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Tumor Microenvironment T-cell Heterogeneity and Prognostic Model Construction in Laryngeal Squamous Cell Carcinoma by Single-cell and Bulk RNA Sequencing. 肿瘤微环境t细胞异质性及单细胞和大量RNA测序在喉鳞癌中的预后模型构建
IF 1.6 4区 医学
Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-10-09 DOI: 10.1080/10255842.2025.2570515
Xin Pan, Jianchao Wang, Fenglei Liu, Chao Du, Yuan Li, Xu-Dong Wei
{"title":"Tumor Microenvironment T-cell Heterogeneity and Prognostic Model Construction in Laryngeal Squamous Cell Carcinoma by Single-cell and Bulk RNA Sequencing.","authors":"Xin Pan, Jianchao Wang, Fenglei Liu, Chao Du, Yuan Li, Xu-Dong Wei","doi":"10.1080/10255842.2025.2570515","DOIUrl":"https://doi.org/10.1080/10255842.2025.2570515","url":null,"abstract":"<p><strong>Objective: </strong>Characterize T-cell profiles in laryngeal squamous cell carcinoma (LSCC) using single-cell RNA sequencing and develop a prognostic model.</p><p><strong>Methods: </strong>ScRNA-seq of LSCC tissues identified T-cell subtypes and marker genes. A prognostic model was constructed using COX and LASSO regressions with TCGA data, validated through bootstrap resampling and GEO dataset.</p><p><strong>Results: </strong>Seven T-cell subtypes were detected. The model (HNRNPM, HSPH1, JMJD6, KDM5C, LCK) effectively predicted prognosis and correlated with immune infiltration, tumor mutational burden, and drug sensitivity.</p><p><strong>Conclusion: </strong>This study provides insights into T-cell heterogeneity in LSCC and establishes a validated prognostic risk model for predicting survival and therapeutic outcomes.</p>","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-31"},"PeriodicalIF":1.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stochastic parameter prediction in cardiovascular problems. 心血管疾病的随机参数预测。
IF 1.6 4区 医学
Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-10-09 DOI: 10.1080/10255842.2025.2569819
Kabir Bakhshaei, Sajad Salavatidezfouli, Giovanni Stabile, Gianluigi Rozza
{"title":"Stochastic parameter prediction in cardiovascular problems.","authors":"Kabir Bakhshaei, Sajad Salavatidezfouli, Giovanni Stabile, Gianluigi Rozza","doi":"10.1080/10255842.2025.2569819","DOIUrl":"https://doi.org/10.1080/10255842.2025.2569819","url":null,"abstract":"<p><p>High-fidelity cardiovascular flow modeling requires accurate velocity boundary data, which strongly affects wall shear stress estimates used to predict diseases such as atherosclerosis. However, in-vivo data like 4D flow MRI are often noisy and low in resolution. We propose a stochastic data assimilation approach combining CFD with an Ensemble Kalman filter to refine boundary estimates in real time. Tested on two- and three-dimensional vascular models, our method reduced errors to below 3% in 2D and about 7% in 3D cases. This improved boundary accuracy enhances patient-specific wall shear stress predictions, supporting more reliable cardiovascular diagnostics and treatments.</p>","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-25"},"PeriodicalIF":1.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism of compressive-performance regulation in bionic tubular scaffolds with integrated cellular structural parameters. 集成细胞结构参数的仿生管状支架压缩性能调控机制。
IF 1.6 4区 医学
Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-10-09 DOI: 10.1080/10255842.2025.2569835
Yilin Su, Xiaogang Ji, Jiaming Xin
{"title":"Mechanism of compressive-performance regulation in bionic tubular scaffolds with integrated cellular structural parameters.","authors":"Yilin Su, Xiaogang Ji, Jiaming Xin","doi":"10.1080/10255842.2025.2569835","DOIUrl":"https://doi.org/10.1080/10255842.2025.2569835","url":null,"abstract":"<p><p>To develop lightweight biological scaffolds with good mechanical properties, this study explores elastic tubular scaffolds' compressive energy-absorption via bionic structures. Inspired by glass sponge microstructures and bamboo joint cross-sections, it designs four bionic cell structures and makes elastic tracheal scaffolds. Integrating lightness, peak crushing force and energy absorption, it builds an evaluation mechanism, clarifies cell structure's effect on mechanics, finds the optimal structure and reveals 50%-55% relative density is most sensitive for better compression. In addition, during axial compression, cells with square units significantly increase the occupancy rate of the energy-absorption platform, whereas during radial compression, the hexagonal cell design exhibits the best performance. These findings provide key references for the customized design of bionic tracheal scaffolds.