Current Pain and Headache Reports最新文献

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Perioperative Management of Patients Receiving Interventional Techniques and Antiplatelet and Anticoagulant Therapy: A Balancing Act. 接受介入技术和抗血小板、抗凝治疗的患者围手术期管理:一种平衡行为。
IF 3.5 2区 医学
Current Pain and Headache Reports Pub Date : 2025-09-18 DOI: 10.1007/s11916-025-01405-z
Laxmaiah Manchikanti, Alan D Kaye, Devi E Nampiaparampil, Mahendra R Sanapati, Alaa Abd-Elsayed, Sahar Shekoohi, Joshua A Hirsch
{"title":"Perioperative Management of Patients Receiving Interventional Techniques and Antiplatelet and Anticoagulant Therapy: A Balancing Act.","authors":"Laxmaiah Manchikanti, Alan D Kaye, Devi E Nampiaparampil, Mahendra R Sanapati, Alaa Abd-Elsayed, Sahar Shekoohi, Joshua A Hirsch","doi":"10.1007/s11916-025-01405-z","DOIUrl":"https://doi.org/10.1007/s11916-025-01405-z","url":null,"abstract":"<p><strong>Purposeof review: </strong>This article aims to evaluate current evidence and guidelines on anticoagulant and antiplatelet therapy for patients undergoing interventional procedures. It provides recommendations for managing these therapies with either continuation or withholding of these drugs in the perioperative period to minimize the risk of bleeding and thromboembolism in clinical practice.</p><p><strong>Recent findings: </strong>Newly published guidelines and research underscore the crucial role of antiplatelet and anticoagulant therapy in interventional procedures, emphasizing the importance of decisions regarding whether to continue or temporarily stop these medications. Studies have categorized procedures into low-, moderate-, and high-risk groups, offering specific guidance on managing anticoagulant and antiplatelet therapy accordingly. The American Society of Interventional Pain Physicians (ASIPP) has developed consensus guidelines based on a synthesis of the best available evidence, incorporating risk stratification and practical recommendations. This review provides an in-depth analysis of medical, surgical, and interventional pain management literature. It highlights the updated ASIPP guidelines and summarizes the society's evidence-based recommendations for clinical practice.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"29 1","pages":"107"},"PeriodicalIF":3.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Part Of the Process, or Adverse Event? Considering the Benefits and Potential Risks of Mindfulness-based Interventions for Migraine. 是过程的一部分,还是不良事件?考虑正念干预偏头痛的益处和潜在风险。
IF 3.5 2区 医学
Current Pain and Headache Reports Pub Date : 2025-09-16 DOI: 10.1007/s11916-025-01415-x
Toby Dresdner, Elizabeth Seng
{"title":"Part Of the Process, or Adverse Event? Considering the Benefits and Potential Risks of Mindfulness-based Interventions for Migraine.","authors":"Toby Dresdner, Elizabeth Seng","doi":"10.1007/s11916-025-01415-x","DOIUrl":"10.1007/s11916-025-01415-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>This goal of this paper is to identify the need to report adverse events (AEs) in mindfulness-based interventions (MBIs) for migraine and highlight conceptual issues related to their reporting. This paper reviews the benefits and AEs in MBIs broadly and considers their application to a migraine population.</p><p><strong>Recent findings: </strong>Due to a lack of standardized protocol for measuring and reporting, there is little published information on AEs in MBIs for migraine. Several recent trials have reported individual cases of AEs, including one instance of posttraumatic re-experiencing. The increasing popularity of MBIs in the treatment of chronic pain conditions, including migraine, makes it necessary for providers to understand which AEs occur. Patients with migraine may be at an elevated risk of experiencing AEs in MBIs.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"29 1","pages":"106"},"PeriodicalIF":3.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mobile Health and Gamification of Chronic Pain Management: A Narrative Review. 慢性疼痛管理的移动健康和游戏化:叙述回顾。
