Frontiers of Hormone Research最新文献_第2页

Beyond Bone Mineral Density: The Impact of Childhood Cancer and Its Treatment on Bone Structure and Strength. 超越骨矿物质密度:儿童癌症及其治疗对骨结构和强度的影响。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-09-30 DOI: 10.1159/000518501

Melissa Fiscaletti, Nathalie Alos, Leanne M Ward

{"title":"Beyond Bone Mineral Density: The Impact of Childhood Cancer and Its Treatment on Bone Structure and Strength.","authors":"Melissa Fiscaletti, Nathalie Alos, Leanne M Ward","doi":"10.1159/000518501","DOIUrl":"https://doi.org/10.1159/000518501","url":null,"abstract":"The spectrum of bone morbidity in childhood cancer survivors (CCS) is broad and extends beyond \"low bone mineral density\" to structural damage including fracture-induced vertebral deformity, and joint collapse due to osteonecrosis or slipped capital femoral epiphysis. In addition, short stature, scoliosis, leg length discrepancy, and vertebral deformity can arise from critical interference with growth plate activity. In some cases, insufficient residual growth potential or irreversible growth plate damage can lead to permanent structural deformity, leaving the patient with chronic functional limitations. In this chapter, we describe the clinical manifestations, natural history, and risk factors for cancer-related bone morbidity, approaches to monitoring and diagnosis, and the (paucity of) data available on prevention and treatment measures. In so doing, we unveil important biological principles about the potential for the pediatric skeleton to recover from bone morbidity, obviating the need for treatment, versus permanent structural damage that can negatively impact quality of life over the long-term. These observations, in turn, illuminate the unmet needs that drive future research to improve musculoskeletal strength and mobility in this setting.","PeriodicalId":50428,"journal":{"name":"Frontiers of Hormone Research","volume":"54 ","pages":"69-90"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39834778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cancer Treatment-Induced Bone Loss in Hormone-Sensitive Cancer: The Paradigm of Cancer Survivor Bone Health Management. 激素敏感癌症治疗诱导的骨质流失:癌症幸存者骨健康管理的范例。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-05-04 DOI: 10.1159/000514692

Nicoletta Fortunati, Filippo Gatti, Francesco Felicetti, Enrico Brignardello

引用次数: 0

Preface. 前言。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-09-28 DOI: 10.1159/000519426

Enrico Brignardello, Francesco Felicetti, Hanneke M van Santen

引用次数: 0

Hypothalamic-Pituitary Outcome after Treatment for Childhood Craniopharyngioma. 儿童颅咽管瘤治疗后的下丘脑-垂体预后。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-05-07 DOI: 10.1159/000515318

Jiska van Schaik, Eelco W Hoving, Hermann L Müller, Hanneke M van Santen

引用次数: 4

The Concept of Cancer Survivorship and Models for Long-Term Follow-Up. 癌症生存的概念和长期随访的模型。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-04-23 DOI: 10.1159/000514693

Rebecca J van Kalsbeek, Renée L Mulder, Roderick Skinner, Leontien C M Kremer

{"title":"The Concept of Cancer Survivorship and Models for Long-Term Follow-Up.","authors":"Rebecca J van Kalsbeek, Renée L Mulder, Roderick Skinner, Leontien C M Kremer","doi":"10.1159/000514693","DOIUrl":"https://doi.org/10.1159/000514693","url":null,"abstract":"With improved survival of childhood, adolescent, and young adult (CAYA) cancer, the European survivor population of 300,000-500,000 continues to expand. Most survivors will experience at least one and often multiple cancer- and treatment-related late effects throughout their lives, including endocrine toxicities. Besides affecting their physical and psychosocial health status, these might reduce life expectancy and quality of life. Prevalent endocrine complications include hypothalamic-pituitary dysfunction, central precocious puberty, primary thyroid, male or female gonadal dysfunction, metabolic syndrome, and low bone mineral density. Long-term follow-up (LTFU) care, including education, risk-based prevention, and surveillance strategies, is essential to reduce the burden of endocrine complications and to allow for timely interventions. To integrate scientific expert knowledge, evidence-based clinical practice guidelines have been developed by the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) and PanCare. These guide LTFU care by describing risk populations and preferred surveillance modalities. Moreover, consensus-based recommendations have been developed by PanCareFollowUp where evidence-based guidance is still awaited. The PanCareSurFup models of care guidelines recommend multidisciplinary team care at or under guidance of a cancer survivorship expert center, so CAYA cancer survivors receive appropriate care and support to optimize health.","PeriodicalId":50428,"journal":{"name":"Frontiers of Hormone Research","volume":"54 ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38905848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Hypothalamic-Pituitary Dysfunctions Other Than Growth Hormone Deficiency in Cancer Survivors. 癌症幸存者中生长激素缺乏以外的下丘脑-垂体功能障碍。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-02-08 DOI: 10.1159/000513806

Laura van Iersel, Wassim Chemaitilly

引用次数: 0

Cardiometabolic Risk, Part 1: Chemotherapy and Radiotherapy - Old Foes Still Threatening Cancer Survivors? 心脏代谢风险，第一部分:化疗和放疗-老敌人仍然威胁癌症幸存者?

