European Journal of Internal Medicine最新文献

{"title":"When inflammatory bowel disease meets pregnancy","authors":"Shiqing Zhao ,&nbsp;Shengpu Zhou ,&nbsp;Junmei Wang ,&nbsp;Yanyan Shi","doi":"10.1016/j.ejim.2025.06.014","DOIUrl":"10.1016/j.ejim.2025.06.014","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD) is a group of chronic and relapsing inflammatory conditions that affect the gastrointestinal tract. Women of reproductive age comprise a significant proportion of patients with IBD. The management of IBD during pregnancy presents unique and complex challenges that have garnered increasing attention recently. Moreover, considerable attention has been directly toward the safety of novel treatments for IBD during pregnancy. This review summarises the complex interaction between pregnancy and IBD, the special management of IBD during pregnancy, and the effects of early life events on IBD of offspring.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106385"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of uric acid levels in heart failure with mildly reduced ejection fraction: Insights from a large retrospective registry","authors":"Alexander Schmitt ,&nbsp;Michael Behnes ,&nbsp;Thomas Bertsch ,&nbsp;Marielen Reinhardt ,&nbsp;Michelle Goertz ,&nbsp;Noah Abel ,&nbsp;Felix Lau ,&nbsp;Kathrin Weidner ,&nbsp;Jonas Dudda ,&nbsp;Henning Johann Steffen ,&nbsp;Mohammad Abumayyaleh ,&nbsp;Daniel Duerschmied ,&nbsp;Ibrahim Akin ,&nbsp;Tobias Schupp","doi":"10.1016/j.ejim.2025.06.033","DOIUrl":"10.1016/j.ejim.2025.06.033","url":null,"abstract":"<div><h3>Background</h3><div>Elevated uric acid (UA) is a recognized biomarker in patients with cardiovascular disease. However, the prognostic significance of UA levels in patients with heart failure (HF), particularly those with HF with mildly reduced ejection fraction (HFmrEF), remains unexplored.</div></div><div><h3>Methods</h3><div>From 2016 to 2022, consecutive patients hospitalized with HFmrEF at one medical centre were retrospectively included. Patients were stratified by pre-specified UA levels (i.e., normal UA: ≥3.5 - ≤6.0 (females) or ≤7.0 (males); low UA: &lt;3.5 and high UA: &gt;6.0 (females) or &gt;7.0 mg/dL (males)), further stratification was performed by UA quintiles. The primary endpoint was all-cause mortality at 30 months (median follow-up), the key secondary endpoint was HF-related rehospitalization.</div></div><div><h3>Results</h3><div>The study cohort comprised 1419 HFmrEF patients with a median UA of 6.0mg/dL. UA levels above (H) and below (L) the normal range (N) were predictive for the risk of all-cause mortality at 30 months (H: 42 % and L: 43 % vs. N: 27 %), which persisted after multivariable adjustments (H vs N: HR=1.230; 95 % CI 1.003–1.508; <em>p</em> = 0.046; L vs N: HR=1.915; 95 % CI 1.383–2.650; <em>p</em> = 0.001). Furthermore, there was a trend towards a higher risk of long-term HF-related rehospitalization in patients with elevated UA levels (H: 20 % vs. N: 9 % vs. L: 8 %). However, this finding failed to reach statistical significance after multivariable adjustment (H vs. N: HR=1.408; 95 % CI 0.995–1.992; <em>p</em> = 0.053).</div></div><div><h3>Conclusion</h3><div>Both elevated and low UA levels were associated with an increased risk of long-term all-cause mortality in patients with HFmrEF.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106404"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic valve calcification as a novel risk marker for kidney function deterioration: insights from the MESA study","authors":"Danqing Hu ,&nbsp;Jiaojiao Fan ,&nbsp;Wei Zhou","doi":"10.1016/j.ejim.2025.106495","DOIUrl":"10.1016/j.ejim.2025.106495","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106495"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonarteritic anterior ischemic optic neuropathy and glucagon-like peptide-1 receptor agonists: Evaluating a potential association","authors":"Laşin Özbek ,&nbsp;Mustafa Güldan ,&nbsp;Derya G. Fidan ,&nbsp;Sama Mahmoud Abdel-Rahman ,&nbsp;Mehmet Kanbay","doi":"10.1016/j.ejim.2025.05.011","DOIUrl":"10.1016/j.ejim.2025.05.011","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106346"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-related differences in the management and outcome of intubated adults with community-acquired pneumonia in Europe: A multicentre study","authors":"Nicolas Garin ,&nbsp;Despoina Koulenti ,&nbsp;Virginie Prendki ,&nbsp;Jordi Rello","doi":"10.1016/j.ejim.2025.06.024","DOIUrl":"10.1016/j.ejim.2025.06.024","url":null,"abstract":"<div><h3>Aims</h3><div>To explore differences between sexes in the prognosis of severe community-acquired pneumonia.</div></div><div><h3>Methods</h3><div>We analysed consecutive patients admitted to 27 intensive care units (ICU) from nine European countries and included in the EU-VAP/CAP cohort. All were mechanically ventilated for severe CAP. Sex was obtained from the medical records. Sexes were compared according to age, severity of illness, chronic health condition, co-morbidities, use of diagnostic procedures, length of mechanical ventilation, stay in the ICU, initial antibiotic treatment, and pathogens. The primary outcome was ICU mortality. We tested in a multivariate logistic regression the association of sex with mortality.</div></div><div><h3>Results</h3><div>We included 257 patients (32 % women; mean age 60.5 years). Mean SAPS II score was 48.6 and 125 patients (50.6 %) were in septic shock, without difference between sexes. Women had more frequently a McCabe score of 0 (61 % vs. 51 % of men, <em>p</em> = 0.13).</div><div>Bronchoscopy was performed in 39 % of men and 26 % of women (<em>p</em> = 0.04). Antibiotic treatment did not differ between sexes. A pathogen was identified in 47 % of patients.</div><div>101 patients (39.3 %) died: 35 % of men and 48 % of women (OR 0.59, 95 % CI 0.34–1.00). Male sex was associated with lower mortality (OR 0.42, 95 % CI 0.21–0.84) after adjusting for age, SAPS II score, McCabe score, and use of bronchoscopy.</div></div><div><h3>Conclusion</h3><div>Women mechanically ventilated at the ICU for severe CAP had higher mortality despite similar severity of disease and better chronic health. Bronchoscopy was performed more frequently in men suggesting differences in management between sexes.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106395"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking-induced “Scleroderma-like Pattern” and digital clubbing in a young adult","authors":"Angelo Nigro","doi":"10.1016/j.ejim.2025.07.023","DOIUrl":"10.1016/j.ejim.2025.07.023","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106427"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmeasured burdens in nonagenarian ICU survivors: A cohort-based perspective","authors":"JiaHao Shi","doi":"10.1016/j.ejim.2025.106454","DOIUrl":"10.1016/j.ejim.2025.106454","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106454"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing polymorbidity in chronic obstructive pulmonary disease: an opportunity to improve outcomes","authors":"David M. Mannino","doi":"10.1016/j.ejim.2025.106499","DOIUrl":"10.1016/j.ejim.2025.106499","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106499"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking atrial cardiomyopathy in middle-aged patients with AF: A call for early detection","authors":"A. Borizanova ,&nbsp;E. Kinova ,&nbsp;A. Goudev","doi":"10.1016/j.ejim.2025.05.021","DOIUrl":"10.1016/j.ejim.2025.05.021","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106356"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing unmet needs in the use of SGLT2 inhibitors in critical and acute care setting","authors":"Damiano D’Ardes ,&nbsp;Fabrizio Ricci ,&nbsp;Paola Simeone ,&nbsp;Andrea Boccatonda ,&nbsp;Francesca Santilli","doi":"10.1016/j.ejim.2025.06.003","DOIUrl":"10.1016/j.ejim.2025.06.003","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106374"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}