European Journal of Cardiovascular Prevention & Rehabilitation最新文献

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Carotid intima–media thickness: a suitable alternative for cardiovascular risk as outcome? 颈动脉内膜-中膜厚度:心血管风险作为预后的合适选择?
European Journal of Cardiovascular Prevention & Rehabilitation Pub Date : 2011-04-01 DOI: 10.1177/1741826710389400
Sanne A E Peters, Diederick E Grobbee, Michiel L Bots
{"title":"Carotid intima–media thickness: a suitable alternative for cardiovascular risk as outcome?","authors":"Sanne A E Peters,&nbsp;Diederick E Grobbee,&nbsp;Michiel L Bots","doi":"10.1177/1741826710389400","DOIUrl":"https://doi.org/10.1177/1741826710389400","url":null,"abstract":"<p><strong>Background: </strong>Surrogate markers for cardiovascular disease might be of great value in observational research, clinical trials, and clinical practice. Carotid intima-media thickness (CIMT) is probably the most commonly used marker for atherosclerotic disease as an alternative for cardiovascular morbidity and mortality. A suitable marker for atherosclerosis, however, should meet several criteria before it can be validly used.</p><p><strong>Methods and results: </strong>We reviewed the literature following a set of criteria for a surrogate marker. These include a comparison with a 'gold standard'; adequate reproducibility; cross-sectional relations with established risk factors and prevalent disease; relations with severity of atherosclerosis elsewhere in the arterial system; relations with the occurrence with future events; ability for a biomarker to change over time; ability to be affected by interventions over time; and relations between change over time in biomarker level and change in risk. A large number of studies from a variety of populations provide evidence for the validity of CIMT as a suitable measure of atherosclerotic disease. Data on the relation between change in CIMT and change in risk, however, is much sparser.</p><p><strong>Conclusion: </strong>CIMT progression meets the criteria of a surrogate for cardiovascular disease endpoints and may be considered as a valid alternative for cardiovascular events as outcome. Further studies should examine the association between changes in CIMT and changes in risk for future events.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29879213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 87
Prevention of coronary heart disease in primary medical care in Poland: results from the LIPIDOGRAM study. 在波兰初级医疗保健中预防冠心病:血脂图研究的结果
European Journal of Cardiovascular Prevention & Rehabilitation Pub Date : 2011-04-01 Epub Date: 2011-01-31 DOI: 10.1177/1741826710389366
Tomasz Tomasik, Jacek Jozwiak, Adam Windak, Katarzyna Rygiel, Miroslaw Mastej, W Henry Smithson, Nigel Mathers, Maciej Tomaszewski, Bernhard M Kaess, Andrzej Tykarski, Ewa Konduracka, Wladyslaw Grzeszczak, Witold Lukas
{"title":"Prevention of coronary heart disease in primary medical care in Poland: results from the LIPIDOGRAM study.","authors":"Tomasz Tomasik,&nbsp;Jacek Jozwiak,&nbsp;Adam Windak,&nbsp;Katarzyna Rygiel,&nbsp;Miroslaw Mastej,&nbsp;W Henry Smithson,&nbsp;Nigel Mathers,&nbsp;Maciej Tomaszewski,&nbsp;Bernhard M Kaess,&nbsp;Andrzej Tykarski,&nbsp;Ewa Konduracka,&nbsp;Wladyslaw Grzeszczak,&nbsp;Witold Lukas","doi":"10.1177/1741826710389366","DOIUrl":"https://doi.org/10.1177/1741826710389366","url":null,"abstract":"<p><strong>Aims: </strong>To determine: (1) achievement of cholesterol therapy goals in patients receiving lipid-lowering drugs in Polish primary care between the years 2004 and 2006; (2) the characteristics of patients that are associated with attainment of these goals.</p><p><strong>Design: </strong>Cross-sectional study in randomly selected Polish primary care practices.</p><p><strong>Method: </strong>5248 patients aged over 30 years in 2004 and 5386 patients in 2006, who were taking cholesterol-lowering treatment took part in the study. Physicians recorded demographic and medical history data using a standardized questionnaire, including weight and height, and collected blood samples of patients to determine their cholesterol level.