Epileptic Disorders最新文献

{"title":"Clinical characteristics associated with photoparoxysmal response in routine electroencephalography.","authors":"Neerrajah Nadarajah, Michael Fahey, Udaya Seneviratne","doi":"10.1002/epd2.70064","DOIUrl":"https://doi.org/10.1002/epd2.70064","url":null,"abstract":"<p><strong>Objective: </strong>Previous studies have reported singular factors that may contribute to the photoparoxysmal response (PPR) captured on routine electroencephalography (EEG). This study aimed to investigate the prevalence and multiple clinical characteristics associated with PPR in patients across the lifespan.</p><p><strong>Methods: </strong>All adult and pediatric patients who underwent routine EEGs at a tertiary hospital in Australia between January 2019 and December 2020 were studied. Intensive care and prolonged EEGs were excluded. Several potential determinants of PPR were investigated, and their strength of association was analyzed with logistic regression to determine adjusted odds ratios (OR) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>In a cohort of 3475 patients, 50 had PPR (1.44%). Significant factors increasing the odds of PPR included sleep deprivation (OR 5.97; 95% CI 2.11-16.89) and generalized epilepsy syndrome (OR 407.21; 95% CI 91.47-1812.85). Patients aged 11-20 (OR 3.77; 95% CI 1.45-9.76) and 21-30 (OR 5.03; 95% CI 1.65-15.32) had increased odds compared with those aged 0-10. Concurrent antiseizure medication during EEG significantly reduced the odds of PPR (OR .33; 95% CI .15-.73).</p><p><strong>Significance: </strong>Sleep deprivation, underlying epilepsy syndrome, antiseizure medications, and age significantly impact the occurrence of PPR on routine EEG.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare utilization in drug-resistant epilepsy: A retrospective cohort study into factors predictive of success during short pediatric EMU admissions.","authors":"Mohamad Chahrour, Richard J Webster, Deepti Reddy, Sajjad Dehnoei, Sarah Healy, Katherine Muir","doi":"10.1002/epd2.70060","DOIUrl":"https://doi.org/10.1002/epd2.70060","url":null,"abstract":"<p><strong>Objective: </strong>The Epilepsy Monitoring Unit (EMU) plays a crucial role in a patient's diagnosis and management of seizures and epilepsy. This is a resource-intensive test; therefore, it is beneficial to be able to predict which patients may need a short admission and which patients may require repeated admissions. The duration of stay required to obtain adequate information is not clear, especially in the pediatric population. In this study, we examine factors that predict success during a short admission and those that predict the need for repeat admissions.</p><p><strong>Methods: </strong>Retrospective review of 462 admissions (2014-2024). We included any patient admitted to CHEO's EMU for four or fewer days.</p><p><strong>Results: </strong>The median (IQR) admission was 2 (1, 2) days. 23.6% (95% CI: 19.9%, 27.7%) of EMU visits were repeat admissions. 82.0% (95% CI: 78.3%, 85.3%) of admissions were successful. A diagnosis of drug-resistant epilepsy is associated with a higher chance of achieving admission goals (OR = 2.2, 95% CI 1.3, 3.7, p = 0.002). Through a binary logistic regression, we show that a previous diagnosis of drug-resistant epilepsy increases the chance of repeat admission to the EMU (odds ratio = 4.2, 95% CI 2.4, 7.6, p < 0.001), when adjusting for seizure type, admission goals, weaning of meds, age, and gender. Seizure type (focal, generalized, or both) has no influence on the likelihood of repeat admission or achieving admission goals.</p><p><strong>Significance: </strong>Having a pediatric EMU monitoring period of 1-4 days was sufficient to achieve admission goals in over 80% of patients in this cohort, suggesting that many pediatric patients can have their EMU goals achieve during short stays. Patients with drug-resistant epilepsy are more likely to have a successful initial admission, but also to require repeat admissions. These results can be used to better plan for resource utilization in a pediatric EMU.