Ideggyogyaszati Szemle-Clinical Neuroscience最新文献

{"title":"Antibodies against SARS-CoV-2 in cerebrospinal fluid: Clinical features and laboratory findings of hospitalized patients with neurologic symptoms in the pandemic era.","authors":"Sezin Alpaydin Baslo, Burcu Yuksel, Isil Baytekin, Araz Ceren Incesoy, Eda Salihoglu Kara, Mesrure Koseoglu, Serap Teker, Begum Cengizler, Fatma Betul Oktelik, Aysu Sen, Dilek Atakli, Gunnur Deniz, Aysun Soysal","doi":"10.18071/isz.77.0136","DOIUrl":"https://doi.org/10.18071/isz.77.0136","url":null,"abstract":"<p><strong>Background and purpose: </strong>High titers of anti-SARS-CoV-2 immunoglobulin G (IgG) have been reported in cerebrospinal fluid (CSF) samples of patients with COVID-19, but the data are limited. Our purpose is to report the clinical features and CSF findings of patients with neurologic symptoms in the pandemic era, and to discuss the origin and importance of anti-SARS-CoV-2 IgG in CSF.</p><p><strong>Methods: </strong>The data of 100 patients hospitalized in neurology inpatient clinics and tested for anti-SARS-CoV-2 IgG antibodies in CSF samples, between May 2021 and March 2022, were evaluated in a retrospective manner. Demographic features, presence of coronavirus disease 2019 (COVID-19) and/or COVID-19 history, vaccination, vaccine type, and neurologic diagnoses were noted. CSF and serum anti-SARS-CoV-2 antibody ratio (AR) were assessed using a Euroimmun ELISA assay. CSF cytology, CSF protein level, oligoclonal band, IgG index, and albumin quotient (QAlb) were analyzed and compared between CSF AR positive and negative groups.</p><p><strong>Results: </strong>QAlb and CSF protein levels were higher in the CSF anti-SARS-CoV-2 AR-positive group compared with CSF anti-SARS-CoV-2 AR-negative group (p.</p><p><strong>Conclusion: </strong>Anti-SARS-CoV-2 antibodies in CSF seem to be related to a past immunization or a pre-existing cross reactive immunity and passive diffusion through a disrupted blood-brain-barrier, but not to an intrathecal antibody synthesis.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 3-04","pages":"136-144"},"PeriodicalIF":0.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Management of migraine without aura in adolescents: The experience of flunarizine use in a Turkish cohort].","authors":"Faik Ilik, Devrimsel Harika Ertem, M Kemal Ilik","doi":"10.18071/isz.77.0122","DOIUrl":"https://doi.org/10.18071/isz.77.0122","url":null,"abstract":"<p><strong>Background and purpose: </strong>Flunarizine is a specific calcium antagonist and is frequently used in adults for the prophylactic treatment of migraine. The use of flunarizine may lead to somnolence and weight gain, depression, and rarely extrapyramidal symptoms in adults. However, studies detecting the efficacy and safety of flunarizine use in adolescents are limited. In the current study, the effectiveness of flunarizine for the management of migraine without aura in Turkish adolescents was evaluated.</p><p><strong>Methods: </strong>Forty-six patients with migraine without aura, receiving flunarizine 5mg per day were included. In this retrospective study, the medical records of the cases were examined. Visual Analog Scale (VAS) and MIDAS scores were compared to assess the efficacy of the 3 months treatment.</p><p><strong>Results: </strong>The mean age was 14.37±1.83 years. There was a significant improvement in the VAS and MIDAS scores of the patients at the end of the third month (p.</p><p><strong>Conclusion: </strong>Although the advancement of migraine research and treatment is inevitable, our findings support that flunarizine should still be considered as an effective and tolerable treatment option in adolescent migraineurs.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 3-04","pages":"122-126"},"PeriodicalIF":0.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of pediatric Sylvian arachnoid cysts. A retrospective study.","authors":"Murat Zaimoglu, Umit Eroglu, Melih Bozkurt, Baran Can Alpergin, Savas Hasimoglu, Onur Ozgural, Gokmen Kahilogullari, Mustafa Agahan Unlu","doi":"10.18071/isz.78.0127","DOIUrl":"https://doi.org/10.18071/isz.78.0127","url":null,"abstract":"<p><strong>Background and purpose: </strong>Neurosurgical approaches in Sylvian arachnoid cysts include microsurgery, endoscopy, and shunting. Yet, their relative safety and efficacy is still under debate. This retrospective study evaluated 36 pediatric patients with Sylvian arachnoid cysts and treated with different surgical types to contribute to global data.</p><p><strong>Methods: </strong>The study included 24, 8, and 4 patients receiving endoscopic, microsurgical, and shunt surgeries, respectively. Preoperative and postoperative assessments included the patients' demographics and symptoms, cyst size and type, psychomotor status, length of hospital stay, and complications with a mean follow-up of 37.3 months.