The Open Cardiovascular Medicine Journal最新文献_第9页

Subject body mass index affects Doppler waveform in celiac artery by duplex ultrasound. 受试者体重指数对腹腔动脉超声多普勒波形的影响。

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The Open Cardiovascular Medicine Journal Pub Date : 2013-04-30 Print Date: 2013-01-01 DOI: 10.2174/1874192401307010040

Akram M Asbeutah, Yousif Y Bakir, Nayanatara Swamy, Abdul Aziz A Absuetah, Muna A Abu-Asi, Prem Sharma

{"title":"Subject body mass index affects Doppler waveform in celiac artery by duplex ultrasound.","authors":"Akram M Asbeutah, Yousif Y Bakir, Nayanatara Swamy, Abdul Aziz A Absuetah, Muna A Abu-Asi, Prem Sharma","doi":"10.2174/1874192401307010040","DOIUrl":"https://doi.org/10.2174/1874192401307010040","url":null,"abstract":"Objective: The aim of this study is to evaluate the effect of body mass index (BMI) on peak systolic velocity (PSV) recording in the celiac artery (CA).Subjects & methods: Forty male participants were entered prospectively into the study. The subjects were divided into two groups according to their body mass index. Group A included subjects with BMI ≤25 Kg/m(2) and those in group B with BMI >25 Kg/m(2). The diameter and PSV at the origin of CA of subjects in both groups were recorded while the subject positioned in supine and during expiration phase and fasted for 4 hours using duplex ultrasound. Both groups were matched for age and sex. Independent Student's t-test was used to test if there is any statistical significance between diameter and PSV in both groups.Results: Group A's, average age (year, ±SD) was 29.35±1.35 and average BMI (Kg/m(2), ±SD) was 23.1±1.60. Group B's, average age was 30±2.1 and their average BMI was 31±5.1. The average diameter (cm, ±SD) of CA in group A was 0.66±0.076 and in group B was 0.80±0.066. However, the average PSV (cm/s, ±SD) was 117±28.1 in group A and 102±12.4 in group B. Independent student t-test showed statistical significance between both groups for the diameter (p=0.005) and just reached statistical significance for PSV (p=0.049).Conclusion: Subjects with higher BMI showed reduced PSV due to a larger CA diameter and probably due to more fatty tissue accumulation around the CA origin.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"7 ","pages":"40-5"},"PeriodicalIF":0.8,"publicationDate":"2013-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/34/b8/TOCMJ-7-40.PMC3681032.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31626954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Quantitative Immunohistochemistry of Desmosomal Proteins (Plakoglobin, Desmoplakin and Plakophilin), Connexin-43, and N-cadherin in Arrhythmogenic Cardiomyopathy: An Autopsy Study. 致心律失常心肌病中桥粒体蛋白(血小板红蛋白、桥粒蛋白和嗜血小板蛋白)、连接蛋白-43和n-钙粘蛋白的定量免疫组化:一项尸检研究。

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The Open Cardiovascular Medicine Journal Pub Date : 2013-03-29 Print Date: 2013-01-01 DOI: 10.2174/1874192401307010028

Fabio Tavora, Mingchang Zhang, Nathaniel Cresswell, Ling Li, David Fowler, Marcello Franco, Allen Burke

