Current Pain and Headache Reports最新文献_第9页

Progress in the Application of Hydrogels in Intervertebral Disc Repair: A Comprehensive Review. 水凝胶在椎间盘修复中的应用进展：全面回顾。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-12-01 Epub Date: 2024-07-10 DOI: 10.1007/s11916-024-01296-6

Xin Chen, Shaoze Jing, Chenhui Xue, Xiaoming Guan

{"title":"Progress in the Application of Hydrogels in Intervertebral Disc Repair: A Comprehensive Review.","authors":"Xin Chen, Shaoze Jing, Chenhui Xue, Xiaoming Guan","doi":"10.1007/s11916-024-01296-6","DOIUrl":"10.1007/s11916-024-01296-6","url":null,"abstract":"Purpose of review: Intervertebral disc degeneration (IVDD) is a common orthopaedic disease and an important cause of lower back pain, which seriously affects the work and life of patients and causes a large economic burden to society. The traditional treatment of IVDD mainly involves early pain relief and late surgical intervention, but it cannot reverse the pathological course of IVDD. Current studies suggest that IVDD is related to the imbalance between the anabolic and catabolic functions of the extracellular matrix (ECM). Anti-inflammatory drugs, bioactive substances, and stem cells have all been shown to improve ECM, but traditional injection methods face short half-life and leakage problems.Recent findings: The good biocompatibility and slow-release function of polymer hydrogels are being noticed and explored to combine with drugs or bioactive substances to treat IVDD. This paper introduces the pathophysiological mechanism of IVDD, and discusses the advantages, disadvantages and development prospects of hydrogels for the treatment of IVDD, so as to provide guidance for future breakthroughs in the treatment of IVDD.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1333-1348"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Neuropathy Associated with Commonly used Chemotherapeutic Agents: A Narrative Review. 与常用化疗药物相关的口腔神经病：叙述性综述。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-12-01 Epub Date: 2024-07-25 DOI: 10.1007/s11916-024-01305-8

Maria Kouri, Martina Rekatsina, Athina Vadalouca, Omar Viswanath, Giustino Varrassi

{"title":"Oral Neuropathy Associated with Commonly used Chemotherapeutic Agents: A Narrative Review.","authors":"Maria Kouri, Martina Rekatsina, Athina Vadalouca, Omar Viswanath, Giustino Varrassi","doi":"10.1007/s11916-024-01305-8","DOIUrl":"10.1007/s11916-024-01305-8","url":null,"abstract":"Purpose of review: Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent complication of cytotoxic chemotherapeutic agents; its incidence largely varies, depending on type, dose, agent and preexisting risk factors. Oral-and-perioral-CIPN (OCIPN) is underreported. Neurotoxic agents can cause jaw pain or numbness. This review aims to present available data on OCIPN RECENT FINDINGS: A narrative literature review, following SANRA guidelines was conducted. PubMed and Cochrane databases were searched until September 2023. Articles referring to neuropathy or neuropathic pain due to head and neck cancer, head and neck radiotherapy, oropharyngeal mucositis, infection or post-surgical pain were excluded. Platinum-based chemotherapeutics, taxanes, vinca alkaloids, immunomodulatory and alkylating agents can cause OCIPN. Platinum-based chemotherapeutics can cause orofacial cold sensitivity, orofacial and jaw pain, oral cavity tingling and teeth hypersensitivity. Taxanes may induce oral cavity and tongue numbness and tingling as well as hot hypersensitivity. Vinca alkaloids may cause jaw, teeth and lips pain and oral mucosa hyperalgesia. Immunomodulatory drugs can cause lips, tongue and perioral numbness, while alkylating agents induce tongue and lips tingling and teeth cold-hypersensitivity. Chemotherapy may cause OCIPN due to changes in cellular structure and function, like alterations in membrane receptors and neurotransmission. OCIPN should be documented and physicians, dentists and health care providers should be alerted.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1209-1217"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: The Role of Platelet Rich Plasma in Vertebrogenic and Discogenic Pain: A Systematic Review and Meta-Analysis. 更正：富血小板血浆在椎间盘源性疼痛中的作用：系统回顾与元分析》。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-12-01 DOI: 10.1007/s11916-024-01300-z

Saurabh Kataria, Jeremiah Hilkiah Wijaya, Utsav Patel, Kevin Yabut, Tawfiq Turjman, Muhammad Abubakar Ayub, Nihar Upadhyay, Moinulhaq Makrani, Hisham Turjman, Ahmed Mostafa Abdalla Mohamed, Alan D Kaye

