Developmental Neuroscience最新文献_第10页

Paternal Deprivation and Female Biparental Family Rearing Induce Dendritic and Synaptic Changes in Octodon degus: II. Nucleus Accumbens. 父系剥夺和双亲母系养育诱导章鱼树突和突触的变化:II。伏隔核。

IF 2.9 4区医学

Developmental Neuroscience Pub Date : 2023-01-01 DOI: 10.1159/000530050

Tony de Schultz, Katharina Braun, Joerg Bock

{"title":"Paternal Deprivation and Female Biparental Family Rearing Induce Dendritic and Synaptic Changes in Octodon degus: II. Nucleus Accumbens.","authors":"Tony de Schultz, Katharina Braun, Joerg Bock","doi":"10.1159/000530050","DOIUrl":"https://doi.org/10.1159/000530050","url":null,"abstract":"While the majority of studies on the importance of parental caregiving on offspring behavioral and brain development focus on the role of the mother, the paternal contribution is still an understudied topic. We investigated if growing up without paternal care affects dendritic and synaptic development in the nucleus accumbens of male and female offspring and if replacement of the father by a female caregiver \"compensates\" the impact of paternal deprivation. We compared (a) biparental rearing by father and mother, (b) monoparental care by a single mother, and (c) biparental rearing by two female caregivers. Quantitative analysis of medium-sized neurons in the nucleus accumbens revealed that growing up without father resulted in reduced spine number in both male and female offspring in the core region, whereas spine frequency was only reduced in females. In the shell region, reduced spine frequency was only found in males growing up in a monoparental environment. Replacement of the father by a female caregiver did not \"protect\" against the effects of paternal deprivation, indicating a critical impact of paternal care behavior on the development and maturation of neuronal networks in the nucleus accumbens.","PeriodicalId":50585,"journal":{"name":"Developmental Neuroscience","volume":"45 3","pages":"147-160"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9675235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinicopathologic Characteristics of PANDAS in a Young Adult: A Case Report. 一名年轻成人 PANDAS 的临床病理特征：病例报告

IF 2.3 4区医学

Developmental Neuroscience Pub Date : 2023-01-01 Epub Date: 2023-09-12 DOI: 10.1159/000534061

Lakshmi Shree Kulumani Mahadevan, Melissa Murphy, Marina Selenica, Elizabeth Latimer, Brent T Harris

{"title":"Clinicopathologic Characteristics of PANDAS in a Young Adult: A Case Report.","authors":"Lakshmi Shree Kulumani Mahadevan, Melissa Murphy, Marina Selenica, Elizabeth Latimer, Brent T Harris","doi":"10.1159/000534061","DOIUrl":"10.1159/000534061","url":null,"abstract":"Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS) is an acute onset or exacerbation of neuropsychiatric symptoms following a group A streptococcus infection. It is believed to be a result of autoimmune response to streptococcal infection, but there is insufficient evidence to fully support this theory. Although this disease is primarily thought to be a disease of childhood, it is reported to occur also in adults. PANDAS is a well-defined clinical entity, but the neuropathology of this condition has not been established yet. We describe the clinical course of a 26-year-old female diagnosed with PANDAS. She committed suicide and her brain was biobanked for further studies. We examined the banked tissue and performed special stains, immunohistochemical, and immunofluorescence analyses to characterize the neuropathology of this condition. Histology of the temporal lobes, hippocampus, and basal ganglia shows mild gliosis and Alzheimer's type II astrocytes. Acute hypoxic ischemic changes were noted in hippocampus CA1 and CA2 areas. Immunostaining shows increased parenchymal/perivascular GFAP staining and many vessels with mild increases in CD3-, CD4-, and CD25-stained lymphocytes in the basal ganglia. The findings suggest that CD4- and CD25-positive T cells might have an important role in understanding the neuroinflammation and pathogenesis of this condition. The case represents the first neuropathological evaluation report for PANDAS.","PeriodicalId":50585,"journal":{"name":"Developmental Neuroscience","volume":" ","pages":"335-341"},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10753865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10224138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder. 感染后炎症、自身免疫和强迫症：Sydenham Chorea、与链球菌感染相关的儿童自身免疫性神经精神障碍（PANDAS）和儿童急性发作性神经精神疾病（PANS）。

