Epileptic Disorders最新文献_第3页

Classic faciobrachial-crural dystonic seizures in LGI1-related autoimmune encephalitis as a cause of recurrent falls in elderly. lgi1相关自身免疫性脑炎的典型面臂-脚肌张力障碍发作是老年人复发性跌倒的原因。

IF 1.9 4区医学

Epileptic Disorders Pub Date : 2025-04-18 DOI: 10.1002/epd2.70029

Kamalesh Tayade, Anarya Karle, Amarnath Chavan, Jivan Morey, Haresh Bharote

引用次数: 0

Physical activity and risk of epilepsy: A 2-sample Mendelian randomization study. 体育活动与癫痫风险：一项双样本孟德尔随机研究。

IF 1.9 4区医学

Epileptic Disorders Pub Date : 2025-04-15 DOI: 10.1002/epd2.70024

Cheng Yang, Mengmeng Wang, Xin Chen, Jianrong Yao, Yazhou Ma, Xuegan Lian

{"title":"Physical activity and risk of epilepsy: A 2-sample Mendelian randomization study.","authors":"Cheng Yang, Mengmeng Wang, Xin Chen, Jianrong Yao, Yazhou Ma, Xuegan Lian","doi":"10.1002/epd2.70024","DOIUrl":"https://doi.org/10.1002/epd2.70024","url":null,"abstract":"Objective: There is currently a lack of evidence from earlier studies about the impact of exercise on the risk of epilepsy. We conducted a 2-sample Mendelian randomization (MR) study to identify the potential causal relationship between physical activity and epilepsy.Methods: We identified single nucleotide polymorphisms (SNPs) associated with physical activity from a recent genome-wide association study of the UK Biobank. Summary statistics of epilepsy were derived from the International League Against Epilepsy (ILAE) Consortium genome-wide association study (GWAS) database.Results: We found that self-reported moderate-to-vigorous physical activity increases the incidence of focal epilepsy with hippocampal sclerosis(OR: 1.18; 95% CI: 1.07-1.30, p = 9 × e-4) and overall acceleration average reduces the risk of childhood absence epilepsy(OR: .99; 95% CI: .98 to 1.00; p = .013).Significance: Different types of epilepsy respond differently to physical activity; it needs further research to explore the physiological mechanism of physical activity and epilepsy.","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adult-onset epilepsy with startle-induced seizure after febrile infection-related epilepsy syndrome: A case report. 发热感染相关癫痫综合征后成人癫痫伴惊厥性发作1例报告。

IF 1.9 4区医学

Epileptic Disorders Pub Date : 2025-04-15 DOI: 10.1002/epd2.70026

Kazutoshi Konomatsu, Yosuke Kakisaka, Kazutaka Jin, Yu Fujiwara, Takafumi Kubota, Maimi Ogawa, Makoto Ishida, Kazushi Ukishiro, Hirohiko Ono, Kimihiko Kaneko, Naoto Sugeno, Masashi Aoki, Nobukazu Nakasato

{"title":"Adult-onset epilepsy with startle-induced seizure after febrile infection-related epilepsy syndrome: A case report.","authors":"Kazutoshi Konomatsu, Yosuke Kakisaka, Kazutaka Jin, Yu Fujiwara, Takafumi Kubota, Maimi Ogawa, Makoto Ishida, Kazushi Ukishiro, Hirohiko Ono, Kimihiko Kaneko, Naoto Sugeno, Masashi Aoki, Nobukazu Nakasato","doi":"10.1002/epd2.70026","DOIUrl":"https://doi.org/10.1002/epd2.70026","url":null,"abstract":"Startle-induced seizure is a rare type of reflex seizure triggered by unexpected sensory stimuli that often occurs in children with early acquired cerebral lesions or brain malformations. We report a unique case of adult-onset epilepsy with startle-induced seizures. A 24-year-old woman had suffered high fever and focal to bilateral tonic-clonic seizures. A diagnosis of febrile infection-related epilepsy syndrome (FIRES) was made based on the febrile infection occurring 7 days to 24 h before the onset of status epilepticus, which met all criteria for cryptogenic new-onset refractory status epilepticus (NORSE) according to the cryptogenic NORSE score. Immunotherapy and several antiseizure medications resulted in transient resolution of the seizures. Four months later, she experienced startle-induced seizures triggered by unexpected stimuli, such as auditory, visual, or unexpected events, and manifesting as initial tachycardia followed by right ear deafness, right hemifacial dysesthesia, eye deviation to the right, and tonic-clonic convulsions. Ictal electroencephalography revealed left temporal initial rhythmic delta activity, followed by rhythmic theta activity. The patient was diagnosed with startle epilepsy associated with FIRES and continued to receive anti-seizure medications. Claustrum-insular-operculum lesions may have been the epileptic focus in this case, in contrast to previous cases of epilepsy with startle-induced seizures originating in a frontoparietal network. This case indicates a new category of adult-onset post-FIRES epilepsy with startle-induced seizures.","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reflex "toothbrushing" epilepsy: Seizure freedom after focal ablation assisted by ictal fMRI. 反射性“刷牙”癫痫：首发功能磁共振成像辅助局灶消融后癫痫发作自由。

