Computer Aided Surgery最新文献

{"title":"Surgically oriented measurements for three-dimensional characterization of tunnel placement in anterior cruciate ligament reconstruction.","authors":"Austin J Ramme,&nbsp;Brian R Wolf,&nbsp;Bryan A Warme,&nbsp;Kiran H Shivanna,&nbsp;Michael C Willey,&nbsp;Carla L Britton,&nbsp;Vincent A Magnotta,&nbsp;Nicole M Grosland","doi":"10.3109/10929088.2012.707230","DOIUrl":"https://doi.org/10.3109/10929088.2012.707230","url":null,"abstract":"<p><strong>Objective: </strong>To develop and evaluate the feasibility and reliability of an alternative three-dimensional (3D) measurement system capable of characterizing tunnel position and orientation in ACL reconstructed knees.</p><p><strong>Methods: </strong>We developed a surgically oriented 3D measurement system for characterizing femoral and tibial drill tunnels from ACL reconstructions. This is accomplished by simulating the positioning of the drill bit originally used to create the tunnels within the bone, which allows for angular and spatial descriptions along defined axes that are established with respect to previously described anatomic landmarks and radiographic views. Computer-generated digital phantoms composed of simplified geometries were used to verify proper calculation of angular and spatial measurements. We also evaluated the inter-observer reliability of the measurements using 10 surfaces generated from cadaveric knees in which ACL tunnels were drilled. The reliability of the measurements was evaluated by intraclass correlation coefficients.</p><p><strong>Results: </strong>The digital phantom evaluation verified the measurement methods by computing angular and spatial values that matched the known values in all cases. The intraclass correlation coefficient was calculated for four users and was found to range from 0.95 to 0.99 for the femoral and tibial measurements, demonstrating near-perfect agreement.</p><p><strong>Conclusions: </strong>The characterization of ACL tunnels has historically concentrated on two-dimensional (2D) measurements; however, it can be difficult to define ACL tunnel placement using 2D methods. We have presented novel techniques for defining graft tunnel placement from 3D surface representations of the ACL reconstructed knee. These measurements provide exact tunnel location spatially and along axes that offer the potential to comparatively analyze ACL reconstructions post-operatively using advanced imaging. These methods are reliable, and have been demonstrated to be applicable to multiple single-bundle techniques for ACL reconstruction.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 5","pages":"221-31"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.707230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30838198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical relationships of human pelvises and their application to registration techniques.","authors":"Martin Haimerl,&nbsp;Mario Schubert,&nbsp;Melanie Wegner,&nbsp;Sabine Kling","doi":"10.3109/10929088.2012.711368","DOIUrl":"https://doi.org/10.3109/10929088.2012.711368","url":null,"abstract":"<p><p>Knowledge of consistent anatomical relationships is an important criterion for establishing registration procedures for orthopedic navigation systems. Based on an analysis of 420 CT data sets, we investigated whether a robust registration of the pelvis in a lateral decubitus position could be achieved based on anatomical relationships. For this purpose, we assessed basic statistics and variation in anatomical parameters. It was found that inter-teardrop and inter-fossa distances exhibit a high degree of consistency in pelvises of the same gender. Additionally, stable relationships were found between the anterior pelvic plane (APP) and other reference planes that rely on acetabular points instead of pubic points. Based on these results, a registration procedure for the pelvis was developed which uses only landmarks that are accessible intra-operatively from the ipsilateral side. The deviation between a standard APP registration and this new registration method was assessed. For a standard cup position (40° inclination, 15° anteversion), the resulting deviations were found to be 0.15 ± 2.86° for inclination and 0.27 ± 3.46° for anteversion. Of the registrations, 99% had cup positions within the Lewinnek safe zone. This shows that accurate lateral pelvis registration based on anatomical relationships is achievable.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 5","pages":"232-9"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.711368","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30838199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of a patient-specific CAD/CAM surgical jig in extremity bone tumor resection and custom prosthetic reconstruction.","authors":"K C Wong,&nbsp;S M Kumta,&nbsp;K Y Sze,&nbsp;C M Wong","doi":"10.3109/10929088.2012.725771","DOIUrl":"https://doi.org/10.3109/10929088.2012.725771","url":null,"abstract":"<p><p>Computer navigation has recently been introduced for bone tumor surgery in the orthopedic field, with the aim of achieving increased accuracy and precision in tumor resection and in custom prosthetic reconstruction. However, the technique requires bulky navigation facilities, the presence of a system operator in the operating room, and surgeons with prior experience in navigated surgery. We describe a new and simple method of using a patient-specific computer-aided design/computer-aided modeling (CAD/CAM) surgical jig to realize the preoperative planning in the surgical field. The accuracy of the proposed method was first tested in a cadaver trial. It took one minute to set the location of the jig prior to the bone resection and three minutes to perform the bone resections via the cutting slits of the jig. The dimensional difference between the achieved and planned bone resection was <1 mm on validation with the help of a junctional plate and a navigation system. The technique was then applied successfully to a patient with a low-grade osteosarcoma of the femur. An intercalated tumor resection was performed using a patient-specific surgical jig, and a custom CAD prosthesis reconstruction matched accurately to the skeletal defect. Further assessment in a larger population is necessary to determine the clinical efficacy of the technique.