Frontiers of Hormone Research最新文献

Endocrine and Metabolic Late Effects in Cancer Survivors 癌症幸存者的内分泌和代谢后期效应

2区医学

Frontiers of Hormone Research Pub Date : 2021-11-01 DOI: 10.1159/isbn.978-3-318-06791-0

Francesco Felicett, E. Brignardello, H. Santen, F. Felicetti, S. Oberfield, J. Chanoine, F. Chiarelli, P. Clayton, W. Cutfield

引用次数: 0

Diabetes in Cancer Patients: Risks, Goals and Management. 癌症患者的糖尿病:风险、目标和管理。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-02-08 DOI: 10.1159/000513807

Alberto Ragni, Francesca Retta, Emanuela Arvat, Marco Gallo

{"title":"Diabetes in Cancer Patients: Risks, Goals and Management.","authors":"Alberto Ragni, Francesca Retta, Emanuela Arvat, Marco Gallo","doi":"10.1159/000513807","DOIUrl":"https://doi.org/10.1159/000513807","url":null,"abstract":"Diabetes mellitus (DM) is commonly found in cancer patients. The relationship between DM and cancer appears to be bidirectional: DM has been associated with an increased risk of developing several types of cancer while also cancer treatments, through the induction of metabolic derangements, can facilitate the onset of DM, or worsen glucose control. In particular, novel antineoplastic treatments such as immunotherapy and targeted therapies have been associated with both acute and long-term metabolic consequences. An adequate management of DM in cancer patients is pivotal, since DM can negatively affect the clinical outcomes of these subjects, being associated with worse survival. However, DM management in cancer patients may be challenging given the peculiarities of these conditions. Lower reliability of HbA1c, a thorough evaluation of the safety profile of antidiabetic drugs, and the need to adapt glycemic targets to patients' prognosis should be taken into consideration. Moreover, DM is commonly encountered also in the ever-growing population of cancer survivors, contributing to their increased cardiovascular risk. In conclusion, taking in consideration the lack of specific guidelines, the particular features of the condition, and the potential impact on prognosis, a multidisciplinary management of DM in cancer patients and survivors is warranted.","PeriodicalId":50428,"journal":{"name":"Frontiers of Hormone Research","volume":"54 ","pages":"103-114"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25345854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Beyond Bone Mineral Density: The Impact of Childhood Cancer and Its Treatment on Bone Structure and Strength. 超越骨矿物质密度:儿童癌症及其治疗对骨结构和强度的影响。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-09-30 DOI: 10.1159/000518501

Melissa Fiscaletti, Nathalie Alos, Leanne M Ward

{"title":"Beyond Bone Mineral Density: The Impact of Childhood Cancer and Its Treatment on Bone Structure and Strength.","authors":"Melissa Fiscaletti, Nathalie Alos, Leanne M Ward","doi":"10.1159/000518501","DOIUrl":"https://doi.org/10.1159/000518501","url":null,"abstract":"The spectrum of bone morbidity in childhood cancer survivors (CCS) is broad and extends beyond \"low bone mineral density\" to structural damage including fracture-induced vertebral deformity, and joint collapse due to osteonecrosis or slipped capital femoral epiphysis. In addition, short stature, scoliosis, leg length discrepancy, and vertebral deformity can arise from critical interference with growth plate activity. In some cases, insufficient residual growth potential or irreversible growth plate damage can lead to permanent structural deformity, leaving the patient with chronic functional limitations. In this chapter, we describe the clinical manifestations, natural history, and risk factors for cancer-related bone morbidity, approaches to monitoring and diagnosis, and the (paucity of) data available on prevention and treatment measures. In so doing, we unveil important biological principles about the potential for the pediatric skeleton to recover from bone morbidity, obviating the need for treatment, versus permanent structural damage that can negatively impact quality of life over the long-term. These observations, in turn, illuminate the unmet needs that drive future research to improve musculoskeletal strength and mobility in this setting.","PeriodicalId":50428,"journal":{"name":"Frontiers of Hormone Research","volume":"54 ","pages":"69-90"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39834778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cancer Treatment-Induced Bone Loss in Hormone-Sensitive Cancer: The Paradigm of Cancer Survivor Bone Health Management. 激素敏感癌症治疗诱导的骨质流失:癌症幸存者骨健康管理的范例。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-05-04 DOI: 10.1159/000514692

Nicoletta Fortunati, Filippo Gatti, Francesco Felicetti, Enrico Brignardello

引用次数: 0

Preface. 前言。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-09-28 DOI: 10.1159/000519426

Enrico Brignardello, Francesco Felicetti, Hanneke M van Santen

引用次数: 0

Hypothalamic-Pituitary Outcome after Treatment for Childhood Craniopharyngioma. 儿童颅咽管瘤治疗后的下丘脑-垂体预后。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-05-07 DOI: 10.1159/000515318

