Colombia Medica最新文献_第8页

Tratamiento de la enfermedad linfoproliferativa post-trasplante renal con Rituximab y conversión a inhibidor m-TOR. 用利妥昔单抗治疗肾移植后淋巴增生性疾病并转化为m-TOR抑制剂。

IF 1.1 4区医学

Colombia Medica Pub Date : 2016-01-01 DOI: 10.25100/cm.v47i4.1989

J. F. Nieto-Ríos, SM Gómez de los Ríos, L. M. Serna-Higuita, Catalina Ocampo-Kohn, Arbey Aristizábal-Alzate, K. Gálvez-Cárdenas, G. Zuluaga-Valencia

引用次数: 0

Therapeutic efficacy of alternative primaquine regimens to standard treatment in preventing relapses by Plasmodium vivax: A systematic review and meta-analysis. 替代伯氨喹方案替代标准治疗预防间日疟原虫复发的疗效：一项系统评价和荟萃分析。

IF 0.7 4区医学

Colombia Medica Pub Date : 2015-12-30

Lina Marcela Zuluaga-Idarraga, María-Eulalia Tamayo Perez, Daniel Camilo Aguirre-Acevedo

{"title":"Therapeutic efficacy of alternative primaquine regimens to standard treatment in preventing relapses by Plasmodium vivax: A systematic review and meta-analysis.","authors":"Lina Marcela Zuluaga-Idarraga, María-Eulalia Tamayo Perez, Daniel Camilo Aguirre-Acevedo","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To compare efficacy and safety of primaquine regimens currently used to prevent relapses by P. vivax.Methods: A systematic review was carried out to identify clinical trials evaluating efficacy and safety to prevent malaria recurrences by P. vivax of primaquine regimen 0.5 mg/kg/ day for 7 or 14 days compared to standard regimen of 0.25 mg/kg/day for 14 days. Efficacy of primaquine according to cumulative incidence of recurrences after 28 days was determined. The overall relative risk with fixed-effects meta-analysis was estimated.Results: For the regimen 0.5 mg/kg/day/7 days were identified 7 studies, which showed an incidence of recurrence between 0% and 20% with follow-up 60-210 days; only 4 studies comparing with the standard regimen 0.25 mg/kg/day/14 days and no difference in recurrences between both regimens (RR= 0.977, 95% CI= 0.670 to 1.423) were found. 3 clinical trials using regimen 0.5 mg/kg/day/14 days with an incidence of recurrences between 1.8% and 18.0% during 330-365 days were identified; only one study comparing with the standard regimen (RR= 0.846, 95% CI= 0.484 to 1.477). High risk of bias and differences in handling of included studies were found.Conclusion: Available evidence is insufficient to determine whether currently PQ regimens used as alternative rather than standard treatment have better efficacy and safety in preventing relapse of P. vivax. Clinical trials are required to guide changes in treatment regimen of malaria vivax.","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"46 4","pages":"183-91"},"PeriodicalIF":0.7,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis. 氧化/亚硝化应激参与登革热发病机制的观察性研究的系统综述。

IF 0.7 4区医学

Colombia Medica Pub Date : 2015-09-30

Raimundo Castro, Hernando Samuel Pinzón, Nelson Alvis-Guzman

{"title":"A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis.","authors":"Raimundo Castro, Hernando Samuel Pinzón, Nelson Alvis-Guzman","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Our objective was to systematically review the published observational research related to the role of oxidative-nitrosative stress in pathogenesis of dengue.Methods: We searched electronic databases (PubMed, EMBASE, The COCHRANE library, ScienceDirect, Scopus, SciELO, LILACS via Virtual Health Library, Google Scholar) using the term: dengue, dengue virus, severe dengue, oxidative stress, nitrosative stress, antioxidants, oxidants, free radicals, oxidized lipid products, lipid peroxides, nitric oxide, and nitric oxide synthase. Articles were selected for review by title and abstract excluding letter, review, in vivo and in vitro studies, and duplicates studies. Selected articles were reviewed for study design, original purposes, sample size, main outcomes, methods, and oxidative-nitrosative stress markers values.Results: In total, 4,331 non-duplicates articles were identified from electronic databases searches, of which 16 were eligible for full text searching. Data from the observational studies originate from Asian countries (50%; 8/16), South American countries (31.2%; 5/16), and Central America and the Caribbean countries (18.8%; 3/16). Case-control study was the type of design most common in researches reviewed. The 1997 World Health Organization (WHO) dengue case classification criteria were used in all studies included in this review.Conclusions: Based on published data found in peer-reviewed literature, oxidative and nitrosative stress are demonstrated by changes in plasma levels of nitric oxide, antioxidants, lipid peroxidation and protein oxidation markers in patients with dengue infection. Additionally, elevated serum protein carbonyls and malondialdehyde levels appear to be associated with dengue disease severity.","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"46 3","pages":"135-43"},"PeriodicalIF":0.7,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atención primaria: una inversión necesaria, vigente y rentable 初级保健:一项必要的、当前的和有利可图的投资

