FEBS Letters最新文献

Assessing Perceptions and Medication Disposal Habits in Rural Michigan. 评估认知和药物处置习惯在农村密歇根州。

4区生物学

FEBS Letters Pub Date : 2023-10-10 eCollection Date: 2023-01-01 DOI: 10.24926/iip.v14i2.5433

Cassandra L Falk, Scott M Sexton

{"title":"Assessing Perceptions and Medication Disposal Habits in Rural Michigan.","authors":"Cassandra L Falk, Scott M Sexton","doi":"10.24926/iip.v14i2.5433","DOIUrl":"10.24926/iip.v14i2.5433","url":null,"abstract":"Background: Inadequate or inappropriate medication disposal is a public health concern that may lead to increased community risk of accidental poisonings, substance misuse, and environmental pollution. Objective: The study's primary objective was to assess medication disposal knowledge and practices of Michigan residents living in rural, underserved areas. Secondary objectives included determining baseline perceptions of at-home drug disposal kits and examining the impact of an educational video intervention on at-home drug disposal kit perceptions. Methods: To measure the objectives, an online 15-question survey was deployed to the general public via convenience sampling from local organizations working with drug disposal. The survey questions assessed medication disposal knowledge and practices in underserved, rural Michigan. Participant responses were assessed categorically and numerically. Results: Inclusion criteria were met by 97 survey participants. Results indicated that Michigan rural residents, regardless of various demographic factors, would benefit from increased drug disposal education. Specifically, at-home drug disposal kits and medication drop boxes have the highest need for additional education. Perceptions related to home disposal safety and ease of use improved significantly with an educational video intervention. Conclusion: All rural residents, regardless of demographics, would benefit from increased drug disposal education. A short, educational video can impact thoughts and attitudes related to at-home drug disposal kits. Similar interventions may be successful in other rural, underserved areas.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":"293 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74540768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ISGylation directly modifies hypoxia-inducible factor-2α and enhances its polysome association. isg酰化直接修饰缺氧诱导因子-2α并增强其多体关联。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2022-11-01 DOI: 10.1002/1873-3468.14476

Gaelan Melanson, Antonia C Du Bois, Caroline Webster, James Uniacke

引用次数: 0

The fusion of quantitative molecular proteomics and immune-oncology: a step towards precision medicine in cancer therapeutics. 定量分子蛋白质组学与免疫肿瘤学的融合:癌症治疗迈向精准医学的一步。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2022-11-01 DOI: 10.1002/1873-3468.14480

James Miles, Stephen G Ward, Banafshé Larijani

{"title":"The fusion of quantitative molecular proteomics and immune-oncology: a step towards precision medicine in cancer therapeutics.","authors":"James Miles, Stephen G Ward, Banafshé Larijani","doi":"10.1002/1873-3468.14480","DOIUrl":"https://doi.org/10.1002/1873-3468.14480","url":null,"abstract":"Innate and adaptive immune systems are built-in homeostatic functions of many multicellular organisms and protect the host against foreign pathogens and infections. Dysregulation of the molecular mechanisms of the immune system can result in autoimmune diseases. The immune system can also be harnessed and manipulated to provide targeted cancer therapies, some of them relying on the blockade of immune-checkpoint receptors. Two prominent immune checkpoints, PD-1/PD-L1 and CTLA-4/CD80, comprise receptor-ligand pairs that prevent the host immune cells from attacking host tissues. However, cancer cells upregulate the respective PD-L1 and CD80 ligands for PD-1 and CTLA-4 and thereby evade the host-immune response. Therapeutic drugs that block PD-1/PD-L1 and CTLA-4/CD80 interactions re-enable the immune system to attack cancer cells, but their prognostic biomarker remains challenging. In this review, we discuss how the use of quantitative molecular imaging can be exploited to predict the response to anti-PD-1/PD-L1 therapies and to identify cancer patients who would benefit from them.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":"596 21","pages":"2721-2735"},"PeriodicalIF":3.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10362339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical and mechanistic insights into the roles of DDX41 in haematological malignancies. DDX41在血液系统恶性肿瘤中作用的临床和机制见解。