</p><p><strong>Results: </strong>All types of surgeries alleviated headaches and seizures in most of the patients. Shunt operations led to the highest reduction in cyst size in the early postoperative period and relieved cranial palsy in all patients. Microsurgery achieved greater healing regarding hemiparesis and seizures, and reduced cyst size more effectively in the early postoperative period than endoscopy. Complication rates were similar between the endoscopy and microsurgery groups.</p><p><strong>Conclusion: </strong>Arachnoid cyst surgery is efficient and relatively safe. The higher efficacy of microsurgery may be associated with the lesser chronic presence of cysts in this group rather than its technical superiority. Endoscopic surgery is challenging, yet it may be advocated to avoid craniotomy and shunt complications. Surgical-type decisions for arachnoid cysts should be patient-tailored based on careful preoperative clinical and radiological examinations.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 3-04","pages":"127-135"},"PeriodicalIF":0.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of computerised interactive devices for stroke patients with hemispatial neglect.","authors":"Ibolya Tavaszi, Gábor Szabó, Petra Erdősi, Benjamin Shenker, Gábor Fazekas","doi":"10.18071/isz.77.0107","DOIUrl":"https://doi.org/10.18071/isz.77.0107","url":null,"abstract":"<p><strong>Background and purpose: </strong>Computerised interactive devices provide various treatment options for post-stroke rehabilitation, and may be applicable to treat neuropsychological deficits. This study aimed to identify a single rehabilitation task capable of improving both motor and cognitive functions in stroke patients.</p><p><strong>Methods: </strong>This prospective randomised controlled trial involved post-stroke patients with hemispatial neglect who were divided into four groups. All groups received conventional treatment. Besides this, the control group made sorter exercises, while the three experimental groups engaged in the following additional activities: exercises with a gravity-supporting exoskeleton; exercises with an upper limb device with sensors on the patient; exercises with an upper limb device with sensors on a touchscreen. All groups used the unaffected side, except the exoskeleton group. Following measures were assessed pre- and post-test: upper limb subsection of the Fugl-Meyer scale (FM-UL), functional independence measure (FIM), line bisection test (LBT), Bells test.</p><p><strong>Results: </strong>The programme (four weeks, 15 sessions) was completed by 59 post-stroke patients (less than 6 months after stroke). Significant associations were observed between time since stroke onset and improvements in FM-UL (p = .039), and motor (p = .021) and total FIM (p = .034). The motion abilities of the affected upper limb improved regardless of the treated side (p FM-UL = 0.45; p FIM = 0.416; p motor FIM = 0.395; p Bells test = 0.347; p LBT = 0.887). Bells test and LBT showed a strong correlation (-0.593). The effectiveness of the computerised interactive rehabilitation exercises in treating hemispatial neglect was comparable to conventional exercises, improving motor abilities of patients, as well as reducing hemispatial neglect in post-stroke patients.</p><p><strong>Conclusion: </strong>This form of therapy is effective for both motor and certain cognitive deficits.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 3-04","pages":"107-121"},"PeriodicalIF":0.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Automated audio analysis and depression: A systematic umbrella review].","authors":"Bálint Hajduska-Dér, Lajos Simon, János Réthelyi, Edit Haluska-Vass","doi":"10.18071/isz.77.0087","DOIUrl":"https://doi.org/10.18071/isz.77.0087","url":null,"abstract":"<p><strong>Background and purpose: </strong>The early and accurate diagnosis of depression is essential for the timely initiation of appropriate treatment. However, the use of traditional diagnostic methods is often subjective, labour-intensive, and time-consuming. Automated voice analysis offers promising solution to overcome these challenges by enabling the objective measurement of voice-based biometric features. The aim of this study is to review the research practice and findings of voice analysis methods supported by machine learning, to uncover inconsistencies, and to formulate constructive suggestions for future research.</p><p><strong>Methods: </strong>This paper presents the results of a so-called umbrella review, which integrates the findings of already published systematic literature reviews and meta-analyses. For the identification of publications, we used the PubMed, Scopus, and ProQuest databases, following the PRISMA guidelines. The search interval covered the last 5 years. The search was conducted using predefined search terms and selection criteria, with the involvement of independent reviewers. Prior to detailed analysis, the methodological quality of the publications was assessed using the AMSTAR2 evaluation system.