{"title":"Quantitative Immunohistochemistry of Desmosomal Proteins (Plakoglobin, Desmoplakin and Plakophilin), Connexin-43, and N-cadherin in Arrhythmogenic Cardiomyopathy: An Autopsy Study.","authors":"Fabio Tavora, Mingchang Zhang, Nathaniel Cresswell, Ling Li, David Fowler, Marcello Franco, Allen Burke","doi":"10.2174/1874192401307010028","DOIUrl":"https://doi.org/10.2174/1874192401307010028","url":null,"abstract":"Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic disorder related to mutations in desmosomal proteins. The current study tests the hypothesis that immunohistochemical staining for desmosomal proteins is of diagnostic utility by studying autopsy-confirmed cases of ARVC.Methods and results: We studied 23 hearts from patients dying suddenly with ARVC. Control subject tissues were 21 hearts from people dying from non-cardiac causes (n=15), dilated cardiomyopathy (n=3) and coronary artery disease (n=3). Areas free of fibrofatty change or scarring were assessed on 50 sections from ARVC (24 left ventricle, 26 right ventricle) and 28 sections from controls. Immunohistochemical stains against plakoglobin, plakophilin, desmoplakin, connexin-43, and N-cadherin were applied and area expression analyzed by computerized morphometry. Desmin was stained as a control for fixation and similarly analyzed. The mean area of desmin expression was similar in controls and ARVC (86% vs. 85%, p=0.6). Plakoglobin expression was 4.9% ± 0.3% in controls, vs. 4.6% ± 0.3% in ARVC (p=0.3). Plakophilin staining was 4.8% ± 0.3% in controls vs. 4.4% ± 03% in ARVC (p=0.3). Desmoplakin staining was 3.4% in controls vs. 3.2 ± 0.2% in ARVC (p=0.6). There were no significant differences when staining was compared between right and left ventricles (all p > 0.1). For non-desmosomal proteins, the mean area of connexin-43 staining showed no significant difference by presence of disease.Conclusions: The small and insignificant decrease in junction protein expression in ARVC suggests that immunohistochemistry is not a useful tool for the diagnosis.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"7 ","pages":"28-35"},"PeriodicalIF":0.8,"publicationDate":"2013-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/e2/TOCMJ-7-28.PMC3680985.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31626952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Braile vena cava filter and greenfield filter in terms of centralization. 盲文腔静脉过滤器和格林菲尔德过滤器在集中方面。

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The Open Cardiovascular Medicine Journal Pub Date : 2013-01-01 Epub Date: 2013-01-31 DOI: 10.2174/1874192401307010009

José Maria Pereira de Godoy, Adinaldo A Menezes da Silva, Luis Fernando Reis, Daniel Miquelin, José Luis Simon Torati

{"title":"Braile vena cava filter and greenfield filter in terms of centralization.","authors":"José Maria Pereira de Godoy, Adinaldo A Menezes da Silva, Luis Fernando Reis, Daniel Miquelin, José Luis Simon Torati","doi":"10.2174/1874192401307010009","DOIUrl":"https://doi.org/10.2174/1874192401307010009","url":null,"abstract":"The aim of this study was to evaluate complications experienced during implantation of the Braile Vena Cava filter (VCF) and the efficacy of the centralization mechanism of the filter. This retrospective cohort study evaluated all Braile Biomédica VCFs implanted from 2004 to 2009 in Hospital de Base Medicine School in São José do Rio Preto, Brazil. Of particular concern was the filter's symmetry during implantation and complications experienced during the procedure. All the angiographic examinations performed during the implantation of the filters were analyzed in respect to the following parameters: migration of the filter, non-opening or difficulties in the implantation and centralization of the filter. A total of 112 Braile CVFs were implanted and there were no reports of filter opening difficulties or in respect to migration. Asymmetry was observed in 1/112 (0.9%) cases. A statistically significant difference was seen on comparing historical data on decentralization of the Greenfield filter with the data of this study. The Braile Biomédico filter is an evolution of the Greenfield filter providing improved embolus capture and better implantation symmetry.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"7 ","pages":"9-11"},"PeriodicalIF":0.8,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/34/01/TOCMJ-7-9.PMC3582014.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31279707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retroperitoneal hemorrhage as a complication of percutaneous intervention: report of 2 cases and review of the literature. 经皮介入治疗并发腹膜后出血2例报告并文献复习。

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The Open Cardiovascular Medicine Journal Pub Date : 2013-01-01 Epub Date: 2013-02-28 DOI: 10.2174/1874192401307010016

Nitin Sajnani, Douglas B Bogart

引用次数: 26

Rosuvastatin was Effective in Acute Heart Failure and Slow Coronary Flow: A Hypothesis-generating Case Report. 瑞舒伐他汀对急性心力衰竭和冠状动脉血流缓慢有效:一个假设生成病例报告。

IF 0.8

The Open Cardiovascular Medicine Journal Pub Date : 2013-01-01 Epub Date: 2013-01-31 DOI: 10.2174/1874192401307010012

Alessio Arrivi, Gaetano Tanzilli, Paolo Emilio Puddu, Luca Iannucci, Enrico Mangieri

引用次数: 0

Increasing physical activity of high intensity to reduce the prevalence of chronic diseases and improve public health. 增加高强度的身体活动，以减少慢性病的流行，改善公众健康。

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The Open Cardiovascular Medicine Journal Pub Date : 2013-01-01 Epub Date: 2013-01-31 DOI: 10.2174/1874192401307010001

