Circulation Journal最新文献

{"title":"Ischemia of the Abdominal Wall Following Intra-Aortic Balloon Pump Insertion in a Patient With Peripheral Artery Disease.","authors":"Takafumi Fujita, Makoto Sugihara, Kaori Mine, Tetsuo Hirata, Takashi Kuwano, Shin-Ichiro Miura","doi":"10.1253/circj.CJ-25-0475","DOIUrl":"https://doi.org/10.1253/circj.CJ-25-0475","url":null,"abstract":"","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Failure-Associated Hepatic Congestion Detection Through Liver T1 Mapping.","authors":"Yumiko Kanzaki, Kazushi Sakane, Sayuri Nakayama, Hiroshi Kusumoto, Hideaki Morita, Masaaki Hoshiga","doi":"10.1253/circj.CJ-25-0517","DOIUrl":"https://doi.org/10.1253/circj.CJ-25-0517","url":null,"abstract":"","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It May Be Time to Reconsider Intravascular Imaging Criteria for the Use of Intravascular Lithotripsy.","authors":"Kenichi Sakakura","doi":"10.1253/circj.CJ-25-0739","DOIUrl":"https://doi.org/10.1253/circj.CJ-25-0739","url":null,"abstract":"","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prehospital Vital Signs, Including SpO₂, Are Significantly Associated With Mortality and Mechanical Circulatory Support Requirement in Acute Myocardial Infarction Patients.","authors":"Tairo Kurita, Yumi Hirota, Hiroki Mori, Yosuke Kirii, Hiromasa Ito, Akihoro Takasaki, Keishi Moriwaki, Takeshi Takamura, Kozo Hoshino, Takashi Tanigawa, Tetsuya Kitamura, Norikazu Yamada, Kaoru Dohi","doi":"10.1253/circj.CJ-25-0584","DOIUrl":"https://doi.org/10.1253/circj.CJ-25-0584","url":null,"abstract":"<p><strong>Background: </strong>Early risk stratification for acute myocardial infarction (AMI) using prehospital vital signs, including percutaneous oxygen before oxygen supply (pre-SpO₂), remains underexplored.</p><p><strong>Methods and results: </strong>We analyzed 3,006 AMI patients from the Mie ACS Registry. Patients were stratified by the prehospital Simple Risk Index (pre-SRI = [heart rate × (age / 10)²] / systolic blood pressure) and pre-SpO₂levels. The primary outcome was 30-day death. Combined assessment of pre-SRI and pre-SpO₂was superior to individual parameters for predicting 30-day death. In the multivariate analysis, combined assessment (SRI ≥34 and SpO₂≤94%) was the strongest independent predictors of 30-day death (hazard ratio 3.98, P<0.001).</p><p><strong>Conclusions: </strong>Prehospital vital signs including pre-SpO₂enable early high-risk identification, improving clinical decision-making for hospital selection.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Intravascular Ultrasound Calcium Scoring System in Guiding Intravascular Lithotripsy During Percutaneous Coronary Intervention.","authors":"Shun Kitajima, Masaomi Gohbara, Kyoko Hattori, Yohei Hanajima, Katsuhiko Tsutsumi, Hidekuni Kirigaya, Jin Kirigaya, Shinnosuke Kikuchi, Hidefumi Nakahashi, Yuichiro Kimura, Kensuke Matsushita, Kozo Okada, Noriaki Iwahashi, Masami Kosuge, Teruyasu Sugano, Toshiaki Ebina, Kiyoshi Hibi","doi":"10.1253/circj.CJ-25-0487","DOIUrl":"https://doi.org/10.1253/circj.CJ-25-0487","url":null,"abstract":"<p><strong>Background: </strong>In Japan, intravascular lithotripsy (IVL) is indicated during percutaneous coronary intervention (PCI) for calcified lesions when the calcium score assessed by intravascular ultrasound (IVUS) or optical coherence tomography (OCT) is ≥3. This study evaluated the effectiveness of IVL in achieving optimal stent expansion in lesions with an OCT calcium score ≥3, regardless of the IVUS calcium score.