Ideggyogyaszati Szemle-Clinical Neuroscience最新文献

{"title":"Selective umami taste impairment in anosmic Parkinson's disease: associations with non-motor symptoms.","authors":"Zehra Yavuz, Halil Önder, Fatma Akçelebi Eldek, Selim Selçuk Çomoglu","doi":"10.18071/isz.79.0315","DOIUrl":"https://doi.org/10.18071/isz.79.0315","url":null,"abstract":"<p><strong>Background and purpose: </strong>Olfactory dysfunction (OD) is a well-established prodromal feature of Parkinson's disease (PD). However, the association between olfactory loss and gustatory alterations - particularly umami perception - and their relationship with non-motor symptoms (NMS), affective status, reward-related eating behavior, and quality of life (QoL) remain incompletely characterized. The purpose of this study was to investigate the relationship between objectively defined anosmia and taste perception, NMS, mood disturbances, reward-driven eating behavior, and QoL in patients with PD.</p><p><strong>Methods: </strong>This cross-sectional study included 150 patients with idiopathic PD. Olfactory function was assessed using the Brief Smell Identification Test (BSIT). Patients with self-reported complete olfactory loss and BSIT scores ≤8 were classified as anosmic (n = 75), while the remaining patients were classified as non-anosmic (n = 75). Gustatory perception of the five basic tastes (sweet, sour, salty, bitter, and umami) was evaluated using visual analogue scales (VAS). Reward-related eating behavior was assessed using the Palatable Eating Motives Scale (PEMS), Food Cravings Questionnaire-Trait (FCQ-T), and Power of Food Scale (PFS). Non-motor symptom burden was evaluated using an olfaction-adjusted Non-Motor Symptoms Scale (NMSS Total*). Mood, anxiety, and QoL were assessed using the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Parkinson's Disease Questionnaire-39 (PDQ-39).</p><p><strong>Results: </strong>Anosmic patients demonstrated significantly lower umami VAS scores compared with non-anosmic patients (p = 0.018), while no significant differences were observed for the other basic taste modalities. NMSS Total* scores were numerically higher in the anosmic group, with significantly greater impairment in the Mood/Cognition and Sexual domains. Depressive symptom severity was significantly higher in anosmic patients (p = 0.023). Although total PDQ-39 scores did not differ between groups, the Mobility and Cognition subdomains were significantly more impaired in anosmic patients. A weak negative correlation was observed between salty taste perception and depressive symptom severity.</p><p><strong>Conclusion: </strong>The findings indicate that anosmia in PD is selectively associated with impaired umami taste perception and increased involvement of specific non-motor symptom domains, particularly affective and motivational features, suggesting a distinct chemosensory-related non-motor symptom profile. In PD, objectively defined anosmia is associated with selective umami taste impairment and increased depressive and non-motor symptom burden, indicating that chemosensory dysfunction reflects a clinically relevant non-motor symptom profile.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"79 9-10","pages":"315-326"},"PeriodicalIF":0.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Stressful situations and their effects among psychiatric residents].","authors":"Judit Lazáry","doi":"10.18071/isz.79.0295","DOIUrl":"https://doi.org/10.18071/isz.79.0295","url":null,"abstract":"<p><strong>Background and purpose: </strong>Numerous studies in the international literature address workplace traumatic experiences affecting psychiatry residents and their impacts. No such survey has been conducted in Hungary so far, so I set as my goal to assess the occurrence of stressful situations affecting Hungarian psychiatry residents and their psychological consequences. Emphasizing the mental health of psychiatry residents and improving prevention in specialist training is an essential condition for training stable, well-prepared specialists.</p><p><strong>Methods: </strong>A total of 80 psychiatry residents from the specialist training programs of the 4 Hungarian universities were included in the survey. The questionnaire consisted of 5 parts: occurrence of stressful situations; psychological reactions; Mini-Oldenburg Burnout Inventory (MOLBI); coping mechanisms; needs for specialist training development.