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 6","pages":"284-93"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.725771","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30949898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer-assisted patellar resection for total knee arthroplasty.","authors":"C Fu,&nbsp;J Wai,&nbsp;E Lee,&nbsp;C Myden,&nbsp;E Batuyong,&nbsp;C R Hutchison,&nbsp;C Anglin","doi":"10.3109/10929088.2011.638399","DOIUrl":"https://doi.org/10.3109/10929088.2011.638399","url":null,"abstract":"<p><p>Incorrect patellar resection during total knee arthroplasty can lead to anterior knee pain, patellar maltracking, patellofemoral impingement, patellar fracture, component loosening and reduced range of motion. A computer-assisted surgery (CAS) system was developed to improve the accuracy of the patellar cut. Twelve cadaveric knee specimens (6 pairs) were surgically prepared and the patella resected by two senior orthopaedic residents using either a conventional sawguide technique (right knee) or a computer-assisted sawguide technique (left knee). Multiple cuts and measurements were permitted for the conventional technique, to reflect the clinical situation, whereas only a single cut was permitted for the CAS technique. Prior training had been provided on artificial bones for both techniques. Custom marker arrays were mounted on the sawguide and patella. The user positioned the sawguide based on a real-time display that compared the current sawguide plane to the ideal resection. The resulting mediolateral and superoinferior resection angles and central thickness were measured from CT scans of the specimens, relative to the anterior surface of the patella. Both techniques resulted in symmetric cuts (<7°). Repeatability in the mediolateral direction was better for the CAS technique than for the conventional technique (p<0.01). This study demonstrated that computer-assisted patellar resection is a feasible approach that can produce results equal to or better than those obtained with conventional techniques, even when the experimental conditions favor the conventional technique. Improvements in the CAS hardware could further improve the accuracy and usability of the system, resulting in reductions in postoperative complications. Patellar CAS could also serve as a valuable tool for feedback and training.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 1","pages":"21-8"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2011.638399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30306147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer-assisted surgery simulations and directed practice of total knee arthroplasty: educational benefits to the trainee.","authors":"C A Myden,&nbsp;C Anglin,&nbsp;G D Kopp,&nbsp;C R Hutchison","doi":"10.3109/10929088.2012.671365","DOIUrl":"https://doi.org/10.3109/10929088.2012.671365","url":null,"abstract":"<p><p>Orthopaedic residents typically learn to perform total knee arthroplasty (TKA) through an apprenticeship-type model, which is a necessarily slow process. Surgical skills courses, using artificial bones, have been shown to improve technical and cognitive skills significantly within a couple of days. The addition of computer-assisted surgery (CAS) simulations challenges the participants to consider the same task in a different context, promoting cognitive flexibility. We designed a hands-on educational intervention for junior residents with a conventional tibiofemoral TKA station, two different tibiofemoral CAS stations, and a CAS and conventional patellar resection station, including both qualitative and quantitative analyses. Qualitatively, structured interviews before and after the course were analyzed for recurring themes. Quantitatively, subjects were evaluated on their technical skills before and after the course, and on a multiple-choice knowledge test and error detection test after the course, in comparison to senior residents who performed only the testing. Four themes emerged: confidence, awareness, deepening knowledge and changed perspectives. The residents' attitudes to CAS changed from negative before the course to neutral or positive afterwards. The junior resident group completed 23% of tasks in the pre-course skills test and 75% of tasks on the post-test (p<0.01), compared to 45% of tasks completed by the senior resident group. High-impact educational interventions, promoting cognitive flexibility, would benefit trainees, attending surgeons, the healthcare system and patients.