Clinical & Translational Oncology最新文献

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Comprehensing the role of serum GGT in colorectal carcinoma: cancer risk, prognostic and diagnostic significance. 全面了解血清 GGT 在结直肠癌中的作用:癌症风险、预后和诊断意义。
IF 2.8 3区 医学
Clinical & Translational Oncology Pub Date : 2025-06-01 Epub Date: 2024-11-20 DOI: 10.1007/s12094-024-03791-z
Sristi Anupam, Simran Goel, Dinesh Kumar Mehta, Rina Das
{"title":"Comprehensing the role of serum GGT in colorectal carcinoma: cancer risk, prognostic and diagnostic significance.","authors":"Sristi Anupam, Simran Goel, Dinesh Kumar Mehta, Rina Das","doi":"10.1007/s12094-024-03791-z","DOIUrl":"10.1007/s12094-024-03791-z","url":null,"abstract":"<p><p>Effective biomarkers are necessary for early diagnosis, prognosis, and therapy monitoring of colorectal cancer (CRC), a disease that continues to be a major worldwide health problem. Due to a potential connection to colorectal cancer, serum gamma-glutamyl transferase (GGT), an important enzyme in metabolism of glutathione and cellular stress response, has drawn attention. GGT is an essential component of the antioxidant system that protects against oxidative stress. It is mostly found in organs such as the liver, kidneys, and biliary tract. Numerous health problems, such as metabolic disorders, liver illnesses, and several types of cancer, are linked to elevated blood GGT levels. This review aims to clarify the function of serum GGT in colorectal cancer by examining clinical research conducted over the past 20 years. A comprehensive analysis of pertinent literature identifies associations between high blood GGT levels and carcinoma of the colon risk, prognosis, and diagnostic potential. Increased GGT and a higher risk of colorectal cancer are positively correlated, according to epidemiological data consistently. The predictive capacity of GGT for colorectal adenomas underscores its use in early identification and preventive approaches. Additional clinical evidence indicates that higher GGT levels in CRC patients are associated with poorer outcomes, such as invasion of lymph nodes, advanced tumour stages, and decreased overall survival. Furthermore, changes in GGT levels after therapy offer information about patient survival and treatment effectiveness, highlighting its importance in therapy monitoring. In summary, this review underscores the multifaceted role of serum GGT in CRC, offering insights into its value as a biomarker for risk assessment, prognosis, and therapeutic monitoring, while emphasizing the need for further research to validate its clinical utility.</p>","PeriodicalId":50685,"journal":{"name":"Clinical & Translational Oncology","volume":" ","pages":"2383-2390"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distinguishing clinical and imaging characteristics of primary central nervous system lymphoma from high-grade glioma and metastatic brain tumors. 区分原发性中枢神经系统淋巴瘤与高级别胶质瘤和转移性脑肿瘤的临床和成像特征。
IF 2.8 3区 医学
Clinical & Translational Oncology Pub Date : 2025-06-01 Epub Date: 2024-10-31 DOI: 10.1007/s12094-024-03771-3
Qian Hu, Shenyang Zhang, Rui Xue Ma, Fengyi Lu, Qi Zhang, Jia Jing, Hafiz Khuram Raza, Shengli Li, Li Cheng, Zuohui Zhang, Lin He, Wenqing Meng, Hao Chen, Wei Chen
{"title":"Distinguishing clinical and imaging characteristics of primary central nervous system lymphoma from high-grade glioma and metastatic brain tumors.","authors":"Qian Hu, Shenyang Zhang, Rui Xue Ma, Fengyi Lu, Qi Zhang, Jia Jing, Hafiz Khuram Raza, Shengli Li, Li Cheng, Zuohui Zhang, Lin He, Wenqing Meng, Hao Chen, Wei Chen","doi":"10.1007/s12094-024-03771-3","DOIUrl":"10.1007/s12094-024-03771-3","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this retrospective analysis was to evaluate the clinical presentations, radiological characteristics, patient outcomes, and therapeutic approaches among individuals diagnosed with primary central nervous system lymphoma (PCNSL), high-grade glioma (HGG), and metastatic brain tumors (METS).</p><p><strong>Methods: </strong>We assembled a cohort of brain tumor patients from two medical centers, with two oncologists independently reviewing their clinical profiles. A retrospective examination of 87 PCNSL, 87 HGG, and 71 METS cases was performed to assess the aforementioned parameters.