IF 3 4区生物学

FEBS Letters Pub Date : 2022-11-01 Epub Date: 2022-09-09 DOI: 10.1002/1873-3468.14487

Joshua T Weinreb, Teresa V Bowman

引用次数: 0

Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region. 非受体酪氨酸激酶Ack1的活性受其Mig6同源区酪氨酸磷酸化的调节。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2022-11-01 DOI: 10.1002/1873-3468.14505

Yağmur Kan, W Todd Miller

引用次数: 2

Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells. 盘状蛋白结构域受体1调控乳腺上皮细胞ErbB2/ErbB3信号通路。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2022-11-01 DOI: 10.1002/1873-3468.14522

Andrés Martin Toscani, Pablo Aguilera, Federico Coluccio Leskow

引用次数: 2

Ubiquitin receptors play redundant roles in the proteasomal degradation of the p53 repressor MDM2. 泛素受体在p53抑制因子MDM2的蛋白酶体降解中发挥冗余作用。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2022-11-01 DOI: 10.1002/1873-3468.14436

Alison Sparks, Christopher J Kelly, Mark K Saville

引用次数: 0

Integrin β1 transduces the signal for LY6D-induced macropinocytosis and mediates senescence-inducing stress-evoked vacuole formation via FAK. 整合素β1通过FAK传导ly6d诱导的巨噬细胞增多症信号并介导诱导衰老的应激诱导液泡形成。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2022-11-01 DOI: 10.1002/1873-3468.14477

Keitaro Nakagawa, Taiki Nagano, Ryoko Katasho, Tetsushi Iwasaki, Shinji Kamada

引用次数: 1

Small RNA sequencing in hypoxic naked mole-rat hearts suggests microRNA regulation of RNA- and translation-related processes. 低氧裸鼹鼠心脏的小RNA测序表明，microRNA调控RNA和翻译相关过程。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2022-11-01 DOI: 10.1002/1873-3468.14499

W Aline Ingelson-Filpula, Hang Cheng, Liam Eaton, Matthew E Pamenter, Kenneth B Storey

引用次数: 2

The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT-20 cells in vitro. 线粒体酶FAHD1调节乳腺癌细胞中复合物II的活性，是体外基础BT-20细胞不可缺少的。

IF 3.5 4区生物学

FEBS Letters Pub Date : 2022-11-01 DOI: 10.1002/1873-3468.14462

Max Holzknecht, Lena Guerrero-Navarro, Michele Petit, Eva Albertini, Elisabeth Damisch, Anna Simonini, Fernando Schmitt, Walther Parson, Heidelinde Fiegl, Alexander Weiss, Pidder Jansen-Duerr

{"title":"The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT-20 cells in vitro.","authors":"Max Holzknecht, Lena Guerrero-Navarro, Michele Petit, Eva Albertini, Elisabeth Damisch, Anna Simonini, Fernando Schmitt, Walther Parson, Heidelinde Fiegl, Alexander Weiss, Pidder Jansen-Duerr","doi":"10.1002/1873-3468.14462","DOIUrl":"https://doi.org/10.1002/1873-3468.14462","url":null,"abstract":"The mitochondrial enzyme fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) was identified to be upregulated in breast cancer tissues. Here, we show that FAHD1 is indispensable for the survival of BT-20 cells, representing the basal breast cancer cell type. A lentiviral knock-down of FAHD1 in the breast cancer cell lines MCF-7 and BT-20 results in lower succinate dehydrogenase (complex II) activity. In luminal MCF-7 cells, this leads to reduced proliferation when cultured in medium containing only glutamine as the carbon source. Of note, both cell lines show attenuated protein levels of the enzyme glutaminase (GLS) which activates programmed cell death in BT-20. These findings demonstrate that FAHD1 is crucial for the functionality of complex II in breast cancer cells and acts on glutaminolysis in the mitochondria.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":"596 21","pages":"2781-2794"},"PeriodicalIF":3.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10739557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1