Critical Reviews in Therapeutic Drug Carrier Systems最新文献_第5页

Immunomodulation and Anticancer Immunity: Reviewing the Potential of Probiotics and Their Delivery with Macromolecular Carriers. 免疫调节和抗癌免疫:益生菌的潜力及其与大分子载体的传递。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI: 10.1615/critrevtherdrugcarriersyst.2021040045

S. Tiwari, M. Dwivedi, Sachin Rathod, P. Bahadur

{"title":"Immunomodulation and Anticancer Immunity: Reviewing the Potential of Probiotics and Their Delivery with Macromolecular Carriers.","authors":"S. Tiwari, M. Dwivedi, Sachin Rathod, P. Bahadur","doi":"10.1615/critrevtherdrugcarriersyst.2021040045","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2021040045","url":null,"abstract":"Probiotics colonize in the gastrointestinal tract and regulate the homeostasis in healthy human hosts. These protect the host against putrefactive organisms and secrete soluble factors exhibiting important transductive roles. However, constitutive processes in human host are deregulated following dysbiosis caused during prolonged exposure to cytotoxic agents and pollutants. Apart from restoring the homeostasis, probiotic administration has shown to minimize carcinogenesis and post-surgery complications in cancer patients. Moreover, ability of microbial cells to colonize at tumor foci can be harnessed to deliver genes, therapeutic proteins and antibodies in a selective manner. In this review, we have discussed immunomodulatory roles of probiotics in context to cancer prevention. The article further proposes the use of dietary interventions for boosting anticancer immunity and as an alternative to detrimental chemotherapeutic agents. After summarizing clinical evidences on probiotic efficacy, formulation approaches have been described for effective delivery of the microorganisms. The literature shows that polysaccharide matrices can be employed to achieve the survivability of probiotics. Formulation approaches have been reviewed together with the risks associated with the migration of live microorganisms to systemic circulation and their ability of transmitting antibiotic resistance factors into human pathogens.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"39 2 1","pages":"97-120"},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67437576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cyclodextrin-Based Supramolecular Ternary Complexes: Emerging Role of Ternary Agents on Drug Solubility, Stability, and Bioavailability. 基于环糊精的超分子三元配合物:三元制剂在药物溶解度、稳定性和生物利用度方面的新作用。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2022038870

Pooja Suvarna, Pinal Chaudhari, Shaila A Lewis

{"title":"Cyclodextrin-Based Supramolecular Ternary Complexes: Emerging Role of Ternary Agents on Drug Solubility, Stability, and Bioavailability.","authors":"Pooja Suvarna, Pinal Chaudhari, Shaila A Lewis","doi":"10.1615/CritRevTherDrugCarrierSyst.2022038870","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2022038870","url":null,"abstract":"The aqueous solubility of active drug moiety plays a crucial role in the development of an efficacious formulation. The poor aqueous solubility of BCS class II and IV drugs is manifested as poor bioavailability. Preparation of cyclodextrin inclusion complex to improve the solubility, stability, and bioavailability is a well-established technique. The latest trend in cyclodextrin research is focused on ternary complexes wherein an auxiliary agent such as water-soluble polymers, organic ions, metals, or amino acids is incorporated in the inclusion complex. The cyclodextrin-based supramolecular ternary complex offers significant advantages over binary complex specifically for oral drug delivery. Compared with the binary complex, the ternary complex exhibits better complexation efficiency and stability constant. Moreover, the ternary complex has a major advantage of reducing the concentration of cyclodextrin required to achieve maximum solubility and stability. Lately, in silico molecular modeling has gained tremendous attention as a preliminary tool to evaluate the cyclodextrin-based ternary or binary complex which has been discussed. This review gives an insight into various ternary agents explored worldwide, significant observations, safety, and clinical studies carried out on ternary cyclodextrin complexes.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"39 5","pages":"1-50"},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40716835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Crafting Immunological Response Using Particulate Vaccines. 利用颗粒疫苗制造免疫反应。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI: 10.1615/critrevtherdrugcarriersyst.2022040656

Amit Bansal, Bernadette D’Souza, D. Kapoor, P. Singh, Gretchen Starr, Kiran Muppireddy

