Epileptic Disorders最新文献

{"title":"Regional epilepsy: Unraveling the epileptic phenomenon.","authors":"Shreyashish Roy-Chowdhury, Elma Paredes-Aragon, Richard S McLachlan, Jorge G Burneo, David A Steven, Ana Suller Marti","doi":"10.1002/epd2.70007","DOIUrl":"https://doi.org/10.1002/epd2.70007","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymmetrical limb dystonia and hypokinesia in anti-Ma2-associated encephalitis.","authors":"Chia-Yen Lin, Hsin Tung","doi":"10.1002/epd2.70009","DOIUrl":"10.1002/epd2.70009","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semiology of seizures with temporo-polar or \"medio-lateral\" temporal origin: A systematic review.","authors":"Andreas Schulze-Bonhage, Victoria San Antonio-Arce","doi":"10.1002/epd2.20329","DOIUrl":"https://doi.org/10.1002/epd2.20329","url":null,"abstract":"<p><p>A systematic review using PRISMA criteria was used to review the literature regarding the specific semiology of seizure arising (a) from the temporal pole or (b) from both medial and lateral temporal cortex. Evidence was analyzed with regard to information provided by intracranial EEG recordings and surgical outcomes, and an estimation of validity of reported signs and symptoms was performed. Semiology of seizures originating from the temporal pole was mostly related to diverse patterns of ictal spread rather than to the localization of seizure origin and comprised a wide variety of early signs and symptoms. Seizures with rapid involvement of temporo-medial and temporo-lateral cortex were intermediate in semiology between medial and lateral onset seizures and may have more frequently early automatisms and early vocalization than seizures arising from temporo-medial or temporo-lateral cortex only. Results of this review are discussed as to limiting factors of origin-based analyses for the understanding of seizure semiology.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ILAE neuroimaging task force highlight: The utility of multimodal neuroimaging in diagnostic and presurgical workup of drug-resistant focal epilepsy.","authors":"Niccolò Biagioli, Maksim Parfyonov, Stefano Meletti, Giacomo Pavesi, John Archer, Boris C Bernhardt, Lorenzo Caciagli, Fernando Cendes, Yotin Chinvarun, Luis Concha, Paolo Federico, William D Gaillard, Eliane Kobayashi, Godwin Ogbole, Stefan Rampp, Shuang Wang, Gavin P Winston, Irene Wang, Anna Elisabetta Vaudano","doi":"10.1002/epd2.70016","DOIUrl":"10.1002/epd2.70016","url":null,"abstract":"<p><p>The ILAE Neuroimaging Task Force publishes educational case reports that highlight basic aspects of neuroimaging in epilepsy, consistent with ILAE's educational mission. In patients with drug-resistant focal epilepsy who are candidates for surgical intervention, the identification of structural abnormalities is a strong predictor of favorable postoperative seizure outcomes. When conventional imaging is insufficient, the integration of multimodal neuroimaging data with structural, metabolic, and functional imaging modalities is often helpful. The following two illustrative cases from two different centers highlight the challenges and needs to integrate the information from multiple imaging modalities for a more accurate diagnosis and resection planning of drug-resistant focal epilepsies. This approach can increase the number of patients eligible for surgery while minimizing the risk of postoperative deficits.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotype, outcome, interleukins, and miRNA levels assessment of new-onset refractory status epilepticus: A prospective cohort study.","authors":"Sharath Adiga, Ravindranadh Chowdary Mundlamuri, Hemanthkumar Thanappa, Gejo Gangadharan, Nandakumar Dalavaikodihalli Nanajaiah, Ajay Asranna, L G Viswanathan, Kenchaiah Raghavendra, P V Prathyusha, Karthik Kulanthaivelu, Sanjib Sinha","doi":"10.1002/epd2.70011","DOIUrl":"https://doi.org/10.1002/epd2.70011","url":null,"abstract":"<p><strong>Objectives: </strong>New-onset refractory status epilepticus (NORSE), a subtype of status epilepticus, poses a critical neurological emergency marked by considerable morbidity and mortality. This study aimed to characterize NORSE phenotypically and assess its outcomes, interleukin levels, and miRNA levels.</p><p><strong>Methods: </strong>Over a 3-year period, patients presenting with NORSE were enrolled. Clinical data were documented, and serum and cerebrospinal fluid (CSF) were collected for inflammatory marker analysis. Results were compared with matched controls, and statistical analyses were conducted.</p><p><strong>Results: </strong>The study comprised 37 patients (M: F-22: 15), with a median age of 23 (IQR: 14-31) years at presentation. The median hospital stay was 22 days, with an in-hospital mortality rate of 32%, and 51% of patients experienced poor outcomes at discharge. Approximately 62% required anesthetic agents and immunomodulators for seizure control, and 42% of survivors developed epilepsy during a mean 9-month follow-up. Serum and CSF levels of IL-6 and IL-8 were elevated in cases compared to controls, though serum IL-8 levels did not reach statistical significance. Levels of miRNA 132 and miRNA 134 were lower in cases than controls, but statistical analysis was limited by sample size.</p><p><strong>Significance: </strong>NORSE represents a grave neurological emergency with substantial mortality and morbidity as well as the development of epilepsy during follow-up. The study indicates upregulation of certain interleukins and downregulation of specific miRNA in the serum and CSF of NORSE patients, yet further investigation is warranted to establish correlations with prognosis, treatment response, and outcomes.