</p>","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-18"},"PeriodicalIF":1.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stroke prediction using synthetic minority over-sampling technique and extreme gradient boosting. 基于合成少数派过采样技术和极端梯度增强的脑卒中预测。
IF 1.6 4区 医学
Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-10-08 DOI: 10.1080/10255842.2025.2570510
Mahdi Hassan, Hamid Nasiri, Mona Esmaeili, Morteza Dorrigiv
{"title":"Stroke prediction using synthetic minority over-sampling technique and extreme gradient boosting.","authors":"Mahdi Hassan, Hamid Nasiri, Mona Esmaeili, Morteza Dorrigiv","doi":"10.1080/10255842.2025.2570510","DOIUrl":"https://doi.org/10.1080/10255842.2025.2570510","url":null,"abstract":"<p><p>Stroke is the world's second leading cause of death; its early prediction benefits from interpretable, high-accuracy models that can guide prevention and care. Using the Kaggle stroke dataset, we applied SMOTE to balance class distribution and trained XGBoost, Random Forest, LightGBM, CatBoost, and SVM models. XGBoost achieved 97.26% accuracy with robust 10-fold cross-validation, outperforming prior baselines. Model outputs were interpreted using the Shapley Additive Explanations (SHAP) algorithm, which identified age and hypertension/blood pressure as dominant predictors, providing both case-level insights and global feature rankings. The proposed pipeline offers practical, interpretable stroke-risk prediction with state-of-the-art performance suitable for clinical decision support.</p>","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-12"},"PeriodicalIF":1.6,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A predictive simulation study on how ankle foot orthosis stiffness affects the sit-to-walk movement. 踝关节足矫形器刚度对坐姿-步行运动影响的预测模拟研究。
IF 1.6 4区 医学
Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-10-08 DOI: 10.1080/10255842.2025.2568051
N F J Waterval, E van der Kruk
{"title":"A predictive simulation study on how ankle foot orthosis stiffness affects the sit-to-walk movement.","authors":"N F J Waterval, E van der Kruk","doi":"10.1080/10255842.2025.2568051","DOIUrl":"https://doi.org/10.1080/10255842.2025.2568051","url":null,"abstract":"<p><p>Ankle-foot orthoses (AFOs) can improve walking mobility in individuals with calf muscle weakness, but their impact on sit-to-walk, a common daily activity, is underexplored. Using predictive simulations, we tested the effects of AFO stiffness on sit-to-walk in case of different degrees of plantarflexor weakness. Results showed that AFO stiffness significantly affects sit-to-walk kinematics and kinetics, with an optimal stiffness for minimizing effort. This optimum stiffness depends on severity of weakness and seat height. These findings emphasize the need to assess and consider the effects of AFO stiffness in daily life activities besides walking.</p>","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-12"},"PeriodicalIF":1.6,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reconstruction of anterior cruciate ligament injury kinetics in sports: methodological feasibility and case report. 重建运动中前交叉韧带损伤动力学：方法可行性及个案报告。
IF 1.6 4区 医学
Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-10-07 DOI: 10.1080/10255842.2025.2569823
Marco Loddo, Alice Ranzini, Fabio Esposito, Francesco Della Villa, Manuela Galli, Matteo Zago
