Clinical Journal of the American Society of Nephrology最新文献_第6页

The Trojan Horse of Kidney Transplantation Returns: A Review and Call for Financial Neutrality 肾移植的特洛伊木马回归：回顾和财政中立的呼吁

IF 9.8 1区医学

Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-22 DOI: 10.2215/cjn.0000000633

Gabriel M. Danovitch

{"title":"The Trojan Horse of Kidney Transplantation Returns: A Review and Call for Financial Neutrality","authors":"Gabriel M. Danovitch","doi":"10.2215/cjn.0000000633","DOIUrl":"https://doi.org/10.2215/cjn.0000000633","url":null,"abstract":"ebate over payments to donors is discussed with particular emphasis on the national and international ramifications of such payments, the impact on normative “altruistic” donation, and the nature of the relationship between the doctor and the patient in the donor work up process. A way forward is proposed through the promotion of “Financial Neutrality” and expanded efforts to prevent chronic kidney disease. Publications in both the lay and academic press suggest that the problem of long waiting lists for deceased donor kidney transplants could be solved if only the National Organ Transplant Act (NOTA) were changed to permit various forms of financial incentives to kidney donors. The history of the debate over payments to donors is discussed with particular emphasis on the national and international ramifications of such payments, the impact on normative “altruistic” donation, and the nature of the relationship between the doctor and the patient in the donor work up process. A way forward is proposed through the promotion of “Financial Neutrality” and expanded efforts to prevent chronic kidney disease. Copyright © 2024 by the American Society of Nephrology...","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"23 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstacles and Opportunities for Albuminuria Testing On the Basis of the Perspective of Primary Care: A Qualitative Study. 基于基层医疗机构视角的白蛋白尿检测障碍与机遇：定性研究。

IF 8.5 1区医学

Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-21 DOI: 10.2215/CJN.0000000620

Agnès Oude Engberink, Julie Marc, Elodie Renk, Philippe Serayet, Gérard Bourrel, Olivier Moranne

引用次数: 0

Treating Metabolic Acidosis for CKD Progression? Need for Higher Quality Data 治疗代谢性酸中毒以防止 CKD 进展？需要更高质量的数据

IF 9.8 1区医学

Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-20 DOI: 10.2215/cjn.0000000632

Stella Kilduff, Denver D. Brown, Michal L. Melamed

引用次数: 0

Risk of Major Adverse Cardiovascular Events in Home Dialysis Compared to In-Center Hemodialysis 家庭透析与中心血液透析相比发生主要不良心血管事件的风险

IF 9.8 1区医学

Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-19 DOI: 10.2215/cjn.0000000579

Wisam Bitar, Jaakko Helve, Mikko Haapio, Virpi Rauta, Eero Honkanen, Patrik Finne

{"title":"Risk of Major Adverse Cardiovascular Events in Home Dialysis Compared to In-Center Hemodialysis","authors":"Wisam Bitar, Jaakko Helve, Mikko Haapio, Virpi Rauta, Eero Honkanen, Patrik Finne","doi":"10.2215/cjn.0000000579","DOIUrl":"https://doi.org/10.2215/cjn.0000000579","url":null,"abstract":"d continuous ambulatory peritoneal dialysis (CAPD), automated peritoneal dialysis (APD) and home hemodialysis (HD) with in-center HD patients. Methods: We included 968 patients who entered dialysis in the Helsinki-Uusimaa healthcare district in Finland from 2004 to 2017, of whom 162 were on CAPD, 229 on APD, 145 on home HD and 432 on in-center HD at day 90 from the start of dialysis. MACE was defined as acute myocardial infarction, stroke, or death due to cardiovascular disease. The cumulative incidence of the first MACE was calculated. Cox regression was used to compare risk of MACE between dialysis modalities with adjustment for potential confounding factors. Results: Of all 968 patients, 195 (20%) experienced a MACE during the entire follow-up and 62 (6%) during the first year of follow-up. The cumulative incidence of first MACE was similar in in-center HD and CAPD patients and higher than that in APD and home HD patients. After adjustment for possible confounders, the hazard ratio (HR) of MACE was 1.22 [95% confidence intervals (CI) 0.73–2.05] for CAPD, 0.86 [95% CI 0.47–1.57] for APD and 0.67 [95% CI 0.30–1.50] for home HD compared to in-center HD. Unexpectedly, compared to in-center HD, PD associated with lower risk of MACE among females (HR 0.37, 95% CI 0.14–0.99) and higher risk among males (HR 1.80, 95% CI 1.11–2.92). Conclusions: In this cohort, the risk of MACE was comparable across in-center and home dialysis modalities. However, the result differed between males and females, which requires further research. Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology...","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"19 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142679170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fracture in Association with Anticoagulant Therapy in Patients with Chronic Kidney Disease and Atrial Fibrillation 慢性肾病和心房颤动患者骨折与抗凝疗法的关系

IF 9.8 1区医学

Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-19 DOI: 10.2215/cjn.0000000578

