Ideggyogyaszati Szemle-Clinical Neuroscience最新文献

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Anterior and posterior parts of diaphragm: A search for the best recording sites and the relevant normative data with surface electrodes. 横膈膜前后部分:寻找最佳记录位置和表面电极的相关规范数据。
IF 0.6 4区 医学
Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2026-01-30 DOI: 10.18071/isz.79.0035
Volkan Tasdemir, Nermin Gorkem Sirin, Ali Emre Oge, Elif Kocasoy Orhan
{"title":"Anterior and posterior parts of diaphragm: A search for the best recording sites and the relevant normative data with surface electrodes.","authors":"Volkan Tasdemir, Nermin Gorkem Sirin, Ali Emre Oge, Elif Kocasoy Orhan","doi":"10.18071/isz.79.0035","DOIUrl":"10.18071/isz.79.0035","url":null,"abstract":"<p><strong>Background and purpose: </strong>Phrenic nerve conduction studies, including comprehensive recording of compound muscle action potentials (CMAP) from all regions of the dia- phragm, can be useful in both neurolo-gical conditions affecting the phrenic nerve or diaphragm and non-neurological conditions such as COPD and GERD, and may have potential diagnostic value. It was aimed (a) to determine the most convenient stimulation and recording sites for phrenic nerve conduction studies (NCS), (b) to record CMAPs reflecting the activity of the posterior part of the diaphragm with surface recording electrodes, (c) to define normative values for these studies.</p><p><strong>Methods: </strong>Sixty-three healthy subjects were included in the study and CMAPs were recorded simultaneously with two anterior and two posterior electrode derivations while stimulating the phrenic nerve behind the sternocleidomastoid muscle.</p><p><strong>Results: </strong>Among the four different electrode placements, the recording electrode pairs providing the highest amplitude CMAPs were those placed 5 cm above the xiphoid process (active) and 16 cm laterally on the costal margin (reference). With this placement method, the upper limit of CMAP latency was 7.70 ms, the lower limit of base-topeak amplitude was 0.30 mV and the lower limit of peak-to-peak amplitude was 0.45 mV. Diaphragmatic CMAPs have been obtained from the majority of volunteers with surface electrodes placed in the posterior regions of the diaphragm, albeit with lower amplitude. Age is the only independent factor affecting the CMAP latency in this study.</p><p><strong>Conclusion: </strong>Normative values with the best recording sites for phrenic NCSs were determined. The posterior aspect of the diaphragm could be recorded with surface electrodes despite the lower amplitude and reliability compared to the anterior part.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"79 1-2","pages":"35-44"},"PeriodicalIF":0.6,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic lesion of corpus callosum associated with cerebral venous sinus thrombosis. 胼胝体细胞毒性病变伴脑静脉窦血栓形成。
IF 0.6 4区 医学
Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2026-01-30 DOI: 10.18071/isz.79.0069
Inci Emekli, Ahmed Serkan Emekli
{"title":"Cytotoxic lesion of corpus callosum associated with cerebral venous sinus thrombosis.","authors":"Inci Emekli, Ahmed Serkan Emekli","doi":"10.18071/isz.79.0069","DOIUrl":"10.18071/isz.79.0069","url":null,"abstract":"<p><p>Introduction - Cytotoxic lesion of corpus callosum (CLOCC) is a rare but increasingly recognized entity. It is associated with various etiologies including drug-related toxicity, epilepsy, infections, metabolic disturbances, and many other conditions. Here we present a rare case of CLOCC due to cerebral venous sinus thrombosis (CVST) in the postpartum period.Case report - A 25-year-old female was admitted due to persistent headaches on the third day of her postpartum period. The neurological examination did not reveal any focal neurological signs. She was diagnosed with CVST and splenium of corpus callosum (SCC) lesion with imaging features of FLAIR/ T2/DWI hyperintensity, ADC hypointensity, and lack of contrast enhancement. Extensive work-up did not unveil any other etiology. She was treated with low-molecular-weight heparin, warfarin, and acetazolamide. Six weeks later, brain imaging showed recanalization of the cerebral sinuses without any signs of permanent lesion in SCC. She was symptom-free at the two-year follow-up.Conclusion - It is crucial to recognize CLOCC and thus to unveil and treat its potential etiology. CVST should be considered in CLOCC cases, particularly in patients with prothrombotic states such as the postpartum period.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"79 1-2","pages":"69-72"},"PeriodicalIF":0.6,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of propranolol with treatment-emergent akathisia during aripiprazole treatment. 心得安与阿立哌唑治疗期间出现的静坐症的关系。
IF 0.6 4区 医学
Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2025-11-30 DOI: 10.18071/isz.78.0395