</p><p><strong>Results: </strong>Notable variations were identified in the incidence of epileptic seizures and cognitive impairments between PCNSL and METS patients. Cerebral hemisphere involvement was predominantly observed in HGG and METS cases. PCNSL cases exhibited a higher likelihood of multiple lesions, whereas HGG showed a greater tendency for recurrence. The median survival times were established at 24.3 months for PCNSL, 44.5 months for HGG, and 27.1 months for METS patients. In PCNSL cases, the number of lesions was identified as a significant predictor of mortality (P = 0.008).</p><p><strong>Conclusions: </strong>Our findings highlight the importance of clinical and imaging features in diagnosing PCNSL, which may present distinct features compared to HGG and METS.</p>","PeriodicalId":50685,"journal":{"name":"Clinical & Translational Oncology","volume":" ","pages":"2629-2637"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of B7-H3 targeted CAR-T cells for renal cell carcinoma therapy: in vitro and in vivo efficacy. 开发用于肾细胞癌治疗的 B7-H3 靶向 CAR-T 细胞:体外和体内疗效。
IF 2.8 3区 医学
Clinical & Translational Oncology Pub Date : 2025-06-01 Epub Date: 2024-11-19 DOI: 10.1007/s12094-024-03792-y
Wenyi Deng, Lvying Wu, Liuyan Chen, Kuanyin Wang, Na Lin, Lingfeng Zhu, Jin Chen
{"title":"Development of B7-H3 targeted CAR-T cells for renal cell carcinoma therapy: in vitro and in vivo efficacy.","authors":"Wenyi Deng, Lvying Wu, Liuyan Chen, Kuanyin Wang, Na Lin, Lingfeng Zhu, Jin Chen","doi":"10.1007/s12094-024-03792-y","DOIUrl":"10.1007/s12094-024-03792-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to develop chimeric antigen receptor (CAR)-T cells specifically targeting B7-H3-expressing renal cell carcinoma (RCC) and to evaluate the feasibility of B7-H3 CAR-T therapy for RCC.</p><p><strong>Methods: </strong>We analyzed B7-H3 expression in RCC using bioinformatics approaches and confirmed it in tissues and cell lines through immunohistochemical staining and Western blot analysis. A lentiviral vector containing a B7-H3 specific CAR was constructed and transfected into human T cells, with CAR expression verified by flow cytometry. Cytotoxic efficacy was evaluated in co-culture experiments, measuring the production of interferon-gamma (IFN-γ), interleukin-2 (IL-2), granzyme B, and lactate dehydrogenase (LDH) release. Xenograft models in nude mice were used to evaluate tumor growth inhibition by B7-H3 CAR-T cells.</p><p><strong>Results: </strong>B7-H3 was significantly expressed in RCC and associated with poor prognosis. Elevated levels of B7-H3 expression were validated in both RCC tissues and cell lines. A B7-H3-specific CAR-T cell was developed, achieving a CAR transduction efficiency of 39.85%, as assessed by flow cytometry. In vitro co-culture assays demonstrated that the CAR-T cells exhibited substantial cytotoxic activity against RCC cell lines, with this activity positively correlating with the effector-to-target ratio. Furthermore, the secretion levels of IFN-γ, IL-2, granzyme B, and LDH were significantly increased compared to the control groups. In vivo experiments further confirmed that B7-H3 CAR-T cells significantly inhibited tumor growth.</p><p><strong>Conclusion: </strong>The current study suggests that B7-H3 CAR-T cells exhibit significant efficacy in targeting and eliminating RCC cells, indicating a promising cellular immunotherapy approach for RCC treatment.</p>","PeriodicalId":50685,"journal":{"name":"Clinical & Translational Oncology","volume":" ","pages":"2667-2678"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective study of the real impact of fusion centered genomic assays in patient management in a national collaborative group: the GETHI-XX-16 study. 以融合为中心的基因组检测对国家协作组患者管理实际影响的前瞻性研究:GETHI-XX-16 研究。
IF 2.8 3区 医学
Clinical & Translational Oncology Pub Date : 2025-06-01 Epub Date: 2024-11-01 DOI: 10.1007/s12094-024-03745-5