</p><p><strong>Results: </strong>Among stressful situations, verbal abuse and discriminatory remarks were the most common. Physical assault affected 34.6% of respondents, and patient suicide occurred in 34.5% of cases. Burnout criteria were met in 62.5% of residents. High scores were achieved on the MOLBI Disengagement subscale by 65% and on the Exhaustion subscale by 90%. Although burnout and disengagement levels were similar, the proportion of those with significant exhaustion was significantly higher in the Budapest sample compared to the national average (94.2% vs. 84.6%). For processing cases, young residents most commonly chose discussion with fellow residents. 100% of respondents supported the development of specialist training programs that would aid the professional processing of difficult situations.</p><p><strong>Conclusion: </strong>The occurrence of stressful situations shows similar trends to international literature data. However, burnout and exhaustion levels are significantly higher, which may have several explanations. The two most important factors to build future development strategies around are more thorough preparation for difficult situations and the programmatic implementation of professional and regular case processing.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"79 9-10","pages":"295-306"},"PeriodicalIF":0.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of electroneuromyography parameters of axillary and accessory nerves in long-term motorcycle riders.","authors":"Yıldız Yener, Elif Sarica Darol, Tuncay Çolak","doi":"10.18071/isz.79.0307","DOIUrl":"https://doi.org/10.18071/isz.79.0307","url":null,"abstract":"<p><strong>Background and purpose: </strong>Long-term motorcycle use may lead to various health problems, such as musculoskeletal disorders and peripheral nerve compression. This study aims to evaluate the effects of prolonged motorcycle use on the peripheral nervous system.</p><p><strong>Methods: </strong>Electroneuromyography (ENMG) data for the axillary nerve and accessory nerve were compared between motorcycle users and non-users. The study included 50 volunteers who had been actively riding motorcycles for at least five years and 50 individuals who did not use motorcycles. Anthropometric measurements were also recorded, and nerve conduction parameters were statistically analyzed.</p><p><strong>Results: </strong>The results revealed that the latencies of the right and left axillary nerves were significantly increased in the motorcycle group (p.</p><p><strong>Conclusion: </strong>These findings indicate that long-term motorcycle use can cause neurophysiological alterations in upper extremity nerve conduction. The outcomes of this study may support the development of ergonomic interventions and protective strategies to mitigate the potential risks associated with prolonged motorcycle use.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"79 9-10","pages":"307-313"},"PeriodicalIF":0.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of hereditary spastic paraplegia with homozygous mutation in the ZFYVE26 gene.","authors":"Betül Özenc, Dogan Dinc Oge, Pelin Yenilmez Yesildas","doi":"10.18071/isz.79.0357","DOIUrl":"https://doi.org/10.18071/isz.79.0357","url":null,"abstract":"<p><p>Hereditary spastic paraplegia (HSP) refers to a group of rare, progressive neurodegenerative disorders characterized by spasticity and weakness predominantly affecting the lower limbs, with significant clinical and genetic heterogeneity. Clinically, HSP is classified into \"pure\" and \"complicated\" forms. SPG15 (ZFYVE26) is a rare autosomal recessive subtype typically presenting in childhood with cognitive decline, followed by the development of gait disturbances and spasticity, often accompanied by thinning of the corpus callosum. Here, we report the case of a 19-year-old female patient, born to consanguineous parents, presenting with gait disturbance, lower limb spasticity, and dysarthria. Neurological examination revealed motor and mental retardation, bilateral lower limb spasticity, increased deep tendon reflexes, thinning of the corpus callosum on brain MRI, white matter hyperintensities, and the characteristic \"lynx ear sign\". Electromyography demonstrated marked sensorimotor demyelinating polyneuropathy in the lower limbs and evidence of anterior horn cell involvement. Genetic analysis, prompted by clinical and radiological findings, revealed a homozygous mutation in exon 19 of the ZFYVE26 gene: c.3382C>T p.Q1128*.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"79 9-10","pages":"357-360"},"PeriodicalIF":0.