Computer Methods in Biomechanics and Biomedical Engineering最新文献_第4页

Finite element simulation of photothermal-mechanical response of skin tissue induced by the non-ablative fractional laser irradiation.

IF 1.7 4区医学

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-03-18 DOI: 10.1080/10255842.2025.2477802

Ren Chen, Xuehao Sang, Liushuan Niu, Dong Li, Bin Chen, Zeyang Li, Qiang Li

引用次数: 0

Ensuring anatomical integrity and shared contact surfaces in vertebra and disc models: a segmentation-based smoothing approach.

IF 1.7 4区医学

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-03-18 DOI: 10.1080/10255842.2025.2473523

Kati Nispel, Ann-Marie Scherzberger, Tanja Lerchl, Gabriel Gruber, Hendrik Moeller, Robert Graf, Veit Senner, Jan S Kirschke

{"title":"Ensuring anatomical integrity and shared contact surfaces in vertebra and disc models: a segmentation-based smoothing approach.","authors":"Kati Nispel, Ann-Marie Scherzberger, Tanja Lerchl, Gabriel Gruber, Hendrik Moeller, Robert Graf, Veit Senner, Jan S Kirschke","doi":"10.1080/10255842.2025.2473523","DOIUrl":"https://doi.org/10.1080/10255842.2025.2473523","url":null,"abstract":"Due to limited MRI resolution, patient-specific simulation models derived from medical images often lack bio-fidelity. To address this, we present a smoothing pipeline for generating high-fidelity meshes of vertebrae and intervertebral discs from medical images, which serve as a base for biomechanical simulations. Using a diverse array of vertebrae smoothing algorithms, including e.g. Laplace and Taubin, we systematically explored 136 combinations across six protocols. Subsequently, an adaptive smoothing algorithm was developed for intervertebral disc meshes. By adjusting vertex locations to those of the vertebra mesh, we ensured seamless alignment of contact surfaces, including shared nodes. Evaluation of our pipeline against conventional smoothing methods demonstrates superior edge preservation and reduced stair-step effects, enhancing the fidelity of the generated meshes. Finite Element Method simulations further confirmed the accuracy of our selective smoothing pipeline, showing increased notch stress. Validated on a diverse dataset, our smoothing pipeline generates patient-specific models with enhanced biomechanical fidelity, enabling large-scale studies and biomechanical insights into spine pathologies.","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of nitric oxide-related key genes in pulmonary hypertension via bioinformatics and in vitro validation for therapeutic target discovery.

IF 1.7 4区医学

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-03-18 DOI: 10.1080/10255842.2025.2468322

Zhuyang Chu, Yiming Li, Jianjun Ge

{"title":"Identification of nitric oxide-related key genes in pulmonary hypertension via bioinformatics and in vitro validation for therapeutic target discovery.","authors":"Zhuyang Chu, Yiming Li, Jianjun Ge","doi":"10.1080/10255842.2025.2468322","DOIUrl":"https://doi.org/10.1080/10255842.2025.2468322","url":null,"abstract":"This study aims to uncover key genes and associated pathways related to nitric oxide (NO) in pulmonary hypertension (PH). By analyzing datasets GSE131793 and GSE703 from the Gene Expression Omnibus (GEO), differentially expressed genes (DEGs) associated with PH were identified. NO-related genes were selected from the GeneCards database and intersected with the DEGs. Subsequently, Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses were conducted to evaluate pathway enrichment, and key genes were selected using the random forest and least absolute shrinkage and selection operator (LASSO) regression algorithms. Immune cell infiltration was analyzed using the CIBERSORT algorithm, and Gene Set Enrichment Analysis (GSEA) was performed to explore potential mechanisms. The transcriptional regulatory networks of key genes were constructed using Cytoscape software. The expression levels of the key genes were validated in peripheral blood samples from PH patients using quantitative real-time PCR (RT-qPCR). A total of 97 DEGs were identified, of which 20 were NO-related genes. Three key genes, HBG2, PRKAB1, and THBD, were further selected. RT-qPCR results revealed significant upregulation of HBG2 and THBD, and downregulation of PRKAB1 in PH patients. CIBERSORT analysis indicated the significant role of immune cells in the pathology of PH. GSEA and transcriptional network analyses further suggested that key genes may participate in the pathogenesis of PH through immune regulation and metabolic pathways. Through bioinformatics analysis and clinical sample validation, this study systematically elucidates the potential mechanisms of NO-related key genes in PH, providing new molecular targets for early diagnosis and targeted therapy of PH.","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is a 3D representation of muscle architecture needed to model craniomaxillofacial skeletal mechanics?

