Maximilian Boesch , Florent Baty , Sanjay Kalra , Martin H. Brutsche , Frank Rassouli
{"title":"Chronicity of disease mandates quality-of-life prioritization – a role for digital health and patient-reported outcome measures","authors":"Maximilian Boesch , Florent Baty , Sanjay Kalra , Martin H. Brutsche , Frank Rassouli","doi":"10.1016/j.ejim.2025.03.006","DOIUrl":"10.1016/j.ejim.2025.03.006","url":null,"abstract":"<div><div>NA.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"135 ","pages":"Pages 1-4"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edoardo Pirera , Domenico Di Raimondo , Lucio D'Anna , Antonino Tuttolomondo
{"title":"Risk trajectory of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis","authors":"Edoardo Pirera , Domenico Di Raimondo , Lucio D'Anna , Antonino Tuttolomondo","doi":"10.1016/j.ejim.2025.01.016","DOIUrl":"10.1016/j.ejim.2025.01.016","url":null,"abstract":"<div><h3>Background</h3><div>Exacerbations of chronic obstructive pulmonary disease (COPD) are known to increase the risk of cardiovascular (CV) events and mortality. However, the temporal trend of this risk has not fully elucidated. This systematic review and meta-analysis aims to quantify the risk of CV events after COPD exacerbations over different time periods.</div></div><div><h3>Objectives</h3><div>To assess the temporal association between CV events, including acute coronary syndrome (ACS), heart failure (HF), acute cereberovascular events, arrhythmia and all-cause mortality after the onset of COPD exacerbations in the following timepoints: 1–30 and 31–180 days; 1–7, 8–14, 15–30, 31–180, 181–365 and >365 days.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted in PubMed, Embase, Web of Science and Cochrane databases, identifying observational studies that reported CV outcomes following COPD exacerbations. Studies were included if they enrolled adults diagnosed with COPD and compared CV event rates during exacerbation and non-exacerbation periods (PROSPERO, CRD42024561490).</div></div><div><h3>Results</h3><div>Sixteen studies with over 1.8 million participants were included. Our meta-analysis demonstrated a significantly increased risk of ACS, HF, cerebrovascular events and arrhythmia, with the highest magnitude of risk observed in the period 1–30 days following an exacerbation. This increased risk showed a decline in time points 31–180, 181–365 days and remained persistently higher for ACS even one year after an acute exacerbation. Notably, the risk of HF was found to be greater compared to the other CV outcomes.</div></div><div><h3>Conclusion</h3><div>COPD exacerbations significantly increase the risk of acute CV events, particularly within the first 30 days. Optimal strategies to reduce cardiopulmonary risk are needed.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"135 ","pages":"Pages 74-82"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Undiagnosed celiac disease. The conundrum of unveiling the dark side of the moon","authors":"Gino Roberto Corazza, Marco Vincenzo Lenti","doi":"10.1016/j.ejim.2025.03.036","DOIUrl":"10.1016/j.ejim.2025.03.036","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"135 ","pages":"Pages 33-35"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of “characteristics of familial mediterranean fever disease after 65 years of age”","authors":"Kazim Besirli","doi":"10.1016/j.ejim.2024.12.022","DOIUrl":"10.1016/j.ejim.2024.12.022","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"135 ","pages":"Page 158"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Camilla Cocchi , Maria Beatrice Zazzara , Elena Levati , Riccardo Calvani , Graziano Onder
{"title":"How to promote healthy aging across the life cycle","authors":"Camilla Cocchi , Maria Beatrice Zazzara , Elena Levati , Riccardo Calvani , Graziano Onder","doi":"10.1016/j.ejim.2025.03.003","DOIUrl":"10.1016/j.ejim.2025.03.003","url":null,"abstract":"<div><div>The global rise in aging populations is challenging healthcare systems, especially in developed countries. Despite advancements in healthcare and living standards, the extension of lifespan has not been matched by an equivalent improvement in healthspan, leading to a higher prevalence of chronic diseases and disabilities in older adults. This review examines strategies to promote healthy aging throughout the life cycle, emphasizing the importance of a comprehensive strategy that integrates individual, healthcare, and environmental approaches.</div><div>Individual strategies include lifestyle factors like diet, physical activity, and social connections. Healthcare approaches focus on improving health literacy, vaccinations, and screenings. Environmental approaches aim to mitigate climate change, reduce pollution, and design longevity-ready cities. A comprehensive strategy combining individual approaches, public health measures, innovative policies, and community support is essential for helping populations live longer, healthier, and more independent lives. Looking forward, this will be complemented by personalized approaches, focusing on individual traits and biological backgrounds. The key to this lies in geroscience, which studies the biological and molecular mechanisms of aging and how they contribute to age-related diseases and functional decline, aiming to design targeted interventions to slow aging and improve quality of life. Artificial intelligence will play a key role in analyzing these complex factors and creating innovative solutions.</div><div>In conclusion, aging is shaped by various factors, requiring more than one solution. A combination of comprehensive and personalized strategies can bridge the gap between public health measures and personalized care, offering the scientific insights needed to slow aging and enhance quality of life.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"135 ","pages":"Pages 5-13"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non-statistical significance and clinical relevance: Are we chasing shadows in the air pollution-peripheral artery disease debate?","authors":"Stephan Peronard Mayntz , Kasper Emil Rosenbech","doi":"10.1016/j.ejim.2025.02.024","DOIUrl":"10.1016/j.ejim.2025.02.024","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"135 ","pages":"Pages 145-146"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}