Ádám Menus, Ádám Kiss, Gábor Csukly, István Bitter, Katalin Monostory, János M Réthely
{"title":"Association of propranolol with treatment-emergent akathisia during aripiprazole treatment.","authors":"Ádám Menus, Ádám Kiss, Gábor Csukly, István Bitter, Katalin Monostory, János M Réthely","doi":"10.18071/isz.78.0395","DOIUrl":"https://doi.org/10.18071/isz.78.0395","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background and purpose: &lt;/strong&gt;Akathisia is a common side effect of aripiprazole treatment, which is associated with subjective distress for patients, and represents a frequent cause of treatment discontinuation. Propranolol and other beta-receptor blockers are commonly used for treatment of akathisia. Cytochrome P450 2D6 (CYP2D6) enzyme plays a major role in the metabolism of aripiprazole. Our previous study has shown that CYP2D6 inhibitory activity of beta-blockers (metoprolol and propranolol) may result in elevated aripiprazole plasma concentrations. The objective of the present retrospective study was to assess the prevalence of akathisia in patients receiving propranolol or metoprolol comedication, as well as in those not receiving any CYP2D6 inhibitors such as propranolol, metoprolol, risperidone.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Using the data of our previous pharmacogenetic study involving 67 patients diagnosed with schizophrenia or schizoaffective disorder and receiving aripiprazole treat- ment, we retrospectively investigated the emergence of akathisia within 6 months following aripiprazole initiation. Information on the onset of akathisia was obtained from patients' medical records. The effects of CYP2D6 genotype, aripiprazole plasma concentration, propranolol and metoprolol comedication on the development of akathisia were analysed. The included patients had already been taking propranolol and metoprolol comedication prior to the initiation of aripiprazole and not for the treatment of akathisia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Schizophrenia and schizoaffective disorder patients treated with propranolol had a significantly higher incidence of documented akathisia (38,5%) compared to the group not receiving CYP2D6 inhibitors (5.9%), and the group treated with metoprolol comedication (7.1%). Among the CYP2D6 inhibitors, only the administration of propranolol increased the risk of akathisia (Wald Chi2=5.5, p=0.02, OR=7.6 [95% CI=1.4-41.4]). The polymorphic CYP2D6 alleles resulting in low CYP2D6 function showed a statistical trend-level association with the occurrence of akathisia (Wald Chi2=2.6, p=0.11, OR=4.7 [95% CI=0.7-30.8]). In a subsequent analysis, we investigated the possible interaction of propranolol and CYP2D6 genotypes on the development of akathisia. The interaction model showed that the effect of propranolol was not dependent on CYP2D6 genotype (Wald Chi2=0.1, p=0.92), however, its independent effect remained significant (Wald Chi2=4.4, p=0.04).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our findings suggest that propranolol comedication increases the risk of the development of akathisia during aripiprazole treatment. It is of paramount importance to avoid propranolol comedication during aripiprazole treatment. However, two major limitations should be considered: akathisia was not assessed using a standardized clinical rating scale, and the majority of patients (80.6%) received antipsychotic combination therapy, which ma","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 11-12","pages":"395-404"},"PeriodicalIF":0.6,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Can the prostate save the brain? When a disadvantage becomes an advantage]. 前列腺能拯救大脑吗?当劣势变成优势时]。
IF 0.6 4区 医学
Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2025-11-30 DOI: 10.18071/isz.78.0389
Ildikó Palló, Attila Valikovics, Csaba Zsolt Oláh
{"title":"[Can the prostate save the brain? When a disadvantage becomes an advantage].","authors":"Ildikó Palló, Attila Valikovics, Csaba Zsolt Oláh","doi":"10.18071/isz.78.0389","DOIUrl":"https://doi.org/10.18071/isz.78.0389","url":null,"abstract":"<p><strong>Background and purpose: </strong>An unpleasant symptom of prostate hyperplasia is that older men get up to urinate at night. However, from the point of view of wake-up stroke, this can be an advantage, as they can detect their neurological deficit sooner due to the urge to urinate and can ask for help and receive definitive care sooner.</p><p><strong>Methods: </strong>Between January 1. 2021 and May 30. 2024, at the Neurology Department of Borsod County University Teaching Hospital, we performed thrombolysis in 298 cases due to stroke within 4,5 hours.</p><p><strong>Results: </strong>We treated 60.4% men and 39.6% women. In this period, we treated 61 wake-up stroke patients, 80.3% of them were men (all were more than 60 years old).</p><p><strong>Conclusion: </strong>In our region more than four times as many male patients can receive definitive care as female patients with regard to wake-up stroke. The awakening caused by prostate hyperplasia can play an important role in detecting symptoms in time.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 11-12","pages":"389-393"},"PeriodicalIF":0.6,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The application of Lee Silverman voice treatment in Parkinson's disease]. 【Lee Silverman声音疗法在帕金森病中的应用】。
