定量分子蛋白质组学与免疫肿瘤学的融合:癌症治疗迈向精准医学的一步。

IF 3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
James Miles, Stephen G Ward, Banafshé Larijani
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引用次数: 1

摘要

先天免疫和适应性免疫系统是许多多细胞生物的内在稳态功能,保护宿主免受外来病原体和感染。免疫系统分子机制失调可导致自身免疫性疾病。免疫系统也可以被利用和操纵来提供靶向癌症治疗,其中一些依赖于免疫检查点受体的阻断。两个重要的免疫检查点,PD-1/PD-L1和CTLA-4/CD80,包括受体-配体对,阻止宿主免疫细胞攻击宿主组织。然而,癌细胞上调PD-1和CTLA-4的PD-L1和CD80配体,从而逃避宿主免疫应答。阻断PD-1/PD-L1和CTLA-4/CD80相互作用的治疗药物使免疫系统能够重新攻击癌细胞,但其预后生物标志物仍然具有挑战性。在这篇综述中,我们讨论了如何利用定量分子成像来预测抗pd -1/PD-L1治疗的反应,并确定将从这些治疗中受益的癌症患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The fusion of quantitative molecular proteomics and immune-oncology: a step towards precision medicine in cancer therapeutics.

Innate and adaptive immune systems are built-in homeostatic functions of many multicellular organisms and protect the host against foreign pathogens and infections. Dysregulation of the molecular mechanisms of the immune system can result in autoimmune diseases. The immune system can also be harnessed and manipulated to provide targeted cancer therapies, some of them relying on the blockade of immune-checkpoint receptors. Two prominent immune checkpoints, PD-1/PD-L1 and CTLA-4/CD80, comprise receptor-ligand pairs that prevent the host immune cells from attacking host tissues. However, cancer cells upregulate the respective PD-L1 and CD80 ligands for PD-1 and CTLA-4 and thereby evade the host-immune response. Therapeutic drugs that block PD-1/PD-L1 and CTLA-4/CD80 interactions re-enable the immune system to attack cancer cells, but their prognostic biomarker remains challenging. In this review, we discuss how the use of quantitative molecular imaging can be exploited to predict the response to anti-PD-1/PD-L1 therapies and to identify cancer patients who would benefit from them.

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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
6.60
自引率
2.90%
发文量
303
审稿时长
1 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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