</p><p><strong>Methods and results: </strong>We retrospectively compared 26 consecutive PCIs in 23 patients who underwent IVL with pre-PCI OCT or optical frequency domain imaging and simultaneous pre- and post-PCI IVUS with 102 patients who underwent PCI without atherectomy but similar imaging protocols. Of all 128 PCIs, 84 with an OCT calcium score ≥3 and a simultaneous IVUS calcium score ≤2 were analyzed. Stent expansion was measured by IVUS. Among the 84 PCIs included in the analysis, 17 were performed using IVL and 67 were performed without atherectomy or IVL (non-IVL group). Stent expansion at the site of maximum superficial calcium was greater in the IVL than non-IVL group (90.9% vs. 84.6%, respectively; P=0.028). The non-IVL group was independently associated with reduced stent expansion at the site of maximum superficial calcium, even after adjusting for IVUS calcium score components (B=-0.817; P<0.001).</p><p><strong>Conclusions: </strong>Even in calcified lesions with an IVUS calcium score ≤2, IVL was independently associated with favorable stent expansion when the OCT calcium score was ≥3.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant Antiplatelet Therapy in Patients With Venous Thromboembolism Treated With Anticoagulants　- Insights From the COMMAND VTE Registry-2.","authors":"Kazuhisa Kaneda, Yugo Yamashita, Takeshi Morimoto, Ryuki Chatani, Yuji Nishimoto, Nobutaka Ikeda, Yohei Kobayashi, Satoshi Ikeda, Kitae Kim, Moriaki Inoko, Toru Takase, Shuhei Tsuji, Maki Oi, Takuma Takada, Kazunori Otsui, Jiro Sakamoto, Yoshito Ogihara, Takeshi Inoue, Shunsuke Usami, Po-Min Chen, Kiyonori Togi, Norimichi Koitabashi, Seiichi Hiramori, Kosuke Doi, Hiroshi Mabuchi, Yoshiaki Tsuyuki, Koichiro Murata, Kensuke Takabayashi, Hisato Nakai, Daisuke Sueta, Wataru Shioyama, Tomohiro Dohke, Ryusuke Nishikawa, Koh Ono, Takeshi Kimura","doi":"10.1253/circj.CJ-25-0464","DOIUrl":"https://doi.org/10.1253/circj.CJ-25-0464","url":null,"abstract":"<p><strong>Background: </strong>Direct oral anticoagulants (DOACs) are commonly used oral anticoagulants for patients with venous thromboembolism (VTE). Sometimes these patients receive concomitant antiplatelet therapy, with limited data supporting the practice. This study investigated the effect of concomitant antiplatelet therapy (CAT) on clinical outcomes in VTE patients treated with anticoagulants.</p><p><strong>Methods and results: </strong>The COMMAND VTE Registry-2 is a multicenter registry that enrolled 5,197 consecutive patients with acute symptomatic VTE across 31 centers in Japan between January 2015 and August 2020. After excluding 407 patients without oral anticoagulants, there were 4,790 VTE patients treated with oral anticoagulants. After propensity score matching, 676 patients (338 matched pairs in the CAT and anticoagulant only [AC] groups) were included for analysis. There were no significant differences between the CAT and AC groups in the cumulative 3-year incidence of recurrent VTE (4.9% vs. 7.3%, respectively; P=0.50), major bleeding (9.4% vs. 12.4%, respectively; P=0.36), or stroke (6.7% vs. 4.1%, respectively; P=0.24). However, the cumulative 3-year incidence of clinically relevant non-major bleeding (CRNMB) was significantly higher in the CAT group than in the AC group (17.7% vs. 10.0%; P=0.047).</p><p><strong>Conclusions: </strong>In a large VTE registry in the DOAC era, concomitant antiplatelet and anticoagulant therapy, compared with anticoagulant alone, was not significantly associated with risks of recurrent VTE, major bleeding, or stroke, but did increase the risk of CRNMB.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Blood Urea Nitrogen With Incident Heart Failure in the Community　- The Atherosclerosis Risk in Communities (ARIC) Study.","authors":"Hairong Liu, Junichi Ishigami, Lena Mathews, Suma Konety, Michael Hall, Patricia P Chang, Chiadi Ndumele, Wayne Rosamond, Kunihiro Matsushita","doi":"10.1253/circj.CJ-24-0502","DOIUrl":"10.1253/circj.CJ-24-0502","url":null,"abstract":"<p><strong>Background: </strong>The association between blood urea nitrogen (BUN) levels and incident heart failure (HF) in the general population is still unclear.