IF 1.1 4区医学

Colombia Medica Pub Date : 2015-09-30 DOI: 10.25100/CM.V46I3.2135

Sandra Lorena Girón

{"title":"Atención primaria: una inversión necesaria, vigente y rentable","authors":"Sandra Lorena Girón","doi":"10.25100/CM.V46I3.2135","DOIUrl":"https://doi.org/10.25100/CM.V46I3.2135","url":null,"abstract":"Por tradicion la atencion primaria en salud se ha enfocado en educacion y en campanas de salud, como una parte de la estrategia para abordar las enfermedades de interes en salud publica1. Como muchos de estos problemas aun permanecen en la agenda de salud publica, es apremiante revisar el concepto de la atencion primaria en salud. En el pasado el control de las enfermedades inmunoprevenibles fue su mayor exito2, 3. Para el futuro es necesario considerar la atencion primaria en salud como una estrategia de alto impacto y dejarla de ver como una serie de actividades de bajo costo, circunscrita a los servicios brindados por promotores y voluntarios, con tecnologias de baja complejidad para atender a la poblacion pobre. El Sistema de Salud requiere una atencion primaria en salud lider, digna de verse como una inversion con rentabilidad social, entendida como la superacion de los beneficios en relacion con los costos generados4-6. De esta manera, la atencion primaria en salud podria ser la estrategia que logre integrar los intereses privados y sociales, al lograr que las ganancias de la prevencion contribuyan a la sostenibilidad economica y al mejoramiento de las condiciones de salud de la poblacion en general. Estos deben ser intereses comunes a las instituciones prestadoras de servicios y al sistema de salud.","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"77 1","pages":"88-89"},"PeriodicalIF":1.1,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87641733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The incorporation of system health care in the Western 西方医疗保健制度的整合

IF 1.1 4区医学

Colombia Medica Pub Date : 2015-09-30 DOI: 10.25100/CM.V46I3.1769

F. Pineda

引用次数: 2

Sodium bicarbonate versus isotonic saline solution to prevent contrast-induced nephropathy : a systematic review and meta-analysis. 碳酸氢钠与等渗盐水预防造影剂肾病：一项系统综述和荟萃分析。

IF 0.7 4区医学

Colombia Medica Pub Date : 2015-09-30

Carlos Andres Zapata-Chica, Diana Bello Marquez, Lina Maria Serna-Higuita, John Fredy Nieto-Ríos, Fabian David Casas-Arroyave, Jorge Hernando Donado-Gómez

{"title":"Sodium bicarbonate versus isotonic saline solution to prevent contrast-induced nephropathy : a systematic review and meta-analysis.","authors":"Carlos Andres Zapata-Chica, Diana Bello Marquez, Lina Maria Serna-Higuita, John Fredy Nieto-Ríos, Fabian David Casas-Arroyave, Jorge Hernando Donado-Gómez","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Contrast-induced nephropathy is one of the main causes of acute kidney injury and increased hospital-acquired morbidity and mortality. The use of sodium bicarbonate for nephroprotection has emerged as a preventative strategy; however, its efficacy is controversial compared to other strategies, such as hydration using 0.9% saline solution.Objective: To compare the effectiveness of sodium bicarbonate vs. hydration using 0.9% saline solution to prevent contrast-induced acute kidney injury.Methods: A systematic review of studies registered in the COCHRANE, PUBMED, MEDLINE, LILACS, SCIELO and EMBASE databases was conducted. Randomized controlled studies that evaluated the use of 0.9% saline solution vs. sodium bicarbonate to prevent contrast-induced nephropathy were included.Results: A total of 22 studies (5,686 patients) were included. Sodium bicarbonate did not decrease the risk of contrast-induced nephropathy (RD= 0.00; 95% CI= -0.02 to 0.03; p= 0.83; I(2)= 0%). No significant differences were found in the demand for renal replacement therapy (RD= 0.00; 95% CI= -0.01 to 0-01; I(2)= 0%; p= 0.99) or in mortality (RD= -0.00; 95% CI= -0.001 to 0.001; I(2)= 0%; p= 0.51).Conclusions: Sodium bicarbonate administration is not superior to the use of 0.9% saline solution for preventing contrast-induced nephropathy in patients with risk factors, nor is it better at reducing mortality or the need for renal replacement therapy.","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"46 3","pages":"90-103"},"PeriodicalIF":0.7,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bicarbonato de sodio versus solución salina isotónica para la prevención de la nefropatía inducida por medio de contraste: Revisión sistemática y meta-análisis 碳酸氢钠与等渗生理盐水预防造影剂诱发肾病:系统综述和荟萃分析

IF 1.1 4区医学

Colombia Medica Pub Date : 2015-09-30 DOI: 10.25100/CM.V46I3.1925

Carlos Andrés Zapata-Chica, L. Serna-Higuita, J. F. Nieto-Ríos, F. D. Casas-Arroyave, J. donado-góMez

引用次数: 11

In vitro-in vivo Pharmacokinetic correlation model for quality assurance of antiretroviral drugs. 用于抗逆转录病毒药物质量保证的体外-体内药代动力学相关模型。

