European Journal of Internal Medicine最新文献

{"title":"Insights into recurrence of hypertriglyceridemia-associated acute pancreatitis: Methodological challenges","authors":"","doi":"10.1016/j.ejim.2024.06.028","DOIUrl":"10.1016/j.ejim.2024.06.028","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"129 ","pages":"Page 154"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of cannabis use and body mass index–The Coronary Artery Risk Development in Young Adults (CARDIA) study","authors":"","doi":"10.1016/j.ejim.2024.07.007","DOIUrl":"10.1016/j.ejim.2024.07.007","url":null,"abstract":"<div><h3>Background</h3><div>With increasing use of cannabis, we need to know if cannabis use and Body Mass Index (BMI) are associated.</div></div><div><h3>Methods</h3><div>The Coronary Artery Risk Development in Young Adults Study followed Black and White adults over 30 years with assessments every 2 to 5 years in four centers in the USA. We assessed self-reported current and computed cumulative cannabis exposure at every visit, and studied associations with BMI, adjusted for relevant covariables in mixed longitudinal models. We also applied marginal structural models (MSM) accounting for the probability of having stopped cannabis over the last 5 years.</div></div><div><h3>Results</h3><div>At the Year 30 visit, 1,912 (58 %) identified as women and 1,600 (48 %) as Black, mean age was 56 (SD 2) years. While 2,849 (85 %) had ever used cannabis, 479 (14 %) currently used cannabis. Overall, participants contributed to 35,882 individual visits over 30 years. In multivariable adjusted models, mean BMI was significantly lower in daily cannabis users (26.6 kg/m², 95 %CI 26.3 to 27.0) than in participants without current use (27.7 kg/m², 95 %CI 27.5 to 27.9, <em>p</em> &lt; 0.001). Cumulative cannabis use was not associated with BMI. The MSM showed no change in BMI when stopping cannabis use over a 5-year period (β=0.2 kg/m² total, 95 %CI -0.2 to 0.6).</div></div><div><h3>Conclusions</h3><div>Current cannabis use was associated with lower BMI, but cumulative cannabis use and cessation were not. This suggests that recreational cannabis use may not lead to clinically relevant changes in BMI and that the association between current cannabis use and lower BMI is likely due to residual confounding.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"129 ","pages":"Pages 41-47"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma levels of myeloperoxidase and resistin independently predict mortality in dialysis patients","authors":"Luca Liberale ,&nbsp;Claudia Torino ,&nbsp;Patrizia Pizzini ,&nbsp;Sabrina Mezzatesta ,&nbsp;Graziella D'Arrigo ,&nbsp;Mercedes Gori ,&nbsp;Federico Carbone ,&nbsp;Elisa Schiavetta ,&nbsp;Valeria Cugno ,&nbsp;Mara Cabri ,&nbsp;Cosimo Sgura ,&nbsp;Elia Maioli ,&nbsp;Danielle Mbarga ,&nbsp;Gianluca Rubini ,&nbsp;Amedeo Tirandi ,&nbsp;Davide Ramoni ,&nbsp;Francesca Mallamaci ,&nbsp;Giovanni Tripepi ,&nbsp;Carmine Zoccali ,&nbsp;Fabrizio Montecucco","doi":"10.1016/j.ejim.2024.07.013","DOIUrl":"10.1016/j.ejim.2024.07.013","url":null,"abstract":"<div><h3>Background</h3><div>In patients with kidney failure (KF) undergoing dialysis, neutrophils are dysfunctionally activated. Such chronic activation does not correspond to increased protection against infections and is thought to cause direct vascular damage accounting for the higher incidence of cardiovascular (CV) events. We hypothesized that circulating levels of neutrophil degranulation products (i.e. myeloperoxidase (MPO) and resistin) can predict overall and CV-specific mortality in dialysis patients.</div></div><div><h3>Methods</h3><div>MPO and resistin levels were assessed in plasma samples from <em>n</em> = 1182 dialysis patients who were followed-up for median 2.9 years (IQR: 1.7–4.2).</div></div><div><h3>Results</h3><div>Patients were 65 ± 14 (SD) years old and 36 % women. Median value of MPO and resistin were 78 ng/mL (IQR: 54 - 123) and 72 ng/mL (IQR: 46 - 110), respectively. MPO and resistin levels correlated with biomarkers of organ damage, nutritional status and inflammation. Both MPO and resistin levels predicted all-cause mortality even after adjustment for traditional risk factors and inflammation, nutritional and KF-related indexes (MPO, HR_{for 1 ln unit increase}: 1.26, 95 %CI 1.11 – 1.42, <em>P</em> &lt; 0.001; Resistin, HR_{for 1 ln unit increase}: 1.25, 95 %CI 1.09 – 1.44, <em>P</em> = 0.001). Similarly, their predictive ability held true also for CV death (MPO, HR_{for 1 ln unit increase}: 1.19, 95 %CI 1.01 – 1.41, <em>P</em> = 0.04; Resistin, HR_{for 1 ln unit increase}: 1.29, 95 %CI 1.07 – 1.56, <em>P</em> = 0.007).</div></div><div><h3>Conclusion</h3><div>Plasma levels of MPO and resistin correlate with prospective overall and CV-specific mortality risk in KF patients undergoing dialysis and might be useful prognostic tools. Mediators of inflammation may be potential target to improve survival of those patients.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"129 ","pages":"Pages 87-92"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Door-to-antibiotic time and mortality in patients with sepsis: Systematic review and meta-analysis","authors":"Ling Yan Leung ,&nbsp;Hsi-Lan Huang ,&nbsp;Kevin KC Hung ,&nbsp;Chi Yan Leung ,&nbsp;Cherry CY Lam ,&nbsp;Ronson SL Lo ,&nbsp;Chun Yu Yeung ,&nbsp;Peter Joseph Tsoi ,&nbsp;Michael Lai ,&nbsp;Mikkel Brabrand ,&nbsp;Joseph H Walline ,&nbsp;Colin A Graham","doi":"10.1016/j.ejim.2024.06.015","DOIUrl":"10.1016/j.ejim.2024.06.015","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate whether the timing of initial antibiotic administration in patients with sepsis in hospital affects mortality.