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The first case of Miller Fisher syndrome associated with anti-GM3 IgG antibodies: Classic triad and an atypical immune response].","authors":"Betül Özenc, Erman Altunisik, Feyza Musabeyoglu","doi":"10.18071/isz.79.0347","DOIUrl":"https://doi.org/10.18071/isz.79.0347","url":null,"abstract":"<p><p>Miller-Fisher syndrome (MFS) is a rare variant of Guillain-Barré Syndrome (GBS), an acute immune-mediated peripheral neuropathy most preceded by infections, particularly Campylobacter jejuni, through a mechanism of molecular mimicry that underlies its predominantly autoimmune pathogenesis. Anti-ganglioside antibodies play a significant role in the pathogenesis of MFS, with a particularly high prevalence of anti-GQ1b antibodies among affected individuals. However, the presence of alternative anti-ganglioside antibodies does not exclude the diagnosis. We report the case of a 72-year-old male who presented with acute-onset diplopia and progressive visual impairment in both eyes, accompanied by gait imbalance. He had a history of gastroenteritis approximately two weeks prior to symptom onset. Neurological examination revealed near-complete ophthalmoplegia with severe diplopia in all directions of gaze, generalized hyporeflexia in the limbs, and impaired coordination. Cerebrospinal fluid analysis was unremarkable. Anti-ganglioside antibody testing was performed using enzyme-linked immunosorbent assay for antibodies against GM1, GM2, GM3, GD1a, GD1b, GT1b, and GQ1b. The results showed isolated strong positivity (+++) for anti-GM3 IgG antibodies. Based on clinical presentation and serological findings, a diagnosis of Miller-Fisher syndrome was established. The presence of anti-ganglioside antibodies may serve as supportive evidence for MFS, but the diagnosis remains primarily clinical.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"79 9-10","pages":"347-349"},"PeriodicalIF":0.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purely transvenous treatment of cervical paraspinal arteriovenous fistulas.","authors":"Laura Margarita Sanchez-Garcia, Patrick Thurner, Jawid Madjidyar, Tilman Schubert, Zsolt Kulcsar","doi":"10.18071/isz.79.0341","DOIUrl":"10.18071/isz.79.0341","url":null,"abstract":"<p><p>The spinal arteriovenous malformations are rare and comprise a heterogeneous spectrum of disease. Paraspinal arteriovenous fistulas (PSAVF) are defined as pathologic connections between arteries and veins in the paraspinal space. Microsurgical, transarterial or combined transarterial and transvenous embolization has been published as the treatment of choice of such lesions. In this report, we elaborate on the principles of the pathoanatomy of the PSAVF with its implications on the concept of purely transvenous treatment. We present two patients with paraspinal arteriovenous fistula treated with purely transvenous approach and describe the procedure. The rationale of purely transvenous embolization relies on the possibility of direct access of the primary venous structure affected by the PSAVF. The multiple existing connections between the internal and external periverterbal venous plexus, the condylar system and the vertebral veins allows for very precise and restricted occlusion of the pathology, reducing the risk of arterial ischemia of the spinal cord.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"79 9-10","pages":"341-346"},"PeriodicalIF":0.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of immature granulocytes as a novel biomarker in migraine: a prospective tertiary-care study.","authors":"Mehmet Akif Bildirici, Oğuzhan Durgan, İmran Sona Ayvali","doi":"10.18071/isz.79.0329","DOIUrl":"https://doi.org/10.18071/isz.79.0329","url":null,"abstract":"<p><strong>Background and purpose: </strong>Migraine has been associated with systemic inflammatory alterations in a limited number of studies, although the evidence remains inconsistent. In this context, immature granulocytes (IGs), early indicators of bone marrow activation, have been proposed as potential biomarkers in migraine research. The aim of this study was to evaluate IG levels in patients with episodic migraine during attack and interictal periods and to investigate their relationship with hematological inflammatory markers and clinical features.