</p><p><strong>Results: </strong>Through the systematic literature search, we identified a total of 162 unique records. Based on the inclusion and exclusion criteria, 6 publications were selected for detailed analysis. The results highlight the background factors limiting the applicability of the developed models and also emphasize the importance of acoustic characteristics that can be identified as biomarkers of depression despite methodological inconsistencies. This review supports the importance of machine learning and voice analysis in advancing the diagnostics of depression. However, to translate research outcomes into practice, beyond the application of standardized methods, validation across diverse test groups is necessary, among other things.</p><p><strong>Conclusion: </strong>The application of machine learning in depression detection promises numerous advantages, such as objective diagnosis or early detection. This technology could offer cost-effective solution in the long run while providing greater access to mental health services. Nevertheless, the field is still evolving, and further research is needed to enhance the reliability of these methods.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 3-04","pages":"87-99"},"PeriodicalIF":0.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difficult clinical decisions regarding carotid artery revascularization in patients with contralateral carotid occlusion.","authors":"Robin Roy Mathews, László Oláh, László Csiba","doi":"10.18071/isz.77.0100","DOIUrl":"https://doi.org/10.18071/isz.77.0100","url":null,"abstract":"<p><p>Background and purpose - Carotid revascularization through carotid endarterectomy (CEA) and carotid artery stenting (CAS) are well established secondary preventive measures after ischemic stroke in unilateral carotid artery stenosis, but in the presence of contralateral carotid occlusion (CCO) the evidence regarding the optimal management of the stenotic carotid is not as clear even though the risk of ischemic stroke is high. The purpose of our review is to summarize recent findings and suggest its future implications. Methods - We conducted a systematic literature review using PubMed and ScienceDirect databases supplemented with studies found from Google Scholar.Results - Recent guidelines recommend CAS over CEA in patients with CCO, but in contrast some studies favor CEA over CAS after analysis of the complications and clinical outcome.Discussion - The decision between CEA and CAS depends upon a variety of factors such as neurological status, surgical risk factors, medical comorbidities, age, and imaging findings (presence of silent infarcts, plaque characteristics and the state of collateral cir-culation). Due to the contradictory ob-ser--vations the authors suggest further mul--ti-cen-ter studies to establish the optimal ma-nagement of patients with carotid ste-no-sis and CCO and also summarize their personal opinion.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 3-04","pages":"100-106"},"PeriodicalIF":0.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prognostic significance of smoldering disease in multiple sclerosis, monitoring progression by imaging].","authors":"Lilla Rácz, Tünde Csépány","doi":"10.18071/isz.77.0079","DOIUrl":"https://doi.org/10.18071/isz.77.0079","url":null,"abstract":"<p><p>Disability progression can occur in all phenotypes of multiple sclerosis (MS) from the early stages of the disease, which may be due to incomplete recovery from clinical relapses and/or more insidious deterioration of neurological functions independent of relapses. Progression independent of relapse is more common in patients with progressive MS than in patients with relapsing-remitting MS. Its main background may be the activation of innate immune cells and the development of chronic active lesions, referred to as smoldering disease. Their identification may help in the early recognition of aggressive forms. Finding effective therapies targeting progressive mechanisms is a major need. A better understanding of the mechanisms underlying the progression of MS, the identification and validation of biomarkers and new therapeutic targets could lead to further success of therapies. In this communication, we summarize the theoretical background of smoldering disease and potential imaging modalities for its detection.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 3-04","pages":"79-85"},"PeriodicalIF":0.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Phenotypic variability in sisters with VPS13A disease (chorea-acanthocytosis)].","authors":"Ozge Gonul Oner, Asuman Orhan Varoglu","doi":"10.18071/isz.78.0069","DOIUrl":"https://doi.org/10.18071/isz.78.0069","url":null,"abstract":"<p><p>Chorea-acanthocytosis (VPS13A disease) is a rare multisystem neurodegenerative disorder with a broad phenotypic spectrum. It is characterized by neuropsychiatric symptoms and the presence of acanthocytes. However, the relationship between acanthocytes and disease severity remains unclear. Diagnosis is established through genetic testing. We present two sisters with VPS13A disease, each exhibiting distinct clinical presentations. The younger presents with severe symptoms including drug-resistant epilepsy, neuropsychiatric issues, chorea, and self-mutilation, along with the presence of acanthocytes in her blood smear (10%). Genetic testing identified a