Current Pain and Headache Reports最新文献

An Update on Emerging Regenerative Medicine Applications: The Use of Extracellular Vesicles and Exosomes for the Management of Chronic Pain. 新兴再生医学应用的最新进展：利用细胞外囊泡和外泌体治疗慢性疼痛。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-04 DOI: 10.1007/s11916-024-01309-4

William D Shipman, Raquel Fonseca, Moises Dominguez, Sadiq Bhayani, Christopher Gilligan, Sudhir Diwan, David Rosenblum, Sait Ashina, Reda Tolba, Alaa Abd-Elsayed, Alan D Kaye, Jamal Hasoon, Michael E Schatman, Timothy Deer, Jason Yong, Christopher L Robinson

{"title":"An Update on Emerging Regenerative Medicine Applications: The Use of Extracellular Vesicles and Exosomes for the Management of Chronic Pain.","authors":"William D Shipman, Raquel Fonseca, Moises Dominguez, Sadiq Bhayani, Christopher Gilligan, Sudhir Diwan, David Rosenblum, Sait Ashina, Reda Tolba, Alaa Abd-Elsayed, Alan D Kaye, Jamal Hasoon, Michael E Schatman, Timothy Deer, Jason Yong, Christopher L Robinson","doi":"10.1007/s11916-024-01309-4","DOIUrl":"https://doi.org/10.1007/s11916-024-01309-4","url":null,"abstract":"Purpose of review: Chronic pain affects nearly two billion people worldwide, surpassing heart disease, diabetes, and cancer in terms of economic costs. Lower back pain alone is the leading cause of years lived with disability worldwide. Despite limited treatment options, regenerative medicine, particularly extracellular vesicles (EVs) and exosomes, holds early promise for patients who have exhausted other treatment options. EVs, including exosomes, are nano-sized structures released by cells, facilitating cellular communication through bioactive molecule transfer, and offering potential regenerative properties to damaged tissues. Here, we review the potential of EVs and exosomes for the management of chronic pain.Recent findings: In osteoarthritis, various exosomes, such as those derived from synovial mesenchymal stem cells, human placental cells, dental pulp stem cells, and bone marrow-derived mesenchymal stem cells (MSCs), demonstrate the ability to reduce inflammation, promote tissue repair, and alleviate pain in animal models. In intervertebral disc disease, Wharton's jelly MSC-derived EVs enhance cell viability and reduce inflammation. In addition, various forms of exosomes have been shown to reduce signs of inflammation in neurons and alleviate pain in neuropathic conditions in animal models. Although clinical applications of EVs and exosomes are still in the early clinical stages, they offer immense potential in the future management of chronic pain conditions. Clinical trials are ongoing to explore their therapeutic potential further, and with more research the potential applicability of EVs and exosomes will be fully understood.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Narrative Review of Ultrasound-Guided and Landmark-based Percutaneous Cryoneurolysis for the Management of Acute and Chronic Pain. 超声引导下和基于地标的经皮冷冻神经溶解术治疗急性和慢性疼痛的叙述性综述。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-07-04 DOI: 10.1007/s11916-024-01281-z

Rodney A Gabriel, Eri C Seng, Brian P Curran, Paul Winston, Andrea M Trescot, Igor Filipovski

{"title":"A Narrative Review of Ultrasound-Guided and Landmark-based Percutaneous Cryoneurolysis for the Management of Acute and Chronic Pain.","authors":"Rodney A Gabriel, Eri C Seng, Brian P Curran, Paul Winston, Andrea M Trescot, Igor Filipovski","doi":"10.1007/s11916-024-01281-z","DOIUrl":"10.1007/s11916-024-01281-z","url":null,"abstract":"Purpose of review: Cryoneurolysis refers to the process of reversibly ablating peripheral nerves with extremely cold temperatures to provide analgesia for weeks to months. With ultrasound-guidance or landmark-based techniques, it is an effective modality for managing both acute and chronic pain. In this review, we summarize the reported literature behind its potential applications and efficacy.Recent findings: Here, we summarize several studies (from case reports to clinical trials) describing the use of ultrasound-guided and landmark-based cryoneurolysis for acute and chronic pain. Acute pain indications included pain related to knee arthroplasty, limb amputations, mastectomies, shoulder surgery, rib fractures, and burn. Chronic pain indications included chronic knee pain (due to osteoarthritis), shoulder pain, painful neuropathies, postmastectomy pain syndrome, phantom limb pain, facial pain/headaches, foot/ankle pain, inguinal pain, and sacroiliac joint pain. For both acute and chronic pain indications, more high quality randomized controlled clinical trials are needed to definitively assess the efficacy of cryoneurolysis versus other standard therapies for a multitude of pain conditions.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1097-1104"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intradiscal Autologous Biologics for the Treatment of Chronic Discogenic Low Back Pain. 治疗慢性椎间盘源性腰痛的椎间盘内自体生物制剂。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-07-17 DOI: 10.1007/s11916-024-01294-8