</div></div><div><h3>Methods</h3><div>This systematic review and meta-analysis included studies from inception up to 19 May 2022. Interventional and observational studies including adult human patients with suspected or confirmed sepsis and reported time of antibiotic administration with mortality were included. Data were extracted by two independent reviewers. Summary estimates were calculated by using random-effects model. The primary outcome was mortality.</div></div><div><h3>Results</h3><div>We included 42 studies comprising 190,896 patients with sepsis. Pooled data showed that the OR for patient mortality who received antibiotics ≤1 hr was 0.83 (95 %CI: 0.67 to 1.04) when compared with patients who received antibiotics &gt;1hr. Significant reductions in the risk of death in patients with earlier antibiotic administration were observed in patients ≤3 hrs versus &gt;3 hrs (OR: 0.80, 95 %CI: 0.68 to 0.94) and ≤6 hrs vs 6 hrs (OR: 0.57, 95 %CI: 0.39 to 0.82).</div></div><div><h3>Conclusions</h3><div>Our findings show an improvement in mortality in sepsis patients with early administration of antibiotics at &lt;3 and &lt;6 hrs. Thus, these results suggest that antibiotics should be administered within 3 hrs of sepsis recognition or ED arrival regardless of the presence or absence of shock.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"129 ","pages":"Pages 48-61"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A peculiar cause of dysphagia","authors":"Pinar Kucukdagli,&nbsp;Ozlem Yilmaz ,&nbsp;Gulistan Bahat","doi":"10.1016/j.ejim.2024.07.023","DOIUrl":"10.1016/j.ejim.2024.07.023","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"129 ","pages":"Pages 125-126"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of psoriatic arthritis development with interleukin-17 inhibitors compared to tumour necrosis factor inhibitors","authors":"","doi":"10.1016/j.ejim.2024.06.014","DOIUrl":"10.1016/j.ejim.2024.06.014","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"129 ","pages":"Pages 143-145"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putting frailty at the forefront of hypertension management in the elderly","authors":"Giacomo Buso ,&nbsp;Claudia Agabiti-Rosei ,&nbsp;Maria Lorenza Muiesan","doi":"10.1016/j.ejim.2024.09.006","DOIUrl":"10.1016/j.ejim.2024.09.006","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"129 ","pages":"Pages 25-27"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial infarction in foreign-born individuals in the total population of Sweden","authors":"","doi":"10.1016/j.ejim.2024.06.011","DOIUrl":"10.1016/j.ejim.2024.06.011","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"129 ","pages":"Pages 140-142"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between large vessel vasculitis and glucocorticoid responsiveness of musculoskeletal inflammation: An unverified issue on polymyalgia rheumatica","authors":"","doi":"10.1016/j.ejim.2024.06.025","DOIUrl":"10.1016/j.ejim.2024.06.025","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"129 ","pages":"Page 153"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of plasma sodium changes in the acutely ill patients: the potential role of tissue sodium content","authors":"S.S.A. Simon ,&nbsp;A.M.C. van Vliet ,&nbsp;L. Vogt ,&nbsp;J.J. Oppelaar ,&nbsp;G. Lindner ,&nbsp;R.H.G. Olde Engberink","doi":"10.1016/j.ejim.2024.07.032","DOIUrl":"10.1016/j.ejim.2024.07.032","url":null,"abstract":"<div><h3>Background</h3><div>Rapid correction of dysnatremias can result in neurological complications. Therefore, various formulas are available to predict changes in plasma sodium concentration ([Na⁺]) after treatment, but these have been shown to be inaccurate. This could be explained by sodium acumulation in skin and muscle tissue, which is not explicitly considered in these formulas. We assessed the association between clinical and biochemical factors related to tissue sodium accumulation and the discrepancy between predicted and measured plasma [Na⁺].</div></div><div><h3>Methods</h3><div>We used data from an intensive care unit (ICU) cohort with complete data on sodium, potassium, and water balance. The predicted plasma [Na⁺] was calculated using the Barsoum-Levine (BL) and the Nguyen-Kurtz (NK) formula. We calculated the discrepancy between predicted and measured plasma sodium and fitted a linear mixed-effect model to investigate its association with factors related to tissue sodium accumulation.</div></div><div><h3>Results</h3><div>We included 594 ICU days of sixty-three patients in our analysis. The mean plasma [Na⁺] at baseline was 147±6 mmol/L. The median (IQR) discrepancy between predicted and measured plasma [Na⁺] was 3.14 mmol/L (1.48, 5.55) and 3.53 mmol/L (1.81, 6.44) for the BL and NK formulas, respectively. For both formulas, estimated total body water (p=0.027), initial plasma [Na⁺] (p&lt;0.001) and plasma [Na⁺] change (p&lt;0.001) were associated with the discrepancy between predicted and measured plasma [Na⁺].</div></div><div><h3>Conclusion</h3><div>In this ICU cohort, initial plasma [Na⁺], total body water, and plasma [Na⁺] changes, all factors that are related to tissue sodium accumulation, were associated with the inaccurateness of plasma [Na⁺] prediction.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"129 ","pages":"Pages 121-124"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}