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sick sinus syndrome diagnosed through an electrocardiogram on an electroencephalogram.","authors":"Daeyoung Kim, Wankiun Lee","doi":"10.1002/epd2.70013","DOIUrl":"https://doi.org/10.1002/epd2.70013","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful seizure control with cenobamate in juvenile myoclonic epilepsy.","authors":"Dalma Tényi, Réka Horváth, József Janszky","doi":"10.1002/epd2.20339","DOIUrl":"https://doi.org/10.1002/epd2.20339","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suspicious looking mu rhythm on SEEG.","authors":"Aayesha J Soni, Ana Suller Marti, Giovanni Pellegrino","doi":"10.1002/epd2.70006","DOIUrl":"https://doi.org/10.1002/epd2.70006","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The localizing value of mimic ictal semiology: A systematic review of the spectrum.","authors":"Vasileios Kokkinos, Elizabeth M Cunningham, Cody L Nathan, Dina Ghandour, Morgan Kisinger, Molly Beestrum, Krystal Madkins, Stephan U Schuele","doi":"10.1002/epd2.70004","DOIUrl":"https://doi.org/10.1002/epd2.70004","url":null,"abstract":"<p><p>We performed a systematic review of the localization value of ictal mimic automatisms-including gelastic, dacrystic, fearful, ritualistic, and kissing semiology-in focal epilepsy. We performed a comprehensive literature search (Medline, EMBASE, Cochrane, Scopus) for patient-level studies, following a PRISMA and QUADAS2 approach. Patients with focal epilepsy displaying mimic automatism, defined as \"stereotyped mimicry or behavior that resembles the usual way one expresses oneself to reflect an affect and that is not accompanied by the corresponding emotion\" were included. Patients with subjective emotional experiences during a seizure, which the patient is aware of, were excluded. Analysis included 936 patients from 104 studies. Gelastic semiology was primarily associated with hypothalamic hamartomas (HH), and secondarily with frontal (cingulate; superior frontal gyrus), temporal (hippocampus; amygdala; pole; parahippocampal and fusiform gyri), insular, and orbitofrontal involvement, without consistent hemispheric lateralization. Dacrystic semiology was associated with HH, as well as temporal lobe seizure onset (mesial and anterior), followed by the less frequent involvement of orbitofrontal (anterior; baso-lateral), insular, and frontal regions; also without consistent hemispheric lateralization. Fearful ictal semiology was equally associated with frontal (cingulate; superior frontal gyrus), orbitofrontal (mesial; posterior), and temporal (hippocampus; amygdala) involvement; most often, but not exclusively, of right hemispheric lateralization. Ritualistic behavior was associated with the temporal lobe origin (hippocampus; amygdala; pole), with strong right hemispheric lateralization. Kissing ictal behavior was associated with temporal lobe origin (pole; hippocampus; amygdala), and secondarily with the frontal lobe (cingulate); most often, but not exclusively, of right hemispheric lateralization. Our systematic review-derived localization of the various manifestations of mimic automatisms supports anatomo-clinical correlations and helps guide interpretation of ictal semiology within the framework of pre-surgical evaluation in focal epilepsies.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert opinions on pediatric EEG training for non-epilepsy specialists in sub-Saharan Africa.","authors":"Veena Kander, Kette D Valente, Jaime Carrizosa, Jorge Vidaurre, Archana A Patel, Chahnez Charfi Triki, Ghaieb Aljandeel, Gagandeep Singh, Mitsuhiro Kato, Lala Seck, Zeinab Kone, Sándor Beniczky, Melody T Asukile, Gretchen L Birbeck, Kevin Jones, Geraldine Boylan, Joanne Hardman, Jo M Wilmshurst","doi":"10.1002/epd2.70010","DOIUrl":"https://doi.org/10.1002/epd2.70010","url":null,"abstract":"<p><p>Ideally, pediatric electroencephalograms (EEGs) should be performed by accredited neurophysiology technologists and interpreted by specialists trained in epileptology However, low- and middle-income countries (LMICs) lack such specialists.</p><p><strong>Aim: </strong>To collate expert consensus on essential curriculum content for non-epilepsy specialists in EEG interpretation and safe post-training practice.</p><p><strong>Method: </strong>A qualitative study on pediatric EEG training curricula needs was designed in collaboration with an adult education specialist. Data were collected via interviews from 15 epilepsy experts with training experience across high- to low-income settings. Thematic analysis was used to identify sub-themes. The experts voted on the key statements in a two-round Delphi to ascertain consensus.</p><p><strong>Results: </strong>Twelve aspects of pediatric EEG training were identified and categorized thematically: relevance; exposure to pediatrics; focus on pediatrics; barriers; resource-limited setting; entry skills; best pedagogy; assessment; critical skills; reinforcement of skills; training model; and recommendations.</p><p><strong>Conclusion: </strong>This study was driven by the inadequate access to training in pediatric EEG for non-epilepsy specialists, which is further exacerbated by the lack of epileptologists and neurophysiologists. The outcomes from the expert consensus opinions promoted consolidation, adaptation, and evolution of existing models that are viable for practice and to be used worldwide. The Delphi consensus demonstrated alignment among regionally located specialists towards the promotion of effective and maintained training for non-epilepsy specialists, as well as highlighting barriers that should be considered and addressed.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}