引用次数: 0

Predicting the Severity of Acute Pain after Cesarean Delivery: A Narrative Review. 预测剖腹产后急性疼痛的严重程度：叙述性综述。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-12-01 Epub Date: 2024-07-23 DOI: 10.1007/s11916-024-01301-y

Lisa Sangkum, Theerawat Chalacheewa, Choosak Tunprasit, Phisut Lavanrattanakul, Henry Liu

{"title":"Predicting the Severity of Acute Pain after Cesarean Delivery: A Narrative Review.","authors":"Lisa Sangkum, Theerawat Chalacheewa, Choosak Tunprasit, Phisut Lavanrattanakul, Henry Liu","doi":"10.1007/s11916-024-01301-y","DOIUrl":"10.1007/s11916-024-01301-y","url":null,"abstract":"Purpose of the review: Cesarean delivery is one of the most common surgical procedures performed worldwide. Approximately 28-78% of the patients have reported experiencing severe pain after Cesarean delivery, which is associated with adverse outcomes. Current analgesic management strategies employ a one-size-fits-all approach, which may not be suitable for all post-Cesarean patients. Our ongoing research and the purpose of this review are focusing on preoperative risk assessment to identify patients at risk of severe pain or needing higher doses of opioid or other analgesics.Recent findings: Recent clinical investigations have found that by utilizing the demographic and psychological evaluations, screening tests, quantitative sensory testing, and assessment of response to local anesthetic infiltration, clinicians were potentially able to stratify the risks for severe post-cesarean pain. Several modalities demonstrated significant correlations with pain outcomes, although most of these correlations were weak to modest. Since consensus statement regarding predicting post-CD pain control are still lacking, these correlations can be clinically helpful. It is possible to identify patients at high risk of developing severe acute pain after cesarean section by preoperative demographic data, screening questionnaires, or other tools. Further studies are needed to identify additional variables or screening tools for more accurate prediction and investigate whether personalized analgesic regimens can lead to improved analgesic outcomes.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1241-1248"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conservative Management of Occipital Neuralgia Supported by Physical Therapy: A Review of Available Research and Mechanistic Rationale to Guide Treatment. 物理治疗支持下的枕神经痛保守治疗：现有研究综述和指导治疗的机制原理。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-12-01 Epub Date: 2024-07-03 DOI: 10.1007/s11916-024-01288-6

Daniel Deuel, Andrew Sandgren, Evan O Nelson, Michael Cropes, Albojay Deacon, Tiffany Houdek, Alaa Abd-Elsayed

{"title":"Conservative Management of Occipital Neuralgia Supported by Physical Therapy: A Review of Available Research and Mechanistic Rationale to Guide Treatment.","authors":"Daniel Deuel, Andrew Sandgren, Evan O Nelson, Michael Cropes, Albojay Deacon, Tiffany Houdek, Alaa Abd-Elsayed","doi":"10.1007/s11916-024-01288-6","DOIUrl":"10.1007/s11916-024-01288-6","url":null,"abstract":"Purpose of review: Conservative management is consistently recommended as a first line intervention for occipital neuralgia (ON); however, there is limited clinical research regarding conservative intervention for ON. This lack of research may lead to underutilization or unwarranted variability in conservative treatment. This article provides mechanism-based guidance for conservative management of ON as a component of a multimodal treatment approach, and discusses the role of the physical therapist in the care team. It also highlights opportunities for further research to refine conservative management of this condition.Recent findings: Published research on conservative interventions specific to ON is limited to very low-quality evidence for the use of TENS. The contemporary shift toward precision pain management emphasizing treatment based on a patient's constellation of clinical features-a phenotype-rather than solely a diagnosis provides more personalized and specifically targeted pain treatment. This paradigm can guide treatment in cases where diagnosis-specific research is lacking and can be used to inform conservative treatment in this case. Various conservative interventions have demonstrated efficacy in treating many of the symptoms and accepted etiologies of ON. Conservative interventions provided by a physical therapist including exercise, manual therapy, posture and biomechanical training, TENS, patient education, and desensitization have mechanistic justification to treat symptoms and causes of ON. Physical therapists have adequate time and skill to provide such progressive and iterative interventions and should be included in a multimodal treatment plan for ON. Further research is required to determine appropriate dosing, sequencing, and progression of conservative treatments.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1321-1331"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is the Status Quo of Patient-Centred Physiotherapy Management of People with Headache within a Biopsychosocial Model? - A Narrative Review. 在生物心理社会模式下，以患者为中心的头痛患者物理治疗管理现状如何？- 叙述性综述。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.1007/s11916-024-01306-7