Wisdom Ufondu, Christopher L Robinson, Nasir Hussain, Ryan S D'Souza, Jay Karri, Trent Emerick, Vwaire J Orhurhu

{"title":"Intradiscal Autologous Biologics for the Treatment of Chronic Discogenic Low Back Pain.","authors":"Wisdom Ufondu, Christopher L Robinson, Nasir Hussain, Ryan S D'Souza, Jay Karri, Trent Emerick, Vwaire J Orhurhu","doi":"10.1007/s11916-024-01294-8","DOIUrl":"10.1007/s11916-024-01294-8","url":null,"abstract":"PURPOSE OF REVIEW: The purpose of this narrative review is to evaluate the efficacy of the most commonly studied intradiscal biologics used for the treatment and alleviation of chronic intractable discogenic low back pain. Additionally, it explores the therapeutic potential and durability of these novel treatment options. RECENT FINDINGS: Recently published literature highlights the therapeutic potential of intradiscal biologics, such as mesenchymal stem cells, platelet-rich plasma, and alpha-2-macroglobulin, in promoting chondrogenesis within the lumbar intervertebral discs to treat discogenic low back pain. Studies demonstrate significant improvements in pain relief, physical function, and quality of life post-treatment. A comprehensive review of the literature evaluating the efficacy of intradiscal biologics suggests some evidence supporting its efficacy in treating discogenic low back pain. However, more rigorous studies into mechanistic modulation and large-scale randomized trials as well as a more thorough understanding of adverse events will be instrumental for including these therapies into clinical practice paradigms.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1079-1095"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methadone and Buprenorphine in the Perioperative Setting: A Review of the Literature. 围手术期的美沙酮和丁丙诺啡：文献综述。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-06-22 DOI: 10.1007/s11916-024-01286-8

Ralph Foglia, Jasper Yan, Anis Dizdarevic

{"title":"Methadone and Buprenorphine in the Perioperative Setting: A Review of the Literature.","authors":"Ralph Foglia, Jasper Yan, Anis Dizdarevic","doi":"10.1007/s11916-024-01286-8","DOIUrl":"10.1007/s11916-024-01286-8","url":null,"abstract":"Purpose of review: The purpose of this review is to highlight the most recent literature and guidelines regarding perioperative methadone and buprenorphine use.Recent findings: Surgical patients taking methadone and buprenorphine are being encountered more frequently in the perioperative period, and providers are becoming more familiar with their pharmacologic properties, benefits as well as precautions. Recommendations pertaining to buprenorphine therapy in the perioperative settings have changed in recent years, owing to more clinical and basic science research. In addition to their use in chronic pain and opioid use disorders, they can also be initiated for acute postoperative pain indications, in select patients and situations. Methadone and buprenorphine are being more commonly prescribed for pain management and opioid use disorder, and their continuation during the perioperative period is generally recommended, to reduce the risk of opioid withdrawal, relapse, or inadequately controlled pain. Additionally, both may be initiated safely and effectively for acute pain management during and after the operating room period.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1105-1111"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune Competence and Pain: A Narrative Review. 免疫能力与疼痛：叙述性综述》（Immune Competence and Pain: A Narrative Review.