IF 0.6 4区 医学
Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2025-11-30 DOI: 10.18071/isz.78.0425
Renáta Vastag-Gyulyás, Judit Bóna, Katalin Jakab, Péter Klivényi
{"title":"[The application of Lee Silverman voice treatment in Parkinson's disease].","authors":"Renáta Vastag-Gyulyás, Judit Bóna, Katalin Jakab, Péter Klivényi","doi":"10.18071/isz.78.0425","DOIUrl":"10.18071/isz.78.0425","url":null,"abstract":"<p><strong>Background and purpose: </strong>Parkinson's disease is a combined motor and nonmotor disorder, including reduced vocal loudness, monotone, slurred speech. The only standardized, evidence-based speech therapy that currently available for people with Parkinson's disease is Lee Silverman Voice Treatment (LSVT).We aimed to present the first results of using LSVT in our country through six case studies.</p><p><strong>Methods: </strong>Six patients with Parkinson's disease were treated at the Neurorehabilitation Department of Department of Neurology, University of Szeged. The average age of patients was 68 years. The patients' antiparkinsonian medication was not changed during the treatment. Patients received speech therapy 16 times, four times a week for 60 minutes for 4 weeks. Data were collected before and after therapy, following the LSVT Loud examining protocol that involved dictaphone recordings about sustained vowel phonation, pitch changes, reading and conversation. The voice recordings were analysed using Praat software, we annotated the sustained vowel phonations, and the pause-to pause speech segments in the reading and conversation tasks.</p><p><strong>Results: </strong>Our results show that the quality of speech and the sound pressure level improved in all patients with the LSVT Loud technique.</p><p><strong>Conclusion: </strong>The prevalence of Parkinson's disease and the changes in speech and voice quality demonstrate the need for expanding the therapeutic options available to manage Parkinson's speech symptoms. In addition to conventional dysarthria therapy, it is recommended to introduce Lee Silverman Voice Treatment (LSVT) into clinical practice, which can significantly improve patients' communication abilities and quality of life. Based on the results, we can say that LSVT can be successfully applied in our country.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 11-12","pages":"425-431"},"PeriodicalIF":0.6,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disease-specific knowledge and differential diagnostic skill in clinical care. 疾病特异性知识和临床护理的鉴别诊断技能。
IF 0.6 4区 医学
Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2025-11-30 DOI: 10.18071/isz.78.0367
Blanka Bernadett Kasza, Kinga Nákity, Andrea Domján
{"title":"Disease-specific knowledge and differential diagnostic skill in clinical care.","authors":"Blanka Bernadett Kasza, Kinga Nákity, Andrea Domján","doi":"10.18071/isz.78.0367","DOIUrl":"https://doi.org/10.18071/isz.78.0367","url":null,"abstract":"<p><strong>Background and purpose: </strong>Back and neck pain are among the most prevalent musculoskeletal complaints, imposing a substantial individual and societal burden on healthcare systems. Effective management requires adequate education, strong clinical decision-making skills, and accurate interpretation of red flags. This narrative literature review explores the educational, diagnostic, and decision-making aspects of back and neck pain among laypeople, healthcare students, and professionals. It aims to synthesize findings from studies assessing disease-specific knowledge to emphasize how targeted educational programs can enhance students' understanding and, consequently, improve their future clinical practice.</p><p><strong>Methods: </strong>A thematic analysis of relevant international literature published between 2000 and 2025 was conducted. The review focused on studies examining disease-specific knowledge, differential diagnostic skills, psychosocial factors, and the interpretation of red flags. Findings were organized by target group and summarized narratively.</p><p><strong>Results: </strong>Across all target groups, substantial gaps were identified in disease-specific knowledge, differential diagnostic competencies, and clinical decision-making skills. While educational interventions demonstra-ted po-sitive effects on knowledge levels and at- titudes, their implementation remains incon- sistent.</p><p><strong>Conclusion: </strong>Structured, targeted educational programs introduced early in healthcare training can significantly enhance students' disease-specific knowledge. Strengthening differential diagnostic skills, improving red flag interpretation, and integrating evidence-based guidelines are essential for promoting safe, effective, and standardized clinical practice.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 11-12","pages":"367-374"},"PeriodicalIF":0.6,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hungarian adaptation of the Suicide Behaviors Questionnaire Revised]. [自杀行为问卷匈牙利版修订版]。
