Critical Reviews in Therapeutic Drug Carrier Systems最新文献_第7页

Role of Exosomes for Delivery of Chemotherapeutic Drugs. 外泌体在化疗药物递送中的作用。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2021036301

Aragaw Gebeyehu, Nagavendra Kommineni, David G Meckes, Mandip Singh Sachdeva

{"title":"Role of Exosomes for Delivery of Chemotherapeutic Drugs.","authors":"Aragaw Gebeyehu, Nagavendra Kommineni, David G Meckes, Mandip Singh Sachdeva","doi":"10.1615/CritRevTherDrugCarrierSyst.2021036301","DOIUrl":"10.1615/CritRevTherDrugCarrierSyst.2021036301","url":null,"abstract":"Exosomes are endogenous extracellular vesicles (30-100 nm) composed with membrane lipid bilayer which carry vesicular proteins, enzymes, mRNA, miRNA and nucleic acids. They act as messengers for intra- and inter-cellular communication. In addition to their physiological roles, exosomes have the potential to encapsulate and deliver small chemotherapeutic drugs and biological molecules such as proteins and nucleic acid-based drugs to the recipient tissue or organs. Due to their biological properties, exosomes have better organotropism, homing capacity, cellular uptake and cargo release ability than other synthetic nano-drug carriers such as liposomes, micelles and nanogels. The secretion of tumor-derived exosomes is increased in the hypoxic and acidic tumor microenvironment, which can be used as a target for nontoxic and nonimmunogenic drug delivery vehicles for various cancers. Moreover, exosomes have the potential to carry both hydrophilic and hydrophobic chemotherapeutic drugs, bypass RES effect and bypass BBB. Exosomes can be isolated from other types of EVs and cell debris based on their size, density and specific surface proteins through ultracentrifugation, density gradient separation, precipitation, immunoaffinity interaction and gel filtration. Drugs can be loaded into exosomes at the biogenesis stage or with the isolated exosomes by incubation, electroporation, extrusion or sonication methods. Finally, exosomal cargo vehicles can be characterized by ultrastructural microscopic analysis. In this review we intend to summarize the inception, structure and function of the exosomes, role of exosomes in immunological regulation and cancer, methods of isolation and characterization of exosomes and products under clinical trials. This review will provide an inclusive insight of exosomes in drug delivery.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"38 5","pages":"53-97"},"PeriodicalIF":2.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691065/pdf/nihms-1762818.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39299711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Understanding Nanotechnology in the Treatment of Oral Cancer: A Comprehensive Review. 了解纳米技术在口腔癌治疗中的应用:综述。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2021036437

Neeraj Taneja, Aftab Alam, Ranjana S Patnaik, Tannu Taneja, Sonia Gupta, Sunil M K

{"title":"Understanding Nanotechnology in the Treatment of Oral Cancer: A Comprehensive Review.","authors":"Neeraj Taneja, Aftab Alam, Ranjana S Patnaik, Tannu Taneja, Sonia Gupta, Sunil M K","doi":"10.1615/CritRevTherDrugCarrierSyst.2021036437","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2021036437","url":null,"abstract":"Oral cancer is the 11th most common cancer in the world with a high morbidity rate. Various conventional therapies have been used for the treatment of oral cancer such as surgery, radiotherapy, and chemotherapy used either alone or in combination but these have many limitations, making them unsuitable for treating oral cancer. Nanotechnology has been emerged out as an innovative tool in the field of oral cancer which has proved to provide effective results overcoming the limitations of conventional drug therapies. This system involves a nanoparticle drug delivery system based on a targeted therapy in which therapeutic drugs or agents act on the targeted cells without affecting normal healthy cells. Literature has shown that several nanoparticles, organic and inorganic nanoparticles, have been used as the drug delivery system in different types of oral cancers such as oral squamous cell carcinoma, cancer of the tongue, head, and neck cancers. Drugs like cisplatin, 5-fluorouracil, methotrexate, doxorubicin, etc., when coated with nano-polymers have shown better results compared with conventional drugs in oral cancer. Other nanoparticles such as liposomes, hydrogels, nanodiamonds, carbon rods, etc. have also been used with minimal side effects. This paper aims to review and discuss various nanotechnology systems in the field of oral cancer and to evaluate the efficacy of these systems in treating oral cancer compared with conventional drug delivery methods.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"38 6","pages":"1-48"},"PeriodicalIF":2.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39470797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Recent Updates on the Role of Nanoparticles in the Treatment of Viral Diseases. 纳米颗粒在病毒性疾病治疗中的作用研究进展。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2020034715