IF 1.7 4区医学

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-03-18 DOI: 10.1080/10255842.2025.2472015

Hanieh Arjmand, Jeffrey A Fialkov, Cari M Whyne

引用次数: 0

EEG-based emotion recognition with autoencoder feature fusion and MSC-TimesNet model.

IF 1.7 4区医学

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-03-17 DOI: 10.1080/10255842.2025.2477801

Jibin Yin, Zhijian Qiao, Luyao Han, Xiangliang Zhang

{"title":"EEG-based emotion recognition with autoencoder feature fusion and MSC-TimesNet model.","authors":"Jibin Yin, Zhijian Qiao, Luyao Han, Xiangliang Zhang","doi":"10.1080/10255842.2025.2477801","DOIUrl":"https://doi.org/10.1080/10255842.2025.2477801","url":null,"abstract":"Electroencephalography (EEG) signals are widely employed due to their spontaneity and robustness against artifacts in emotion recognition. However, existing methods are often unable to fully integrate high-dimensional features and capture changing patterns in time series when processing EEG signals, which results in limited classification performance. This paper proposes an emotion recognition method (AEF-DL) based on autoencoder fusion features and MSC-TimesNet models. Firstly, we segment the EEG signal in five frequency bands into time windows of 0.5 s, extract power spectral density (PSD) features and differential entropy (DE) features, and implement feature fusion using the autoencoder to enhance feature representation. Based on the TimesNet model and incorporating the multi-scale convolutional kernels, this paper proposes an innovative deep learning model (MSC-TimesNet) for processing fused features. MSC-TimesNet efficiently extracts inter-period and intra-period information. To validate the performance of the proposed method, we conducted systematic experiments on the public datasets DEAP and Dreamer. In dependent experiments with subjects, the classification accuracies reached 98.97% and 95.71%, respectively; in independent experiments with subjects, the accuracies reached 97.23% and 92.95%, respectively. These results demonstrate that the proposed method exhibits significant advantages over existing methods, highlighting its effectiveness and broad applicability in emotion recognition tasks.","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-18"},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plate materials for cardiopulmonary protection: a computational modeling study.

IF 1.7 4区医学

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-03-17 DOI: 10.1080/10255842.2025.2476192

Maayan Lustig, Yoram Epstein, Amit Gefen

{"title":"Plate materials for cardiopulmonary protection: a computational modeling study.","authors":"Maayan Lustig, Yoram Epstein, Amit Gefen","doi":"10.1080/10255842.2025.2476192","DOIUrl":"https://doi.org/10.1080/10255842.2025.2476192","url":null,"abstract":"Personal body armor, such as ballistic protective plates (BPPs), plays a vital role in protecting the torso against high-energy impacts, yet Behind Armor Blunt Trauma (BABT) remains a concern. BABT can inflict damage on critical organs, particularly the heart and lungs. This study investigates the protective performance of BPP materials and padding configurations. We employed a finite element (FE) model of the torso, incorporating detailed anatomical features, to simulate non-penetrating impacts on the heart and lungs. Three BPP materials - Kevlar-29, Ultra-High-Molecular-Weight Polyethylene (UHMWPE), and Alumina, were analyzed with and without 6 mm and 12 mm padding layers against a 5.56 mm bullet impact at 500 m/s. The results demonstrated that Alumina plates provided superior protection, resulting in 186% lower peak strain and 229% lower peak stress in the heart compared to Kevlar and UHMWPE. The addition of padding further reduced strains and stresses, with 12 mm padding yielding average reductions of 44% in peak strain and 36% in peak stress in the heart. Similarly, in the lungs, 12 mm padding led to reductions of 38% in peak strain and 34% in peak stress. The model was validated against experimental force measurements using a life-sized torso phantom, demonstrating strong agreement with piezoelectric sensor measurements (less than 4% difference). These findings underscore the importance of selecting appropriate BPP materials and padding thickness to minimize biomechanical impacts on vital organs.","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-23"},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Finite element analysis of various fixation patterns in mandible bone fracture.