IF 1.9 4区医学

Epileptic Disorders Pub Date : 2025-04-08 DOI: 10.1002/epd2.70027

Michael Ginevra, John Archer, Kristian Bulluss, Chris Tailby, Graeme D Jackson, David N Vaughan

{"title":"Reflex \"toothbrushing\" epilepsy: Seizure freedom after focal ablation assisted by ictal fMRI.","authors":"Michael Ginevra, John Archer, Kristian Bulluss, Chris Tailby, Graeme D Jackson, David N Vaughan","doi":"10.1002/epd2.70027","DOIUrl":"https://doi.org/10.1002/epd2.70027","url":null,"abstract":"A 22-year-old female presented with drug-resistant focal motor seizures with onset at age 14. This manifested as daily episodes of right facial dystonia triggered by toothbrushing, but also by eating, talking, and strenuous exercise. On ictal scalp EEG, there was low-voltage fast activity over the left pericentral area. Structural MRI did not identify a definite lesion. Functional MRI (fMRI) of a reflex seizure, as well as task-based fMRI during toothbrushing, both demonstrated focal activation at the left low pericentral cortex. Stereoelectroencephalography (sEEG) showed recurrent ictal trains of focal spiking concordant with the fMRI activation. Radiofrequency (RF) thermocoagulation was applied at the posterior bank of the left low pre-central gyrus, with post-operative MRI confirming small ablative lesions immediately deep to the ictal fMRI activation, and the patient remains seizure-free more than 3 years after this treatment. Toothbrushing epilepsy is a rare form of reflex epilepsy where seizures are induced by toothbrushing. In this unique case, ictal fMRI assisted targeting of the sEEG implantation, to confirm seizure onset and enable minimally invasive treatment via RF thermocoagulation, resulting in seizure freedom.","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring biomarkers of neurodegeneration in epilepsy: Critical insights. 探索癫痫神经退行性变的生物标志物：关键见解。

IF 1.9 4区医学

Epileptic Disorders Pub Date : 2025-04-08 DOI: 10.1002/epd2.70023

Rida Farhan, Syeda Amrah Hashmi, Jaideep Kapur, Anelyssa D'Abreu, Vineet Punia, Carol Manning, Vanessa L Smith, Ifrah Zawar

{"title":"Exploring biomarkers of neurodegeneration in epilepsy: Critical insights.","authors":"Rida Farhan, Syeda Amrah Hashmi, Jaideep Kapur, Anelyssa D'Abreu, Vineet Punia, Carol Manning, Vanessa L Smith, Ifrah Zawar","doi":"10.1002/epd2.70023","DOIUrl":"https://doi.org/10.1002/epd2.70023","url":null,"abstract":"The advent of biofluid biomarkers for neurodegenerative disorders has precipitated a surge in recent evidence regarding their role in epilepsy. In this literature review, we examine the diagnostic, prognostic, and therapeutic potential of several biomarkers, including amyloid-beta (Aβ) protein, total (t-tau), phosphorylated tau (p-tau) protein, alpha-synuclein, neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and others in epilepsy. Recent studies highlight mid-life Aβ levels as a risk factor for late-onset epilepsy. Several studies also show that amyloid pathology correlates with cognitive impairment in people with epilepsy (PWE). T-tau and p-tau levels in CSF and serum show diagnostic potential, particularly for temporal lobe epilepsy (TLE). Tau may also have significant prognostic utility in cognition of PWE and status epilepticus. Despite promising findings, larger prospective studies are needed to validate these biomarkers for routine clinical use in older PWE. Mouse models demonstrate tau's association with increased seizure susceptibility and mortality and the association of tau reduction with reduced seizure severity. This further highlights the need to investigate tau-targeting therapies in future studies in older PWE. Recent small-scale retrospective studies link NfL's role in cognitive impairment and status epilepticus, suggest a prognostic role of alpha-synuclein in certain epilepsies, and propose emerging diagnostic and prognostic roles of other biomarkers in epilepsy, including GFAP, cytoskeletal proteins, and S100B. However, larger longitudinal studies are needed to confirm these findings. We propose integrating some of these biomarkers into clinical practice for selected older adults with epilepsy. This integration could improve diagnostic accuracy, prognosticate outcomes, and identify therapeutic targets that may improve seizure control and mitigate the progression of cognitive decline in PWE.","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistence of EEG abnormalities in KCNT1-related DEE in an adult patient. 1例成人kcnt1相关DEE患者脑电图持续异常

IF 1.9 4区医学

Epileptic Disorders Pub Date : 2025-04-05 DOI: 10.1002/epd2.70018

Haania Kakwan, Omar Nofal, Doyle Yuan, Irfan S Sheikh

引用次数: 0

Addressing the long-term growth impact of the modified Atkins diet in pediatric epilepsy: A call for further research. 解决改良阿特金斯饮食对儿童癫痫的长期生长影响：呼吁进一步研究。