Anam Javaid, Duaa Zahra, Ayesha Asim, Nehdia Javaid, Usman Ali Ashfaq

{"title":"Recent Updates on the Role of Nanoparticles in the Treatment of Viral Diseases.","authors":"Anam Javaid, Duaa Zahra, Ayesha Asim, Nehdia Javaid, Usman Ali Ashfaq","doi":"10.1615/CritRevTherDrugCarrierSyst.2020034715","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2020034715","url":null,"abstract":"Viral infections such as AIDS, hepatitis, herpes keratitis, and herpes labialis became resistant to drugs and it is difficult to design vaccine. In current era drug-resistant viruses are now treated by nanoparticles (NPs) and this field is known as nanobiotechnology that relates nanoscience with the biological system. NPs due to their antiviral activity are used in the treatment of viral diseases. The advantages of using the NP is its specific target action and increase the efficiency of treatment with minimum side effects. Liposomes, quantum dots, polymeric NPs, solid lipid NPs, silver NPs, gold NPs, and magnetic NPs are used to treat viral infections. NP-based therapeutics have completely replaced the usage of drugs and vaccines for viral diseases treatment. Nano vaccines have been investigated for the delivery of drugs; biomaterials-based NPs are in development to be formulated into nano vaccines. But there are limitations in the manufacturing and stabilization of NPs in the body. This review focuses on the antiviral activity of several NPs, its uptake by different viruses for viral disease treatment, nano vaccines, and the limitation of the NPs as nanotherapeutics.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"38 2","pages":"75-102"},"PeriodicalIF":2.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25411550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Synthesis and Therapeutic Potential of Nanoceria against Cancer: An Update. 纳米子宫颈细胞的合成及其抗癌潜力研究进展。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2021037662

Duaa Zahra, Anam Javaid, Mudassir Iqbal, Iqra Akbar, Usman Ali Ashfaq

{"title":"Synthesis and Therapeutic Potential of Nanoceria against Cancer: An Update.","authors":"Duaa Zahra, Anam Javaid, Mudassir Iqbal, Iqra Akbar, Usman Ali Ashfaq","doi":"10.1615/CritRevTherDrugCarrierSyst.2021037662","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2021037662","url":null,"abstract":"Applications of nanoceria in the biomedical field are quite promising, as previous data has shown potential use of nanoceria as therapeutics via radical scavenging and oxidative stress mitigating properties. But, still, there are contradicting reports regarding nanoceria activity, mode of action, and in vitro toxicity in the cell. There are different nanoceria synthesis methods and Ligands for functionalization and loading of nanoceria into drugs for targeted drug delivery. Redox chemistry of nanoceria exerts their anticancer properties through apoptosis and oxidative stress as it can switch between Ce3+ and Ce4+ and act as free radical scavengers. For breast cancer treatment, cerium oxide nanoparticles (CeONPs) can act as protectant for healthy cells against on-going radiotherapy. Similarly, CeONPs were used to make pancreatic cancer cells more sensitive to radiation damage setting them on the apoptotic pathway. Herein, the study reflects the use of nanoceria as a drug delivery system in chemotherapy due to its efficiency in acidic pH and oxidase activity in the microenvironment. A controlled drug delivery system was adapted using a nano-complexes of AMD-GCCNP-DOX, which were then employed against the retinoblastoma cells from the human eye to target the overexpressing chemokine receptor 4 (CXCR4). In radiotherapy, nanoceria acts as radioprotectants due to their free radical scavenging property and inhibit the proliferation and migration of gastric cancer. This paper summarizes the synthesis methods and application of nanoceria in cancer.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"38 5","pages":"1-26"},"PeriodicalIF":2.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39298205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