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-02-08 DOI: 10.1159/000513921

Maja Vestmø Maraldo, Alessandro Andreis, Ilenia Iamundo de Cumis, Marzia Cerrato, Angelisa Vella, Umberto Ricardi, Mario Levis

引用次数: 1

Gonadal Failure and Infertility in Cancer Survivors: Clinical Management and Strategies for Prevention. 癌症幸存者的性腺功能衰竭和不孕:临床管理和预防策略。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-05-06 DOI: 10.1159/000515460

Marco Zavattaro, Fabio Lanfranco, Francesca Salvagno, Giovanna Motta, Marta Sestero, Lorenzo Marinelli, Stefano Canosa, Alberto Revelli

{"title":"Gonadal Failure and Infertility in Cancer Survivors: Clinical Management and Strategies for Prevention.","authors":"Marco Zavattaro, Fabio Lanfranco, Francesca Salvagno, Giovanna Motta, Marta Sestero, Lorenzo Marinelli, Stefano Canosa, Alberto Revelli","doi":"10.1159/000515460","DOIUrl":"https://doi.org/10.1159/000515460","url":null,"abstract":"Modern advances in oncological treatments determined a significant improvement in survival rates for several malignancies. Nevertheless, survivorship and quality of life of cancer survivors may be negatively impaired by metabolic and endocrine side effects related to anticancer treatments, including alterations of pituitary-gonadal axis function. In fact, both medical (chemo- and radiotherapy) and surgical approaches may negatively impact on gonadal function, leading to transient or permanent hypogonadism and infertility. In view of these considerations, fertility preservation (FP) should be a primary concern in all oncological patients who may potentially achieve parenthood, irrespectively from their sex and pubertal status at treatment, and adequate counselling should be provided before undergoing gonadotoxic therapy or gonadectomy. Cryopreservation of gametes, when feasible, represents the mainstay for FP in postpubertal age, while procedures involving storage of tissue specimens or stem cells should still be considered as experimental. Given the complexity of both hormonal and psychological implications in this clinical setting, a multidisciplinary approach is advisable for optimal FP and for early diagnosis and treatment of hypogonadism.","PeriodicalId":50428,"journal":{"name":"Frontiers of Hormone Research","volume":"54 ","pages":"58-68"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38876420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Growth Hormone Deficiency and Growth Hormone Replacement in Childhood Cancer Survivors. 儿童癌症幸存者的生长激素缺乏和生长激素替代。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-04-30 DOI: 10.1159/000515111

Briana C Patterson, Lillian R Meacham

引用次数: 1

Accelerated Aging as a Paradigm to Understand the Late Effects of Cancer Therapies. 加速衰老是理解癌症治疗晚期效应的一个范例。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-09-24 DOI: 10.1159/000518816

Saskia Martine Francesca Pluijm

{"title":"Accelerated Aging as a Paradigm to Understand the Late Effects of Cancer Therapies.","authors":"Saskia Martine Francesca Pluijm","doi":"10.1159/000518816","DOIUrl":"https://doi.org/10.1159/000518816","url":null,"abstract":"Long-term childhood adolescent and young adult (CAYA) cancer survivors may develop health conditions that often coexist at young adulthood or middle age and that normally occur in persons aged 65 years and older, including cardiovascular and musculoskeletal diseases, metabolic syndrome, and secondary malignancies, suggesting that a process of accelerated aging occurs. This chapter summarizes epidemiological evidence and physiological mechanisms of accelerated aging, and possible preventive measures to delay the process of accelerated aging in CAYA cancer survivors. Evidence is mounting that in addition to a high prevalence of specific and multiple aging-related chronic diseases (multimorbidity), CAYA cancer survivors seem to also have a higher risk of other aging phenotypes, including frailty, poor physical performance, and changes in body composition (low muscle and high fat mass). Risk factors for these aging phenotypes include treatment-related factors (cranial-spinal radiotherapy, anthracyclines), sociodemographic factors (higher age, female sex, low socioeconomic status), and unhealthy lifestyle factors (i.e., physical inactivity, obesity, smoking, excess alcohol consumption). The process of accelerated aging may be prevented or delayed by adopting and maintaining a healthy lifestyle, so that CAYA cancer survivors may live a life with optimal quality of life after cancer.","PeriodicalId":50428,"journal":{"name":"Frontiers of Hormone Research","volume":"54 ","pages":"16-24"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39455356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3