Paloma Navarro, Carmen Beato, Juan Francisco Rodriguez-Moreno, Sergio Ruiz-Llorente, Xabier Mielgo, Estela Pineda, Miguel Navarro, Gema Bruixola, Tatiana P Grazioso, Antonio Viudez, Jose Fuster, Esther Nogueron, Maria Dolores Mediano, Carmen Balaña, Carlos Mendez, Rosa María Rodriguez, Sonia Del Barco Berron, Beatriz Gongora, Alberto Carmona-Bayonas, Jesus Garcia-Donas
{"title":"Prospective study of the real impact of fusion centered genomic assays in patient management in a national collaborative group: the GETHI-XX-16 study.","authors":"Paloma Navarro, Carmen Beato, Juan Francisco Rodriguez-Moreno, Sergio Ruiz-Llorente, Xabier Mielgo, Estela Pineda, Miguel Navarro, Gema Bruixola, Tatiana P Grazioso, Antonio Viudez, Jose Fuster, Esther Nogueron, Maria Dolores Mediano, Carmen Balaña, Carlos Mendez, Rosa María Rodriguez, Sonia Del Barco Berron, Beatriz Gongora, Alberto Carmona-Bayonas, Jesus Garcia-Donas","doi":"10.1007/s12094-024-03745-5","DOIUrl":"10.1007/s12094-024-03745-5","url":null,"abstract":"<p><strong>Purpose: </strong>Precision medicine represents a paradigm shift in oncology. Access to genetic testing and targeted therapies is frequently limited. Assays based on DNA sequencing can miss druggable alterations. We aimed to determine the impact of a free access program to RNA tests in patient management.</p><p><strong>Methods: </strong>We designed a multicenter prospective observational study within the Spanish National Group for Translational Oncology and Rare and Orphan Tumors (GETTHI). Eligible patients were adults with solid cancers that had progressed on standard therapies. Tumor samples were analyzed using two RNA sequencing assays (Trailblaze Pharos<sup>TM</sup> and Archer FusionPlex Solid Tumor<sup>TM</sup>). A central committee evaluated the actionability of genetic alterations and reported the findings to attending physicians, who made the final clinical management decisions.</p><p><strong>Results: </strong>Between November 2016 and April 2019, 395 patients with 41 different tumors across 30 hospitals were included. Molecular analysis revealed actionable genetic alterations in 57 individuals (14.4%). Targeted therapies were advised for 23 and seven received a matched targeted therapy: two lung cancers (EML4-ALK and CD74-ROS1 fusion), three glioblastomas (EGFR point mutations), one oligodendroglioma (FGFR3-TACC3 fusion) and a prostate cancer (SND1-BRAF fusion). The outcomes included two tumor responses, one disease stabilization, one early withdrawal due to toxicity, one progression, and one unknown.</p><p><strong>Conclusion: </strong>Despite the growing knowledge of cancer biology and its translation to drug development, the overall impact of personalized treatments remains low. Access to comprehensive molecular tests covering properly all known actionable alterations and programs for a wide access to targeted therapies seem to be critical steps.</p>","PeriodicalId":50685,"journal":{"name":"Clinical & Translational Oncology","volume":" ","pages":"2719-2730"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammation-related biomarkers as predictors of pathological complete response in early-stage breast cancer. 炎症相关生物标志物作为早期乳腺癌病理完全缓解的预测因子
IF 2.8 3区 医学
Clinical & Translational Oncology Pub Date : 2025-06-01 Epub Date: 2024-12-12 DOI: 10.1007/s12094-024-03814-9
Oraianthi Fiste, Evangelos Mavrothalassitis, Alexandros Kokkalis, Maximilian Anagnostakis, Georgia Gomatou, Athanasios Kontogiannis, Dimitra Karaviti, Eleftheria Karaviti, Nikolaos Konstantinos Syrigos, Athanasios Kotsakis, Elias Alexandros Kotteas
{"title":"Inflammation-related biomarkers as predictors of pathological complete response in early-stage breast cancer.","authors":"Oraianthi Fiste, Evangelos Mavrothalassitis, Alexandros Kokkalis, Maximilian Anagnostakis, Georgia Gomatou, Athanasios Kontogiannis, Dimitra Karaviti, Eleftheria Karaviti, Nikolaos Konstantinos Syrigos, Athanasios Kotsakis, Elias Alexandros Kotteas","doi":"10.1007/s12094-024-03814-9","DOIUrl":"10.1007/s12094-024-03814-9","url":null,"abstract":"<p><strong>Background: </strong>Neoadjuvant systemic therapy (NAT) represents an attractive option for improved outcomes of early-stage breast cancer (BC) patients, as it can significantly reduce tumor burden thus permitting breast-conserving resections. Equally important, the eradication of viable cancer cells post-NAT, also known as pathological complete response (pCR), has emerged as a strong prognostic biomarker, reflecting tumor's biology and subsequent treatment responses. Yet to date, no validated markers predictive of pCR have been identified.