IF 0.6 4区 医学
Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2025-11-30 DOI: 10.18071/isz.78.0375
Melinda Reinhardt, Hunor Girasek, Alexandra Soós, Zsolt Horváth, Gábor Gazdag
{"title":"[Hungarian adaptation of the Suicide Behaviors Questionnaire Revised].","authors":"Melinda Reinhardt, Hunor Girasek, Alexandra Soós, Zsolt Horváth, Gábor Gazdag","doi":"10.18071/isz.78.0375","DOIUrl":"https://doi.org/10.18071/isz.78.0375","url":null,"abstract":"<p><strong>Background and purpose: </strong>Previous suicidal intent and attempt(s) are strong risk factors for current suicidal behaviour. In psy- chiatric practice, however, there are few self-report-based suicide risk assessment measures that can cover the past suicidal spectrum from multiple aspects and identify a cut-off point for suicidal risk. Our aim was therefore to introduce the Suicide Behaviors Questionnaire Revised (SBQ-R) into the Hungarian test battery.</p><p><strong>Methods: </strong>In our cross-sectional questionnaire study, 229 hospitalized adult psychiatric patients (mean age = 41.64 ys; SD = 14.41; 56.3% female) participated. Beside the SBQ-R, the Rihmer's Brief Suicide Questionnaire, 6-item version, the Beck Hopelessness Scale and the Minnesota Multiphasic Persona-lity Inventory-2 (MMPI-2) clinical personality questionnaire were completed.</p><p><strong>Results: </strong>We confirmed the single-factor structure of the SBQ-R with excellent model fit indices in a Hungarian sample. The reliability of the questionnaire is adequate and its construct validity is optimal: it shows moderate to strong correlations with other measures of the suicide spectrum, with hopelessness and with the clinical scales of the MMPI-2. The cut-off point for suicidal risk was set at 7 points, broadly in line with international studies; patients at or above this value are 9 times more likely to have an expressed suicide risk. Hopelesness increases by 13.5% the possibility of the high-risk group membership based on the SBQ-R, while previous suicidal act(s) increase this odds five times higher.</p><p><strong>Conclusion: </strong>The self-report-based SBQ-R is a reliable, valid, multi-faceted assessment of suicidal behaviour and an effective tool for screening suicidal risk.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 11-12","pages":"375-387"},"PeriodicalIF":0.6,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective evaluation of children under five years of age with head injuries: Single center experience. 5岁以下儿童头部损伤的回顾性评价:单中心经验。
IF 0.6 4区 医学
Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2025-11-30 DOI: 10.18071/isz.78.0407
Mehmet Kilic, Atakan Besnek, Halil Aslan, İhsan Yildirim, Bariş Erdogan
{"title":"Retrospective evaluation of children under five years of age with head injuries: Single center experience.","authors":"Mehmet Kilic, Atakan Besnek, Halil Aslan, İhsan Yildirim, Bariş Erdogan","doi":"10.18071/isz.78.0407","DOIUrl":"https://doi.org/10.18071/isz.78.0407","url":null,"abstract":"<p><strong>Background and purpose: </strong>Head trauma is one of the leading causes of morbidity and mortality in childhood and can lead to traumatic brain injury (TBI). In our study, we present a retrospective analysis of the clinical and radiological findings of patients presenting with head trauma in 0-5 age range, examining the relationship between pediatric skull and brain development and age-related changes in trauma mechanisms. The study aims to evaluate the clinical characteristics and injury mechanisms in young children with head trauma, providing insights for improved management strategies tailored to this vulnerable population.</p><p><strong>Methods: </strong>The study assessed patients who presented to Şanliurfa Education and Research Hospital between January 1, 2016, and January 1, 2022. The clinical and radiological data of 1216 patients aged 5 years and younger who were admitted due to head trauma were analyzed. Symptoms, physical examination findings, trauma mechanisms, and CT findings were evaluated for each age group.</p><p><strong>Results: </strong>Among the included 1216 patients 62.9% (n=765) were male and 37.1% (n=451) were female. The incidence of scalp hematoma showed a significant difference in the 0-1 and 1-2 age groups (p.