Jiska van Schaik, Eelco W Hoving, Hermann L Müller, Hanneke M van Santen

引用次数: 4

The Concept of Cancer Survivorship and Models for Long-Term Follow-Up. 癌症生存的概念和长期随访的模型。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-04-23 DOI: 10.1159/000514693

Rebecca J van Kalsbeek, Renée L Mulder, Roderick Skinner, Leontien C M Kremer

{"title":"The Concept of Cancer Survivorship and Models for Long-Term Follow-Up.","authors":"Rebecca J van Kalsbeek, Renée L Mulder, Roderick Skinner, Leontien C M Kremer","doi":"10.1159/000514693","DOIUrl":"https://doi.org/10.1159/000514693","url":null,"abstract":"With improved survival of childhood, adolescent, and young adult (CAYA) cancer, the European survivor population of 300,000-500,000 continues to expand. Most survivors will experience at least one and often multiple cancer- and treatment-related late effects throughout their lives, including endocrine toxicities. Besides affecting their physical and psychosocial health status, these might reduce life expectancy and quality of life. Prevalent endocrine complications include hypothalamic-pituitary dysfunction, central precocious puberty, primary thyroid, male or female gonadal dysfunction, metabolic syndrome, and low bone mineral density. Long-term follow-up (LTFU) care, including education, risk-based prevention, and surveillance strategies, is essential to reduce the burden of endocrine complications and to allow for timely interventions. To integrate scientific expert knowledge, evidence-based clinical practice guidelines have been developed by the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) and PanCare. These guide LTFU care by describing risk populations and preferred surveillance modalities. Moreover, consensus-based recommendations have been developed by PanCareFollowUp where evidence-based guidance is still awaited. The PanCareSurFup models of care guidelines recommend multidisciplinary team care at or under guidance of a cancer survivorship expert center, so CAYA cancer survivors receive appropriate care and support to optimize health.","PeriodicalId":50428,"journal":{"name":"Frontiers of Hormone Research","volume":"54 ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38905848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Hypothalamic-Pituitary Dysfunctions Other Than Growth Hormone Deficiency in Cancer Survivors. 癌症幸存者中生长激素缺乏以外的下丘脑-垂体功能障碍。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-02-08 DOI: 10.1159/000513806

Laura van Iersel, Wassim Chemaitilly

引用次数: 0

Cardiometabolic Risk, Part 1: Chemotherapy and Radiotherapy - Old Foes Still Threatening Cancer Survivors? 心脏代谢风险，第一部分:化疗和放疗-老敌人仍然威胁癌症幸存者?

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-02-08 DOI: 10.1159/000513921

Maja Vestmø Maraldo, Alessandro Andreis, Ilenia Iamundo de Cumis, Marzia Cerrato, Angelisa Vella, Umberto Ricardi, Mario Levis

引用次数: 1

Gonadal Failure and Infertility in Cancer Survivors: Clinical Management and Strategies for Prevention. 癌症幸存者的性腺功能衰竭和不孕:临床管理和预防策略。

2区医学

Frontiers of Hormone Research Pub Date : 2021-01-01 Epub Date: 2021-05-06 DOI: 10.1159/000515460

Marco Zavattaro, Fabio Lanfranco, Francesca Salvagno, Giovanna Motta, Marta Sestero, Lorenzo Marinelli, Stefano Canosa, Alberto Revelli

{"title":"Gonadal Failure and Infertility in Cancer Survivors: Clinical Management and Strategies for Prevention.","authors":"Marco Zavattaro, Fabio Lanfranco, Francesca Salvagno, Giovanna Motta, Marta Sestero, Lorenzo Marinelli, Stefano Canosa, Alberto Revelli","doi":"10.1159/000515460","DOIUrl":"https://doi.org/10.1159/000515460","url":null,"abstract":"Modern advances in oncological treatments determined a significant improvement in survival rates for several malignancies. Nevertheless, survivorship and quality of life of cancer survivors may be negatively impaired by metabolic and endocrine side effects related to anticancer treatments, including alterations of pituitary-gonadal axis function. In fact, both medical (chemo- and radiotherapy) and surgical approaches may negatively impact on gonadal function, leading to transient or permanent hypogonadism and infertility. In view of these considerations, fertility preservation (FP) should be a primary concern in all oncological patients who may potentially achieve parenthood, irrespectively from their sex and pubertal status at treatment, and adequate counselling should be provided before undergoing gonadotoxic therapy or gonadectomy. Cryopreservation of gametes, when feasible, represents the mainstay for FP in postpubertal age, while procedures involving storage of tissue specimens or stem cells should still be considered as experimental. Given the complexity of both hormonal and psychological implications in this clinical setting, a multidisciplinary approach is advisable for optimal FP and for early diagnosis and treatment of hypogonadism.","PeriodicalId":50428,"journal":{"name":"Frontiers of Hormone Research","volume":"54 ","pages":"58-68"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38876420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3