</p><p><strong>Methods: </strong>The present retrospective study aimed to explore the value of neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as potential predictors of pCR.</p><p><strong>Results: </strong>Despite no statistically significant associations have been reported, NLR and PLR dynamics during NAT, as longitudinal inflammatory phenotypes, merit further investigation in larger cohorts.</p><p><strong>Conclusion: </strong>In the future, the integration of a comprehensive inflammatory biomarker panel into clinical practice could assist in a priori treatment selection process.</p>","PeriodicalId":50685,"journal":{"name":"Clinical & Translational Oncology","volume":" ","pages":"2453-2460"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A real‑world study of clinical characteristics, treatment sequence and outcomes of patients with non-small cell lung cancer and EGFR exon 20 insertion mutations. 一项关于非小细胞肺癌和表皮生长因子受体 20 外显子插入突变患者的临床特征、治疗顺序和疗效的真实世界研究。
IF 2.8 3区 医学
Clinical & Translational Oncology Pub Date : 2025-06-01 Epub Date: 2024-11-05 DOI: 10.1007/s12094-024-03776-y
Guillermo Suay, Paloma Martín-Martorell, Francisco Aparisi, María Arnal, María Guirado, Aitor Azkárate, Javier Garde-Noguera, José David Cumplido-Burón, Amelia Insa, José Francisco González-Muñoz, Sarai Palanca, María Díaz, Alfredo Sánchez-Hernández, Óscar Juan-Vidal
{"title":"A real‑world study of clinical characteristics, treatment sequence and outcomes of patients with non-small cell lung cancer and EGFR exon 20 insertion mutations.","authors":"Guillermo Suay, Paloma Martín-Martorell, Francisco Aparisi, María Arnal, María Guirado, Aitor Azkárate, Javier Garde-Noguera, José David Cumplido-Burón, Amelia Insa, José Francisco González-Muñoz, Sarai Palanca, María Díaz, Alfredo Sánchez-Hernández, Óscar Juan-Vidal","doi":"10.1007/s12094-024-03776-y","DOIUrl":"10.1007/s12094-024-03776-y","url":null,"abstract":"<p><strong>Objectives: </strong>EGFR exon 20 insertion (EGFRex20ins) mutations are found in up to 4% of all patients with non-small cell lung cancer (NSCLC). These patients are often insensitive to EGFR-tyrosine kinase inhibitors (TKIs) and have worse prognosis than patients with more common EGFR mutations. In this multicenter, retrospective, real-world study, we sought to determine whether the administration of recently approved treatments that specifically target EGFRex20ins mutations could significantly improve outcomes in this patient population.</p><p><strong>Materials and methods: </strong>We evaluated the clinical features of 41 patients diagnosed with NSCLC and EGFRex20ins mutations, their evolution, and response to treatments received across 7 hospitals in the Valencian Community, Spain, between 31st December 2012 and 31st December 2022.</p><p><strong>Results: </strong>32 patients (72%) developed metastatic disease, and 29 (71%) of them received oncological treatment. We found that administering a targeted therapy against EGFRex20ins mutations (amivantamab, mobocertinib and/or sunvozertinib) at some point during the course of treatment, significantly increased the median OS of metastatic patients from 8 months (95% CI 0-21.7) to 30 months (95% CI 11.1-48.8; Hazard ratio = 0.297, p = 0.02).</p><p><strong>Conclusion: </strong>Our findings contribute to the evolving standard of care for this specific population and highlight the clinical benefits of targeted cancer therapies.</p>","PeriodicalId":50685,"journal":{"name":"Clinical & Translational Oncology","volume":" ","pages":"2568-2578"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reirradiation Practice in Gynecological Cancer: Insights from a National Survey in Spain. 妇科癌症的再照射实践:来自西班牙全国调查的见解。
IF 2.8 3区 医学
Clinical & Translational Oncology Pub Date : 2025-06-01 Epub Date: 2024-12-05 DOI: 10.1007/s12094-024-03804-x
