European Journal of Cardiovascular Prevention & Rehabilitation最新文献

{"title":"Poster Session IV. Prevention, socio demography and sudden cardiac death","authors":"","doi":"10.1177/17418267100170s229","DOIUrl":"https://doi.org/10.1177/17418267100170s229","url":null,"abstract":"","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S93 - S97"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Session II: Exercise physiology","authors":"A. Ascione, M. Borgia, A. Sciarappa, M. Aversa, S. Erbs, A. Linke, V. Adams, M. Sandri, E. Beck, R. Hambrecht, Schuler, E. Normandin, G. Billon, T. Guiraud, L. Bosquet, M. Juneau, Nigam","doi":"10.1177/17418267100170s215","DOIUrl":"https://doi.org/10.1177/17418267100170s215","url":null,"abstract":"P244 Exercise oscillatory breathing and increased ventilation to carbon dioxide production in women with cronic heart failure and type 2 diabetes mellitus A Ascione, M Borgia, A Sciarappa, M Aversa Buon Consiglio Fatebenefratelli Hospital, Naples, Italy, Vincenzo Monaldi Hospital, Naples, Italy Topic: Exercise physiology, testing and training Background: Cardio-pulmonary exercise test with determination 02 consumption (CPET) is generally used for assessing patients with heart failure (HF). Increased slope of exercise ventilation to carbon dioxide production (VE/VCO2) is an established prognosticator in patients with heart failure. Recently, the occurrence of exercise oscillatory breathing (EOB) has emerged as an additional strong predictor even more powerful than VE/VCO2 slope. Objective: The aim of this study is to define the respective prognostic significance of these variables in female patients with type 2 diabetes mellitus. Methods:One hundred (100) womenwere recruited (mean age 54 12 years, of whom 80NYHA class II and 20 NYHA class III). As diabetics, these women were being treated with insulin and/ or oral hypoglycaemic drugs. All patients were receiving optimised therapy with beta-blockers, statins, nitro-derivatives, ACE-inhibitors and platelet anti-aggregants, and all had stable sinus rhythms. These women had been recruited in order to undergo CPETs and echocardiograms within a maximum period of 14 days. The CPETs were conducted utilising a protocol calling for testing on a cyclette with increments of 10 Watts per minute. None of them were obese. They were in stable chronic HF(average left ventricular ejection fraction, 33 þ/ 13%). We analyzed the prognostic relevance of VE/VCO2 slope, EOB, 02 pulse and peak Vo2 was evaluated bymultivariate Cox regression. Results: During a mean interval of 22 months, 22 patients died of cardiac reasons. Fifty-five percent presented with EOB. Among patients exhibiting EOB, 54% had an elevated VE/VCO2 slope and poor 02 pulse. The optimal threshold value for the VE/VCO2 slope identified by receiver operating characteristic analysis was <36.2 or >36.2 (sensitivity, 77%; specificity,64%;P<.001).Univariate predictors of death included low left ventricular ejection fraction, low peak Vo2, high VE/VCO2 slope,and EOB presence. The VE/VCO2 slope (threshold,<36.2 or>36.2) was the only other exercise test variable retained in the regression. The hazard ratio for subjects with EOB and a VE/VCO2 slope>36.2 was 14.4(95% confidence interval, 4.9-26.5; P< .001). Conclusion:These findings identify EOB as a strong survival predictor evenmore powerful than VE/VCO2 slope in diabetic women with HF.Even more in these patients EOB presence does not necessarily imply an elevated VE/VCO2 slope, but combination of either both yields to a burden of high risk.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S53 - S54"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderated Poster Session I: Prevention & health policy","authors":"B. Rauch, R. Schiele, S. Schneider, H. Gohlke, H. Katus, J. Senges, L. Palmieri, R. Rielli, O. Brignoli, A. Cuffari, P. Ciccarelli, S. Giampaoli","doi":"10.1177/17418267100170s201","DOIUrl":"https://doi.org/10.1177/17418267100170s201","url":null,"abstract":"P13 Prognostic effect of omega-3 fatty acid supplementation on top of current guideline adjusted therapy of acute myocardial infarction the OMEGA trial B Rauch, R Schiele, S Schneider, H Gohlke, H Katus, J Senges ZAR Ludwigshafen Klinikum, Center for Ambulatory Rehabilitation, Cardiology, Angiology, Neurology, Ludwigshafen am Rhein, Germany, Clinical Center of Ludwigshafen, Department of Cardiology, Ludwigshafen amRhein, Germany, Heart Attack Research Center at the University of Heidelberg, Ludwigshafen am Rhein, Germany, Heart Centre Bad Krozingen, Bad Krozingen, Germany, University Hospital Heidelberg, Internal Medicine