What's New in Allergen Immunotherapy Patents? A Review. 过敏原免疫治疗专利有什么新进展?复习一下。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2021037145

Anamaria Mendonça Santos, Carina Carvalho Dos Santos, Tiago Bittencourt de Oliveira, Mairim Russo Serafini, Izabel Almeida Alves

{"title":"What's New in Allergen Immunotherapy Patents? A Review.","authors":"Anamaria Mendonça Santos, Carina Carvalho Dos Santos, Tiago Bittencourt de Oliveira, Mairim Russo Serafini, Izabel Almeida Alves","doi":"10.1615/CritRevTherDrugCarrierSyst.2021037145","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2021037145","url":null,"abstract":"In recent years, allergies are on the rise. The growth of allergies cases has changed the immune system's response to new pathogens. The therapy used to treat these diseases is based on allergen avoidance, pharmacotherapy and allergen-specific immunotherapy. The last one has received a lot of interest in the research field, due to the possibility of leading the patient to a cure. In this sense, new allergen immunotherapy need to be developed or improved to increase safety and efficiency. This review aims to evaluate patents published, from 2015 to July 2020, that have developed allergic immunotherapy treatment and administration routes, as well as new alternatives of vehicles, carriers and delivery systems in this context. The advance of new patents has been mostly seen in China and United States. The oral route is the most used in the development of new allergy treatments. However, due to the challenges that still exist in allergy therapy, association with other pathways is interesting to amplify the possibilities and alternatives of treatment. Thus, other routes of administration for allergen-specific immunotherapy such as topical, sublingual and intranasal have been explored in the research and industrial fields. Nevertheless, it has been observed that few studies are using these alternative administration routes, probably due to the higher cost and lack of investments. The delivery systems are also other tools that can be more explored in the allergen immunotherapy formulations. The effectiveness, safety and acceptance of this therapy depends on the development of new formulations and routes of administration.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"38 6","pages":"105-125"},"PeriodicalIF":2.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39470799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Nanoformulations and Highlights of Clinical Studies for Ocular Drug Delivery Systems: An Overview. 纳米配方和眼科药物输送系统临床研究的重点:综述。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2021035767

Munira M Momin, Shaikh Darakhshan Afreen

引用次数: 6

Insights into Novel Excipients of Self-Emulsifying Drug Delivery Systems and Their Significance: An Updated Review. 自乳化给药系统的新型赋形剂及其意义:最新综述。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2020034975

Earle Radha Rani, G V Radha

引用次数: 3

Nanocarriers for Anticancer Drug Targeting: Recent Trends and Challenges. 抗癌药物靶向的纳米载体:最新趋势和挑战。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2021035650

Sunita Dahiya, Rajiv Dahiya, Eliud Hernández

{"title":"Nanocarriers for Anticancer Drug Targeting: Recent Trends and Challenges.","authors":"Sunita Dahiya, Rajiv Dahiya, Eliud Hernández","doi":"10.1615/CritRevTherDrugCarrierSyst.2021035650","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2021035650","url":null,"abstract":"Nanocarriers are nanostructured vehicles employed to deliver anticancer drugs to the targeted tumor sites in the body. Nanocarriers have been successfully employed to circumvent certain limitations of conventional anticancer drug delivery while providing greater bioavailability, prolonged circulation time and higher tumor accumulation for enhanced therapeutic outcomes in cancer treatment. Nanocarriers are also responsive to functionalization to tailor their pharmaco-kinetics and achieve enhanced therapeutic outcomes in cancer therapy. Among organic, inorganic and hybrid type, several nanocarriers have gained approval for use in cancer patients, while many more are under clinical development. For the last two decades, cancer immunotherapy-based advanced targeting approaches such as monoclonal antibodies, antibody drug conjugates and immune checkpoint inhibitors that utilize human immune system functions have vastly developed which furnish better treatment options in several intractable cancers compared with traditional cancer therapies. This review discusses the imperative role of tumor vasculature in passive and active targeting of anticancer drugs using organic and inorganic nanocarriers and the current research efforts underway. The advanced targeting approaches for treatment of various cancers and their most recent clinical development scenario have been comprehensively explored. Further, potential challenges associated with each type of nanocarrier, and their translational obstacles are addressed.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"38 6","pages":"49-103"},"PeriodicalIF":2.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39470798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Role of In Vitro Models for Development of Ophthalmic Delivery Systems. 体外模型在眼科给药系统开发中的作用。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2021035222