</p><p><strong>Conclusion: </strong>The findings of this study reveal distinct differences in head trauma presentations among the various age groups, indicating that younger children experience different trauma mechanisms and types of injuries compared to older children. Recognizing these differences is crucial for tailoring prevention strategies and therapeutic interventions, allowing for more effective management of head trauma in pediatric patients. This study emphasizes the significance of analyzing head trauma in rapidly developing age groups. The observed variations in trauma mechanisms and clinical findings necessitate age-specific approaches in patient management, which can ultimately enhance treatment outcomes for young patients suffering from head trauma.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 11-12","pages":"407-416"},"PeriodicalIF":0.6,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptive and terminal endoplasmic reticulum stress genes methylation levels in Parkinson patients' peripheral blood. 帕金森患者外周血适应性和终末内质网应激基因甲基化水平。
IF 0.6 4区 医学
Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2025-11-30 DOI: 10.18071/isz.78.0417
Yagmur Inalkac Gemici, Muhammed Dundar, Harika Gozde Gozukara, Ahmet Koc
{"title":"Adaptive and terminal endoplasmic reticulum stress genes methylation levels in Parkinson patients' peripheral blood.","authors":"Yagmur Inalkac Gemici, Muhammed Dundar, Harika Gozde Gozukara, Ahmet Koc","doi":"10.18071/isz.78.0417","DOIUrl":"https://doi.org/10.18071/isz.78.0417","url":null,"abstract":"<p><strong>Background and purpose: </strong>Misfolded protein stress has come to the fore among the molecular mechanisms that can cause degeneration. Whereas one of the most important protein of adaptive Endoplasmic Reticulum stress (ERS) is XBP1, CHOP and ASK proteins are associated with apoptosis and terminal ERS. To the best of our knowledge, methylation levels of adaptive and terminal ERS genes in Parkinson's Disease (PD) patients' blood are unknown. We aimed to evaluate if there is a difference in the DNA methylation levels of the ERS related protein-coding genes in peripheral blood of PD patients compared with healthy controls. The clinical significance of these gene methylation levels was evaluated as the second aim.</p><p><strong>Methods: </strong>DNA was isolated from the blood of PD patients (n=23) and controls (n=19). We used a methylation-specific qPCR approach to assess the methylation status of the ERS genes. The correlation between clinical findings and the methylation levels in PD patients were evaluated with appropriate statistical methods.</p><p><strong>Results: </strong>Terminal ERS related genes were statistically significantly hypomethylated in PD (ASK1 p=0.020, and CHOP p.</p><p><strong>Conclusion: </strong>PD patients' peripheral blood methylation levels of adaptive and terminal ERS related genes are significantly different from healthy controls'. While XBP1 is known to be neuroprotective, CHOP and ASK are important proteins in apoptosis, and their methylation differences in peripheral blood provide a clue that they could be used as biomarkers in the future. Therefore, further biomarker and treatment studies should be conducted on these proteins and their pathways.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 11-12","pages":"417-423"},"PeriodicalIF":0.6,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Neuromyelitis optica spectrum disorder: new international recommendations and emerging therapeutic options; current status of domestic practice in diagnostics and therapeutic strategies]. 视神经脊髓炎谱系障碍:新的国际建议和新兴的治疗方案;诊断和治疗策略的国内实践现状[j]。
IF 0.6 4区 医学
Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2025-09-30 DOI: 10.18071/isz.78.0295
Cecília Rajda
{"title":"[Neuromyelitis optica spectrum disorder: new international recommendations and emerging therapeutic options; current status of domestic practice in diagnostics and therapeutic strategies].","authors":"Cecília Rajda","doi":"10.18071/isz.78.0295","DOIUrl":"10.18071/isz.78.0295","url":null,"abstract":"<p><p>Neuromyelitis optica spectrum disorder is a rare neuroimmunological disease associated with unpredictable deterioration. Even the first signs of the disease can be severe enough to lead to permanent neurological impairment, such as loss of vision or paralysis. Early symptoms can often be mistaken for another disease, leaving patients bouncing between several specialists, leading to diagnostic delay. Early detection of the disease can save lives and quality of life, as appropriate therapy started early can prevent neurologically debilitating deterioration. In Hungary, the \"off label\" rituximab has so far been given a facilitated procedure for therapy, while evidence-based medicines are not yet available to us.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 9-10","pages":"295-305"},"PeriodicalIF":0.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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