Dina Najjari-Jamal, Angels Rovirosa, Marta Gimeno-Morales, Katarina Majercakova, Maria Sánchez, Sonia Garcia, Diana Guevara, Teresa Muñoz, Cristina De la Fuente, Soraya Micó, Milica Stefanovic, Raul Matute, Sofia Córdoba
{"title":"Reirradiation Practice in Gynecological Cancer: Insights from a National Survey in Spain.","authors":"Dina Najjari-Jamal, Angels Rovirosa, Marta Gimeno-Morales, Katarina Majercakova, Maria Sánchez, Sonia Garcia, Diana Guevara, Teresa Muñoz, Cristina De la Fuente, Soraya Micó, Milica Stefanovic, Raul Matute, Sofia Córdoba","doi":"10.1007/s12094-024-03804-x","DOIUrl":"10.1007/s12094-024-03804-x","url":null,"abstract":"<p><strong>Purpose: </strong>Given the lack of standardisation in gynecological cancer reirradiation, the Gyneacologial Radiation Oncology (GINECOR) working group on behalf of the Spanish Society of Radiation Oncology (SEOR), works towards to inquire the current state of reirradiation practices among the radiation oncology departments in Spain.</p><p><strong>Methods: </strong>An online 37-question survey was sent to all GINECOR members, representing most Spanish centers. The survey addressed general aspects of reirradiation, including experience, reirradiation sites, and techniques used. It included seven clinical case scenarios on reirradiation, and a final section on technical aspects of external beam radiotherapy (EBRT) and brachytherapy (BT) treatment. Descriptive statistics were used for data analysis.</p><p><strong>Results: </strong>Out of 58 centers, 29 responded, with 51.7% performing ≥ 5 reirradiation cases annually. While most centers offer multiple techniques, only 16/29 have access to BT. For in-field local relapse with surgery contraindicated, 79.3% performed BT in endometrial cancer, but only 27.5% treated with BT in cervical cancer recurrence. In this case, 17.2% used SBRT. For endometrial and cervical cancer, 44.8% and 65.4% of centers prescribed doses based on organ-at-risk tolerance, respectively. For pelvic wall/parametrial in-field relapse, 46.4% of the centres reirradiated with stereotactic body radiotherapy (SBRT), and 32.1% with BT. In nodal reirradiation, SBRT was preferred by 90% of centers. Variability was observed in target volume definitions for EBRT and proton therapy.</p><p><strong>Conclusions: </strong>Reirradiation for gynecological cancer remains unstandardized, presenting significant challenges in clinical practice. To improve reirradiation protocols in gynecological cancer, the GINECOR working group is currently conducting a systematic review and formulating Delphi recommendations.</p>","PeriodicalId":50685,"journal":{"name":"Clinical & Translational Oncology","volume":" ","pages":"2494-2501"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding β-catenin expression patterns in ovarian serous carcinoma with clinicopathological implications: insights from National Cancer Institute. 解码卵巢浆液性癌中具有临床病理学意义的β-catenin表达模式:美国国立癌症研究所的见解。
IF 2.8 3区 医学
Clinical & Translational Oncology Pub Date : 2025-06-01 Epub Date: 2024-11-13 DOI: 10.1007/s12094-024-03770-4
Noura A A Ebrahim, Amany A Abou-Bakr, Hassan N Tawfik, Hanan R Nassar, Iman Adel
{"title":"Decoding β-catenin expression patterns in ovarian serous carcinoma with clinicopathological implications: insights from National Cancer Institute.","authors":"Noura A A Ebrahim, Amany A Abou-Bakr, Hassan N Tawfik, Hanan R Nassar, Iman Adel","doi":"10.1007/s12094-024-03770-4","DOIUrl":"10.1007/s12094-024-03770-4","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to examine the immunohistochemical expression of β-catenin in serous ovarian carcinoma and to investigate its relationship with clinicopathological features and disease outcomes.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 67 cases of serous ovarian carcinoma diagnosed at the Pathology Department of the Egyptian National Cancer Institute, Cairo University, between January 1, 2015, and December 31, 2017.