</p><p><strong>Results: </strong>18.5% of patients attained their optimal goals of therapy (total cholesterol, TC; low-density lipoprotein cholesterol, LDL-C) in 2004 compared to 25.2% in 2006 (p < 0.001). In both 2004 and 2006, more patients achieved their target levels for LDL-C than for TC and statins were the most commonly used medication (85% and 91%, respectively). Male sex, smoking, and higher education were the strongest correlates of the therapeutic outcome. The odds ratio of achieving cholesterol therapy goals in men, non-smokers, and university graduates was estimated at 1.51, 0.70, 1.38 in 2004 and 1.50, 0.73, 1.34 in 2006, respectively.</p><p><strong>Conclusion: </strong>There was a measurable improvement in the effectiveness of hypercholesterolaemia treatment between 2004 and 2006 but the majority of patients remain inadequately treated, with goals not being achieved. There is a need to raise the standard of lipid-lowering management in Poland.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389366","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29779840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Decreasing systolic blood pressure and declining mortality rates in an untreated population: results from the Copenhagen City Heart Study. 在未经治疗的人群中收缩压降低和死亡率下降:来自哥本哈根市心脏研究的结果
European Journal of Cardiovascular Prevention & Rehabilitation Pub Date : 2011-04-01 Epub Date: 2011-02-11 DOI: 10.1177/1741826710389355
Ulla O Andersen, Jacob L Marott, Gorm B Jensen
{"title":"Decreasing systolic blood pressure and declining mortality rates in an untreated population: results from the Copenhagen City Heart Study.","authors":"Ulla O Andersen,&nbsp;Jacob L Marott,&nbsp;Gorm B Jensen","doi":"10.1177/1741826710389355","DOIUrl":"https://doi.org/10.1177/1741826710389355","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the present study was to evaluate developments in 30 years mortality risk that may be associated with developments in population systolic blood pressure (SBP) and to evaluate possible secular trends in BP-associated mortality risk in the untreated population.</p><p><strong>Design: </strong>The Copenhagen City Heart Study is a prospective longitudinal epidemiological study. The present analysis comprised participants from survey 1 (1976-78) and 3 (1991-94).</p><p><strong>Methods: </strong>BP measurements and other methods were fully standardized and unchanged throughout the observation period. Questionnaires were completed by the participants and double checked by the technicians while they were interviewing the participants.</p><p><strong>Results: </strong>18 077 persons participated. Age, systolic BP, diastolic BP, cholesterol, BMI, diabetes, gender and habitual physical activity were significant predictors of all-cause death in all age groups. Risk factor adjusted risk for all-cause death was significantly lower in survey 3 compared with survey 1. Among elderly people, there was no development in mortality risk. In the age groups 40-49 years and 50-59 years there were survey differences indicating a significant trend towards longer life expectancy compared with their age-matched counterparts in survey 1. The association between BP and mortality remained unchanged.</p><p><strong>Conclusion: </strong>A declining risk of all-cause death was observed in the younger and middle-aged cohorts of the population. The decrease in systolic BP and decline in mortality risk in the same age groups points to a role of systolic BP in age-cohort differentiated improvements of life expectancy. The effect of systolic BP on mortality did not change during follow-up.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389355","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29779938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
LDL cholesterol goals and cardiovascular risk during statin treatment: the IDEAL study. 他汀类药物治疗期间LDL胆固醇目标和心血管风险:IDEAL研究