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsy phenotype and developmental outcome in girls with mosaicism in X-linked neurodevelopmental disorders.","authors":"Evelina Carapancea, Donya Eizadkhah, Roberto Santalucia, Damien Lederer, Florence A Arts, Lieven Lagae, Solomon L Moshe, Maria Roberta Cilio","doi":"10.1002/epd2.70058","DOIUrl":"https://doi.org/10.1002/epd2.70058","url":null,"abstract":"<p><p>CDKL5 deficiency disorder (CDD) and SMC1A-related epilepsy are X-linked neurodevelopmental disorders characterized by early-onset, mostly intractable epilepsy and severe intellectual disability. While recent advances in next-generation sequencing improved diagnostic yields, detecting low-frequency mosaicism remains challenging. We retrospectively analyzed the epilepsy and developmental phenotype of four female patients with mosaic CDKL5 or SMC1A variants. Clinical data, including seizure types, electroencephalographic findings, neurodevelopmental milestones, and genetic analyses, were reviewed. The two girls with CDKL5 mosaicism presented at 5 and 6 weeks with tonic seizures, rapidly developing hypermotor-tonic-spasms sequence seizures. Both achieved independent walking by age two and developed speech by 3 years. The two girls with SMC1A mosaicism presented clusters of focal impaired awareness, myoclonic, and tonic-clonic seizures at 19 and 20 months of age. They demonstrated milder intellectual disabilities, with one achieving normal speech and the other speaking over 100 words by age four. Both achieved independent walking, which is uncommon in germline patients. Girls with mosaic CDKL5 and SMC1A variants share the same epilepsy phenotype as the germline females but have milder intellectual and motor disabilities compared to germline patients. Recognizing specific seizure patterns may direct genetic testing, enabling earlier diagnosis and access to precision treatment.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latency to presentation after seizure onset and drug resistance to a comprehensive epilepsy center in an urban tertiary care center.","authors":"Meghana Srinivas, Kristen Lucas, Rebecca Weber, Scott Millis, Mona Elsayed, Deepti Zutshi, Maysaa M Basha, Rohit Marawar","doi":"10.1002/epd2.70050","DOIUrl":"https://doi.org/10.1002/epd2.70050","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate latency to presentation among persons with epilepsy at an urban National Association of Epilepsy Centers Level IV epilepsy center and assess the impact of socioeconomic status and race on this latency. Less than 1% of persons with epilepsy are referred to specialized centers in the United States, often taking over twenty years to undergo surgery, significantly affecting quality of life and healthcare costs. Our primary objective was to assess latency to presentation at our Level IV epilepsy clinic in Detroit, Michigan. The secondary objective was to evaluate the impact of low socioeconomic status and Black race on latency to presentation.</p><p><strong>Methods: </strong>We retrospectively analyzed persons with epilepsy seen at our clinic in 2014, excluding those previously seen at an epilepsy center. Persons with epilepsy were divided into drug-resistant epilepsy and non-drug-resistant epilepsy groups. We calculated latency to presentation for all patients and both groups and assessed drug resistance for the drug-resistant epilepsy group. Regression models were fitted using latency to presentation as the outcome variable.</p><p><strong>Results: </strong>A total of 648 unique persons with epilepsy were seen, with 408 included in the analysis. Among these, 66.42% were Black, and 63.72% had low socioeconomic status. The drug-resistant epilepsy group had more patients with known etiology and temporal lobe epilepsy (p < 0.05). The mean latency to presentation was 13.21 years for all patients and 16.04 years for the drug-resistant epilepsy group; since drug resistance, it was 14.74 years. Persons with low socioeconomic status showed longer latency, but significance did not persist after regression. No differences were found between Black and White persons.</p><p><strong>Significance: </strong>Optimal epilepsy care in the United States remains delayed with first presentation to the epilepsy clinic taking more than 13 years. Future studies should explore reasons for these delays rather than focusing solely on epilepsy surgery referrals.