Sarah Mingels, Marita Granitzer, Kerstin Luedtke, Wim Dankaerts

{"title":"What is the Status Quo of Patient-Centred Physiotherapy Management of People with Headache within a Biopsychosocial Model? - A Narrative Review.","authors":"Sarah Mingels, Marita Granitzer, Kerstin Luedtke, Wim Dankaerts","doi":"10.1007/s11916-024-01306-7","DOIUrl":"10.1007/s11916-024-01306-7","url":null,"abstract":"Purpose of review: Patient-centred care (PCC) is deemed essential in the rehabilitation of musculoskeletal pain. Integrating such care within a biopsychosocial framework, enables to address all facets of the individual pain experience, and to manage the individual instead of the condition. This narrative review describes the status quo of PCC physiotherapy management of people with headache within a biopsychosocial model. PubMed, EMBASE, Web of Science, Scopus were searched (update 07.05.2024). The search-query comprised terminology relating to \"headache\", \"patient-centred\", \"biopsychosocial\", \"physiotherapy\". Additional eligibility criteria were reviews, trials, cohort, case report, case-control studies in English, Dutch, French.Recent findings: Gaps are exposed in patient-centred physiotherapy management of migraine, tension-type headache, and cervicogenic headache. While a biopsychosocial approach is advised to manage migraine and tension-type headache, its use in clinical practice is not reflected by the literature. A biopsychosocial approach is not advised in cervicogenic headache. Psychosocial-lifestyle interventions are mainly delivered by health-care providers other than physiotherapists. Additionally, psychologically-informed practice is barely introduced in physiotherapy headache management. Though, managing the social context within a biopsychosocial framework is advised, the implementation by physiotherapists is unclear. Comparable conclusions apply to PCC. PCC is recommended for the physiotherapy management of primary and secondary headache. Such recommendation remains however theoretical, not reaching clinical implementation. Yet, a shift from the traditional disease-centred model of care towards PCC is ongoing and should be continued in physiotherapy management. With this implementation, clinical and economical studies are needed to evaluate its effectiveness.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1195-1207"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intradiscal Autologous Biologics for the Treatment of Chronic Discogenic Low Back Pain. 治疗慢性椎间盘源性腰痛的椎间盘内自体生物制剂。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-07-17 DOI: 10.1007/s11916-024-01294-8

Wisdom Ufondu, Christopher L Robinson, Nasir Hussain, Ryan S D'Souza, Jay Karri, Trent Emerick, Vwaire J Orhurhu

{"title":"Intradiscal Autologous Biologics for the Treatment of Chronic Discogenic Low Back Pain.","authors":"Wisdom Ufondu, Christopher L Robinson, Nasir Hussain, Ryan S D'Souza, Jay Karri, Trent Emerick, Vwaire J Orhurhu","doi":"10.1007/s11916-024-01294-8","DOIUrl":"10.1007/s11916-024-01294-8","url":null,"abstract":"PURPOSE OF REVIEW: The purpose of this narrative review is to evaluate the efficacy of the most commonly studied intradiscal biologics used for the treatment and alleviation of chronic intractable discogenic low back pain. Additionally, it explores the therapeutic potential and durability of these novel treatment options. RECENT FINDINGS: Recently published literature highlights the therapeutic potential of intradiscal biologics, such as mesenchymal stem cells, platelet-rich plasma, and alpha-2-macroglobulin, in promoting chondrogenesis within the lumbar intervertebral discs to treat discogenic low back pain. Studies demonstrate significant improvements in pain relief, physical function, and quality of life post-treatment. A comprehensive review of the literature evaluating the efficacy of intradiscal biologics suggests some evidence supporting its efficacy in treating discogenic low back pain. However, more rigorous studies into mechanistic modulation and large-scale randomized trials as well as a more thorough understanding of adverse events will be instrumental for including these therapies into clinical practice paradigms.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1079-1095"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Narrative Review of Ultrasound-Guided and Landmark-based Percutaneous Cryoneurolysis for the Management of Acute and Chronic Pain. 超声引导下和基于地标的经皮冷冻神经溶解术治疗急性和慢性疼痛的叙述性综述。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-07-04 DOI: 10.1007/s11916-024-01281-z

Rodney A Gabriel, Eri C Seng, Brian P Curran, Paul Winston, Andrea M Trescot, Igor Filipovski