IF 1.9 4区医学

Epileptic Disorders Pub Date : 2025-04-04 DOI: 10.1002/epd2.70022

Shih-Jie Wang, Lien-Chung Wei

引用次数: 0

Clinical and anatomical characteristics of basal temporal seizures: A systematic review. 基底颞区癫痫发作的临床和解剖学特征：系统综述。

IF 1.9 4区医学

Epileptic Disorders Pub Date : 2025-04-04 DOI: 10.1002/epd2.70020

Fabrice Bartolomei, Francesca Pizzo, Stanislas Lagarde

{"title":"Clinical and anatomical characteristics of basal temporal seizures: A systematic review.","authors":"Fabrice Bartolomei, Francesca Pizzo, Stanislas Lagarde","doi":"10.1002/epd2.70020","DOIUrl":"https://doi.org/10.1002/epd2.70020","url":null,"abstract":"This review aimed to characterize the clinical semiology and anatomical correlates of seizures originating in the basal temporal region, an underrecognized epilepsy subtype, and to identify features that distinguish it from other forms of temporal lobe epilepsies (TLE). We performed a systematic review of the literature following PRISMA guidelines. The search included terms related to the basal temporal region (e.g., fusiform gyrus and rhinal cortex) and epilepsy, encompassing clinical, anatomical, and neurophysiological studies. Studies with video-EEG monitoring, SEEG evaluations, and surgical outcomes were prioritized. Semiological features, imaging findings, and post-surgical outcomes were extracted and analyzed. Fifteen studies encompassing 83 patients were analyzed. Most cases involved MRI-detectable lesions. Findings revealed that basal temporal seizures frequently present with language disturbances, motor phenomena, and less pronounced emotional and sensory signs compared to other TLE forms. SEEG identified epileptogenic zones predominantly in the fusiform gyrus, rhinal cortices, and parahippocampal region. Post-surgical outcomes revealed 57% of patients achieving Engel Class I results after 1 year, highlighting the potential benefits of accurate diagnosis and intervention. However, diagnostic challenges persist due to overlapping with other TLE subtypes, emphasizing the importance of advanced imaging and SEEG. Further studies are needed to refine diagnostic criteria and improve understanding of the functional implications of basal temporal epilepsies.","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early postoperative seizures in patients with adult-type diffuse gliomas: Incidence, risk factors, and clinical outcomes. 成人型弥漫性胶质瘤患者术后早期癫痫发作：发病率、危险因素和临床结果

IF 1.9 4区医学

Epileptic Disorders Pub Date : 2025-04-04 DOI: 10.1002/epd2.70019

Jiajia Liu, Gan You, Shengyu Fang, Shimeng Weng, Zhong Zhang, Xing Fan, Hui Qiao

{"title":"Early postoperative seizures in patients with adult-type diffuse gliomas: Incidence, risk factors, and clinical outcomes.","authors":"Jiajia Liu, Gan You, Shengyu Fang, Shimeng Weng, Zhong Zhang, Xing Fan, Hui Qiao","doi":"10.1002/epd2.70019","DOIUrl":"https://doi.org/10.1002/epd2.70019","url":null,"abstract":"Objective: The current study aimed to clarify the representation of early postoperative seizures (EPSs) in different glioma subtypes under the 2021 WHO classification, explore the risk factors for EPSs in glioma patients, and investigate the clinical impact of EPSs on seizure and survival outcomes.Methods: Data from 78 patients were analyzed. The differences in clinical-pathological features between patients with EPSs and those without were compared using appropriate statistical methods. Multivariate binary logistic regression analysis was subsequently conducted to explore potential risk factors for EPSs. Finally, the Kaplan-Meier method was applied to analyze the correlation of EPSs with progression-free survival and overall survival.Results: Early postoperative seizures occurred in 17 patients (21.8%). The incidence of EPSs was highest in patients with oligodendroglioma, IDH-mutant, and 1p/19q-codeleted (25.7%), followed by astrocytoma, IDH-mutant (20.8%), and glioblastoma, IDH-wildtype (12.5%). An extent of resection (EOR) of less than 92.24% was identified as the only independent predictor for EPSs (Odds ratio 8.490, 95% confidence interval 1.873-38.488, p = .006) through multivariate regression analysis. In addition, EPSs showed no significant impact on late postoperative seizure occurrence and survival outcome.Significance: In glioma patients, EPSs are considered neurological disorders induced by surgery-related factors rather than a tumor-related mechanism. EPSs are more prone to occur in patients with an EOR of less than 92.24%, which can contribute to improving individualized glioma management.","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ictal SPECT in hypothalamic lesions. 下丘脑病变的SPECT。

IF 1.9 4区医学

Epileptic Disorders Pub Date : 2025-04-02 DOI: 10.1002/epd2.70021

Christine Van Winssen, Poul Espino Alvarado, Jorge Burneo, David A Steven, Ana Suller-Marti

引用次数: 0