</p><p><strong>Methods and results: </strong>We assessed the association of BUN level with incident HF in 14,167 ARIC participants without a history of HF at baseline (1987-1989) (mean age 54.1 years, 54.4% female, 25.2% Black). BUN levels (mg/dL) were divided into quartiles, with the highest quartile further divided into tertiles (Q1 ≤13, Q2 13-15, Q3 15-17, Q4a 17-19, Q4b 19-21, Q4c >21). HF events were identified through to December 31, 2019, using diagnostic codes on discharge records or death certificates. Hazard ratios (HRs) were estimated using multivariable Cox models. During a median follow-up of 26.2 years, 3,482 participants developed HF (incidence rate 10.7 per 1,000 person-years). In a multivariable Cox model adjusted for sociodemographic variables, the highest BUN quartile (Q4) had a HR of 1.19 (95% confidence interval [CI] 1.09, 1.31) compared with Q1. HRs for Q4a, Q4b, and Q4c were 1.14 (95% CI 1.02, 1.28), 1.11 (0.96, 1.28), and 1.42 (1.22, 1.63), respectively. After further adjustment for clinical factors, the association remained significant for Q4c (HR 1.23 [1.06, 1.43]). Associations were consistent across demographic and clinical subgroups.</p><p><strong>Conclusions: </strong>In this community-based cohort, higher BUN levels were significantly associated with incident HF. BUN, routinely measured in clinical care, may help identify individuals at risk of HF.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1637-1643"},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Selexipag for Pediatric Pulmonary Arterial Hypertension in Japanese Patients　- An Open-Label Phase 2 Study.","authors":"Toru Iwasa, Ryo Inuzuka, Hiroshi Ono, Yuichiro Sugitani, Hirokuni Yamazawa, Chihiro Hiraishi, Naoki Shiota, Shinichi Tanaka, Chieko Yamamoto, Ken-Ichi Kurosaki, Masaru Miura, Satoshi Yasukochi","doi":"10.1253/circj.CJ-24-0429","DOIUrl":"10.1253/circj.CJ-24-0429","url":null,"abstract":"<p><strong>Background: </strong>Selexipag, an oral prostacyclin (PGI₂) receptor agonist, is approved for adult patients with pulmonary arterial hypertension (PAH). This study evaluated the efficacy and safety of selexipag for Japanese pediatric patients with PAH.</p><p><strong>Methods and results: </strong>The study enrolled 6 patients who received selexipag twice daily at an individualized dose based on body weight; maintenance doses were determined for each patient by 12 weeks after starting administration. Efficacy, including pulmonary hemodynamics, was evaluated after 16 weeks, and efficacy and safety were further evaluated 52 weeks after treatment was initiated in the last enrolled patient. The mean (±SD) change in the pulmonary vascular resistance index from baseline to Week 16 (the primary endpoint of the study) was -5.55±6.88 Wood units·m²; improvements were also seen in other pulmonary hemodynamic parameters. The 6-min walk distance increased and N-terminal pro-B-type natriuretic peptide decreased up to Week 64, but the between-subject variability was large. The World Health Organization functional class was improved in 1 of 6 patients at Week 16 and in 2 of 4 patients at Week 64. No patient worsened. The major side effects of selexipag were those characteristic of PGI₂, and the safety profile of selexipag was similar to that in adult patients.</p><p><strong>Conclusions: </strong>The efficacy and safety of selexipag in Japanese pediatric patients with PAH were demonstrated.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1701-1708"},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and Age Differences in Exercise Frequency and Exercise Capacity After Home-Based Cardiac Rehabilitation During the Coronavirus Disease 2019 (COVID-19) Pandemic.","authors":"Tomoaki Hama, Audry S Chacin-Suarez, Thomas G Bissen, Adam M Shultz, Rosalyn M Salstrand, Joshua R Smith, Amanda R Bonikowske, Thomas P Olson","doi":"10.1253/circj.CJ-25-0227","DOIUrl":"10.1253/circj.CJ-25-0227","url":null,"abstract":"<p><strong>Background: </strong>The impact of home-based cardiac rehabilitation (HBCR) during the Coronavirus Disease 2019 (COVID-19) pandemic on changes in exercise frequency and capacity according to sex and age has not been studied.