{"title":"A Narrative Review of Ultrasound-Guided and Landmark-based Percutaneous Cryoneurolysis for the Management of Acute and Chronic Pain.","authors":"Rodney A Gabriel, Eri C Seng, Brian P Curran, Paul Winston, Andrea M Trescot, Igor Filipovski","doi":"10.1007/s11916-024-01281-z","DOIUrl":"10.1007/s11916-024-01281-z","url":null,"abstract":"Purpose of review: Cryoneurolysis refers to the process of reversibly ablating peripheral nerves with extremely cold temperatures to provide analgesia for weeks to months. With ultrasound-guidance or landmark-based techniques, it is an effective modality for managing both acute and chronic pain. In this review, we summarize the reported literature behind its potential applications and efficacy.Recent findings: Here, we summarize several studies (from case reports to clinical trials) describing the use of ultrasound-guided and landmark-based cryoneurolysis for acute and chronic pain. Acute pain indications included pain related to knee arthroplasty, limb amputations, mastectomies, shoulder surgery, rib fractures, and burn. Chronic pain indications included chronic knee pain (due to osteoarthritis), shoulder pain, painful neuropathies, postmastectomy pain syndrome, phantom limb pain, facial pain/headaches, foot/ankle pain, inguinal pain, and sacroiliac joint pain. For both acute and chronic pain indications, more high quality randomized controlled clinical trials are needed to definitively assess the efficacy of cryoneurolysis versus other standard therapies for a multitude of pain conditions.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1097-1104"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methadone and Buprenorphine in the Perioperative Setting: A Review of the Literature. 围手术期的美沙酮和丁丙诺啡：文献综述。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-06-22 DOI: 10.1007/s11916-024-01286-8

Ralph Foglia, Jasper Yan, Anis Dizdarevic

{"title":"Methadone and Buprenorphine in the Perioperative Setting: A Review of the Literature.","authors":"Ralph Foglia, Jasper Yan, Anis Dizdarevic","doi":"10.1007/s11916-024-01286-8","DOIUrl":"10.1007/s11916-024-01286-8","url":null,"abstract":"Purpose of review: The purpose of this review is to highlight the most recent literature and guidelines regarding perioperative methadone and buprenorphine use.Recent findings: Surgical patients taking methadone and buprenorphine are being encountered more frequently in the perioperative period, and providers are becoming more familiar with their pharmacologic properties, benefits as well as precautions. Recommendations pertaining to buprenorphine therapy in the perioperative settings have changed in recent years, owing to more clinical and basic science research. In addition to their use in chronic pain and opioid use disorders, they can also be initiated for acute postoperative pain indications, in select patients and situations. Methadone and buprenorphine are being more commonly prescribed for pain management and opioid use disorder, and their continuation during the perioperative period is generally recommended, to reduce the risk of opioid withdrawal, relapse, or inadequately controlled pain. Additionally, both may be initiated safely and effectively for acute pain management during and after the operating room period.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1105-1111"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune Competence and Pain: A Narrative Review. 免疫能力与疼痛：叙述性综述》（Immune Competence and Pain: A Narrative Review.

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-06-27 DOI: 10.1007/s11916-024-01282-y

Stefano Coaccioli, Piercarlo Sarzi-Puttini, Diego M M Fornasari, Vittorio Schweiger, Panagiotis Zis, Omar Viswanath, Giustino Varrassi

{"title":"Immune Competence and Pain: A Narrative Review.","authors":"Stefano Coaccioli, Piercarlo Sarzi-Puttini, Diego M M Fornasari, Vittorio Schweiger, Panagiotis Zis, Omar Viswanath, Giustino Varrassi","doi":"10.1007/s11916-024-01282-y","DOIUrl":"10.1007/s11916-024-01282-y","url":null,"abstract":"Purpose of review: This review aims to summarize current knowledge on the pathophysiology of pain and the role of neuro-immune crosstalk in the development of acute and chronic pain (CP). Specifically, the review focuses on the role of immune cells involved in the innate and acquired immune response, emphasizing their bidirectional interactions with the nervous systems and discussing the implications of this crosstalk on acute and CP management.Recent findings: In the last two decades, multiple studies have uncovered the important role of the immune system in initiating, maintaining, and resolving pain stimuli. Furthermore, researchers discovered that the immune system interacts tightly with the nervous system, creating a bidirectional crosstalk in which immune cells influence the response of peripheral and central nerve fibers while neurotransmitters and neuropeptides released by nociceptors directly and indirectly modulate the immune response. The neuro-immune crosstalk in acute and CP is a complex and not fully understood process that comprise the interactions of multiple diverse molecules, bidirectional interferences, and numerous redundant processes. Despite the complexity, important steps have been taken in recent years toward explaining the specific roles of each immune cell type and molecule in the initiation, maintenance and resolution of pain. These findings may set the basis for innovative therapeutic options that target the immune system, overcoming the limitations of current treatments in providing pain relief and the disadvantages associated with opioid therapy.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1145-1154"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0