsuka Umezawa, Takahiko Sugihara, Yoshiko Watanabe, Naoto Tamura, Yoshikazu Nakaoka","doi":"10.1253/circj.CJ-26-0679","DOIUrl":"https://doi.org/10.1253/circj.CJ-26-0679","url":null,"abstract":"Takayasu arteritis (TAK) is a chronic, refractory large-vessel vasculitis designated as a Designated Intractable Disease in Japan. The Japanese diagnostic criteria for TAK, last revised in 2017, have been updated to the 2026 version as part of the Japanese Circulation Society 2026 guidelines on the management of large vessel vasculitis, and are presented here in English for the first time. The revision was conducted through a 3-round modified Delphi process involving a panel of 21 experts, supplemented by email discussion and an in-person meeting. The updated criteria incorporate 3 major changes: new symptoms were added and a qualifying statement introduced in Section A; pulmonary artery involvement was elevated to a main criterion in Section B; and IgG4-related periaortitis, Cogan syndrome, and drug-induced aortitis were added in Section C. These updates reflect advances in imaging technology and international classification frameworks, with an emphasis on improving diagnostic sensitivity to reduce missed diagnoses.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0