homozygous synonymous mutation in the VPS13A gene (Chromosome 9: 79971783 G>C, exon 55, c.7806G>C, Pro2602=). Conversely, the older sister experiences only well controlled epileptic seizures and elevated creatine kinase levels, with no acanthocytes in peripheral blood smears, which have been performed three times. She also harbors the same homozygous synonymous mutation in the VPS13A gene. Our report highlights siblings with identical mutations but differing clinical presentations, emphasizing the variability in VPS13A disease manifestations. The younger sister has acanthocytosis and chorea, whereas the older did not demonstrate those features. The term \"VPS13A disease\" is proposed to encompass this group of diseases, acknowledging that acanthocytes or chorea may not always be present. Our findings support this terminological shift. Additionally, we first mentioned this synonymous mutation (NM_033305.3: c.7806G>C exon 55, p. Pro2602=) in the VPS13A gene, contributing to the understanding of this condition.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 1-2","pages":"69-72"},"PeriodicalIF":0.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The role of dietary factors in cognitive decline].","authors":"Zita Breitenbach, Olívia Kulcsár, Fruzsina Péter, István Gáti, Éva Polyák","doi":"10.18071/isz.78.0005","DOIUrl":"https://doi.org/10.18071/isz.78.0005","url":null,"abstract":"<p><p>The increasing morbidity and mortality of dementia places a significant burden on society in economic, social and health terms. In addition to the therapy of partially detectable etiologies, diet can also play a major role in reducing the risk of dementia. The most commonly studied dietary patterns in relation to cognitive decline are the Mediterranean diet, the DASH (Dietary Approaches to Stop Hypertension) diet for the prevention of hypertension, and the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet, which has emerged as a new approach in the last decade, combining elements of the Mediterranean and DASH diets, but there is also considerable research on the ketogenic diet and intermittent fasting. This study aims to summarise all dietary factors that may play a role in the prevention and development of cognitive decline.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 1-2","pages":"5-18"},"PeriodicalIF":0.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between angiotensin receptor blocker therapy and acute seizures in patients with stroke.","authors":"Zoltán Szupera, György Czifra, Bence Fülöp, Zsuzsa Hermann, Benjamin Jassoy, Alexandra Koszta, Katalin Kovács-Kusza, Edit Pordány-Bagoly, Szandra Singoszki, Gábor Szegleti, Vince Varga, Zoltán Kiss","doi":"10.18071/isz.78.0047","DOIUrl":"https://doi.org/10.18071/isz.78.0047","url":null,"abstract":"<p><strong>Background and purpose: </strong>There are some new results that the angiotensin receptor blockers (ARB) therapy may associate with a lower risk of epilepsy. However, its pathomechanism and the patient characteristics are lacking. We asses, whether ARB therapy is associates with lower incidence of acute symptomatic seizures, compared with no ARB therapy in patients with acute stroke.</p><p><strong>Methods: </strong>There was a single-center, retrospective, observational cross-sectional study, enrolled patients with acute stroke admitted to our hospital, from 1 January 2019 to 31 December 2021. The data source was our hospital medical database. We allocated the enrolled patients into two groups, by receiving or not ARB therapy and defined a 7 days exposure window after stroke onset whether acute seizures appear. The primary outcome was the incidence of acute seizures associated with ARB therapy compared with no ARB therapy. The comparison of these groups was performed with t-test for independent samples. Analysis of seizure predictors was tested in univariable and multivariable logistic regression models.</p><p><strong>Results: </strong>The study included 1611 patients, mean [SD] age was 72.1 [±13.3] years; 801 (49.7%) were women, and 811 (50.3%) were men. The acute symptomatic seizures occurred in 4 of 235 patients (1.70%) in the ARB group and 78 of 1376 patients (5.67%) in the control group (P=0.014). In univariable analysis the variables significantly associated with acute symptomatic seizures: ARB the-rapy (odds ratio [OR], 0.29; 95% CI, 0.10-0.79; p=0.016), and with inverse association the hemorrhagic stroke (OR, 1.60; 95% CI, 1.50-4.52; p<0.001). In multivariable analy-sis, in addition to haemorrhage (OR, 2,46; 95% CI, 1,41-4,40; p<0.001) the ARB therapy remains significant (OR, 0.33; 95% CI, 0.12-0.91; p=0.032) as an independent predictor.</p><p><strong>Conclusion: </strong>Due to our results the ARB therapy associates with a lower incidence of acute symptomatic seizures, which raise a question about its antiseizure property. Therefore, additional studies require to give more evidences about advantage of ARB therapy in these patients.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"78 1-2","pages":"47-55"},"PeriodicalIF":0.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}