Xijian Ke, Christopher L Robinson, Henry Liu, Wei Mei, Sahar Shekoohi, Alan D Kaye
{"title":"Applications of Celiac Plexus Block in Chronic Pancreatitis or Pancreatic Cancer.","authors":"Xijian Ke, Christopher L Robinson, Henry Liu, Wei Mei, Sahar Shekoohi, Alan D Kaye","doi":"10.1007/s11916-026-01495-3","DOIUrl":"https://doi.org/10.1007/s11916-026-01495-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>Celiac plexus block (CPB) is an established interventional technique for the management of severe upper abdominal pain, particularly in patients with chronic pancreatitis (CP) and pancreatic cancer (PC). Pain in these conditions is complex, involving visceral and neuropathic mechanisms and, in CP, additional contributions from neuropathic remodeling, central sensitization, and altered descending modulation play a role.</p><p><strong>Recent findings: </strong>CPB provides targeted neural blockade to disrupt nociceptive transmission from the upper abdominal viscera, thereby improving analgesia, reducing opioid requirements, and enhancing quality of life. This chapter emphasizes the role of CPB in treating pain resulting from CP and PC, with a specific focus on therapeutic timing, procedural approaches, technical considerations, efficacy, durability of pain relief, side effects, and recent advances. Current evidence suggests that CPB is highly effective in PC pain but provides only modest and short-lived benefit in CP, where it should be reserved for carefully selected refractory cases. Future directions include advanced imaging modalities, improved neurolytic agents, and integration of CPB into multimodal, mechanism-based strategies for comprehensive pain control.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"30 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drake P Duplechin, Joseph G Wentling, Tucker L Apgar, Ethan J Cazayoux, Shahab Ahmadzadeh, Varsha Allampalli, Sahar Shekoohi, Matthew R Eng, Alan D Kaye
{"title":"Paravertebral Block for Postoperative Pain Management After Open Thoracotomy: A Review of Efficacy and Risks.","authors":"Drake P Duplechin, Joseph G Wentling, Tucker L Apgar, Ethan J Cazayoux, Shahab Ahmadzadeh, Varsha Allampalli, Sahar Shekoohi, Matthew R Eng, Alan D Kaye","doi":"10.1007/s11916-026-01493-5","DOIUrl":"https://doi.org/10.1007/s11916-026-01493-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>Paravertebral block (PVB) is an increasingly utilized regional anesthesia technique for managing postoperative pain in patients undergoing open thoracotomy. Effective pain control following thoracic surgery is crucial for optimizing patient recovery, reducing opioid consumption, and minimizing respiratory complications.</p><p><strong>Recent findings: </strong>PVB provides unilateral analgesia by delivering local anesthetic to the paravertebral space, effectively blocking somatic and sympathetic nerve fibers. PVB has gained popularity as an alternative to epidural analgesia due to its efficacy and improved safety profile. While epidural analgesia remains the traditional gold standard for thoracic procedures, it is associated with complications such as hypotension, urinary retention, motor blockade, and the need for catheter placement. In contrast, PVB is easier to administer, produces less hemodynamic instability, and reduce systemic side effects. Recent literature suggests that PVB offers similar or improved pain control, reduced opiod requirements, and fewer postoperative complications. Risks such as vascular puncture, local anesthetic systemic toxicity, and incomplete spread persists; however, ultrasound guidance has iproved block reliability. Given its favorable safety profile and efficacy, PVB is emerging as a preferred option for postoperative pain control in open thoracotomy patients. Further research and randomized trials are needed to standardize technique, dosing, and peroperative protocols.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"30 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metabolic Dysfunction and Metabolic Management in Episodic Migraine.","authors":"Delora E Denney, Michael J Marmura","doi":"10.1007/s11916-026-01500-9","DOIUrl":"10.1007/s11916-026-01500-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>Evidence suggests a significant link between migraine and metabolic syndrome,, especially in those with chronic or refractory migraine. Weight loss and exercise may effectively prevent migraine. Here, we review the evidence behind exercise and weight loss as migraine treatments.</p><p><strong>Recent findings: </strong>While metabolic syndrome and pain have long had a known association, only recently have strong studies demonstrated a higher risk of developing metabolic syndrome in people with migraine. Additionally, other sequelae of metabolic syndrome, obesity, hypertension, hypercoagulability, and diabetes also interplay with migraine. New medications like GLP-1 agonists may be a potential treatment for migraine as well as obesity. For patients with migraine, metabolic syndrome, and obesity, care should be taken when selecting prophylactic medications, favoring those without a propensity to induce weight gain. Additionally, there is strong evidence for weight loss and exercise for improving migraine outcomes.