Shallu Kutlehria, Mandip Singh Sachdeva

{"title":"Role of In Vitro Models for Development of Ophthalmic Delivery Systems.","authors":"Shallu Kutlehria, Mandip Singh Sachdeva","doi":"10.1615/CritRevTherDrugCarrierSyst.2021035222","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2021035222","url":null,"abstract":"There is emergent need for in vitro models which are physiologically correct, easy to reproduce, and mimic characteristic functionalities of desired tissue, organ, or diseases state for ophthalmic drug screening, as well as disease modeling. To date, a variety of in vitro models have been developed for the applications ranging from 2D cell culture-based monolayers, multilayer, or co-culture models, to 3-dimensional (3D) organoids, 3D printed and organ on chip systems. Each model has its own pros and cons. While simple models are easier to create, and faster to reproduce, they lack recapitulation of the complex framework, functionalities, and properties of tissues or their subunits. Recent advancements in technologies and integration with tissue engineering and involvement of microfluidic systems have offered novel platforms which can better mimic the in vivo microenvironment, thus possessing potential in transformation of ophthalmic drug development. In this review we summarize existing in vitro ocular models while discussing applicability, drawbacks associated with them, and possible future applications.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"38 3","pages":"1-31"},"PeriodicalIF":2.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694856/pdf/nihms-1762824.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39283798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

COVID-19 Infection: Targeting Possibilities for Treatment. COVID-19感染:靶向治疗的可能性。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2021035392

Tanweer Haider, Vishal Gour, Vikas Pandey, Indu Lata Kanwar, Rahul Tiwari, Monika Vishwakarma, Avijit Kumar Bakshi, Arkadeep Sarkar, Ravishankar Yadav, Sakshi Soni, Vandana Soni

{"title":"COVID-19 Infection: Targeting Possibilities for Treatment.","authors":"Tanweer Haider, Vishal Gour, Vikas Pandey, Indu Lata Kanwar, Rahul Tiwari, Monika Vishwakarma, Avijit Kumar Bakshi, Arkadeep Sarkar, Ravishankar Yadav, Sakshi Soni, Vandana Soni","doi":"10.1615/CritRevTherDrugCarrierSyst.2021035392","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2021035392","url":null,"abstract":"The outbreak of novel coronavirus (nCoV) or severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in December 2019 in Wuhan, China, has posed an international public health emergency worldwide and forced people to be confined in their homes. This virus is of high-risk category and is declared a pandemic by the World Health Organization (WHO). The worldwide researchers and various health professionals are working together to determine the best way to stop its spread or halt this virus's spread and circumvent this pandemic condition threatening millions of human lives. The absence of definitive treatment is possible to explore to reduce virus infection and enhance patient recovery. Along with off-label medicines, plasma therapy, vaccines, the researchers exploit the various plants/herbs and their constituents to effectively treat nCoV infection. The present study aimed to present brief and most informative salient features of the numerous facts regarding the SARS-CoV-2, including the structure, genomic sequence, recent mutation, targeting possibility, and various hurdles in research progress, and off-labeled drugs, convalescent plasma therapy, vaccine and plants/herbs for the treatment of coronavirus disease-2019 (COVID-19). Results showed that off-labeled drugs such as hydroxychloroquine, dexamethasone, tocilizumab, antiviral drug (remdesivir, favipiravir), etc., give positive results and approved for use or approved for restricted use in some countries like India. Future research should focus on these possibilities that may allow the development of an effective treatment for COVID-19.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"38 3","pages":"75-115"},"PeriodicalIF":2.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39283799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3