III, Department of Cardiology, Angiology and Pneumology, Heidelberg, Germany Topic: Controlled clinical trials Background:Omega-3 fatty acids are regarded to be effective in improving prognosis after acute myocardial infarction, but there is no randomized, double blind trial testing their prognostic effect on top of current, guideline adjusted treatment. Methods: OMEGA is a randomized, placebo-controlled, double blind, multicenter trial to test the effects of omega-3-acid ethyl esters-90 (one gram per day for one year) on the rate of sudden cardiac death, total mortality, and non fatal clinical events in survivors of acute myocardial infarction with and without ST-elevation (STEMI and NSTEMI), if given on top to current guideline adjusted treatment. Patients were randomized 3 14 days after myocardial infarction from October 2003 until June 2007. Results: The trial included 3,851 patients (STEMI 59,0%; NSTEMI 41.0%; female 25.6%; mean age 64.0 years). From these patients 66.5% had a history of hypertension, 49.5% had elevated cholesterol levels, 27% had diabetes, and 36.7% were smokers. Acute coronary angiography was performed in 93.8%, acute percutaneous coronary intervention in 77.8% of all patients. Discharge medication included aspirin 95.3%, clopidogrel 88.4%, ACE-inhibitors 83.3%, beta-blockers 94.1%, and statins 94.2%. Duringthe follow-up of 365 days the event rates were as follows (placebo/verum): sudden cardiac death 1.5/1.5%, p1⁄40.84; total mortality 3.7/ 4.6%, p1⁄40.18; reinfarction in survivors 4.1/4.5%, p1⁄40.63; stroke in survivors 0.7/1.4%, p1⁄40.07. Conclusion: The OMEGA-trial demonstrates a high degree of guideline adjusted treatment of acute myocardial infarction in selected German centers. Under these conditions on top application of omega-3 fatty acids did not provide an additional prognostic benefit within one year of follow-up.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S1 - S2"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderated Poster Session III: Basic science","authors":"B. Giusti, A. Gori, F. Cesari, R. Marcucci, S. Agouri, V. Dao, O. Kocgirli, M. Oppermann, T. Suvorava, P. Pignatelli, R. Carnevale, S. Santo, V. Sanguigni, M. Proietti, A. Plebani, F. Violi","doi":"10.1177/17418267100170s209","DOIUrl":"https://doi.org/10.1177/17418267100170s209","url":null,"abstract":"P151 Cytochrome P450 2c19 polymorphism and cardiovascular recurrences in patients under clopidogrel treatment: a meta-analysis F Sofi, B Giusti, AM Gori, F Cesari, R Marcucci, R Abbate, GF Gensini University of Florence, Florence, Italy Topic: Genetic-environmental interactions Introduction: Nonresponsiveness to clopidogrel has been reported to be an independent predictor of clinical recurrences in patients with coronary artery disease under clopidogrel treatment. Recently, several polymorphisms in gene encoding platelet components or cytochrome P450 (CYP) enzymes have been proposed as possible mechanisms for nonresponsiveness to clopidogrel. Among them, a great deal of attention has been posed on a loss-of-function CYP2C19 2 (or 681 G>A) polymorphism. To evaluate the role of such polymorphism in recurrent atherothrombotic events in patients with CAD under clopidogrel treatment, we considered all available studies in a meta-analysis. Material and Methods: Cohort prospective studies evaluating the association between CYP2C19 2 polymorphism and adverse clinical outcome were searched in MEDLINE, EMBASE, Web of Science, The Cochrane Systematic Review Database and bibliographies of retrieved articles up to January, 2009. The principal prior hypothesis was that the presence of the 2 variant allele of the polymorphism would be associated with an increased risk of clinical recurrence. Results: Data were available for a total of 7,950 patients from 6 cohort prospective studies who were followed for a time ranging from 6 months to 8.4 years. The summary risk ratios for included cohort prospective studies showed a significant association between the CYP2C19 2 polymorphism and an increased risk of major adverse cardiac events in the follow-up [RR: 1.80 (1.02-3.19); p1⁄40.04].When studies evaluating stent thrombosis (n1⁄44) for a total of 4,975 patients were considered, the presence of the variant allele was associated with an increased risk of stent thrombosis [RR: 2.82 (1.43-5.56); p1⁄40.0001]. Conclusion: The present meta-analysis performed on nearly 8,000 patients with CAD under clopidogrel treatment shows that the CYP2C19 2 polymorphism is associated with an increased risk of major adverse cardiac events and stent thrombosis. These results need to be confirmed by further studies.