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological and clinical markers of SUDEP risk in pediatric epilepsy.","authors":"Pinar Ozbudak, Salih Akbas, Alev Elci Karaduman, Ayse Serdaroglu, Tugba Hirfanoglu, Ebru Arhan","doi":"10.1002/epd2.70057","DOIUrl":"https://doi.org/10.1002/epd2.70057","url":null,"abstract":"<p><strong>Objective: </strong>Sudden unexpected death in epilepsy (SUDEP) is a major cause of epilepsy-related mortality, especially in patients with drug-resistant epilepsy. However, pediatric data remain limited, and specific risk assessment tools for children are lacking. This study evaluates the association between peri-ictal prone positioning, postictal generalized EEG suppression (PGES), and SUDEP-7 Inventory scores in pediatric patients with epilepsy.</p><p><strong>Methods: </strong>A retrospective review was conducted on 273 generalized convulsive seizures (GCS) from 117 pediatric patients who underwent video-EEG monitoring from 2002 to 2022. We assessed body position during seizures, PGES presence and duration, and SUDEP-7 Inventory scores. Statistical comparisons were made across PGES-positive and -negative, and prone vs. non-prone subgroups.</p><p><strong>Results: </strong>Prone positioning occurred in 5.86% of seizures, with 91.6% of prone-onset seizures remaining in the prone position throughout. PGES was present in 50.4% of patients (mean duration: 120.5 s). SUDEP-7 scores were significantly higher in PGES-positive patients (mean: 7.04) compared to PGES-negative (mean: 6.36; p = 0.031). Daytime GCS occurred significantly earlier after sleep onset than night time GCS (53.3 vs. 131.4 minutes; p = 0.001).</p><p><strong>Significance: </strong>PGES appears to be a reliable marker associated with higher SUDEP-7 scores and may indicate increased SUDEP risk in children. While SUDEP-7 has limitations in pediatric use, it remains the most accessible clinical tool. Integrating EEG and body position metrics could enhance individualized monitoring for pediatric patients at risk.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A curriculum for epilepsy surgery: A report from the Surgical Commission's Epilepsy Surgery Educational Task Force and the Educational Council of the ILAE.","authors":"Christian Dorfer, Johannes M Nico Enslin, Carrie R Muh, Xiongfei Wang, Tatiana von Hertwig Fernandes de Olivera, Samuel Wiebe, Guy M McKhann, Eyiyemisi Damisah, Faisal Al-Otaibi, Gagandeep Singh, Ingmar Blümcke, Bertil Rydenhag, Rushna P Ali, Dario J Englot, Mario Alonso Vanegas, J Helen Cross, Arthur Cukiert","doi":"10.1002/epd2.70054","DOIUrl":"10.1002/epd2.70054","url":null,"abstract":"<p><strong>Objective: </strong>There is a need to develop a comprehensive, formalized, and globally applicable epilepsy surgery curriculum in order to help standardize the quality of epilepsy surgery practice in the world.</p><p><strong>Methods: </strong>The Epilepsy Surgery Educational Task Force of the ILAE developed a competency-based epilepsy surgery educational curriculum comprised of four domains: Diagnosis, Counseling, Pre-surgical Work-up, and Surgical Techniques. To evaluate this educational curriculum, a survey questionnaire consisting of 11 items was sent out for feedback to ILAE and IESS members. The survey questionnaire asked respondents to rate the degree of importance of each competency on a five-point scale that ranged from \"extremely important\" to \"not at all important\" and provided space for free text comments. All competencies that were rated as \"slightly important\" or \"somewhat important\" by more than 10% of responders, as well as all free text feedback comments, were fully reviewed, and the final curriculum was adjusted accordingly.</p><p><strong>Results: </strong>One hundred and twenty-two responses (n = 122) were submitted by the ILAE and IESS communities. Seventy-one percent (71.9%) of the responses came from neurosurgeons of varied experience and training levels. Ninety-four percent (94.4%) of responders stated that they \"support a curriculum to determine the competency of neurosurgeons participating in the care of people with epilepsy in my country,\" and 94.3% confirmed that they \"would be interested in taking or would recommend an ILAE course based on these competencies, that would provide an ILAE certificate of completion.\" Relevant changes within the curriculum were made based on feedback.</p><p><strong>Significance: </strong>The newly developed ILAE comprehensive epilepsy surgery educational curriculum has a high level of support from neurosurgeons and neurologists around the world and shows potential for broad acceptance and implementation.