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 3","pages":"113-27"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.671365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30563678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinematics and laxity of a linked total elbow arthroplasty following computer navigated implant positioning.","authors":"James R Brownhill,&nbsp;Colin P McDonald,&nbsp;Louis M Ferreira,&nbsp;J W Pollock,&nbsp;James A Johnson,&nbsp;Graham J W King","doi":"10.3109/10929088.2012.706644","DOIUrl":"https://doi.org/10.3109/10929088.2012.706644","url":null,"abstract":"<p><p>Aseptic loosening in total elbow arthroplasty (TEA) remains the most common cause of long-term failure. While several different mechanisms of implant loosening have been suggested, it is likely that one important underlying cause is implant malpositioning, resulting in changes in joint kinematics and loading. Although use of computer navigation has been shown to improve component positioning in other joints, no such system currently exists for the elbow. This study used real-time computer feedback for humeral, ulnar, and radial component positioning in 11 cadaveric extremities. An elbow motion simulator evaluated joint kinematics. Endosteal abutment of the stems of the humeral and ulnar components precluded optimal positioning in 5 and 6 specimens, respectively. Loss of the normal valgus angulation following elbow arthroplasty (p < 0.05) suggests that errors in humeral component positioning translate directly into changes in joint kinematics during active motion. These findings suggest that although computer navigation can reproduce normal joint kinematics, optimal implant positioning may require a TEA system which allows for some modularity to accommodate the normal variations in osseous morphology of the elbow.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 5","pages":"249-58"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.706644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30790682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy assessment of an imaging technique to examine ulnohumeral joint congruency during elbow flexion.","authors":"Emily A Lalone,&nbsp;Terry M Peters,&nbsp;Graham W King,&nbsp;James A Johnson","doi":"10.3109/10929088.2012.673638","DOIUrl":"https://doi.org/10.3109/10929088.2012.673638","url":null,"abstract":"<p><p>A CT-based imaging technique to investigate ulnohumeral joint congruency of elbows undergoing physiologic flexion is introduced. This technique, which employed landmark registration and a previously developed inter-bone distance algorithm, was validated experimentally. Results obtained with this imaging technique were validated in a single specimen by comparing the resulting joint congruency maps to results obtained with experimental casting in a static position. Additionally, the accuracy of the registration technique was assessed in four specimens using fiducial and target registration error to evaluate the positional and angular accuracy. Preliminary data from an intact cadaveric elbow was shown to demonstrate the utility of this technique. The overall accuracy of the registration was better than 1 mm, and the congruency maps showed excellent correspondence with the casting, validating the use of a CT-based imaging technique to examine the congruency of joints undergoing quasi-static flexion.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 3","pages":"142-52"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.673638","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30563679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of measurements of herniary area and volume and abdominal cavity volume in the treatment of incisional hernia: application of CT 3D reconstruction in 17 cases.","authors":"Sheng Yao,&nbsp;Ji-ye Li,&nbsp;Fei-de Liu,&nbsp;Li-juan Pei","doi":"10.3109/10929088.2011.636453","DOIUrl":"https://doi.org/10.3109/10929088.2011.636453","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the value of CT 3D reconstruction in the diagnosis and treatment of incisional hernia and the related factor of abdominal cavity volume.</p><p><strong>Methods: </strong>Abdominal wall defect and herniary volume were measured using 3D reconstruction based on plain CT scans in 17 patients with incisional hernias.</p><p><strong>Results: </strong>The herniary diameter, area and volume could be measured in the 17 patients and the abdominal cavity volume was also measured in 10 patients using the 3D reconstruction technique. The correlation indices of the abdominal cavity volume with the patient's height, weight and body mass index (BMI) were all less than 0.01.</p><p><strong>Conclusion: </strong>Herniary area and volume and abdominal cavity volume can be accurately calculated through CT 3D reconstruction. The patch area should be more than 5 times as large as the defect area; combined with the perioperative overlap margin measurement method, this results in more scientific surgical management. The ratio of the herniary volume to the abdominal cavity volume may be conducive to preoperative assessment of the risk of abdominal compartment syndrome (ACS); however, the ratio that may lead to postoperative ACS remains to be determined. There are correlations of abdominal cavity volume with patient height, weight and BMI, especially with weight. We therefore propose that the abdominal cavity volume should be evaluated with internationally accepted indices.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 1","pages":"40-5"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2011.636453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30305510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Image guided navigation by intraoperative CT scan for cochlear implantation.","authors":"Klaus Stelter,&nbsp;Georg Ledderose,&nbsp;John Martin Hempel,&nbsp;Dominik F B Morhard,&nbsp;Wilhelm Flatz,&nbsp;Eike Krause,&nbsp;Joachim Mueller","doi":"10.3109/10929088.2012.668937","DOIUrl":"https://doi.org/10.3109/10929088.2012.668937","url":null,"abstract":"<p><strong>Introduction: </strong>For successful cochlear implantation in difficult ears, image guided navigation systems can help identify surgical landmarks or confirm the surgeon's anatomical knowledge. In this pilot case study, exact navigation based on intraoperative CT scanning was investigated and helped confirm important and necessary landmarks, such as the facial nerve, cochlea and intracochlear structures, and at least adequate placement of a straight electrode array.