IF 1.7 4区医学

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-03-13 DOI: 10.1080/10255842.2025.2476187

Tayebeh Tazh, Siamak Khorramymehr, Kamran Hassani, Mohammad Nikkhoo

{"title":"Finite element analysis of various fixation patterns in mandible bone fracture.","authors":"Tayebeh Tazh, Siamak Khorramymehr, Kamran Hassani, Mohammad Nikkhoo","doi":"10.1080/10255842.2025.2476187","DOIUrl":"https://doi.org/10.1080/10255842.2025.2476187","url":null,"abstract":"Mandibular fractures are among the most serious injuries to the maxillofacial region, with controversy surrounding their diagnosis, classification, and management Fixation mini-plate systems are commonly used for treatment of mandibular fractures. Previous studies have examined plate configurations with various locking systems. However, the impact of plate thickness on the performance of unlocking screw mechanisms has not been investigated in the literature. Also, there exist conflicting findings concerning the impact of the locking and unlocking screw mechanisms on the concentration of stress within the screws. This study investigates the effect of plate thickness and plate-screw locking mechanisms on the performance of the fixation system using the finite element analysis. The complex relation between jawbone thickness and occurred cracks or fractions made us build a precised model for investigating the fixation patterns. Results showed that the locking screw mechanism reduced the von Miss stress in the buccal and lingual regions of the bone. Increasing the plate thickness also decreased the von Miss stress and maximum pressure in the bone. The unlocking screws application resulted in lower values of stress and displacement in the plate and screws compared to the locking screws. Moreover, while using a plate with a higher thickness resulted in a pronounced decrease in plate von Mises stress, it led to a higher stress on the screws. The study investigated crack propagation by analyzing bone density, which was directly related to age and an individual's lifestyle. This method enables a more precise use of the viscoelastic characteristics of mandibular bones tailored to everyone. The outcomes of this study indicated that the locking screw mechanism demonstrated enhanced features in light of the reduced stress on the bone. Nevertheless, the screws and plate experienced an elevated stress level using this mechanism.","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-16"},"PeriodicalIF":1.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of cement-bone composite material on the biomechanical properties of cervical partial vertebral osteotomy fusion surgery.

IF 1.7 4区医学

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-03-13 DOI: 10.1080/10255842.2025.2477208

Dong-Xiang Zhang, Li-Xin Guo

引用次数: 0

Consistency assessment of tissue-level brain injury criteria in FEHM.

IF 1.7 4区医学

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-03-13 DOI: 10.1080/10255842.2025.2476181

Yuting Zhang, Liqun Tang, Yiping Liu, Bao Yang, Zhenyu Jiang, Zejia Liu, Licheng Zhou

引用次数: 0

Knowledge mapping and research trends of cathelicidin peptide LL-37 from 1995 to 2024: a bibliometric study.

IF 1.7 4区医学

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-03-13 DOI: 10.1080/10255842.2025.2477218

Hongxin Shi, Peizhou Shu, Zhihao Wang, Chen Meng, Rao Yu, YongQing Xu, Chuan Li

引用次数: 0