{"title":"Crafting Immunological Response Using Particulate Vaccines.","authors":"Amit Bansal, Bernadette D’Souza, D. Kapoor, P. Singh, Gretchen Starr, Kiran Muppireddy","doi":"10.1615/critrevtherdrugcarriersyst.2022040656","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2022040656","url":null,"abstract":"To achieve optimal immunogenicity, particulates present a promising vehicle for antigen delivery and have the potential to skew immune response. Particulate vaccine offers several advantages including targeting of antigen to sentinel cells, protection from degradation, sustained release, and itself acts an adjuvant mimics viral structure. Adjuvant presence is vital in overcoming the poor immunogenicity of vaccines, e.g., subunit vaccines. Adjuvants have antigen dose sparing potential and provide danger signals to alert the immune system. Various particulate carriers received attention in the delivery of vaccine antigens such as virus-like particles, liposomes, immunostimulating complexes, and polymeric particles. This review also discussed the properties of particles such as size, shape, and rigidity affecting the immunological outcome. It further highlights the cellular uptake of the particulate vaccine, antigen processing, and its presentation by antigen-presenting cells. For mass vaccination, especially in countries lacking resources, effect of storage temperature condition on stability of vaccine is pivotal. The current COVID-19 pandemic is not showing any signs of abatement and role of nanocarriers are highly relevant in SARS-CoV-2 pandemic as an effective immunization strategy. Eradication of pandemic demands the rapid evaluation of multiple approaches that can provides successful vaccination platform, enabling scalability and global distribution.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"39 4 1","pages":"49-82"},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67437625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Challenges and Strategies for Topical and Transdermal Delivery of Bioactive Peptides. 生物活性肽局部和透皮递送的挑战和策略。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2021038141

Antonio Jiménez-Rodríguez, Daniela Guardado-Félix, Marilena Antunes-Ricardo

{"title":"Challenges and Strategies for Topical and Transdermal Delivery of Bioactive Peptides.","authors":"Antonio Jiménez-Rodríguez, Daniela Guardado-Félix, Marilena Antunes-Ricardo","doi":"10.1615/CritRevTherDrugCarrierSyst.2021038141","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2021038141","url":null,"abstract":"Bioactive peptides have gained the attention and interest of researchers and the industry for their therapeutic effects and high specificity, thus reducing the risks of side effects and making them an attractive alternatives in developing new biopharmaceuticals or cosmeceuticals. Nevertheless, their incorporation into formulations and administration presents challenges such as low stability under different storage conditions and gastrointestinal degradation after oral delivery. Likewise, the parenteral route is an invasive method that is painful and therefore reduces patient compliance. Topical delivery of bioactive peptides is a painless noninvasive alternative to reduce peptide degradation, exert local effects in the applied area, and improve patient compliance. In this review, we discuss the physicochemical properties of peptides and the mechanisms involved in their degradation. In addition, the most important aspects of skin structure and skin permeation routes, and the requirements for topical and transdermal drug delivery are also discussed in this article. Finally, nanocarrier development advances for the topical delivery of peptides (water-in-oil-in-water emulsions, microemulsions, nanoparticles, solid lipid nanoparticles, liposomes, niosomes, and microneedles) and other strategies, such as metal complexation, cell-penetrating peptides, and synthetic modification, are also reviewed. All these topics consider the perspective of their effect to improve skin permeability to peptides and their stability over time during storage.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"39 1","pages":"1-31"},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39746604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Recent Advancements in Electrospun Nanofibers for Wound Healing: Polymers, Clinical and Regulatory Perspective. 用于伤口愈合的电纺纳米纤维的最新进展:聚合物、临床和调控观点。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI: 10.1615/critrevtherdrugcarriersyst.2022039840

Zeeshan Patel, Sankalp Gharat, M. Altabakha, A. Ashames, S. Boddu, M. Momin

{"title":"Recent Advancements in Electrospun Nanofibers for Wound Healing: Polymers, Clinical and Regulatory Perspective.","authors":"Zeeshan Patel, Sankalp Gharat, M. Altabakha, A. Ashames, S. Boddu, M. Momin","doi":"10.1615/critrevtherdrugcarriersyst.2022039840","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2022039840","url":null,"abstract":"Wound management is an unmet therapeutic challenge and a global healthcare burden. Current treatment strategies provide limited efficiency in wound management, thus undergoing constant evolution in the treatment approaches. As wound healing is a complex physiological process involving precise synchronization of various phases like hemostasis, inflammation and remodelling, which necessitates innovative treatment strategies. Nanotechnology platforms like polymeric nanofibers (NFs) offer a promising solution for wound management. NFs contain a porous mesh-like structure that mimics the natural extracellular matrix and promote the cell adhesion and proliferation in the wound bed, thus displaying a great potential as a wound healing scaffold. Electrospinning is a simple, versatile and scalable technique for producing highly porous and tuneable NFs with a high surface area. Electrospun NFs are presenting extensive application in wound management, especially for burns and diabetic foot ulcers. This review briefly discusses the wound physiology and conventional treatment strategies. It also provides an overview of the electrospinning process and its principle, highlighting the application of electrospun polymeric NFs in wound management. The authors have made an attempt to emphasizes on the clinical challenges and future perspectives along with regulatory aspects of NFs as a wound dressing.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"39 4 1","pages":"83-118"},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67437589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Armamentarium in Drug Delivery for Colorectal Cancer. 大肠癌给药中的器械。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2022039241