Tommy Aune Rehn, Richard A Winett, Ulrik Wisløff, Oivind Rognmo

引用次数: 33

Low vitamin d and cardiovascular risk factors in males and females from a sunny, rich country. 来自阳光充足、富裕国家的男性和女性的维生素d含量低和心血管风险因素。

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The Open Cardiovascular Medicine Journal Pub Date : 2012-01-01 Epub Date: 2012-06-27 DOI: 10.2174/1874192401206010076

Ayman El-Menyar, Ali Rahil, Khalid Dousa, Walid Ibrahim, Talal Ibrahim, Rasha Khalifa, Mohamed Osman Abdel Rahman

{"title":"Low vitamin d and cardiovascular risk factors in males and females from a sunny, rich country.","authors":"Ayman El-Menyar, Ali Rahil, Khalid Dousa, Walid Ibrahim, Talal Ibrahim, Rasha Khalifa, Mohamed Osman Abdel Rahman","doi":"10.2174/1874192401206010076","DOIUrl":"https://doi.org/10.2174/1874192401206010076","url":null,"abstract":"Background: Low serum vitamin (vit) D levels are common even in sunny countries. We assessed the prevalence and relationship of low vit D with cardiovascular risk factors in Qatar.Methods: Data were collected retrospectively from January 2008 and November 2009. In patients who had low vi t D (< 30 ng/ml ) , demographic and clinical profiles were analyzed and compared in males and females.Results: The overall mean level of vit D among 547 patients was 14.4±11 ng/mL. Among the low vitamin D group, 56% were females (mean age 48±12) and 44% males (mean age 49.6±13). Severely low vit D levels (<10 ng/mL) were found in 231 (46%) patients with mean age of 46±12 years. Compared with females, males with low vitamin D were more likely to have diabetes mellitus (38 vs 22%, p=0.001), dyslipidemia (41 vs 29%, p=0.007), myocardial infarction (5.5 vs 1.5%, p=0.001) and angiographically documented coronary artery disease (CAD) (53 vs 17%, p=0.001). Multivariate logistic regression analysis showed that in the presence of low vit D, age and hypertension were independent predictors of CAD (OR 1.07;95% CI: 1.02-1.11) and OR 8.0; 95% CI: 1.67-39.82), respectively.Conclusions: Our study supports the widespread prevalence of low vit D in sunny regions. Low vit D is associated with 3 times increase in the rate of MI among males. Hypertension increases the risk of CAD 8 times in the presence of low vit D regardless of gender.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"6 ","pages":"76-80"},"PeriodicalIF":0.8,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2a/b1/TOCMJ-6-76.PMC3401885.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30790485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Patient with hypertriglyceridemia, type 2 diabetes, and chronic kidney disease treated with atorvastatin and omega-3 Fatty Acid ethyl esters. 阿托伐他汀和omega-3脂肪酸乙酯治疗的高甘油三酯血症、2型糖尿病和慢性肾病患者。

IF 0.8

The Open Cardiovascular Medicine Journal Pub Date : 2012-01-01 Epub Date: 2012-09-20 DOI: 10.2174/1874192401206010122

Vasilios G Athyros, Dimitri P Mikhailidis

{"title":"Patient with hypertriglyceridemia, type 2 diabetes, and chronic kidney disease treated with atorvastatin and omega-3 Fatty Acid ethyl esters.","authors":"Vasilios G Athyros, Dimitri P Mikhailidis","doi":"10.2174/1874192401206010122","DOIUrl":"https://doi.org/10.2174/1874192401206010122","url":null,"abstract":"This is a case report that describes a 67-year-old woman with mixed hyperlipidemia and diabetic nephropathy. She was initially prescribed a combination of simvastatin plus gemfibrozil by her general practitioner (GP). When referred to our cardiovascular unit, we further diagnosed the patient to have mixed hyperlipidemia and rhabdomyolysis. Because of concerns with her chronic kidney disease (CKD), we temporarily stopped all her drug treatments and started insulin treatment for her type 2 diabetes (T2D). A month later when her T2D was stabilised, we prescribed atorvastatin and an omega-3 fatty acid ethyl ester supplement to treat her hypertriglyceridemia. Within two months her blood lipids were within the recommended range. In patients with stage 3-5 CKD, it is not advisable to prescribe the fibrate gemfibrozil, particularly in combination with a statin that is metabolised predominantly in the kidneys. To minimise adverse events without compromise on efficacy, we used a combination of omega-3 fatty acid ethyl esters, which are not metabolised in the kidneys, with a statin that is minimally metabolised in the kidneys for the treatment of her hyperlipidemia.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"6 ","pages":"122-5"},"PeriodicalIF":0.8,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4a/da/TOCMJ-6-122.PMC3468870.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30977068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Two Valid Measures of Self-rated Physical Activity and Capacity. 两种自评体力活动和能力的有效测量方法。