</p><p><strong>Material and methods: </strong>Intraoperative imaging was performed on a 40-slice sliding-gantry CT scanner (Siemens SOMATOM Sensation 40 Open) with an expanded gantry bore (82 cm). Raw image data were reconstructed with a slice thickness and increment of 0.6 mm and were imported to a frameless infrared-based navigation station (BrainLAB VectorVision Sky). In a preoperative accuracy and feasibility study, a phantom skull was scanned and registered five times by the navigation system. Based on the encouraging results, the system was then applied to a male patient with post-traumatic sensorineural hearing loss. The intraoperative target positioning error was measured by a \"blinded\" colleague who defined the distance of the pointer from different sections of the facial nerve without seeing the intraoperative field.</p><p><strong>Results: </strong>The average deviation in the phantom skull was 0.91 mm (SD 0.27 mm) on the mastoid, 1.01 mm (SD 0.21 mm) on the round window, and 0.9 mm (SD 0.18 mm) on the inner ear canal. Surgery could be performed without major complications. The distance of the pointer from the facial nerve could be defined exactly using navigation in ten measurements. The cochleostomy and electrode insertion were performed with the aid of navigation. After insertion, direct intraoperative control of the electrode position was achieved by means of a low-dose CT scan. Two months postoperatively, the patient had a satisfactory open-set speech understanding of 85%.</p><p><strong>Conclusion: </strong>With the use of intraoperative acquisition of CT images (or digital volume tomography devices) and automatic volumetric registration for navigation, surgical precision can be improved, thereby allowing successful cochlear implant surgery in patients with complex malformations or who have undergone multiple previous ear surgeries and consequently lack anatomical landmarks. Our study clearly shows that this high-technology combination is superior to other registration methods in terms of accuracy and precision. Further investigations should aim at developing automatic segmentation and applications for minimally invasive surgery of the lateral skull base.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 3","pages":"153-60"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.668937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30532746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel device for preoperative registration and automatic tracking in cranio-maxillofacial image guided surgery.","authors":"Wenbin Zhang,&nbsp;Chenhao Wang,&nbsp;Guofang Shen,&nbsp;Xudong Wang,&nbsp;Ming Cai,&nbsp;Haijun Gui,&nbsp;Yuncai Liu,&nbsp;Danling Yang","doi":"10.3109/10929088.2012.710251","DOIUrl":"https://doi.org/10.3109/10929088.2012.710251","url":null,"abstract":"<p><strong>Objective: </strong>Two key issues in image guided surgery are accurate patient-to-image registration and ongoing tracking of the patient's motion. To address these concerns, a novel device for preoperative registration and automatic tracking was designed, and the accuracy attainable with the device was evaluated in experiments with a skull and in a clinical study.</p><p><strong>Methods: </strong>The device consists of a system of four titanium screws and four fluorescent spheres fixed to carbon bars which can be easily mounted on the maxillary dentition splint. Before surgery, CT image data of a skull with the device in place was acquired and registered in a navigation system. The rigidity and reproducibility of positioning of the device were measured in 15 repeated CT acquisitions of the skull with the device in place. The registration accuracy was compared to that obtained using micro-screw markers fixed to the maxillary alveolus. To determine the potential of the device in aiding image guided cranio-maxillofacial surgery, registration accuracy and surgical outcome were assessed.</p><p><strong>Results: </strong>Fifteen tests were performed for CT scanning with no loosening of the splint and device. The arithmetic mean of the standard deviation (SD) ranged from 0.47 mm to 0.70 mm. When the device was used for registration, the mean deviations for the eight anatomical structures investigated ranged from 0.56 mm at the left infra-orbital foramen to 0.96 mm at the right temple. Compared with the method in which titanium screws are fixed to the maxillary alveolus, the target registration error (TRE) obtained using the new device was much less. Using this device, clinical reduction of a zygomatic-orbital-maxillary complex fracture was successfully completed with a registration discrepancy of less than 0.5 mm.</p><p><strong>Conclusions: </strong>By successfully addressing the two key issues of image guided surgery, the device could be considered accurate and potentially useful for assisting in cranio-maxillofacial surgery.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 5","pages":"259-67"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.710251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30838200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}