IF 1.1 4区医学

Colombia Medica Pub Date : 2015-09-30

Ricardo Rojas Gómez, Piedad Restrepo Valencia

{"title":"In vitro-in vivo Pharmacokinetic correlation model for quality assurance of antiretroviral drugs.","authors":"Ricardo Rojas Gómez, Piedad Restrepo Valencia","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: The in vitro-in vivo pharmacokinetic correlation models (IVIVC) are a fundamental part of the drug discovery and development process. The ability to accurately predict the in vivo pharmacokinetic profile of a drug based on in vitro observations can have several applications during a successful development process.Objective: To develop a comprehensive model to predict the in vivo absorption of antiretroviral drugs based on permeability studies, in vitro and in vivo solubility and demonstrate its correlation with the pharmacokinetic profile in humans.Methods: Analytical tools to test the biopharmaceutical properties of stavudine, lamivudine y zidovudine were developed. The kinetics of dissolution, permeability in caco-2 cells and pharmacokinetics of absorption in rabbits and healthy volunteers were evaluated.Results: The cumulative areas under the curve (AUC) obtained in the permeability study with Caco-2 cells, the dissolution study and the pharmacokinetics in rabbits correlated with the cumulative AUC values in humans. These results demonstrated a direct relation between in vitro data and absorption, both in humans and in the in vivo model.Conclusions: The analytical methods and procedures applied to the development of an IVIVC model showed a strong correlation among themselves. These IVIVC models are proposed as alternative and cost/effective methods to evaluate the biopharmaceutical properties that determine the bioavailability of a drug and their application includes the development process, quality assurance, bioequivalence studies and pharmacosurveillance.","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"46 3","pages":"109-16"},"PeriodicalIF":1.1,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Second toe-to-hand transfer. A surgical option for amputations in the hand 第二次手到脚的转移。手部截肢的手术选择

IF 1.1 4区医学

Colombia Medica Pub Date : 2015-07-01 DOI: 10.25100/CM.V46I2.1551

E. Amador

{"title":"Second toe-to-hand transfer. A surgical option for amputations in the hand","authors":"E. Amador","doi":"10.25100/CM.V46I2.1551","DOIUrl":"https://doi.org/10.25100/CM.V46I2.1551","url":null,"abstract":"Background: The toe to hand transplantation is a method of reconstruction on the unique or multiple amputations of the fingers. It can be used the whole toe or with certain modifications as a wrap-around flap from the big toe or fingertip. It is a widely accepted option for the thumb. Methods: It is a series of patients with amputation of one or more fingers of the hand were operated with second toe to hand transplantation. The survival was evaluated and the sensory recovery by 2-point discrimination. Results: We practiced 12 transplants, 8 thumb, and 4 in other fingers. Ten were adults and 2 children. All transplants survived. Two patients required tenolysis flexor. The sensibility was recovered with good 2-point discrimination of 8 mm. Discussion: In the more proximal finger amputations, a second toe is the most appropriate, with lower morbidity of the donor site. The rates of success are between 95 to 100%. We had a success rate of 100%. The resulting defect is in the foot is minimum when the second toe was used. The decision to use one of these techniques depends on the decision and transplant surgeon training. We always used the second toe for transfers to the hand, considering that it will be thinner than the original thumb; our patients had no complaint about the appearance. Conclusion: Toe-to-hand transplantation is a good technique, providing a very good aesthetic appearance and allowing the recovery of sensitivity. The defect that is created in the foot does not produce significant aesthetic and functional alterations","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"352 1","pages":"71-74"},"PeriodicalIF":1.1,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76615318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Increasing collaboration between health professionals: Clues and challenges 加强卫生专业人员之间的合作:线索和挑战

IF 1.1 4区医学

Colombia Medica Pub Date : 2015-04-01 DOI: 10.25100/CM.V46I2.1526

N. Aguirre-Duarte

{"title":"Increasing collaboration between health professionals: Clues and challenges","authors":"N. Aguirre-Duarte","doi":"10.25100/CM.V46I2.1526","DOIUrl":"https://doi.org/10.25100/CM.V46I2.1526","url":null,"abstract":"Background:\u0000\u0000Scholars have recently started to pay more attention in the potential of the inter-professional relationship between general practitioners and specialists to improve outcomes, through consideration given to the effect on prescribing practices. However, more empirical research is needed.\u0000Objective:\u0000\u0000To explore inter-professional network factors that may explain effects on General Practitioners prescription behaviours.\u0000Methods:\u0000\u0000A qualitative study was conducted in an integrated diabetes care program. Data was collected through semi-structured interviews from 16 health practices and a hospital diabetes clinic, using a convenience sample of general practitioners, practices nurses, diabetes nurse specialists and endocrinologists. A conceptual mapping was performed to identify factors underlying networks and effects on patient outcomes.\u0000Results:\u0000\u0000Four themes with their concepts emerged from the conceptual map. These demonstrated the need for building effective channels of communication to share experience and knowledge timely in diabetes care. Communication, collaboration and coordination are critical factors to influence prescription behaviours within primary and secondary care.\u0000Conclusions:\u0000\u0000conceptual mapping allowed understanding factors that might explain how links between health professionals can improve patient outcomes at the primary and secondary care interface.","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"106 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88045799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8