</p><p><strong>Results: </strong>The age of the patients ranged from 26 to 76 years. Aberrant β-catenin expression was defined by the presence of cytoplasmic staining with or without membranous staining in at least 10% of tumor cells. Of the cases analyzed, thirty exhibited cytoplasmic staining, 18 demonstrated preserved expression on the cell membrane, 15 showed combined cytoplasmic and membranous staining, while four cases were entirely negative. Significant correlations were observed between β-catenin positivity and both tumor grade and p53 expression, with p values of 0.004 for each correlation.</p><p><strong>Conclusions: </strong>Positive β-catenin expression significantly correlated with tumor grade in serous ovarian carcinoma. Most low-grade serous carcinoma cases exhibited membranous β-catenin expression, whereas high-grade serous carcinoma cases predominantly displayed cytoplasmic staining. Therapeutic strategies aimed at inhibiting β-catenin signaling could provide a novel approach to improving outcomes for patients with high-grade ovarian cancer.</p>","PeriodicalId":50685,"journal":{"name":"Clinical & Translational Oncology","volume":" ","pages":"2461-2466"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive investigation of associations between cell death pathways and molecular and clinical features in pan-cancer. 全面调查泛癌症中细胞死亡途径与分子和临床特征之间的关联。
IF 2.8 3区 医学
Clinical & Translational Oncology Pub Date : 2025-06-01 Epub Date: 2024-11-02 DOI: 10.1007/s12094-024-03769-x
Yin He, Xiaosheng Wang
{"title":"A comprehensive investigation of associations between cell death pathways and molecular and clinical features in pan-cancer.","authors":"Yin He, Xiaosheng Wang","doi":"10.1007/s12094-024-03769-x","DOIUrl":"10.1007/s12094-024-03769-x","url":null,"abstract":"<p><strong>Background: </strong>Regulated cell death (RCD) pathways play significant roles in tumorigenesis. However, systematic investigation into correlations between RCD and various molecular and clinical features, particularly anti-tumor immunity and immunotherapy response in pan-cancer remains lacking.</p><p><strong>Methods: </strong>Using the single-sample gene set enrichment analysis, we quantified the activities of six RCD pathways (apoptosis, autophagy, ferroptosis, cuproptosis, necroptosis, and pyroptosis) in each cancer specimen. Then, we explored associations of these six RCD pathways with tumor immunity, genomic instability, tumor phenotypes and clinical features, and responses to immunotherapy and targeted therapies in pan-cancer by statistical analyses.</p><p><strong>Results: </strong>Our results showed that the RCD (except autophagy) activities were oncogenic signatures, as evidenced by their hyperactivation in late stage or metastatic cancer patients, positive correlations with tumor proliferation, stemness, genomic instability and intratumor heterogeneity, and correlation with worse survival outcomes in cancer. In contrast, autophagy was a tumor suppressive signature as its associations with molecular and clinical features in cancer shows an opposite pattern compared to the other RCD pathways. Furthermore, heightened RCD (except cuproptosis) activities were correlated with increased sensitivity to immune checkpoint inhibitors. Additionally, elevated activities of pyroptosis, autophagy, cuproptosis and necroptosis were associated with increased drug sensitivity in a broad spectrum of anti-tumor targeted therapies, while the elevated activity of ferroptosis was correlated with decreased sensitivity to numerous targeted therapies.</p><p><strong>Conclusion: </strong>RCD (except autophagy) activities correlate with unfavorable cancer prognosis, while the autophagy activity correlate with favorable clinical outcomes. RCD (except cuproptosis) activities are positive biomarkers for anti-tumor immunity and immunotherapy response.</p>","PeriodicalId":50685,"journal":{"name":"Clinical & Translational Oncology","volume":" ","pages":"2731-2749"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of worst patterns of invasion on survival outcomes in oral cavity cancer: implications for adjuvant therapy and prognostic stratification. 口腔癌最坏侵袭模式对生存结果的影响:对辅助治疗和预后分层的影响。
IF 2.8 3区 医学
Clinical & Translational Oncology Pub Date : 2025-06-01 Epub Date: 2024-11-29 DOI: 10.1007/s12094-024-03788-8
Beste Melek Atasoy, Gülşah Özden, Leyla Cinel, Dilek Gül, Ali Cemal Yumuşakhuylu, Zeynep Akdeniz Doğan
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