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of neural complexity and consciousness in temporal lobe seizures: Effects of high-frequency pulvinar stimulation.","authors":"Ionuț-Flavius Bratu, Nada El Youssef, Stanislas Lagarde, Fabrice Bartolomei","doi":"10.1002/epd2.70056","DOIUrl":"10.1002/epd2.70056","url":null,"abstract":"<p><strong>Background: </strong>Loss of consciousness/awareness during temporal lobe seizures significantly affects quality of life and is closely linked to pathological thalamocortical synchronization and loss of cortical signal complexity. The medial pulvinar nucleus (PUM) contributes to seizure propagation and awareness impairment, making it a potential target for neuromodulation. Acute high-frequency PUM stimulation has previously been shown to reduce seizure severity and improve awareness, potentially by disrupting excessive synchrony.</p><p><strong>Aims: </strong>In this study, we investigated the effects of PUM stimulation on signal complexity and its relationship to ictal awareness using permutation entropy (PE) in SEEG recordings.</p><p><strong>Materials and methods: </strong>Eight patients with focal drug-resistant temporal epilepsy underwent hippocampus-induced seizures with and without additional high-frequency PUM stimulation. SEEG complexity changes were quantified using PE and ictal awareness was assessed using the Consciousness Seizure Scale (CSS).</p><p><strong>Results: </strong>Our results showed that PUM stimulation attenuated entropy reductions during seizures, suggesting a preservation of neural complexity. Moreover, reduced entropy alterations correlated with improved CSS scores.</p><p><strong>Discussion: </strong>These findings support the role of PUM stimulation in mitigating pathological neural complexity alterations, with potential implications for preserving both consciousness and cognitive function in epilepsy.</p><p><strong>Conclusion: </strong>Further studies are needed to confirm these findings in larger cohorts and to explore the long-term effects of thalamic deep brain stimualtion in drug-resistant epilepsy as well as the interaction between neural complexity, awareness, and cognition in this context.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing vagus nerve stimulation for Super Refractory Status Epilepticus: A case series and systematic review.","authors":"Diego Pichardo-Rojas, Karen Janely Camarena-Rubio, Irene Gómez-Oropeza, Jonathan Ulises Macias-López, Alder Fernando Valenzuela-Rangel, Brandon Flores-Patiño, María Fernanda Castelo-Pablos, Valeria Isabel Bravo-Osorno, Manuel Alejandro Del Río Quiñones, Laura Hernández Vanegas, Sonia Iliana Mejía-Pérez, Elma Paredes-Aragón","doi":"10.1002/epd2.70053","DOIUrl":"10.1002/epd2.70053","url":null,"abstract":"<p><p>Super Refractory Status Epilepticus (SRSE) is a neurological emergency characterized by a status epilepticus that persists or recurs despite 24 h of treatment with anesthetic therapy (A-T). Vagus Nerve Stimulation (VNS) is a well-established treatment for drug-resistant epilepsy (DRE). In this study, we explore the safety and efficacy of VNS for SRSE. A database search was conducted until August 14, 2024 to identify patients who were implanted with a VNS as a surgical neuromodulation therapy for SRSE. We report on the etiology of SRSE, previous DRE diagnosis, VNS parameters required for SRSE resolution, and long-term outcomes. Out of 257 screened studies, 24 met inclusion criteria, encompassing 30 published cases. Alongside 3 institutional cases, our study analyzed 33 patients. VNS was associated with SRSE resolution in 29/33 patients (87.87%). Median age at surgery was 15 years (range: neonate to 67 years). Seventeen had prior DRE diagnoses. Days on A-T before implantation ranged from 5 to 420 (median 25, IQR 12-42.5). Median VNS output for resolution was 1.375 milliamperes (mA) (IQR = 1-1.75), with 1 mA being the most common setting (11/30, 36.6%). Median time to reach therapeutic VNS parameters was 2 days (IQR = 1.25-7.75). SRSE resolved at a median of 7 days post-op 7 (IQR: 4.75-14). At follow-up of DRE patients, McHugh scores were as follows: 1 (8/15, 53.3%), 2 (4/15, 26.6%), 3 (1/15, 6.6%), and 5 (2/15, 13.3%). VNS was associated with SRSE resolution in 87.87% of cases. Based on available observational data, VNS may be considered for SRSE after 2 weeks of treatment nonresponse. Proposed titration strategies to reach ≥1 mA include immediate (within 20 min post-op), rapid (within 24-36 h), and accelerated (within 2 weeks). Titration should be individualized based on SRSE duration and patient tolerance. Further studies are needed to define the role of VNS in SRSE.