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S29 - S30"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Session IV. Basic science: cardiovascular risk","authors":"","doi":"10.1177/17418267100170s234","DOIUrl":"https://doi.org/10.1177/17418267100170s234","url":null,"abstract":"","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S114 - S115"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relation of heart rate recovery to psychological distress and quality of life in patients with chronic heart failure.","authors":"Roland von Känel,&nbsp;Hugo Saner,&nbsp;Sonja Kohls,&nbsp;Jürgen Barth,&nbsp;Hansjörg Znoj,&nbsp;Gaby Saner,&nbsp;Jean-Paul Schmid","doi":"10.1097/HJR.0b013e3283299542","DOIUrl":"https://doi.org/10.1097/HJR.0b013e3283299542","url":null,"abstract":"<p><strong>Background: </strong>Psychological distress, poor disease-specific quality of life (QoL), and reduction in vagally mediated early heart rate recovery (HRR) after exercise, all previously predicted morbidity and mortality in patients with chronic heart failure (CHF). We hypothesized lower HRR with greater psychological distress and poorer QoL in CHF.</p><p><strong>Design: </strong>All assessments were made at the beginning of a comprehensive cardiac outpatient rehabilitation intervention program.</p><p><strong>Methods: </strong>Fifty-six CHF patients (mean 58+/-12 years, 84% men) completed the Hospital Anxiety and Depression Scale and the Minnesota Living With Heart Failure Questionnaire. HRR was determined as the difference between HR at the end of exercise and 1 min after exercise termination (HRR-1).</p><p><strong>Results: </strong>Elevated levels of anxiety symptoms (P=0.005) as well as decreased levels of the Minnesota Living With Heart Failure Questionnaire total (P = 0.025), physical (P=0.026), and emotional (P=0.017) QoL were independently associated with blunted HRR-1. Anxiety, total, physical, and emotional QoL explained 11.4, 8, 7.8, and 9.0%, respectively, of the variance after controlling for covariates. Depressed mood was not associated with HRR-1 (P=0.20).</p><p><strong>Conclusion: </strong>Increased psychological distress with regard to elevated anxiety symptoms and impaired QoL were independent correlates of reduced HRR-1 in patients with CHF. Reduced vagal tone might explain part of the adverse clinical outcome previously observed in CHF patients in relation to psychological distress and poor disease-specific QoL.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":" ","pages":"645-50"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/HJR.0b013e3283299542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40054818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-evaluating the Rose approach: comparative benefits of the population and high-risk preventive strategies.","authors":"Marie-Therese Cooney,&nbsp;Alexandra Dudina,&nbsp;Peter Whincup,&nbsp;Simon Capewell,&nbsp;Alessandro Menotti,&nbsp;Pekka Jousilahti,&nbsp;Inger Njølstad,&nbsp;Raphel Oganov,&nbsp;Troels Thomsen,&nbsp;Aage Tverdal,&nbsp;Hans Wedel,&nbsp;Lars Wilhelmsen,&nbsp;Ian Graham","doi":"10.1097/HJR.0b013e32832b38a1","DOIUrl":"https://doi.org/10.1097/HJR.0b013e32832b38a1","url":null,"abstract":"<p><strong>Background: </strong>Options for the prevention of cardiovascular disease, the greatest global cause of death, include population preventive measures (the Rose approach), or specifically seeking out and managing high-risk cases. However, the likely benefit of a population approach has been recently questioned.</p><p><strong>Objective: </strong>To compare the estimated effects of population strategies at varying levels of population-wide risk factor reduction and high-risk strategies at varying rates of screening uptake on cardiovascular disease mortality.</p><p><strong>Methods: </strong>Data (of 109 954 participants) were pooled from six European general population cohort studies [the high-risk cohorts from the SCORE (Systematic COronary Risk Evaluation) dataset]. The effects of various population and high-risk strategies for the reduction of risk factors were estimated by calculating the change in 10-year risk of cardiovascular disease mortality (SCORE risk) before and after the particular intervention. Risk factors studied were: total cholesterol, blood pressure and smoking.