{"title":"Reconstruction of anterior cruciate ligament injury kinetics in sports: methodological feasibility and case report.","authors":"Marco Loddo, Alice Ranzini, Fabio Esposito, Francesco Della Villa, Manuela Galli, Matteo Zago","doi":"10.1080/10255842.2025.2569823","DOIUrl":"https://doi.org/10.1080/10255842.2025.2569823","url":null,"abstract":"<p><p>Anterior cruciate ligament (ACL) injuries are among the most debilitating traumas in team sports, frequently resulting in long-term consequences. Despite extensive research, injury incidence remains unchanged, highlighting the need for enhanced biomechanical understanding. This study presents a novel pipeline integrating model-based image matching (MBIM) using injury video footage, with dynamic musculoskeletal simulations to reconstruct ground reaction forces (GRFs), center of pressure (CoP), and joint loads during ACL injuries. GRFs were estimated <i>via</i> dynamic simulations, while CoP was calculated using the zero moment point method from sidestep maneuvers performed by three healthy participants (Tegner score: 6). The root mean square error (RMSE) between model predictions and experimental measurements was calculated for joint kinematics, GRFs, CoP and joint loads. Additionally, a custom pipeline transferred Blender-processed kinematics (model-based image matching) to OpenSim. The methodology was applied to a real-world non-contact ACL injury in a professional soccer player. Validation yielded a mean RMSE of 11° (hip), 4.6° (knee), and 4.2° (ankle), 0.2 BW for GRFs and 64 mm for CoP and a mean joint loads RMSE of 0.92 Nm/kg across all degrees of freedom, demonstrating robustness despite requiring further refinement. A case study demonstrated the pipeline's ability to extract dynamic forces during ACL injuries. Peak vertical GRFs were five times lower (BW), while anteroposterior and mediolateral components were three times higher than literature values. Elevated mediolateral forces contribute to increased abduction moments at the knee and hip, consistent with biomechanical ACL injury models. This study establishes a foundation for extracting previously inaccessible biomechanical data.</p>","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of a novel therapeutic target and development of a prognostic model for primary glioblastoma based on ferroptosis-related genes. 基于嗜铁相关基因的原发性胶质母细胞瘤新治疗靶点分析及预后模型的建立。
IF 1.6 4区 医学
Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-10-07 DOI: 10.1080/10255842.2025.2569829
Wenhua Zhang, Yaxiong Li, Conghui Li, Qiang Huang
{"title":"Analysis of a novel therapeutic target and development of a prognostic model for primary glioblastoma based on ferroptosis-related genes.","authors":"Wenhua Zhang, Yaxiong Li, Conghui Li, Qiang Huang","doi":"10.1080/10255842.2025.2569829","DOIUrl":"https://doi.org/10.1080/10255842.2025.2569829","url":null,"abstract":"<p><p>This study establishes a novel prognostic signature based on seven ferroptosis-related genes (FRGs) for primary glioblastoma (GBM). The model independently predicts patient survival and is associated with distinct immune microenvironment profiles, including altered infiltration of NK cells and regulatory T cells. The low-risk group demonstrated potential heightened sensitivity to immunotherapy. These findings propose the FRG signature as a valuable tool for prognosis assessment and personalized treatment strategy in GBM.</p>","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-17"},"PeriodicalIF":1.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bio-inspired beveled-tip puncture needles with enhanced flexibility and damage sensing. 仿生斜尖穿刺针，具有增强的灵活性和损伤传感。
IF 1.6 4区 医学
Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-10-06 DOI: 10.1080/10255842.2025.2568976
Lu Yu, Mateng Bai, Yuanming Gao, Yubo Fan