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-06-27 DOI: 10.1007/s11916-024-01282-y

Stefano Coaccioli, Piercarlo Sarzi-Puttini, Diego M M Fornasari, Vittorio Schweiger, Panagiotis Zis, Omar Viswanath, Giustino Varrassi

{"title":"Immune Competence and Pain: A Narrative Review.","authors":"Stefano Coaccioli, Piercarlo Sarzi-Puttini, Diego M M Fornasari, Vittorio Schweiger, Panagiotis Zis, Omar Viswanath, Giustino Varrassi","doi":"10.1007/s11916-024-01282-y","DOIUrl":"10.1007/s11916-024-01282-y","url":null,"abstract":"Purpose of review: This review aims to summarize current knowledge on the pathophysiology of pain and the role of neuro-immune crosstalk in the development of acute and chronic pain (CP). Specifically, the review focuses on the role of immune cells involved in the innate and acquired immune response, emphasizing their bidirectional interactions with the nervous systems and discussing the implications of this crosstalk on acute and CP management.Recent findings: In the last two decades, multiple studies have uncovered the important role of the immune system in initiating, maintaining, and resolving pain stimuli. Furthermore, researchers discovered that the immune system interacts tightly with the nervous system, creating a bidirectional crosstalk in which immune cells influence the response of peripheral and central nerve fibers while neurotransmitters and neuropeptides released by nociceptors directly and indirectly modulate the immune response. The neuro-immune crosstalk in acute and CP is a complex and not fully understood process that comprise the interactions of multiple diverse molecules, bidirectional interferences, and numerous redundant processes. Despite the complexity, important steps have been taken in recent years toward explaining the specific roles of each immune cell type and molecule in the initiation, maintenance and resolution of pain. These findings may set the basis for innovative therapeutic options that target the immune system, overcoming the limitations of current treatments in providing pain relief and the disadvantages associated with opioid therapy.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1145-1154"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Post Dural Puncture Headache During Spinal Cord Stimulation Trials: A Review of Current Literature. 脊髓刺激试验期间硬膜穿刺后头痛的处理：当前文献综述。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-06-25 DOI: 10.1007/s11916-024-01289-5

Ronnie Stotts, Rishabh Jain, Amit Aggarwal DO, Rana Al-Jumah

引用次数: 0

Advances in the Treatment of Neuropathic Pain by Sympathetic Regulation. 通过交感神经调节治疗神经性疼痛的进展。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-06-22 DOI: 10.1007/s11916-024-01285-9

Ping Xu, Han Rui Fan, En Ming Zhang, Hao Nan Zhang, Yong Fei

{"title":"Advances in the Treatment of Neuropathic Pain by Sympathetic Regulation.","authors":"Ping Xu, Han Rui Fan, En Ming Zhang, Hao Nan Zhang, Yong Fei","doi":"10.1007/s11916-024-01285-9","DOIUrl":"10.1007/s11916-024-01285-9","url":null,"abstract":"Purpose of review: To explore the mechanism and therapeutic effect of sympathetic nerve regulation on neuropathic pain.Recent findings: A comprehensive search was conducted in the PubMed and CNKI libraries, using the following keywords: stele ganglion block, neuropathic pain, sympathetic nerve block, sympathetic chemical destruction, and sympathetic radiofrequency thermocoagulation. We selected and critically reviewed research articles published in English that were related to sympathetic modulation in the treatment of neuropathic pain. The collected literature will be classified according to content and reviewed in combination with experimental results and clinical cases. Neuropathic pain was effectively treated with sympathetic regulation technology. Its mechanism includes the inhibition of sympathetic nerve activity, regulation of the inflammatory response, and inhibition of pain transmission, which greatly alleviates neuropathic pain in patients. Stellate ganglion blocks, thoracic and lumbar sympathectomies, chemical destruction, and radiofrequency thermocoagulation have been widely used to treat neuropathic pain. Sympathetic regulation can effectively relieve pain symptoms and improve the patient's quality of life by inhibiting sympathetic nerve activity, reducing the production and release of pain-related mediators, and inhibiting pain transmission. CT-guided radiofrequency thermocoagulation of the thoracic and lumbar sympathetic nerves is effective and durable, with few complications, and is recommended as a treatment for intractable neuropathic pain.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1167-1176"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontiers in Acute Pain Management: Emerging Concepts in Pain Pathways and the Role of VX-548 as a Novel NaV1.8 Inhibitor: A Narrative Review. 急性疼痛治疗的前沿：疼痛途径的新概念以及 VX-548 作为新型 NaV1.8 抑制剂的作用：叙述性综述。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-07-04 DOI: 10.1007/s11916-024-01295-7