IF 3.5 2区 医学
Current Pain and Headache Reports Pub Date : 2025-07-31 DOI: 10.1007/s11916-025-01416-w
Helen S Jung, Michael E Schatman, Franzes Anne Z Liongson, Michael D Kritzer, R Jason Yong, Derick Davis, Alan D Kaye, Ken W K Lee, Mohammed Issa, Jason E Crowther, Giuliano Lo Bianco, Paul J Christo, Christopher L Robinson
{"title":"Mobile Health and Gamification of Chronic Pain Management: A Narrative Review.","authors":"Helen S Jung, Michael E Schatman, Franzes Anne Z Liongson, Michael D Kritzer, R Jason Yong, Derick Davis, Alan D Kaye, Ken W K Lee, Mohammed Issa, Jason E Crowther, Giuliano Lo Bianco, Paul J Christo, Christopher L Robinson","doi":"10.1007/s11916-025-01416-w","DOIUrl":"https://doi.org/10.1007/s11916-025-01416-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>The current literature on gamifying mobile health (mHealth) applications to address chronic pain management is evaluated in this narrative review. These approaches include utilizing wearable devices to track progress of various biomarkers, collecting digital rewards for utilizing in-app self-management educational tools, completing challenges to encourage the use of mental health resources, and leaderboards to promote shared learning and overcome social withdrawal.</p><p><strong>Recent findings: </strong>There continues to be a growing emphasis on the collaboration between patients with chronic pain and physicians to form comprehensive management strategies to address patients' unique pharmacological, physical, and psychosocial needs. Despite the accessibility of mHealth apps, they usually fail to integrate easily into a patient's lifestyle. Moreover, there is promise for enhanced psychosocial support through mHealth apps. A small fraction of chronic pain mHealth apps have utilized principles of gamification to motivate patients to adhere to care plans. Evidence suggests that incorporating game-like elements in future mHealth app designs must be prioritized to improve user engagement and subsequently facilitate positive health behaviors and outcomes for more effective pain control.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"29 1","pages":"105"},"PeriodicalIF":3.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Administration of an Expectation Survey at a Pain Medicine Clinic to Improve Patient Satisfaction: A Prospective Study. 在疼痛医学诊所实施期望调查以提高病人满意度:一项前瞻性研究。
IF 3.5 2区 医学
Current Pain and Headache Reports Pub Date : 2025-07-30 DOI: 10.1007/s11916-025-01406-y
Emmanuella Borukh, Phuong Nguyen, Geum Yeon Sim, Jasal Patel, Andrew Bloomfield, Sarang S Koushik, Jagun Raghavan, Omar Viswanath, Kevin Zacharoff, Kateryna Slinchenkova, Karina Gritsenko, Naum Shaparin
{"title":"The Administration of an Expectation Survey at a Pain Medicine Clinic to Improve Patient Satisfaction: A Prospective Study.","authors":"Emmanuella Borukh, Phuong Nguyen, Geum Yeon Sim, Jasal Patel, Andrew Bloomfield, Sarang S Koushik, Jagun Raghavan, Omar Viswanath, Kevin Zacharoff, Kateryna Slinchenkova, Karina Gritsenko, Naum Shaparin","doi":"10.1007/s11916-025-01406-y","DOIUrl":"10.1007/s11916-025-01406-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>Patients' expectations are important aspects to consider for improving patients' satisfaction and willingness to return for continued care. While expectation surveys are not novel in Pain Medicine, none specifically aim to improve satisfaction. This study evaluates whether administering an expectation survey during an initial pain clinic visit improves satisfaction with treatment plans and outcomes. We hypothesized that completing the survey could increase awareness and help align expectations and satisfaction.