盘状蛋白结构域受体1调控乳腺上皮细胞ErbB2/ErbB3信号通路。

IF 3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Andrés Martin Toscani, Pablo Aguilera, Federico Coluccio Leskow
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引用次数: 2

摘要

ErbB2受体酪氨酸激酶在乳腺发育中起关键作用。它形成大簇,作为整合细胞外信息的信号平台。盘状蛋白结构域受体(DDR)家族是胶原蛋白受体酪氨酸激酶,与ErbB2一起参与许多生理和病理过程。在这里,我们研究了ErbB2和DDR1受体在乳腺癌细胞中的相互作用。与β -整合素相反,DDR1在膜簇中与ErbB2共定位,无论其表达水平如何。我们证明了这种空间共存是这些受体之间物理相互作用的结果。此外,这些受体在正常乳腺中共表达,而在乳腺肿瘤样本中不表达。总之,这些结果表明DDR1是ErbB2/ErbB3信号通路的一种新型调节剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells.

The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway.

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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
6.60
自引率
2.90%
发文量
303
审稿时长
1 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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