Alan D Kaye, Erin S Everett, Arianna M Lehuquet, Joseph W Mason, Rebecca Maitski, Michael J Plessala, Sonnah Barrie, Carlo Jean Baptiste, George Mychaskiw, Shahab Ahmadzadeh, Sahar Shekoohi, Giustino Varrassi

{"title":"Frontiers in Acute Pain Management: Emerging Concepts in Pain Pathways and the Role of VX-548 as a Novel NaV1.8 Inhibitor: A Narrative Review.","authors":"Alan D Kaye, Erin S Everett, Arianna M Lehuquet, Joseph W Mason, Rebecca Maitski, Michael J Plessala, Sonnah Barrie, Carlo Jean Baptiste, George Mychaskiw, Shahab Ahmadzadeh, Sahar Shekoohi, Giustino Varrassi","doi":"10.1007/s11916-024-01295-7","DOIUrl":"10.1007/s11916-024-01295-7","url":null,"abstract":"Purpose of review: Despite ongoing research into alternative postsurgical pain treatments, opioids remain widely used analgesics regardless of associated adverse effects, including dependence and overdose, as demonstrated throughout the current opioid crisis. This is likely related to a failure in proving the efficacy of alternative analgesics in clinical trials, despite strong evidence supporting the potential for effective analgesia through in vitro studies. While NaV1.7 and NaV1.8 channels have shown to be key components of pain perception, studies regarding pharmacological agents utilizing these channels as targets have largely failed to demonstrate the efficacy of these proposed analgesics when compared to current multimodal pain treatment regimens.Recent findings: However, the novel NaV1.8 channel inhibitor, VX-548 has surpassed previously studied NaV1.8 inhibitors in clinical trials and continues to hold promise of a novel efficacious analgesic to potentially be utilized in multimodal pain treatment on postsurgical patients. Additionally, NaV1.8 is encoded by the SCN10A, which has been shown to be minimally expressed in the brain, suggesting a lower likelihood of adverse effects in the CNS, including dependence and abuse. Novel pharmacologic analgesics that are efficacious without the significant side effects associated with opioids have lacked meaningful development. However, recent clinical trials have shown promising results in the safety and efficacy of the pharmacological agent VX-548. Still, more clinical trials directly comparing the efficacy of VX-548 to standard of care post-surgical drugs, including opioids like morphine and hydromorphone are needed to demonstrate the long-term viability of the agent replacing current opioids with an unfavorable side effect profile.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1135-1143"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Peripheral Nerve Blocks for Total hip Arthroplasty. 在全髋关节置换术中使用外周神经阻滞。

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-06-22 DOI: 10.1007/s11916-024-01287-7

Leon Grinman, Brett Elmore, Alberto E Ardon, Adnan Hussain, Mohammed Faysal Malik, Nadia Hernandez, Mackenzie Janice Jacoby

引用次数: 0

IF 3.2 2区医学

Current Pain and Headache Reports Pub Date : 2024-11-01 Epub Date: 2024-06-27 DOI: 10.1007/s11916-024-01283-x

Karina Stech, Behnum Habibi

{"title":"Pain Related Quality of Life in Neurofibromatosis Type 1: A Narrative Review.","authors":"Karina Stech, Behnum Habibi","doi":"10.1007/s11916-024-01283-x","DOIUrl":"10.1007/s11916-024-01283-x","url":null,"abstract":"Purpose of review: The purpose of this narrative review is to summarize pain symptomatology and mechanisms in neurofibromatosis type 1 (NF1), discuss the pain related quality of life impacts of NF1, and discuss the literature exploring interventions to improve quality of life.Recent findings: Chronic pain in NF1 is described as headache and non-headache pain. The literature describes mechanisms contributing to neuronal hyperexcitability in the setting of reduced neurofibromin as key contributors to pain in NF1. Pain in NF1 negatively impacts quality of life with pain interference, depression, anxiety, and cognitive functioning acting as important mediators. Mitogen-activated protein kinase (MEK) inhibitors are pharmacologic agents that interfere with pain mechanisms. Mind-body interventions improve coping skills to improve quality of life. Chronic pain in NF1 is heterogeneous with negative impacts on quality of life. New developments in pharmacological and non-pharmacological interventions offer promising approaches to pain management and quality of life improvement. Additional research is necessary to validate the use of MEK inhibitors and mind-body interventions in the treatment of NF1.","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":" ","pages":"1177-1183"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0