</p><p><strong>Recent findings: </strong>This study was conducted at an outpatient multidisciplinary pain clinic at an urban academic hospital and 100 first-time, English speaking adult patients were recruited. Fifty patients completed a pre-visit questionnaire on pain and expectations (intervention group), while 50 did not (control group). A follow-up survey was completed six months later by 85% of participants to assess satisfaction level with pain treatment, meeting of goals and expectations, and overall clinic experience. No significant differences were found between intervention and control groups for pain treatment satisfaction (3.46 ± 1.31 vs. 3.50 ± 1.28, p = 0.48), goal achievement (3.76 ± 1.14 vs. 3.49 ± 1.20, p = 0.30), or overall experience (3.83 ± 1.20 vs. 3.72 ± 1.14, p = 0.67). Dissatisfaction stemmed from inadequate pain relief, lack of follow-up, and unmet expectations. The lack of statistical significance suggests that merely assessing expectations without patient education or provider engagement may be insufficient. Future studies could explore how patient education, communication, and treatment understanding can impact satisfaction to potentially improve pain management experiences.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"29 1","pages":"104"},"PeriodicalIF":3.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stellate Ganglion Block for Management of Nicolau's Syndrome Following Intravenous Ibuprofen Injection: a Case Report and Literature Review. 星状神经节阻滞治疗静脉注射布洛芬后Nicolau综合征1例报告及文献复习。
IF 3.5 2区 医学
Current Pain and Headache Reports Pub Date : 2025-07-26 DOI: 10.1007/s11916-025-01407-x
Islam Mohammad Shehata, Samar Ashraf Hassan, Rana Aboul Ella Rabie, Jamal Hasoon, Ahmed Abd-Eldayem Abd-Elhak
{"title":"Stellate Ganglion Block for Management of Nicolau's Syndrome Following Intravenous Ibuprofen Injection: a Case Report and Literature Review.","authors":"Islam Mohammad Shehata, Samar Ashraf Hassan, Rana Aboul Ella Rabie, Jamal Hasoon, Ahmed Abd-Eldayem Abd-Elhak","doi":"10.1007/s11916-025-01407-x","DOIUrl":"10.1007/s11916-025-01407-x","url":null,"abstract":"<p><strong>Purpose of the review: </strong>Nicolau's syndrome (NS) is a rare but serious drug reaction that occurs after administration of many drugs through various routes, with a broad spectrum of manifestations ranging from severe pain up to skin necrosis. In this review, we reported a case of advanced-grade NS following intravenous injection of ibuprofen. Moreover, we reviewed the existing knowledge and current practice to present in-depth any possible pathogeneses involved in this condition and highlight the specific pharmacological properties of the offending drugs that may play a role in the development of this syndrome. Eventually, we provided recommendations to prevent and treat the incidence of NS, with a focus on the therapeutic role of stellate ganglion block as a novel intervention in such cases.</p><p><strong>Recent findings: </strong>We reported a case of Nicolau's syndrome after iatrogenic intravenous injection of ibuprofen, which caused severe upper limb ischemia. Notably, the condition was successfully managed with stellate ganglion block, representing a promising effective approach in the management of this serious complication. Early Stellate ganglion block may help in treating this condition effectively with its vasodilatory effect. To our knowledge, it is the first time stellate ganglion block has been implemented in managing this syndrome, fostering new hope in curing these cases.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"29 1","pages":"103"},"PeriodicalIF":3.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors and Consequences of Cutaneous Allodynia among Individuals with Migraine: A Scoping Review. 偏头痛患者皮肤异常性痛的危险因素和后果:一项范围综述。
IF 3.2 2区 医学
Current Pain and Headache Reports Pub Date : 2025-07-22 DOI: 10.1007/s11916-025-01417-9
K S Sruthi, Eslavath Rajkumar, Aswathy Gopi, Grace Jacob Julia, John Romate