Asad Ali, Juber Akhtar, Usama Ahmad, Abdul Samad Basheer, Neha Jaiswal, Afroz Jahan

{"title":"Armamentarium in Drug Delivery for Colorectal Cancer.","authors":"Asad Ali, Juber Akhtar, Usama Ahmad, Abdul Samad Basheer, Neha Jaiswal, Afroz Jahan","doi":"10.1615/CritRevTherDrugCarrierSyst.2022039241","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2022039241","url":null,"abstract":"Colorectal cancer (CRC) is the second most common cause of cancer related deaths in the United States. However, more than half of all incidence and mortality are caused by risk factors such as smoking, unhealthy diet, excessive alcohol consumption, inactivity, and excess weight, and thus can be protected. CRC morbidity and mortality can also be reduced by proper screening and monitoring. Over the last few years the amalgamation of nanotechnology with healthcare system has brought about the potential to administer the delivery of certain therapeutic drugs to cancer cells without affecting normal tissues. Recent strategies combine the diagnostic and therapeutic approaches to improve the overall performance of cancer nanomedicines. Targeted cancer nanotherapeutics provides many more opportunities for the selective detection of toxic chemicals within cancer cells. The distinctive features of nanoparticles, such as their small size, large surface to volume ratio, and the ability of nanoparticles to achieve several interactions of ligands at surface, offer great benefits of nanomedicines to treat various types of cancers. This review highlights the molecular mechanisms of colorectal carcinogenesis and discusses various key concepts in the development of nanotherapeutics targeted for CRC treatment.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"40 1","pages":"1-48"},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40684465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Peptides as Diagnostic, Therapeutic, and Theranostic Tools: Progress and Future Challenges. 多肽作为诊断、治疗和治疗工具:进展和未来的挑战。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2022040322

Reena Thakur, Chander Raman Suri, Indu Pal Kaur, Praveen Rishi

{"title":"Peptides as Diagnostic, Therapeutic, and Theranostic Tools: Progress and Future Challenges.","authors":"Reena Thakur, Chander Raman Suri, Indu Pal Kaur, Praveen Rishi","doi":"10.1615/CritRevTherDrugCarrierSyst.2022040322","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2022040322","url":null,"abstract":"Peptides are emerging as a promising candidate for therapeutic as well as diagnostic applications within the domain of clinical and scientific research. They are recognized for being highly selective, sensitive and efficacious with minimal or no toxicity. Small size, non-immunogenicity, ease of synthesis and huge scope of modification are some of the well-established properties of peptides, which make them an excellent alternative to not only small drug molecules but also to protein-based biopharmaceuticals such as antibodies and enzymes. The attractive pharmacological profile and intrinsic properties of peptides also make them an interesting diagnostic tool for imaging at the molecular and cellular levels. Molecular imaging coupled with targeted therapy using peptides as theranostics is a two-edged sword. Besides, traditional peptide formats, multifunctional newer peptide designs with improved pharmacokinetics and targetability are also being explored presently. In this review, we come up with a comprehensive summary of the latest progress on peptides and their potential applications in therapeutics and diagnosis for infectious and non-infectious diseases. The last part of the review discusses suitable carrier systems for the delivery of peptides along with highlighting the future challenges.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"40 1","pages":"49-100"},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40684466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Getting into the Brain: Are We in Yet or Just Knocking at the Door? 进入大脑:我们是已经进入还是只是敲门?

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI: 10.1615/critrevtherdrugcarriersyst.2021038918

K. Nagpal, Dhirender Singh, Amit Bhatia, P. Kumar

{"title":"Getting into the Brain: Are We in Yet or Just Knocking at the Door?","authors":"K. Nagpal, Dhirender Singh, Amit Bhatia, P. Kumar","doi":"10.1615/critrevtherdrugcarriersyst.2021038918","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2021038918","url":null,"abstract":"Nanomedicine, a promising addition to the spectrum of biomedicine, has viewed countless breakthroughs in the implementations of \"site-specific\" drug delivery. The promises of nanomedicines revolve around their unique physicochemical properties that permit the transport of therapeutics to the desired site of action, improve the pharmacokinetic endpoint, maximize the pharmacological influence of treatment, and overcome the limitation of remedies that otherwise would impede the therapeutic effectiveness. One of most insurmountable challenge possessed by conventional drug-delivery in getting therapeutics across the central-nervous-system is to conquer the harsh passage of the blood-brain barrier (BBB). Many published studies revealed BBB to be a complex, dynamic interface that acclimatizes to the needs of the central nervous system (CNS). These physical and biochemical barriers pose a significant challenge to the effective management of brain-related disorders such as neurodegenerative diseases. This challenge is widely accepted and defeated with the advent of a new class of brain-targeted nanomedicines. This review is an effort to overview the key research trends in nanotechnology over the past decade concerning the BBB as a regulatory interface and factors affecting CNS drug delivery. The review further summarized the specific diversity of various nanomedicinal approaches, the critical and elementary structural component of their design, the surface engineering of vehicles carrying drug at the nanoscale, selected current clinical successes, and future prospects along with hidden perils.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"47 1","pages":"1-44"},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67437525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Anti-Aging Nanoformulations: Recent Developments in Excipients for Nanocosmeceuticals and Regulatory Guidelines. 抗衰老纳米制剂综述:纳米药妆辅料的最新发展和监管指南。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2021039544