</p><p><strong>Results: </strong>At population level, if a 10-year reduction of blood cholesterol level of 10%, a BP reduction of 10% and a 10% reduction in the prevalence of smoking is considered possible, then 9125 lives per million of the population would be saved over 10 years. In contrast, an approach that treats all high-risk individuals with a polypill containing statin, three half-dose antihypertensives and aspirin, with a 20-80% uptake, would save 1861-7452 lives per million. However, the high-risk estimates are very optimistic, as their achievement would require complete compliance.</p><p><strong>Conclusion: </strong>High-risk and population strategies are complementary. These estimates of the benefits of each may be useful to health planners, when combined with their local knowledge. Recently, benefits of population strategies have been underestimated.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":" ","pages":"541-9"},"PeriodicalIF":0.0,"publicationDate":"2009-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/HJR.0b013e32832b38a1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40029766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderated Poster Session VI. Exercise Physiology","authors":"M. Polovina, M. Ostojic, V. Giga, T. Potpara, N. Mujović, M. Grujić, S. Mutikainen, M. Alen, T. Leskinen, J. Karjalainen, T. Rantanen, J. Kaprio, U. Kujala, M. Angevaren, L. Vanhees, A. Nooyens, W. Wendel-Vos, W. Verschuren, G. Slavich, D. Tuniz, R. Fregolent, P. Mapelli, M. Slavich","doi":"10.1177/17418267090160s113","DOIUrl":"https://doi.org/10.1177/17418267090160s113","url":null,"abstract":"M428 Relationship of self-reported habitual physical activity and brachial artery flowmediated dilation in healthy adults M Polovina, M Ostojic, V Giga, T Potpara, N Mujovic, M Grujic Institute for Cardiovascular Diseases, Belgrade, Serbia Topic: Physical activity Background: Exercise training improves endothelial function in adults with increased cardiovascular risk. The influence of leisure-time physical activity on endothelial function in healthy grown-up individuals is less well established. Methods: We analysed association of self-reported daily habitual physical activity with brachial artery flow-mediated dilation (FMD) in 115 healthy individuals (age: 21 to 67 yrs, 55 male). Based on self-reported habitual physical activity, participants were divided in 2 subgroups ’ Subgroup 1 (n=59): 30 min of daily brisk walking recreational sports (jogging, bicycling, swimming’Î) and Subgroup 2 (n=56): sedentary individuals (<30 min of daily physical activity). Maximal FMD value (FMD%) and FMD time-course (time to the maximal endotheliumdependent dilation) were determined using high-resolution vascular ultrasound, with offline measurements of brachial artery diameter every 10 seconds, 0 to 240 seconds after cuff release. Results: Physically active individuals achieved maximal endothelium dependent dilation faster than sedentary individuals (Subgroup 1: 59.5 11.2 seconds versus Subgroup 2: 82.7 16.7 seconds, p<0.001), and their maximal FMD% was higher (Subgroup 1: 7.3 2.9% versus Subgroup 2: 5.7 2.3%, p=0.001). In the multivariate analysis of the whole group, after adjustments for age, sex, brachial artery diameter, body mass index, total serum cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, serum creatinine, glucose, high-sensitivity C-reactive protein, systolic and diastolic blood pressure, heart rate, and smoking, physical activity emerged as a multivariate determinant of both FMD time-course (b=-12.03, p<0.001), and FMD% (b=0.96, p=0.023). Conclusions: Habitual physical activity is associated with faster endothelium-dependent dilation, and augmented FMD response, independent of other factors. Regular leisure-time physical activity has beneficial effects on endothelial function in healthy adults.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"S91 - S93"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65490860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young Investigators' Award Session","authors":"Zy Yin, L. Wei, H-C Wang, M. Sandri, S. Gielen, N. Mangner, R. Hoellriegel, S. Erbs, A. Linke, -. SMoebius, Winkler, G. Schuler, J. Rawlins, F. Carré, M. Papadakis, C. Edwards, N. Chandra, S. Sharma, A. Egger, J. Niebauer","doi":"10.1177/17418267090160s117","DOIUrl":"https://doi.org/10.1177/17418267090160s117","url":null,"abstract":"O576 Cardiac microvascular dysfunction in diabetes and insulin treatment: Role of glucoseinduced PKC-BII activity ZY Yin, LP Wei, HC Wang Xijing Hospital, Xi’an, China, People’s Republic of Topic: Heart disease Purpose: Diabetes mellitus is an independent risk factor for cardiovascular disease and little attention is addressed on PKC-bII in cardiac microvascular dysfunction. Methods: In animal experiment, normal Sprague-Dawley rat, streptozotocin-induced diabetic rat, insulin-treated and physiological