{"title":"Risk Factors and Consequences of Cutaneous Allodynia among Individuals with Migraine: A Scoping Review.","authors":"K S Sruthi, Eslavath Rajkumar, Aswathy Gopi, Grace Jacob Julia, John Romate","doi":"10.1007/s11916-025-01417-9","DOIUrl":"https://doi.org/10.1007/s11916-025-01417-9","url":null,"abstract":"","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"29 1","pages":"102"},"PeriodicalIF":3.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Pain in the Neck: Occipital Neuralgia vs. Cervicogenic Headache vs. Migrainous Cervicalgia. 颈痛:枕神经痛vs颈源性头痛vs偏头痛性颈痛。
IF 3.2 2区 医学
Current Pain and Headache Reports Pub Date : 2025-07-21 DOI: 10.1007/s11916-025-01419-7
Paul G Mathew, Samuel Sailesh
{"title":"A Pain in the Neck: Occipital Neuralgia vs. Cervicogenic Headache vs. Migrainous Cervicalgia.","authors":"Paul G Mathew, Samuel Sailesh","doi":"10.1007/s11916-025-01419-7","DOIUrl":"https://doi.org/10.1007/s11916-025-01419-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>Occipital neuralgia, cervicogenic headache, and migraine are disorders that are commonly accompanied by neck pain. Although these disorders may present with similar features, coexist in the same patient, and have variable degrees of involvement of the C2 and C3 nerve roots, it is important to distinguish between these three entities, as the presumed diagnosis can lead to different diagnostic and therapeutic modalities.</p><p><strong>Recent findings: </strong>Occipital neuralgia in particular is underdiagnosed, occipital nerve blocks are underutilized, and technical aspects that can influence the efficacy of occipital nerve blocks are not taught in most clinical training programs. There are often significant delays in referring refractory cases for interventional and surgical management. In patients presenting with headache and neck pain, making an accurate diagnosis is critical in order to optimize management. Without addressing comorbid diagnoses, patients tend to have suboptimal responses to both acute and preventative headache pharmacological therapies.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"29 1","pages":"101"},"PeriodicalIF":3.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Clinical Role of Rhomboid Intercostal Nerve Block for Postoperative Pain Management: a Narrative Review. 肋间菱形神经阻滞治疗术后疼痛的疗效及临床作用:综述。
IF 3.2 2区 医学
Current Pain and Headache Reports Pub Date : 2025-07-21 DOI: 10.1007/s11916-025-01418-8
Alan D Kaye, James Ilochi, Austin Thomassen, Nicholas L Thomas, Sophie I DeOliveira, Camille Robichaux, Shahab Ahmadzadeh, Sahar Shekoohi
{"title":"Efficacy and Clinical Role of Rhomboid Intercostal Nerve Block for Postoperative Pain Management: a Narrative Review.","authors":"Alan D Kaye, James Ilochi, Austin Thomassen, Nicholas L Thomas, Sophie I DeOliveira, Camille Robichaux, Shahab Ahmadzadeh, Sahar Shekoohi","doi":"10.1007/s11916-025-01418-8","DOIUrl":"https://doi.org/10.1007/s11916-025-01418-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>This narrative review evaluates the efficacy and clinical applications of the rhomboid intercostal nerve block (RINB) for postoperative pain management. With growing interest in ultrasound-guided regional anesthetic techniques, RINB has emerged as a promising approach for thoracic, abdominal, and breast surgeries. We aim to synthesize current evidence on its analgesic effectiveness, opioid-sparing potential, and comparative advantages.</p><p><strong>Recent findings: </strong>An ultrasound guided rhomboid intercostal nerve block (RINB), delivers anesthetic into the intercostal muscles to relieve chest wall pain, including thoracoscopic, abdominal, and mastectomy surgeries. Anesthetic delivered between the rhomboid major and intercostal muscle demonstrated clinical efficacy resulting in improved patient recovery, post-operative analgesia, and reduced opioid consumption. Clinical studies have demonstrated that RINB has comparable and even more effective analgesic efficacy of previously utilized ultrasound guided nerve blocks with an excellent safety profile in patients receiving thoracoscopic, abdominal, and mastectomy surgeries.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"29 1","pages":"100"},"PeriodicalIF":3.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Efficacy and Risks of Intradiscal Orthobiological Injections: A Narrative Review. 椎间盘内骨科注射的临床疗效和风险:一个叙述性的回顾。