{"title":"Bio-inspired beveled-tip puncture needles with enhanced flexibility and damage sensing.","authors":"Lu Yu, Mateng Bai, Yuanming Gao, Yubo Fan","doi":"10.1080/10255842.2025.2568976","DOIUrl":"https://doi.org/10.1080/10255842.2025.2568976","url":null,"abstract":"<p><p>Puncture needles have attracted wide attention in clinical applications due to their micro-invasive property and controllability. However, the complex human anatomy is calling for higher flexibility and safety. In this study, puncture needles with different sidewall grooves inspired by the structure of mosquitos' labrum were designed. It was proved that the sidewall groove could magnify the deformation of needles caused by the beveled tip. The sidewall groove also moved the high-stress area from the tip to the bottom, which made the needle damage more noticeable. This bio-inspired structure can enhance the flexibility of puncture needles and improve the sensitivity of needle damage detection.</p>","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exoskeleton assistance optimization for Charcot-Marie-Tooth patients based on customized forward predictive simulation. 基于自定义正向预测模拟的腓骨肌综合征患者外骨骼辅助优化。
IF 1.6 4区 医学
Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-10-05 DOI: 10.1080/10255842.2025.2566963
Yiying Peng, Fengchao Zhang, Liping Wang, Jianda Han, Juanjuan Zhang
{"title":"Exoskeleton assistance optimization for Charcot-Marie-Tooth patients based on customized forward predictive simulation.","authors":"Yiying Peng, Fengchao Zhang, Liping Wang, Jianda Han, Juanjuan Zhang","doi":"10.1080/10255842.2025.2566963","DOIUrl":"https://doi.org/10.1080/10255842.2025.2566963","url":null,"abstract":"<p><p>Charcot-Marie-Tooth (CMT) disease causes gait abnormalities like foot-drop. While powered orthoses can assist, their effectiveness varies. This study optimized ankle torque assistance for CMT patients using forward predictive simulation with customized musculoskeletal models. Gait data from patients informed model customization, improving simulation accuracy. The optimized assistive torque profile, applied to a patient-specific model, reduced simulated metabolic cost by 9.9% compared to normal walking and significantly decreased soleus and gastrocnemius activity. This simulation framework provides guidance for exoskeleton assistance and the design of assistive devices for CMT patients.</p>","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of vascular stenosis on hemodynamics during vascular robot intervention diagnosis and treatment. 血管机器人介入诊疗中血管狭窄对血流动力学的影响。
IF 1.6 4区 医学
Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-10-03 DOI: 10.1080/10255842.2025.2568049
Haoyu Xia, Zongming Zhu, Hongwei Yu, Jian Zhou, Yanghui Xiang, Liang Liang, Puhua Tang
{"title":"Effects of vascular stenosis on hemodynamics during vascular robot intervention diagnosis and treatment.","authors":"Haoyu Xia, Zongming Zhu, Hongwei Yu, Jian Zhou, Yanghui Xiang, Liang Liang, Puhua Tang","doi":"10.1080/10255842.2025.2568049","DOIUrl":"https://doi.org/10.1080/10255842.2025.2568049","url":null,"abstract":"<p><p>Current hemodynamic studies on vascular stenosis conditions are mostly limited to cases without interventional devices or where the devices remain stationary. To address this limitation, a bidirectional fluid-structure interaction (FSI) method was employed to theoretically evaluate the blood flow characteristics in vessels with varying stenosis rates and spacing distances, accounting for the coupling between blood flow and vascular deformation. In parallel, particle image velocimetry (PIV) was utilized to experimentally assess the pulsatile flow field within a tube containing the developed vascular interventional robot. The results indicate that under pulsatile blood flow, significant differences arise in the hemodynamic parameters of vessels with different degrees of stenosis. As the stenosis rate increases, key parameters such as blood flow velocity, blood pressure, and vascular wall shear stress (WSS) also increase. In vessels with two stenotic regions, the influence of the spacing distance between them on hemodynamic parameters becomes more pronounced with higher stenosis rates. Moreover, the spatial distribution and magnitude of the numerical simulation results closely match those obtained from experimental measurements, validating the accuracy and reliability of the computational method.</p>","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-13"},"PeriodicalIF":1.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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