Understanding the Role of Androgen Action in Female Adipose Tissue.

2区医学 Q2 Medicine

Frontiers of Hormone Research Pub Date : 2019-01-01 DOI:10.1159/000494901

L. Schiffer, W. Arlt, M. O’Reilly

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引用次数: 17

Abstract

Adipose tissue is an important target of androgen action in humans. Androgens exert important effects on adipose tissue biology, including fat mass expansion and distribution, insulin signalling and lipid metabolism. In conditions of female androgen excess such as polycystic ovary syndrome (PCOS), androgens exert metabolically deleterious effects on adipose tissue function in a depot-specific manner. Androgen excess in women is metabolically deleterious, and adverse metabolic effects may be mediated by effects on preadipocyte differentiation and adipocyte hypertrophy. Circulating androgen burden correlates with adiposity in women, and drives visceral fat mass accumulation. Adipose tissue is also an important organ of pre-receptor androgen metabolism, and is host to a complex network of androgen activating and inactivating enzymes. Adipose androgen generation is increased in subcutaneous (SC) adipose tissue in women with PCOS, and intra-adipose concentrations of potent androgens may exceed those measured in peripheral circulation. Increased expression of the key androgen-activating enzyme aldo-ketoreductase type 1C3 in PCOS SC adipose tissue leads to high concentrations of testosterone and dihydrotestosterone. Enhanced local androgen generation may further contribute to the adverse metabolic profile of women with PCOS by exerting lipotoxic effects on local adipose biology.

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了解雄激素在女性脂肪组织中的作用。

脂肪组织是人类雄激素作用的重要靶点。雄激素在脂肪组织生物学中发挥重要作用，包括脂肪团的扩张和分布、胰岛素信号传导和脂质代谢。在女性雄激素过多的情况下，如多囊卵巢综合征(PCOS)，雄激素以一种特定的方式对脂肪组织功能产生代谢有害影响。女性雄激素过量对代谢有害，不良代谢效应可能通过影响前脂肪细胞分化和脂肪细胞肥大来介导。循环雄激素负荷与女性肥胖相关，并驱动内脏脂肪堆积。脂肪组织也是雄激素前受体代谢的重要器官，是雄激素激活和灭活酶复杂网络的宿主。患有多囊卵巢综合征的女性皮下脂肪组织中脂肪雄激素的产生增加，脂肪内雄激素的浓度可能超过外周循环中测量的雄激素浓度。PCOS SC脂肪组织中关键雄激素激活酶醛酮还原酶1C3型的表达增加导致高浓度的睾酮和双氢睾酮。局部雄激素生成的增强可能通过对局部脂肪生物学施加脂毒性作用，进一步促进PCOS女性的不良代谢特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers of Hormone Research 医学-内分泌学与代谢

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期刊介绍： A series of integrated overviews on cutting-edge topics New sophisticated technologies and methodological approaches in diagnostics and therapeutics have led to significant improvements in identifying and characterizing an increasing number of medical conditions, which is particularly true for all aspects of endocrine and metabolic dysfunctions. Novel insights in endocrine physiology and pathophysiology allow for new perspectives in clinical management and thus lead to the development of molecular, personalized treatments. In view of this, the active interplay between basic scientists and clinicians has become fundamental, both to provide patients with the most appropriate care and to advance future research.