IF 3.2 2区 医学
Current Pain and Headache Reports Pub Date : 2025-07-11 DOI: 10.1007/s11916-025-01414-y
Macie A Serio, Rachael Bartolina, Sanjana Sudini, Ellie M MacDonald, Austin S Thomassen, Sahar Shekoohi, Azem A Chami, Alan D Kaye
{"title":"Clinical Efficacy and Risks of Intradiscal Orthobiological Injections: A Narrative Review.","authors":"Macie A Serio, Rachael Bartolina, Sanjana Sudini, Ellie M MacDonald, Austin S Thomassen, Sahar Shekoohi, Azem A Chami, Alan D Kaye","doi":"10.1007/s11916-025-01414-y","DOIUrl":"https://doi.org/10.1007/s11916-025-01414-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>Chronic discogenic low back pain (LBP) is a common cause of disability worldwide. Current management options include conservative, surgical, and minimally invasive interventional injections. Intradiscal orthobiological injections of platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and mesenchymal stem cells (MSCs) have been introduced as regenerative treatment options.</p><p><strong>Recent findings: </strong>Many studies have demonstrated improvements in patients' reported outcomes (PROMs) measuring the areas of pain, disability, function, and satisfaction. The results are promising with statistical improvements shown throughout various studies. Adverse events such as increased pain and infection have been reported with these injections; however, the complication rate has yet to be delineated. Numerous studies report no adverse events in their sample size. The present investigation summarizes recent evidence for the efficacy and risks of PRP, BMAC, and MSC injections.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"29 1","pages":"99"},"PeriodicalIF":3.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Implications of Antidepressants and Associated Risk of Bleeding: A Narrative Review. 抗抑郁药和相关出血风险的临床意义:一篇叙述性综述。
IF 3.2 2区 医学
Current Pain and Headache Reports Pub Date : 2025-06-25 DOI: 10.1007/s11916-025-01412-0
Alan D Kaye, Harrison D Cooper, Sydney A Mashaw, Ahmed I Anwar, Alex V Hollander, Austin S Thomassen, Anushka Singh, Sahar Shekoohi
{"title":"Clinical Implications of Antidepressants and Associated Risk of Bleeding: A Narrative Review.","authors":"Alan D Kaye, Harrison D Cooper, Sydney A Mashaw, Ahmed I Anwar, Alex V Hollander, Austin S Thomassen, Anushka Singh, Sahar Shekoohi","doi":"10.1007/s11916-025-01412-0","DOIUrl":"https://doi.org/10.1007/s11916-025-01412-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), are widely prescribed for mental health disorders. These medications, however, are linked to increased bleeding risks related to inhibition of serotonin reuptake, which impairs platelet aggregation. The present investigation explores the pharmacodynamics of antidepressants, clinical evidence of bleeding complications, and strategies to manage these risks.</p><p><strong>Recent findings: </strong>While SSRIs and SNRIs pose the highest risk, tricyclic and atypical antidepressants show comparatively lower bleeding incidences. The concomitant use of anticoagulants, NSAIDs, or antiplatelet agents significantly amplifies bleeding risk. Current guidelines stress individualized risk assessment, alternative drug selection, and preventive measures, such as gastroprotective agents. Future research may offer novel approaches to mitigate bleeding while maintaining therapeutic efficacy, ensuring the safety of antidepressants in clinical practices.</p>","PeriodicalId":50602,"journal":{"name":"Current Pain and Headache Reports","volume":"29 1","pages":"97"},"PeriodicalIF":3.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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