Epileptic Disorders最新文献

{"title":"Persistence of electroclinical findings in an adult patient with SETD1B-related epilepsy.","authors":"Rohan Shankar, Abdulrahman Bukhari, Irfan S Sheikh","doi":"10.1002/epd2.70414","DOIUrl":"https://doi.org/10.1002/epd2.70414","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating rapid response teams and structured care pathways improves outcomes in status epilepticus: A prospective cohort study.","authors":"Xiao Fan, Yueming Dong, Jian Wu, Guanghui Zhang","doi":"10.1002/epd2.70397","DOIUrl":"https://doi.org/10.1002/epd2.70397","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness of an integrated nursing model combining a rapid response team (RRT) with a structured care pathway (SCP) for the emergency management of status epilepticus (SE).</p><p><strong>Methods: </strong>This study included 168 SE patients treated at the First Affiliated Hospital of Kangda College of Nanjing Medical University. Patients were divided into an intervention group (n = 86), managed via the novel RRT-SCP model (June 2023-May 2025), and a historical control group (n = 82), which received routine care (June 2021-May 2023). Key performance indicators included the 2-h seizure control rate, physician response time, diagnostic test completion time, nonconvulsive SE (NCSE) recognition rate, complication incidence, and family satisfaction.</p><p><strong>Results: </strong>The intervention group demonstrated a significantly higher 2-h seizure control rate compared to the control group (87.2% vs. 72.0%, p < 0.05). Both physician response time (5.2 ± 1.5 min vs. 8.4 ± 1.7 min) and diagnostic test completion time (37.1 ± 10.5 min vs. 53.6 ± 12.8 min) were significantly shorter in the intervention group (p < 0.01). Furthermore, the intervention group showed superior early recognition of NCSE (77.8% vs. 23.1%, p < 0.01), a reduced complication rate (17.4% vs. 49.0%, p < 0.05), and higher family satisfaction (91.2% vs. 74.7%, p < 0.01). Year-by-year sensitivity analyses showed generally consistent directions of effect, particularly for response time and complication reduction.</p><p><strong>Conclusion: </strong>The RRT-SCP model can significantly improve the rescue efficiency and success rate for SE patients while reducing complications.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of an AI agent to improve epilepsy diagnosis.","authors":"Juan G Ochoa, Angie Zuniga, Luis Carlos Mayor","doi":"10.1002/epd2.70401","DOIUrl":"https://doi.org/10.1002/epd2.70401","url":null,"abstract":"<p><strong>Objective: </strong>To assess the efficacy of an AI-driven History of Present Illness (HPI) tool in improving the diagnostic accuracy of epilepsy.</p><p><strong>Background: </strong>Diagnosing epilepsy remains a significant challenge, particularly for non-neurologists and primary care providers. The median diagnostic delay for patients with new-onset focal epilepsy is estimated at 12 months. This study investigates whether an AI agent can improve diagnosis by standardizing the collection of clinical history.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of de-identified histories from 40 consecutive patients admitted to an inpatient Epilepsy Monitoring Unit. The quality of histories recorded by neurology residents was evaluated by a blinded, independent, and experienced epileptologist. We developed a web-based AI agent incorporating critical diagnostic questions. The AI Epilepsy HPI tool was used to process the clinical data, and its results were compared against video EEG Monitoring, the \"gold standard\" of epilepsy diagnosis.</p><p><strong>Results: </strong>The independent epileptologist determined that the HPIs obtained by residents were adequate for diagnosis in only 58% of cases. Consequently, the expert's diagnostic accuracy based on those HPIs alone was also 58%. In contrast, the AI Epilepsy HPI tool achieved a diagnostic accuracy of 90% when compared to the video-EEG results. Also, the expert diagnosis was improved by the AI tool to 80% accuracy.</p><p><strong>Significance: </strong>This study demonstrates that an AI agent can effectively assist providers in the systematic collection of clinical symptomatology for epilepsy. By standardizing the history-taking process, this tool has the potential to improve the education of junior neurology residents.