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"30 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pain Unraveled: Kinesio Taping as a Novel Approach to Myofascial Pain Management.","authors":"Prateek Mittal, Saurabh Mittal","doi":"10.1007/s11916-026-01498-0","DOIUrl":"https://doi.org/10.1007/s11916-026-01498-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>Myofascial pain syndrome (MPS) is a musculoskeletal system disorder that is exceedingly painful and distinct from other chronic pain syndromes. MPS can occur on its own or in conjunction with other muscle disorders. Symptoms of MPS include tense bands in muscles, weakening at the afflicted region, radial or repeated pain, restricted range of motion (ROM), and hot and red skin. In addition, symptoms of MTrPs include tense bands in muscles, weakening at the afflicted region, radial or repeated pain, restricted range of motion (ROM), and/or hot and red skin. Kenzo Kase, a Japanese chiropractor, invented Kinesiology Tape (KT) in the 1970s, with a potential role in modulating pain, enhancing muscle function and improving ROM. This review aims to examine the underlying mechanisms of MPS and evaluate current therapeutic strategies, with particular emphasis on the mechanism and clinical application of KT in managing MPS.</p><p><strong>Recent findings: </strong>Recent literature highlights the advances in understanding the pathophysiology of MTrP, conventional therapies and their limitations. KT is a dynamic, stretchable tape that resembles human skin which may be utilised to treat pain and muscle activity as well as increase range of motion (ROM). The majority of the time, KT is used in the treatment and prevention of sports injuries. Clinical studies report improvements in pain intensity, muscle flexibility, and ROM following KT application in individuals with MPS, particularly in sports and rehabilitation settings. MPS is a complex pain disorder requiring multimodal management. KT represents a promising non-invasive intervention that may address both pain and functional restoration through neurophysiological and biomechanical mechanisms. While clinical findings are promising, regulatory protocols are yet to be standardised to ensure long term safety and efficacy of KT in the treatment of MPS.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"30 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jamal Hasoon, Omar Viswanath, Ivan Urits, Giustino Varrassi, Alan D Kaye
{"title":"Discrepancies in Urine Drug Screening Among Patients Receiving Chronic Opioid Therapy for Non-Cancer Pain: A Retrospective Review.","authors":"Jamal Hasoon, Omar Viswanath, Ivan Urits, Giustino Varrassi, Alan D Kaye","doi":"10.1007/s11916-026-01496-2","DOIUrl":"https://doi.org/10.1007/s11916-026-01496-2","url":null,"abstract":"","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"30 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isaac Daybell, Christopher Wie, Brooks Johnson, Stephen Covington, John Freeman, Scott Pew, Jillian Maloney
{"title":"The OPRM1 A118G Polymorphism Revisited: Recent Developments and Implications for Personalized Treatment.","authors":"Isaac Daybell, Christopher Wie, Brooks Johnson, Stephen Covington, John Freeman, Scott Pew, Jillian Maloney","doi":"10.1007/s11916-026-01485-5","DOIUrl":"https://doi.org/10.1007/s11916-026-01485-5","url":null,"abstract":"","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"30 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medication Overuse Headache in Children and Adolescents: A Narrative Review.","authors":"Joshua Ransick, Juliana VanderPluym","doi":"10.1007/s11916-026-01497-1","DOIUrl":"https://doi.org/10.1007/s11916-026-01497-1","url":null,"abstract":"","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"30 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shahab Ahmadzadeh, Mary O'Dell Duplechin, Alex V Hollander, Francis C Thompson, Kristin Nicole Bembenick, Sahar Shekoohi, Alan D Kaye
{"title":"Efficacy of Rectus Sheath Block in the Management of Laparoscopic Cholecystectomy Mediated Pain: A Narrative Review.","authors":"Shahab Ahmadzadeh, Mary O'Dell Duplechin, Alex V Hollander, Francis C Thompson, Kristin Nicole Bembenick, Sahar Shekoohi, Alan D Kaye","doi":"10.1007/s11916-026-01484-6","DOIUrl":"https://doi.org/10.1007/s11916-026-01484-6","url":null,"abstract":"","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"30 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alan D Kaye, Mary O'Dell Duplechin, Andrew T Bolton, Bennett M Ford, Alex V Hollander, Yair Lopez Torres, Sahar Shekoohi, Shahab Ahmadzadeh
{"title":"Clinical Efficacy and Risks of Intra-Operative Intravenous Methadone in Spine Surgeries: A Narrative Review.","authors":"Alan D Kaye, Mary O'Dell Duplechin, Andrew T Bolton, Bennett M Ford, Alex V Hollander, Yair Lopez Torres, Sahar Shekoohi, Shahab Ahmadzadeh","doi":"10.1007/s11916-026-01492-6","DOIUrl":"https://doi.org/10.1007/s11916-026-01492-6","url":null,"abstract":"","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"30 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}