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The Open Cardiovascular Medicine Journal Pub Date : 2012-01-01 Epub Date: 2012-12-28 DOI: 10.2174/1874192401206010156

Marit Sundal Holen, Rønnaug Een, Thomas Mildestvedt, Geir Egil Eide, Eivind Meland

{"title":"Two Valid Measures of Self-rated Physical Activity and Capacity.","authors":"Marit Sundal Holen, Rønnaug Een, Thomas Mildestvedt, Geir Egil Eide, Eivind Meland","doi":"10.2174/1874192401206010156","DOIUrl":"https://doi.org/10.2174/1874192401206010156","url":null,"abstract":"Objectives: Questionnaires on physical activity (PA) and physical capacity (PC) are valuable tools, as they are cost beneficial, and have high response rates. The validity of short versions of such questionnaires has not been examined satisfactorily. Therefore, we aimed at examining the validity of a set of questions coding for PA and PC.Design: The questions were administered to 217 men and women attending a cardiac rehabilitation program. Participants also gave blood samples, measuring HDL cholesterol, triglycerides (TG), insulin, glucose, and microCRP. The relations between PA and PC and biological markers were examined by linear regression analyses.Results: Measures for PC and for PA were identified by factor analysis, which proved internally consistent. TG, homeostatic model assessment (HOMA) score, and mCRP were all significantly associated with the measures of PC and PA.Conclusions: The measures of PA and PC are valid compared with biological markers, allowing cost-beneficial and time-efficient evaluation of important measures for cardiovascular health.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"6 ","pages":"156-62"},"PeriodicalIF":0.8,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/7e/TOCMJ-6-156.PMC3551239.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31185059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Injection of human bone marrow and mononuclear cell extract into infarcted mouse hearts results in functional improvement. 将人骨髓和单个核细胞提取物注射到梗死小鼠心脏中，可改善其功能。

IF 0.8

The Open Cardiovascular Medicine Journal Pub Date : 2012-01-01 Epub Date: 2012-04-17 DOI: 10.2174/1874192401206010038

Franca S Angeli, Yan Zhang, Richard Sievers, Kristine Jun, Sarah Yim, Andrew Boyle, Yerem Yeghiazarians

{"title":"Injection of human bone marrow and mononuclear cell extract into infarcted mouse hearts results in functional improvement.","authors":"Franca S Angeli, Yan Zhang, Richard Sievers, Kristine Jun, Sarah Yim, Andrew Boyle, Yerem Yeghiazarians","doi":"10.2174/1874192401206010038","DOIUrl":"https://doi.org/10.2174/1874192401206010038","url":null,"abstract":"Background: We have previously shown that mouse whole bone marrow cell (BMC) extract results in improvement of cardiac function and decreases scar size in a mouse model of myocardial infarction (MI), in the absence of intact cells. It is not clear if these results are translatable to extracts from human BMC (hBMC) or mononuclear cells (hMNC), which would have significant clinical implications.Methods: Male C57BL/6J (10-12 weeks old) mice were included in this study. MI was created by permanent ligation of the left anterior descending artery. Animals were randomized into three groups to receive ultrasound-guided myocardial injections with either hBMCs extract (n=6), hMNCs extract (n=8) or control with 0.5% bovine serum albumin (BSA) (n=7). Cardiac function was assessed by echocardiography at baseline, 2 and 28 days post-MI. Infarct size and vascularity was assessed at 28 days post-MI.Results: hBMC and hMNC extract preserve cardiac function and result in smaller scar size post-MI when compared with the control group.Conclusions: The current study for the first time reports that hBMC and hMNC extracts improve cardiac function post-MI in a mouse MI model. Further studies are necessary to fully address the potential clinical benefits of these therapies.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"6 ","pages":"38-43"},"PeriodicalIF":0.8,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2b/6c/TOCMJ-6-38.PMC3339429.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30587450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12