Vivek Basudkar, Sankalp Gharat, M. Momin, Mihika Shringarpure

{"title":"A Review of Anti-Aging Nanoformulations: Recent Developments in Excipients for Nanocosmeceuticals and Regulatory Guidelines.","authors":"Vivek Basudkar, Sankalp Gharat, M. Momin, Mihika Shringarpure","doi":"10.1615/CritRevTherDrugCarrierSyst.2021039544","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2021039544","url":null,"abstract":"Skin aging is the progressive biological process generally characterized by the appearance of wrinkles, age spots, sagging of skin, and dryness. Since skin is an essential part of physical appearance, this has led to increased concerns about skincare. Anti-aging products help in improving the quality and health of the skin by nourishing it. However, due to large particle size they are less efficacious. Nanotechnological approaches for topical anti-aging products have a significant effect on the product performance. Lipidic, polymeric, and metallic nanoparticles have shown potential advantages like enhanced stability and efficacy due to their smaller size. The excipients used in these nanoformulations play an important role in improving the efficacy and shelf-life of the product. The optimal selection of excipients plays a major role in the nanoformulation approach for their enhanced efficacy and stability. For the past three decades the ingredients of natural origin for cosmetic formulations have been widely recognized for being safe and less toxic. The objective of this article is to review the nanoformulations used in anti-aging along with the potential excipients used, currently marketed formulations, and patents filed for cosmetic use. Recent updates related to regulatory aspects of the nanocosmetics have also been highlighted.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"39 3 1","pages":"45-97"},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67437535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Receptor-Targeted Surface-Engineered Nanomaterials for Breast Cancer Imaging and Theranostic Applications. 受体靶向表面工程纳米材料在乳腺癌成像和治疗中的应用。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2022040686

Javed Ahmad, Md Rizwanullah, Teeja Suthar, Hassan A Albarqi, Mohammad Zaki Ahmad, Parameswara Rao Vuddanda, Mohammad Ahmed Khan, Keerti Jain

{"title":"Receptor-Targeted Surface-Engineered Nanomaterials for Breast Cancer Imaging and Theranostic Applications.","authors":"Javed Ahmad, Md Rizwanullah, Teeja Suthar, Hassan A Albarqi, Mohammad Zaki Ahmad, Parameswara Rao Vuddanda, Mohammad Ahmed Khan, Keerti Jain","doi":"10.1615/CritRevTherDrugCarrierSyst.2022040686","DOIUrl":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2022040686","url":null,"abstract":"Breast cancer is one of the most frequently diagnosed cancers in women and the major cause of worldwide cancer-related deaths among women. Various treatment strategies including conventional chemotherapy, immunotherapy, gene therapy, gene silencing and deliberately engineered nanomaterials for receptor mediated targeted delivery of anticancer drugs, antibodies, and small-molecule inhibitors, etc are being investigated by scientists to combat breast cancer. Smartly designed/fabricated nanomaterials are being explored to target breast cancer through enhanced permeation and retention effect; and also, being conjugated with suitable ligand for receptor-mediated endocytosis to target breast cancer for diagnostic, and theranostic applications. These receptor-targeted nanomedicines have shown efficacy to target specific tumor tissue/cells abstaining the healthy tissues/cells from cytotoxic effect of anticancer drug molecules. In the last few decades, theranostic nanomedicines have gained much attention among other nanoparticle systems due to their unique ability to deliver chemotherapeutic as well as diagnostic agents, simultaneously. Theranostic nanomaterials are emerging as novel paradigm with ability for concurrent delivery of imaging (with contrasting agents), targeting (with biomarkers), and anticancer therapeutics with one delivery system (as cancer theranostics) and can transpire as promising strategy to overcome various hurdles for effective management of breast cancer including its most aggressive form, triple-negative breast cancer.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"39 6","pages":"1-44"},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40649106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5