European Journal of Cardiovascular Prevention & Rehabilitation Pub Date : 2011-04-01 Epub Date: 2011-02-08 DOI: 10.1177/1741826710389391
Anders G Olsson, Christina Lindahl, Ingar Holme, Rana Fayyad, Ole Faergeman, John J P Kastelein, Matti J Tikkanen, Mogens Lytken Larsen, Terje R Pedersen
{"title":"LDL cholesterol goals and cardiovascular risk during statin treatment: the IDEAL study.","authors":"Anders G Olsson,&nbsp;Christina Lindahl,&nbsp;Ingar Holme,&nbsp;Rana Fayyad,&nbsp;Ole Faergeman,&nbsp;John J P Kastelein,&nbsp;Matti J Tikkanen,&nbsp;Mogens Lytken Larsen,&nbsp;Terje R Pedersen","doi":"10.1177/1741826710389391","DOIUrl":"https://doi.org/10.1177/1741826710389391","url":null,"abstract":"<p><strong>Aims: </strong>We assessed the proportion of patients treated with either simvastatin 20 or 40 mg or atorvastatin 80 mg who achieved low-density lipoprotein cholesterol (LDL-C) goals of 2.5 or 2.0 mmol/l in the Incremental Decrease in End Points Through Aggressive Lipid Lowering (IDEAL) study. We explored how lipoprotein components related to cardiovascular disease (CVD) outcomes in these groups.</p><p><strong>Methods and results: </strong>For subjects who reached on-treatment LDL-C goals, Cox regression models were used to assess the ability of lipoprotein components to predict CVD events. Treatment with simvastatin or atorvastatin resulted in 40 per cent and 80 per cent of patients, respectively, reaching the 2.5 mmol/l goal and 12 per cent and 52 per cent, respectively, reaching the 2.0 mmol/l goal, after 1 year (all p < 0.001 between groups). Adjusting for baseline LDL-C levels, hazard ratio (HR) for those reaching 2.0-2.5 mmol/l LDL-C versus those reaching <2.0 mmol/l was 1.16 (95% confidence interval [CI], 1.02-1.33, p = 0.023). An increase of the apolipoprotein B/A1 (apoB/A1) ratio by 1 standard deviation in participants who reached 2.0 mmol/l showed a HR for CVD of 1.14 (95% CI, 1.04-1.25, p = 0.004).</p><p><strong>Conclusion: </strong>More CVD patients treated with atorvastatin than simvastatin achieved either LDL-C goal and those reaching the 2.0 mmol/l goal exhibited significantly less CVD than those only reaching 2.5 mmol/l. In those reaching the 2.0 mmol/l goal, the apoB/A1 ratio still bears a relation to CVD outcome. The use of apoB/A1 ratio may provide additional predictive value to that of LDL-C.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389391","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29779940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
A comparison of home and hospital-based exercise training in heart failure: immediate and long-term effects upon physical activity level. 家庭和医院运动训练治疗心力衰竭的比较:对身体活动水平的近期和长期影响
European Journal of Cardiovascular Prevention & Rehabilitation Pub Date : 2011-04-01 Epub Date: 2011-02-18 DOI: 10.1177/1741826710389389
Aynsley Cowie, Morag K Thow, Malcolm H Granat, Sarah L Mitchell
{"title":"A comparison of home and hospital-based exercise training in heart failure: immediate and long-term effects upon physical activity level.","authors":"Aynsley Cowie,&nbsp;Morag K Thow,&nbsp;Malcolm H Granat,&nbsp;Sarah L Mitchell","doi":"10.1177/1741826710389389","DOIUrl":"https://doi.org/10.1177/1741826710389389","url":null,"abstract":"<p><strong>Background: </strong>In heart failure, reduced physical activity level can adversely affect physical and psychosocial functioning. No previous heart failure research has compared effects of home and hospital-based exercise training upon physical activity level, or has objectively assessed their long-term effects upon physical activity. This study used an activPAL™ monitor to examine immediate and long-term effects of home and hospital-based aerobic exercise training upon physical activity level.</p><p><strong>Design: </strong>Randomized controlled trial.