</p><p><strong>Methods and results: </strong>This cohort study included 118 patients participating in HBCR and 149 patients participating in center-based cardiac rehabilitation (CBCR) for whom data on exercise and peak oxygen uptake (V̇O_2peak) were available at program enrollment and completion. Changes in these parameters were compared HBCR and CBCR, and according to sex and age in the HBCR group. The change in HBCR group was equivalent to or superior to CBCR group. In the HBCR group, there were no differences between males and females in the change in exercise (1.7±2.7 vs. 1.6±2.5 days/week and 18±19 vs. 19±18 min/day), or V̇O_2peak(5.5±6.5 vs. 3.8±4.5 mL/kg/min). Although there was no difference in the change in exercise between the younger and older groups (1.4±2.7 vs. 1.9±2.7 days/week and 19±19 vs. 17±18 min/day), the increase in V̇O_2peakwas greater for younger than older patients (7.1±6.1 vs. 3.2±5.3 mL/kg/min). After adjustment for potential confounders, linear regression revealed that the change in V̇O_2peakwas larger among younger patients.</p><p><strong>Conclusions: </strong>During the COVID-19 pandemic, exercise frequency and capacity increased similarly among men and women. Younger patients showed a greater improvement in exercise capacity than older patients.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1616-1626"},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Anthracyclines on Pericardial Adipose Tissue Assessed by Magnetic Resonance Imaging　- An Animal Experiment.","authors":"Mengxi Li, Xingyuan Kou, Xue Zheng, Xi Guo, Wanyin Qi, Cao Li, Jing Chen","doi":"10.1253/circj.CJ-24-0794","DOIUrl":"10.1253/circj.CJ-24-0794","url":null,"abstract":"<p><strong>Background: </strong>Anthracyclines are widely used in cancer treatment, yet their potential for anthracycline-induced cardiotoxicity (AIC) limits their clinical utility. Despite the significant anatomical relevance of pericardial adipose tissue (PeAT) to cardiovascular disease, its response to anthracycline exposure remains poorly understood.</p><p><strong>Methods and results: </strong>Male New Zealand White rabbits (n=17) received weekly doxorubicin injections and underwent magnetic resonance imaging (MRI) scans biweekly for 10 weeks. PeAT volumes (total, left paraventricular, right paraventricular) were measured together with ventricular function. Histopathological evaluations were also conducted. A mixed linear model identified the earliest timeframe for detectable changes in PeAT volume and left ventricular function. Total PeAT volume decreased from the 6th week (1.17±0.06, P<0.05) and continued to decrease until the 8th week (0.96±0.06, P<0.05) and left paraventricular adipose tissue volume decreased significantly, but no changes were observed in right paraventricular adipose tissue volume. The volume of PeAT exhibited a positive correlation with left ventricular ejection fraction (LVEF) (r=0.43, P<0.05), which declined below 50% by the 8th week, and a negative correlation with myocardial cell injury scores (r=-0.595, P<0.05).</p><p><strong>Conclusions: </strong>Anthracycline administration led to an early reduction in PeAT volume, particularly in the left paraventricular region, detectable by MRI as early as the 6th week. Changes in PeAT volume preceded alterations in LVEF and were associated with declines in cardiac function and myocardial cell damage.</p>","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1693-1700"},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}