IF 2.9 4区医学

Developmental Neuroscience Pub Date : 2023-01-01 Epub Date: 2023-09-22 DOI: 10.1159/000534261

Allison Vreeland, Denise Calaprice, Noga Or-Geva, Richard E Frye, Dritan Agalliu, Herbert M Lachman, Christopher Pittenger, Stefano Pallanti, Kyle Williams, Meiqian Ma, Margo Thienemann, Antonella Gagliano, Elizabeth Mellins, Jennifer Frankovich

{"title":"Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder.","authors":"Allison Vreeland, Denise Calaprice, Noga Or-Geva, Richard E Frye, Dritan Agalliu, Herbert M Lachman, Christopher Pittenger, Stefano Pallanti, Kyle Williams, Meiqian Ma, Margo Thienemann, Antonella Gagliano, Elizabeth Mellins, Jennifer Frankovich","doi":"10.1159/000534261","DOIUrl":"10.1159/000534261","url":null,"abstract":"Postinfectious neuroinflammation has been implicated in multiple models of acute-onset obsessive-compulsive disorder including Sydenham chorea (SC), pediatric acute-onset neuropsychiatric syndrome (PANS), and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). These conditions are associated with a range of autoantibodies which are thought to be triggered by infections, most notably group A streptococci (GAS). Based on animal models using huma sera, these autoantibodies are thought to cross-react with neural antigens in the basal ganglia and modulate neuronal activity and behavior. As is true for many childhood neuroinflammatory diseases and rheumatological diseases, SC, PANS, and PANDAS lack clinically available, rigorous diagnostic biomarkers and randomized clinical trials. In this review article, we outline the accumulating evidence supporting the role neuroinflammation plays in these disorders. We describe work with animal models including patient-derived anti-neuronal autoantibodies, and we outline imaging studies that show alterations in the basal ganglia. In addition, we present research on metabolites, which are helpful in deciphering functional phenotypes, and on the implication of sleep in these disorders. Finally, we encourage future researchers to collaborate across medical specialties (e.g., pediatrics, psychiatry, rheumatology, immunology, and infectious disease) in order to further research on clinical syndromes presenting with neuropsychiatric manifestations.","PeriodicalId":50585,"journal":{"name":"Developmental Neuroscience","volume":" ","pages":"361-374"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41145233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caspase-3 Inhibition toward Perinatal Protection of the Developing Brain from Environmental Stress. Caspase-3对发育中的大脑免受环境应激的围产期保护的抑制作用。

IF 2.9 4区医学

Developmental Neuroscience Pub Date : 2023-01-01 Epub Date: 2023-01-13 DOI: 10.1159/000529125

Anna Arjun Kaji, Masaaki Torii, Seiji Ishii

引用次数: 1

Author Index Vol. 44, No. 4-5, 2022 作者索引第44卷，第4-5期，2022

IF 2.9 4区医学

Developmental Neuroscience Pub Date : 2022-09-01 DOI: 10.1159/000526742

引用次数: 0

Subject Index Vol. 44, No. 4-5, 2022 课题索引第44卷，第4-5期，2022

IF 2.9 4区医学

Developmental Neuroscience Pub Date : 2022-09-01 DOI: 10.1159/000526743

引用次数: 0

Front & Back Matter 正面和背面

IF 2.9 4区医学

Developmental Neuroscience Pub Date : 2022-09-01 DOI: 10.1159/000527001

S. Levison, Christian P. Speer Würzburg, J. Loturco, P. Bhide, J. Lauder, A. Obenaus, J. Pasquini

引用次数: 0

Sex-Dependent Gliovascular Interface Abnormality in the Hippocampus following Postnatal Immune Activation in Mice 小鼠出生后免疫激活后海马性别依赖性胶质血管界面异常