</p><p><strong>Methods: </strong>Sixty patients with heart failure (mean age 66 years; NYHA class II/III; 51 male/9 female) were randomized to home training, hospital training or control. Both programmes consisted of aerobic circuit training, undertaken twice a week for one hour, for eight weeks. All participants wore the activPAL™ at baseline, and after eight weeks, for one week. Six months after cessation of training, a subgroup of participants from the home and hospital training groups (n = 10 from each group) wore the activPAL™ for a further week.</p><p><strong>Results: </strong>Hospital-based training significantly increased steps taken per day during 'extra long' (P = 0.04) and 'long' (P = 0.01) walks. Neither programme had any immediate effect upon physical activity level otherwise. Though daily upright duration for the home group significantly improved six months after cessation of training (P = 0.02), generally physical activity level was maintained in the long term for both training groups.</p><p><strong>Conclusions: </strong>Hospital-based training enabled participants to walk for longer periods. It is clinically important that both training groups maintained physical activity level in the long term, given the potential for heart failure to worsen over this time period.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29781521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 57
Maximal exercise, limb ischemia, and endothelial progenitor cells. 最大运动,肢体缺血和内皮祖细胞。
European Journal of Cardiovascular Prevention & Rehabilitation Pub Date : 2011-02-01 DOI: 10.1097/HJR.0b013e32833ba654
Marcus Sandri, Ephraim Bernhard Beck, Volker Adams, Stephan Gielen, Karsten Lenk, Robert Höllriegel, Norman Mangner, Axel Linke, Sandra Erbs, Sven Möbius-Winkler, Dierk Scheinert, Rainer Hambrecht, Gerhard Schuler
{"title":"Maximal exercise, limb ischemia, and endothelial progenitor cells.","authors":"Marcus Sandri,&nbsp;Ephraim Bernhard Beck,&nbsp;Volker Adams,&nbsp;Stephan Gielen,&nbsp;Karsten Lenk,&nbsp;Robert Höllriegel,&nbsp;Norman Mangner,&nbsp;Axel Linke,&nbsp;Sandra Erbs,&nbsp;Sven Möbius-Winkler,&nbsp;Dierk Scheinert,&nbsp;Rainer Hambrecht,&nbsp;Gerhard Schuler","doi":"10.1097/HJR.0b013e32833ba654","DOIUrl":"https://doi.org/10.1097/HJR.0b013e32833ba654","url":null,"abstract":"<p><strong>Objectives: </strong>The concept of neovascularization in response to tissue ischemia was recently extended by the finding of postnatal vasculogenesis through circulating endothelial progenitor cells (EPCs). The aim of this study was to assess the role of acute ischemia for EPC mobilization in patients with peripheral arterial occlusive disease (PAOD) and in healthy volunteers.</p><p><strong>Methods: </strong>The number of circulating EPCs was analyzed by flow cytometry in PAOD patients (n = 23) with exercise-induced limb ischemia for up to 72 h after a maximal treadmill test and in healthy volunteers (n = 17) who underwent a 15-min suprasystolic occlusion of one lower extremity to induce limb ischemia. Plasma concentrations of vascular endothelial growth factor, basic fibroblast growth factor, tumor necrosis factor-α, and granulocyte macrophage-colony stimulating factor were determined by ELISA.</p><p><strong>Results: </strong>EPCs (CD 34 pos/KDRpos) increased significantly in both PAOD patients from 82 ± 20 to 256 ± 52 (P < 0.05) and healthy volunteers from 144 ± 39 to 590 ± 61 cells per 1 million events (P < 0.05) in response to induced ischemia, with a maximum after 24 h and returned to baseline within 72 h. The relative increase in EPC numbers was significantly lower in patients with PAOD as compared with healthy volunteers (P < 0.05). Plasma levels of vascular endothelial growth factor increased from 27.4 ± 3.1 to 126.4 ± 12 pg/ml in patients with PAOD (P < 0.05) and from 30.7 ± 6.1 to 134.1 ± 12.4 pg/ml in healthy volunteers (P < 0.05).</p><p><strong>Conclusion: </strong>Both patients with symptomatic PAOD and healthy volunteers respond to a single episode of limb ischemia with a time-dependent increase in circulating EPCs. The increase of EPC numbers in response to ischemia is reduced when vascular disease is present, underlining the reduced vasculogenic potential of patients with PAOD.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/HJR.0b013e32833ba654","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29074967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