Nazleen F. Khan, Seoyoung C. Kim, Su Been Lee, Katsiaryna Bykov, Julie M. Paik

{"title":"Fracture in Association with Anticoagulant Therapy in Patients with Chronic Kidney Disease and Atrial Fibrillation","authors":"Nazleen F. Khan, Seoyoung C. Kim, Su Been Lee, Katsiaryna Bykov, Julie M. Paik","doi":"10.2215/cjn.0000000578","DOIUrl":"https://doi.org/10.2215/cjn.0000000578","url":null,"abstract":". Methods: We conducted a new user, active comparator cohort study in a United States-based commercial claims database spanning 2013 through 2020 to quantify the comparative risk of fracture associated with select DOACs (apixaban or rivaroxaban) versus warfarin. Individuals were required to have International Classification of Diseases diagnosis codes for CKD (stages 3-5) and atrial fibrillation during the 365-day baseline period before anticoagulant initiation. Primary analyses quantified non-vertebral fracture risk between patients initiating DOACs and warfarin using a 1:1 propensity score-matched design. Cox proportional hazards regression was used to obtain hazard ratios (HRs) and 95% confidence intervals (CIs) of non-vertebral fracture. Secondary analyses evaluated risks of hip fracture and all-cause mortality. Results: The 1:1 propensity score-matched population included 14,370 DOAC initiators and 14,370 warfarin initiators. The mean age at anticoagulant initiation was 77 years, and 45% were female. The HR for non-vertebral fracture comparing DOACs to warfarin was 1.12 (95% CI 0.95, 1.32), and the corresponding incidence rate difference (IRD) per 1,000 person-years was 3.55 (95% CI -1.67, 8.76). The HR and IRD comparing DOACs to warfarin were 0.98 (95% CI 0.68, 1.41) and -0.13 (95% CI, -2.52, 2.25), respectively for hip fracture and 0.91 (95% CI 0.85, 0.98) and -17.23 (95% CI, -29.49, -4.96), respectively for all-cause mortality. Conclusions: In patients with CKD and atrial fibrillation, we did not observe a difference in the rates of fracture between DOAC and warfarin initiators. DOAC use relative to warfarin was associated with a lower risk of all-cause mortality. Copyright © 2024 by the American Society of Nephrology...","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"14 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142679177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peritoneal Dialysis Modality Choice: Not an Automated Decision 腹膜透析方式的选择：非自动决定

IF 9.8 1区医学

Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-18 DOI: 10.2215/cjn.0000000627

Adrian McGrath, Jeffrey Perl, Edwina A Brown

引用次数: 0

Use of Aspirin and Initial Cardiovascular and Bleeding Risk in Patients with Chronic Kidney Disease 阿司匹林的使用与慢性肾病患者最初的心血管和出血风险

IF 9.8 1区医学

Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-14 DOI: 10.2215/cjn.0000000619

Jae Young Kim, Hyunsun Lim, Cheol Ho Park, Hyung Woo Kim, Tae Ik Chang, Seung Hyeok Han

{"title":"Use of Aspirin and Initial Cardiovascular and Bleeding Risk in Patients with Chronic Kidney Disease","authors":"Jae Young Kim, Hyunsun Lim, Cheol Ho Park, Hyung Woo Kim, Tae Ik Chang, Seung Hyeok Han","doi":"10.2215/cjn.0000000619","DOIUrl":"https://doi.org/10.2215/cjn.0000000619","url":null,"abstract":"d the first cardiovascular and bleeding events using Korean nationwide cohort data. Methods: Among individuals aged 40–79 years with an estimated glomerular filtration rate between 15 and 59 mL/min/1.73 m2 who underwent routine health examinations between 2011 and 2016, 15,861 individuals who were newly prescribed aspirin at a dose of 100 mg/day were matched with 79,305 aspirin non-users by propensity score matching. The primary efficacy outcome was a composite of nonfatal atherosclerotic CVD or cardiovascular death. The primary safety outcome was hospitalization due to intracranial or gastrointestinal bleeding. Results: During a mean follow-up of 6.9±2.9 years, the incidence rates for the primary efficacy outcome in aspirin users and non-users were 8.0 and 9.0 per 1,000 person-years, respectively. Aspirin therapy initiation was not associated with the primary efficacy outcome (hazard ratio [HR], 0.93; 95% confidence intervals [CI], 0.86-1.04). However, the primary safety outcome of major bleeding was more frequent in aspirin users than in non-users (6.7 versus 4.7 per 1,000 person-years). The HR for this outcome in aspirin users versus non-users was 1.45 (95% CI, 1.32-1.59). Conclusions: No association was observed between aspirin use and the risk of nonfatal atherosclerotic CVD or cardiovascular death in patients with CKD stages G3 and G4 without prior CVD. Aspirin use was associated with higher risk of major bleeding. Copyright © 2024 by the American Society of Nephrology...","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"7 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142679174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bisphosphonate Use after Kidney Transplantation Is Associated with Lower Fracture Risk. 肾移植后使用双膦酸盐可降低骨折风险

IF 8.5 1区医学

Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-05 DOI: 10.2215/CJN.0000000591

Joseph M Kahwaji, Su-Jau Yang, John J Sim, Chong Young Parke, Roland L Lee

引用次数: 0

Gender Differences in Citation Rate: An Analysis of Randomized Controlled Trials in Nephrology High-Impact Journals Over Two Decades. 引用率的性别差异：对二十年来肾脏病学高影响力期刊上随机对照试验的分析。

IF 8.5 1区医学

Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-01 Epub Date: 2024-08-06 DOI: 10.2215/CJN.0000000000000511

Qandeel H Soomro, Shuojohn Li, Angela McCarthy, Dalila Varela, Javaughn Ways, Amalya M Charytan, Colin Keane, Giana Ramos, Joey Nicholson, David M Charytan

引用次数: 0

Association of Intake of Whole Grains with Health Outcomes in the Chronic Renal Insufficiency Cohort Study. 慢性肾功能不全队列研究中全谷物摄入量与健康结果的关系

IF 8.5 1区医学

Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-01 Epub Date: 2024-08-14 DOI: 10.2215/CJN.0000000000000538

Dillon Winkelman, Julie Smith-Gagen, Casey M Rebholz, Orlando M Gutierrez, David E St-Jules

引用次数: 0