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond \"status non-epilepticus\": Toward a unified, accurate, and non-stigmatizing terminology.","authors":"Stephane Legriel","doi":"10.1002/epd2.70424","DOIUrl":"https://doi.org/10.1002/epd2.70424","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status non-epilepticus: Authors' response to León-Ruiz et al.","authors":"Ronen Spierer, Moshe Herskovitz","doi":"10.1002/epd2.70426","DOIUrl":"https://doi.org/10.1002/epd2.70426","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsy with eyelid myoclonia in a patient with CUX1-related disorder.","authors":"L Maltoni, F Palombo, G Novelli, C Giulianelli","doi":"10.1002/epd2.70405","DOIUrl":"https://doi.org/10.1002/epd2.70405","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Status non-epilepticus.","authors":"Moisés León-Ruiz, Julián Benito-León, Carlos Castañeda-Cabrero","doi":"10.1002/epd2.70423","DOIUrl":"https://doi.org/10.1002/epd2.70423","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status non-epilepticus: Authors' response to Legriel.","authors":"Ronen Spierer, Moshe Herskovitz","doi":"10.1002/epd2.70425","DOIUrl":"https://doi.org/10.1002/epd2.70425","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsy in Alkuraya-Kučinskas syndrome: A longitudinal clinical characterization.","authors":"Gaetano Maria Celardo, Matilde Neri, Gemma Marinella, Elena Andreucci, Silvia Romano, Rosa Pasquariello, Emanuele Bartolini","doi":"10.1002/epd2.70419","DOIUrl":"https://doi.org/10.1002/epd2.70419","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating blood biomarkers after traumatic brain injury: A subanalysis of the biperiden phase III randomized, double-blind clinical trial (NCT01048138).","authors":"Michele Longoni Calió, Maira Licia Foresti, Luis Eduardo Santos, Amanda Cristina Mosini, Clivandir Severino Silva, Clara Pompeu, Juliana Willers, Thyago Leal Calvo, Almir Ferreira de Andrade, Saul Almeida da Silva, Eliana Garzon, Luiz Eugênio Mello","doi":"10.1002/epd2.70372","DOIUrl":"https://doi.org/10.1002/epd2.70372","url":null,"abstract":"<p><strong>Objective: </strong>Traumatic brain injury (TBI) is a leading cause of acquired epilepsy, death, and long-term disability, yet reliable biomarkers to predict chronic sequelae such as post-traumatic epilepsy (PTE) remain limited. We evaluated the associations between circulating blood biomarkers of neuronal, glial, and synaptic injury and the subsequent development of PTE.</p><p><strong>Methods: </strong>This prespecified subanalysis was conducted within a randomized phase III clinical trial of biperiden in adults with acute TBI. Participants were randomly assigned to receive intravenous biperiden (4 mg every 6 h for 10 days) or placebo. Serum samples collected during the acute (1-15 days) or chronic (90-270 days) post-injury periods were analyzed for total tau (t-Tau), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase L1 (UCHL1), and synaptosomal-associated protein 25 (SNAP25) using an ultrasensitive single-molecule array (SiMoA) platform. Exploratory multivariable analyses were performed to assess associations between biomarker concentrations and PTE.</p><p><strong>Results: </strong>A total of 123 patients were enrolled. Blood samples were obtained from 58 participants (60 serum samples) for biomarker analysis, with most participants contributing a single sample and only two participants providing paired samples collected at different post-injury time points. The median age was 42 years and 48 participants (82.8%) were men. Only six patients (10.3%) developed PTE during follow-up, four in the biperiden group and two in the placebo group. NfL and GFAP concentrations varied according to injury severity and sampling period. Compared with patients who did not develop PTE, those who later developed epilepsy showed descriptively lower NfL and SNAP25 and higher t-Tau, GFAP, and UCHL1 concentrations. SNAP25 was detected in serum for the first time; however, concentrations were frequently below the assay's lower limit of quantification, limiting interpretation of this biomarker and no association with epilepsy development was observed.</p><p><strong>Significance: </strong>Circulating biomarkers reflecting axonal, glial, and synaptic injury provide a descriptive characterization of biological processes following TBI. Given the limited number of PTE events, these analyses are exploratory and hypothesis generating. Further studies are needed to evaluate whether blood-based biomarkers can reliably identify individuals at risk of post-traumatic epileptogenesis.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}