Aerobic exercise training intensity in patients with chronic heart failure: principles of assessment and prescription. 慢性心力衰竭患者有氧运动训练强度:评估原则及处方。
European Journal of Cardiovascular Prevention & Rehabilitation Pub Date : 2011-02-01 DOI: 10.1097/HJR.0b013e32833a9c63
Vitor Oliveira Carvalho, Alessandro Mezzani
{"title":"Aerobic exercise training intensity in patients with chronic heart failure: principles of assessment and prescription.","authors":"Vitor Oliveira Carvalho,&nbsp;Alessandro Mezzani","doi":"10.1097/HJR.0b013e32833a9c63","DOIUrl":"https://doi.org/10.1097/HJR.0b013e32833a9c63","url":null,"abstract":"<p><p>Chronic heart failure (CHF) is a significant cause of worldwide mortality and morbidity, whose clinical picture is characterized by exercise intolerance and impaired quality of life. Aerobic exercise training is a well-established nonpharmacological tool improving the CHF’s pathophysiological, clinical, and prognostic picture, and prescription of an adequate training intensity is crucial to obtain both exercise-induced benefits and a reasonable control of exercise-related risk. However, clarity is still lacking regarding the definition of exercise intensity domains and the lower and upper intensity limits of prescriptible aerobic exercise in CHF patients. The purpose of this review is to provide an update of the methods for the exercise intensity assessment and continuous aerobic training intensity prescription in the CHF population, furnishing indications useful for implementation of physical rehabilitation programs in these patients.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/HJR.0b013e32833a9c63","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28992428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 70
Low-dose acetylsalicylic acid and blood pressure control in drug-treated hypertensive patients. 低剂量乙酰水杨酸与药物治疗高血压患者血压控制。
European Journal of Cardiovascular Prevention & Rehabilitation Pub Date : 2011-02-01 DOI: 10.1097/HJR.0b013e32833ace3a
Veli-Matti Leinonen, Juha Varis, Risto Vesalainen, Johanna Päivärinta, Minna Sillanpää, Ilkka Kantola
{"title":"Low-dose acetylsalicylic acid and blood pressure control in drug-treated hypertensive patients.","authors":"Veli-Matti Leinonen,&nbsp;Juha Varis,&nbsp;Risto Vesalainen,&nbsp;Johanna Päivärinta,&nbsp;Minna Sillanpää,&nbsp;Ilkka Kantola","doi":"10.1097/HJR.0b013e32833ace3a","DOIUrl":"https://doi.org/10.1097/HJR.0b013e32833ace3a","url":null,"abstract":"<p><strong>Background: </strong>Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase blood pressure (BP) and potentially reduce the efficacy of several antihypertensive drugs. We evaluated the effect of low-dose acetylsalicylic acid (ASA) on BP control in drug-treated hypertensive patients in a primary care population.</p><p><strong>Design/methods: </strong>Nine hundred and five successive patients aged 25–91 years (mean 65.5 years) from 15 health centers in south-west Finland were studied. The patients were on antihypertensive monotherapy (45.7%) or on combination therapy (54.3%). Office BP was measured twice with a 2-min interval after at least a 10-min rest using an ordinary sphygmomanometer.</p><p><strong>Results: </strong>Patients receiving ASA (n = 246) showed lower diastolic BP (83.9 ± 9.0 vs. 87.0 ± 9.6 mmHg; P < 0.001) compared with those who were not using any NSAIDs (n = 659). No significant difference in systolic BP was observed between the groups. As a result, pulse pressure was slightly higher in the ASA group (66.9 ± 18.9 vs. 63.3 ± 17.7 mmHg, P = 0.01). Mean arterial pressure was lower in the ASA group (106.2 ± 10.6 vs. 108.1 ± 10.4 mmHg, P = 0.02). In a stepwise linear multivariate model, ASA remained a significant predictor of lower diastolic BP even after the adjustment with the confounding effects of age and sex.</p><p><strong>Conclusion: </strong>According to our population-based study low-dose ASA does not have deleterious effects on BP control in drug-treated hypertensive patients.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/HJR.0b013e32833ace3a","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29016239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia. 低总睾酮浓度与不良血脂和增加的血脂异常事件的前瞻性关联。