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seminars in epileptology: How to diagnose status epilepticus in adults and children.","authors":"M Leitinger, P Bosque-Varela, G Kuchukhidze, U Leitner, J Höfler, G Kalss, F Rossini, G Pilz, H Novak, M Mauritz, K Poppert, A Toma, E Trinka","doi":"10.1002/epd2.70033","DOIUrl":"https://doi.org/10.1002/epd2.70033","url":null,"abstract":"<p><p>Status epilepticus (SE) can be regarded as the most severe expression of seizure activity characterized by a low probability of spontaneous cessation and mechanisms leading to metabolic and inflammatory derangements with increased risk of brain damage, alterations of neural networks, and potentially life-threatening systemic complications. Time-based criteria are fundamental in diagnosing SE as response to treatment and outcomes worsen with increasing duration in terms of neurological impairment and mortality. Classification of status epilepticus includes four axes: semiology, EEG correlates, etiology, and age. Semiology, especially when evolving from SE with prominent motor phenomena (SE-PM) to nonconvulsive status epilepticus (NCSE) with impaired consciousness, is associated with drug resistance and poor prognosis. The Salzburg EEG criteria define four subcategories of NCSE. The umbrella term ictal-interictal continuum (IIC) includes a wide spectrum of EEG changes ranging from almost non-epileptic situations to conditions that just fail to fulfill the criteria of NCSE. From a pathophysiologic point of view, EEG patterns on the IIC might be generated by both the underlying etiology and the superimposed hypersynchronous epileptic activity. It is impossible to disentangle their relative contributions by visual inspection of the EEG. However, it is essential to identify the contribution of ictal activity in an individual patient as it may be amenable to treatment with antiseizure medication (ASM). The main approach is to perform a diagnostic intravenous ASM trial (diagnostic IV-ASM trial) during EEG recording and to assess for both EEG and clinical response. Furthermore, CT- and MRI-perfusion studies help to clarify the diagnosis. Early and consequent treatment is necessary to minimize the total time spent in status, also called seizure burden. This educational review focuses on the diagnosis of status epilepticus in children and adults, excluding neonatal status.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Challenges in the Neuropsychology of Epilepsy: Report of the ILAE Neuropsychology Task Force Diagnostic Methods Commission: 2021-2025.","authors":"Mary Lou Smith, Mayu Fujikawa, Genevieve Rayner, Seth A Margolis, Bruce Hermann, Gus Baker, Sallie Baxendale, Robyn Busch, Aimee Dollman, Vicki Ives-Deliperi, Carrie R McDonald, Urvashi Shah, Sarah Wilson","doi":"10.1002/epd2.70052","DOIUrl":"https://doi.org/10.1002/epd2.70052","url":null,"abstract":"<p><p>Increasingly, it has been recognized that non-seizure-related factors influence how people with epilepsy perform on neuropsychological tests. Therefore, neuropsychologists need to recognize the constellation of factors that can contribute to the neurocognitive presentation of a person with epilepsy and consider these factors in the interpretation of their assessment results. In this paper, we highlight common scenarios prompting the need to account for such factors when conducting and interpreting neuropsychological assessments. To illustrate these complexities, a case study is presented of a woman with early onset epilepsy complicated by a traumatic brain injury in adulthood who was a candidate for epilepsy surgery. A discussion of the need to consider neurodevelopmental, psychiatric, and psychosocial factors in conducting an assessment and arriving at a sound interpretation of results is presented. Clinical take-away points are offered for guidance in undertaking such assessments.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}