Clinical Efficacy and Risks of Intradiscal Orthobiological Injections: A Narrative Review.

IF 3.2 2区医学 Q2 CLINICAL NEUROLOGY

Current Pain and Headache Reports Pub Date : 2025-07-11 DOI:10.1007/s11916-025-01414-y

Macie A Serio, Rachael Bartolina, Sanjana Sudini, Ellie M MacDonald, Austin S Thomassen, Sahar Shekoohi, Azem A Chami, Alan D Kaye

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Abstract

Purpose of review: Chronic discogenic low back pain (LBP) is a common cause of disability worldwide. Current management options include conservative, surgical, and minimally invasive interventional injections. Intradiscal orthobiological injections of platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and mesenchymal stem cells (MSCs) have been introduced as regenerative treatment options.

Recent findings: Many studies have demonstrated improvements in patients' reported outcomes (PROMs) measuring the areas of pain, disability, function, and satisfaction. The results are promising with statistical improvements shown throughout various studies. Adverse events such as increased pain and infection have been reported with these injections; however, the complication rate has yet to be delineated. Numerous studies report no adverse events in their sample size. The present investigation summarizes recent evidence for the efficacy and risks of PRP, BMAC, and MSC injections.

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椎间盘内骨科注射的临床疗效和风险：一个叙述性的回顾。

综述目的：慢性椎间盘源性腰痛（LBP）是世界范围内致残的常见原因。目前的治疗方案包括保守、手术和微创介入注射。椎间盘内原位生物注射富血小板血浆（PRP）、骨髓抽液浓缩液（BMAC）和间充质干细胞（MSCs）已被引入作为再生治疗的选择。最近的发现：许多研究已经证明了患者报告结果（PROMs）的改善，测量疼痛，残疾，功能和满意度。结果是有希望的统计改进显示在各种研究中。据报道，这些注射会导致疼痛和感染增加等不良事件；然而，并发症的发生率尚未确定。许多研究报告在他们的样本量中没有不良事件。本研究总结了PRP、BMAC和MSC注射的疗效和风险的最新证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Pain and Headache Reports CLINICAL NEUROLOGY-

CiteScore

6.10

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings regarding the diagnosis, treatment, and management of pain and headache. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of pain and headache. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anesthetic techniques in pain management, cluster headache, neuropathic pain, and migraine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.