IF 2.9 4区医学

Developmental Neuroscience Pub Date : 2022-06-15 DOI: 10.1159/000525478

M. Ardalan, Tetyana Chumak, Alexandra Quist, Seyedeh Marziyeh Jabbari Shiadeh, Anna-Jean Mallard, A. Rafati, C. Mallard

{"title":"Sex-Dependent Gliovascular Interface Abnormality in the Hippocampus following Postnatal Immune Activation in Mice","authors":"M. Ardalan, Tetyana Chumak, Alexandra Quist, Seyedeh Marziyeh Jabbari Shiadeh, Anna-Jean Mallard, A. Rafati, C. Mallard","doi":"10.1159/000525478","DOIUrl":"https://doi.org/10.1159/000525478","url":null,"abstract":"The neuro-gliovascular unit is a crucial structure for providing a balanced well-functioning environment for neurons and their synapses. Activation of the immune system during the developmental period is believed to affect the gliovascular unit, which may trigger neurodevelopmental and neurological/neuropsychiatric diseases. In this study, we hypothesized that vulnerability of the male brain to a neonatal insult was conditioned by sex-dependent differences in the impairment of the hippocampal gliovascular unit. Male and female C57BL/6J pups received lipopolysaccharide (LPS) (1 mg/kg) or saline on postnatal day (P) 5. Brains were collected at P12 and morphological quantifications of hippocampal fibrillary glial acid protein (GFAP+) astrocytes and ionized calcium-binding adaptor molecule 1 protein (Iba1+) microglia were performed by using 3-D image analysis together with measuring the length of CD31+ and aquaporin-4 (AQP4+) vessels. We found a significant increase in the length of CD31+ capillaries in the male LPS group compared to the saline group; however, coverage of capillaries by astrocytic end-feet (AQP4+) was significantly reduced. In contrast, there was a significant increase in AQP4+ capillary length in female pups 1 week after LPS injection. GFAP+ astrocytes via morphological changes in the hippocampus showed significant enhancement in the activity 1 week following LPS injection in male mice. We propose that neonatal inflammation could induce susceptibility to neurodevelopmental disorders through modification of hippocampal gliovascular interface in a sex-dependent manner.","PeriodicalId":50585,"journal":{"name":"Developmental Neuroscience","volume":"44 1","pages":"320 - 330"},"PeriodicalIF":2.9,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42804155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurologic Consequences of Neonatal Necrotizing Enterocolitis 新生儿坏死性小肠结肠炎的神经系统后果

IF 2.9 4区医学

Developmental Neuroscience Pub Date : 2022-06-13 DOI: 10.1159/000525378

Jonathan A. Berken, Jill Chang

引用次数: 9

Differential Effects of Urban Particulate Matter on BV2 Microglial-Like and C17.2 Neural Stem/Precursor Cells 城市颗粒物对BV2微胶质样细胞和C17.2神经干细胞/前体细胞的差异影响

IF 2.9 4区医学

Developmental Neuroscience Pub Date : 2022-05-02 DOI: 10.1159/000524829

Rebecca H Morris, G. Chabrier, S. Counsell, I. McGonnell, C. Thornton

{"title":"Differential Effects of Urban Particulate Matter on BV2 Microglial-Like and C17.2 Neural Stem/Precursor Cells","authors":"Rebecca H Morris, G. Chabrier, S. Counsell, I. McGonnell, C. Thornton","doi":"10.1159/000524829","DOIUrl":"https://doi.org/10.1159/000524829","url":null,"abstract":"Air pollution affects the majority of the world’s population and has been linked to over 7 million premature deaths per year. Exposure to particulate matter (PM) contained within air pollution is associated with cardiovascular, respiratory, and neurological ill health. There is increasing evidence that exposure to air pollution in utero and in early childhood is associated with altered brain development. However, the underlying mechanisms for impaired brain development are not clear. While oxidative stress and neuroinflammation are documented consequences of PM exposure, cell-specific mechanisms that may be triggered in response to air pollution exposure are less well defined. Here, we assess the effect of urban PM exposure on two different cell types, microglial-like BV2 cells and neural stem/precursor-like C17.2 cells. We found that, contrary to expectations, immature C17.2 cells were more resistant to PM-mediated oxidative stress and cell death than BV2 cells. PM exposure resulted in decreased mitochondrial health and increased mitochondrial ROS in BV2 cells which could be prevented by MitoTEMPO antioxidant treatment. Our data suggest that not only is mitochondrial dysfunction a key trigger in PM-mediated cytotoxicity but that such deleterious effects may also depend on cell type and maturity.","PeriodicalId":50585,"journal":{"name":"Developmental Neuroscience","volume":"44 1","pages":"309 - 319"},"PeriodicalIF":2.9,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41532716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0