Physical activity and risk of epilepsy: A 2-sample Mendelian randomization study.

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Epileptic Disorders Pub Date : 2025-04-15 DOI:10.1002/epd2.70024

Cheng Yang, Mengmeng Wang, Xin Chen, Jianrong Yao, Yazhou Ma, Xuegan Lian

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引用次数: 0

Abstract

Objective: There is currently a lack of evidence from earlier studies about the impact of exercise on the risk of epilepsy. We conducted a 2-sample Mendelian randomization (MR) study to identify the potential causal relationship between physical activity and epilepsy.

Methods: We identified single nucleotide polymorphisms (SNPs) associated with physical activity from a recent genome-wide association study of the UK Biobank. Summary statistics of epilepsy were derived from the International League Against Epilepsy (ILAE) Consortium genome-wide association study (GWAS) database.

Results: We found that self-reported moderate-to-vigorous physical activity increases the incidence of focal epilepsy with hippocampal sclerosis(OR: 1.18; 95% CI: 1.07-1.30, p = 9 × e-4) and overall acceleration average reduces the risk of childhood absence epilepsy(OR: .99; 95% CI: .98 to 1.00; p = .013).

Significance: Different types of epilepsy respond differently to physical activity; it needs further research to explore the physiological mechanism of physical activity and epilepsy.

查看原文本刊更多论文

体育活动与癫痫风险：一项双样本孟德尔随机研究。

目的：目前缺乏关于运动对癫痫风险影响的早期研究证据。我们进行了一项两样本孟德尔随机化（MR）研究，以确定体育活动与癫痫之间的潜在因果关系。方法：我们从英国生物银行最近的一项全基因组关联研究中确定了与身体活动相关的单核苷酸多态性（snp）。癫痫的汇总统计数据来源于国际抗癫痫联盟（ILAE）全基因组关联研究（GWAS）数据库。结果：我们发现自我报告的中高强度体育活动增加局灶性癫痫伴海马硬化的发生率(OR: 1.18；95% CI: 1.07-1.30, p = 9 × e-4)，总体加速平均降低儿童期缺失性癫痫的风险(OR: 0.99；95% CI: 0.98 ~ 1.00；p = .013)。意义：不同类型癫痫对体力活动的反应不同；体力活动与癫痫的生理机制有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epileptic Disorders 医学-临床神经学

CiteScore

4.10

自引率

8.70%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Epileptic Disorders is the leading forum where all experts and medical studentswho wish to improve their understanding of epilepsy and related disorders can share practical experiences surrounding diagnosis and care, natural history, and management of seizures. Epileptic Disorders is the official E-journal of the International League Against Epilepsy for educational communication. As the journal celebrates its 20th anniversary, it will now be available only as an online version. Its mission is to create educational links between epileptologists and other health professionals in clinical practice and scientists or physicians in research-based institutions. This change is accompanied by an increase in the number of issues per year, from 4 to 6, to ensure regular diffusion of recently published material (high quality Review and Seminar in Epileptology papers; Original Research articles or Case reports of educational value; MultiMedia Teaching Material), to serve the global medical community that cares for those affected by epilepsy.