saline-treated diabetic rat were administrated with a serial of evaluations including pressure measurements, angiogenesis and permeability observations under electron microscope, histopathologic analysis for cardiac microvascular endothelium cell (CMECs), TUNEL, and Western blotting for PKC-bII. In cell research part, CMECs in four different mediums (normal medium, high-glucose concentration medium, insulin-stimulated and physiological saline-stimulated high-glucose medium) were investigated with MTT, apoptosis, quantitative permeability assessment and Western blotting. Results: 1. Accompanied with more active expression of PKC-bII and higher apoptosis rate in diabetic model, either increased microvascular permeability or pathological angiogenesis is observed, and which is attenuated in certain extent while receiving insulin treatment. 2. Accordant results from cell research were obtained. Compared with normal group, CMECs in high-glucose medium are demonstrated with poor proliferation, more notable apoptosis, increased permeability of cell monolayer, and augmented PKC-bII expression. Insulin-stimulated group poses a midst performance between normal and high-glucose group. Conclusions: Increased PKC-bII activity has been implicated responsible for the pathogenesis of cardiac microvascular dysfunction in diabetes and elevated glucose is sufficient to induce these effects. PKC-bII is indicated to occupy an important position in the whole process of insulin treatment.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"S121 - S122"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Session I Risk factors: from population to PCI","authors":"T. Aspelund, V. Gudnason, B. Magnúsdóttir, K. Andersen, G. Sigurdsson, -. JCritch, Ley, M. O’Flaherty, S. Capewell, B. Jefferis, DALawlor, S. Ebrahim, SGWannamethee, D. Cook, P. Whincup, U. Toft, C. Pisinger, M. Aadahl, T. Jørgensen, L. Yan, L. Thijs, J. Boggia, C. T. Pedersen, J. Jeppesen, H. Ibsen, Ja, Staessen","doi":"10.1177/17418267090160s108","DOIUrl":"https://doi.org/10.1177/17418267090160s108","url":null,"abstract":"O379 Explaining the massive declines in coronary heart disease mortality rates in Iceland, 1981 2006 T Aspelund, V Gudnason, B Magnusdottir, K Andersen, G Sigurdsson, J Critchley, M O’Flaherty, S Capewell Icelandic Heart Association, Kopavogur, Iceland, Unversity of Iceland, Reykjavik, Iceland, University Hospital, Reykjavik, Iceland, University of Newcastle, Newcasle, United Kingdom, University of Liverpool, Liverpool, United Kingdom Topic: Cardiovascular epidemiology Background: coronary heart disease mortality rates have been decreasing in Iceland since the 1980s. We used the validated IMPACT model to examine how much of the decrease in Iceland between 1981 and 2006 could be attributed to medical and surgical treatments and how much to changes in cardiovascular risk factors. Methods: the previously validated IMPACT mortality model was used to combine and analyse data on uptake and effectiveness of cardiological treatments and risk factor trends in the entire Iceland population. The main data sources were official statistics, national quality registers, published trials and meta-analyses, clinical audits and a series of national population surveys. Sensitivity analyses were then conducted. Results: between 1981 and 2006, coronary heart disease mortality rates in Iceland decreased by 80% in men and women aged 25 to 74 years. This fall resulted in 295 fewer deaths in 2006. Approximately one quarter of this decrease was attributable to treatments in individuals (including some 7% to secondary prevention, 6% to heart failure treatments, 5% to initial treatments of acute coronary syndrome, and 1% to hypertension treatments). Approximately three quarters of the mortality decrease was attributable to population risk factor reductions (principally cholesterol, 36%; smoking, 20%; systolic bloodpressure, 25% and physical activity, 5%). Adverse trends were seen for diabetes (-5%), and obesity (-4%). Conclusions: approximately three quarters of the large coronary heart disease mortality decrease in Iceland between 1981 and 2006 was attributable to reductions in major cardiovascular risk factors in population, (mainly decreases in total serum cholesterol, smoking and bloodpressure levels). These findings emphasise the value of a comprehensive strategy that promotes tobacco control and a healthier diet. It also highlights the potential importance of effective, evidence based medical treatments.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"S80 - S81"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}