European Journal of Cardiovascular Prevention & Rehabilitation Pub Date : 2011-02-01 DOI: 10.1097/HJR.0b013e32833c1a8d
Robin Haring, Sebastian E Baumeister, Henry Völzke, Marcus Dörr, Stephan B Felix, Heyo K Kroemer, Matthias Nauck, Henri Wallaschofski
{"title":"Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia.","authors":"Robin Haring,&nbsp;Sebastian E Baumeister,&nbsp;Henry Völzke,&nbsp;Marcus Dörr,&nbsp;Stephan B Felix,&nbsp;Heyo K Kroemer,&nbsp;Matthias Nauck,&nbsp;Henri Wallaschofski","doi":"10.1097/HJR.0b013e32833c1a8d","DOIUrl":"https://doi.org/10.1097/HJR.0b013e32833c1a8d","url":null,"abstract":"<p><strong>Background: </strong>Earlier studies have suggested that total testosterone concentrations influence the lipid metabolism. Whether these concentrations are prospectively associated with an adverse lipid profile and an increased risk of incident dyslipidemia has not yet been investigated.</p><p><strong>Methods and results: </strong>Our study population consisted of 1468 men, aged 20–79 years, who were repeatedly examined as part of the population-based Study of Health in Pomerania. Serum total testosterone concentrations measured by the chemiluminescent enzyme immunoassays were categorized into age-specific quartiles. We used generalized estimating equations models to assess the prospective association between total testosterone concentrations and lipid profile components including total cholesterol (TC), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride (TG) concentrations, as well as incident dyslipidemia after 5 years of follow-up. Multivariate models revealed that total testosterone concentrations in the lowest quartile were associated with higher TC and TG concentrations in both cross-sectional [TC: 0.23 mmol/l (95% confidence interval, CI, 0.02–0.42); TG: 0.73 mmol/l (95% CI, 0.53–0.94)] and longitudinal analyses [TC: 0.20 mmol/l (95% CI, 0.03–0.27); TG: 0.62 mmol/l (95% CI, 0.43–0.80)], but not with high-density lipoprotein cholesterol or low-density lipoprotein cholesterol concentrations. Baseline prevalence of dyslipidemia was 57.1% with a crude incidence rate of 46.6 per 1000 person-years. Total testosterone concentrations in the lowest quartile predicted dyslipidemia; age-adjusted relative risks (RR) for men in quartiles 1, 2, and 3 as compared to quartile 4 (highest, reference) were 1.28 (95% CI, 1.06–1.54), 1.10 (95% CI, 0.91–1.33), and 1.05 (95% CI, 0.86–1.29), respectively. This effect was particularly strong among men aged 20–39 years (relative risk, 1.51; 95% CI, 1.08–2.10).</p><p><strong>Conclusion: </strong>Low total testosterone concentrations are prospectively associated with an adverse lipid profile and increased risk of incident dyslipidemia. These findings are particularly interesting and may contribute to an explanation for the higher cardiovascular disease risk in men with lower total testosterone concentrations.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/HJR.0b013e32833c1a8d","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29067427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 78
Behavioural interventions to increase the physical activity of cardiac patients: a review. 增加心脏病患者身体活动的行为干预:综述。
European Journal of Cardiovascular Prevention & Rehabilitation Pub Date : 2011-02-01 DOI: 10.1097/HJR.0b013e32833ace0e
Suzanne Ferrier, Chris M Blanchard, Michael Vallis, Nicholas Giacomantonio
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引用次数: 93
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