</p><p><strong>Methods: </strong>This prospective case-control study enrolled 53 patients with episodic migraine and 53 healthy controls matched for age and sex. Blood samples were collected during acute migraine attacks and interictal periods. Inflammatory parameters, including IG, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio (LMR), systemic inflammation response index (SIRI), and platelet indices were analyzed. Correlations with clinical characteristics such as headache frequency, aura, white matter lesions, and migraine disability assessment scale (MIDAS) scores were assessed.</p><p><strong>Results: </strong>IG levels did not differ significantly between migraineurs and controls. However, lower IG levels were associated with higher headache frequency (ρ = -0.453, p = 0.001) and MIDAS scores (ρ = -0.291, p = 0.037). LMR was significantly lower and SIRI higher in the attack-period patients versus controls (p = 0.028 and p = 0.023, respectively). Platelet indices such as MPV, PDW, and P-LCR elevated during attacks, while platelet counts increased during interictal periods. ROC analyses showed limited discriminative power of platelet indices (AUC < 0.61).</p><p><strong>Conclusion: </strong>These findings suggest that IG levels and inflammatory indices such as LMR and SIRI may reflect migraine-related immune activity and disease burden during the migraine attack phase, though their clinical utility requires further validation.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"79 9-10","pages":"329-339"},"PeriodicalIF":0.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FOXG1 syndrome: genetic background revealed by trio WES in case of a critically ill neonate.","authors":"Behich Koyutourk, Dize Deryali, Ayla Turgay, Ismet Zaimagaoglu, Ceyhun Dalkan, Mahmut Cerkez Ergoren","doi":"10.18071/isz.79.0351","DOIUrl":"https://doi.org/10.18071/isz.79.0351","url":null,"abstract":"<p><p>FOXG1 syndrome, also referred to as congenital Rett syndrome, is an autosomal dominant neurodevelopmental disorder characterised by early-onset developmental delay, microcephaly, movement abnormalities, and epilepsy. We report a case of a male infant who presented with hypotonia and abnormal respiratory effort at birth. Due to the non-specific but serious clinical presentation, the infant underwent trio whole-exome sequencing (WES). WES-Trio revealed a de novo heterozygous frameshift mutation in FOXG1 (c.459_460delGG; p.Glu154Glyfs). Despite intensive care, the infant died within 24 hours of birth. This case description emphasises the importance of rapid clinical care through trio WES for ill neonates, where an accurate diagnosis was made possible by identifying a de novo pathogenic variant related to FOXG1 syndrome. Early genetic diagnoses for severe neonatal encephalopathy of otherwise unexplainable aetiology are noteworthy/critical in terms of management and prognosis, and importantly for parental counselling.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"79 9-10","pages":"351-355"},"PeriodicalIF":0.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid in-stent restenosis and re-restenosis treated with drug-eluting balloon dilation - case report and literature review.","authors":"Benedek Oláh, Csaba Zsolt Oláh","doi":"10.18071/isz.79.0274","DOIUrl":"https://doi.org/10.18071/isz.79.0274","url":null,"abstract":"<p><p>According to relevant multicenter studies, significant in-stent stenosis develops in 5-6% of cases after internal carotid artery stenting. We present the risks, pathomechanism, diagnostics and treatment options of in-stent stenosis, the evidence, and the discrepancy between conservative and endovascular treatment. If the in-stent stenosis reaches a significant level, repeated endovascular treatment may be considered. The results of drug-eluting balloon dilation are better than balloon dilation. We present the case of a 72-year-old female patient. In an asymptomatic state, 80% stenosis of both internal carotid arteries was confirmed. Both sides were stented without complications. The patient did not have drug resistance, and the patient's compliance was very good. After 4 months, the patient was asymptomatic, and significant bilateral in-stent restenosis was confirmed. We performed drug-eluting balloon dilation in two sessions. In 3 months, we confirmed 85% in-stent restenosis again on the left side, due to which we performed repeated drug-eluting balloon dilation. The patient was asymptomatic and complaintfree. According to the last controls, there is currently no stenosis within the stents. Restenosis in the carotid stent can be effectively managed using drug-eluting balloon dilation, ensuring a high degree of safety. Our case, when a restenosis develops within a short time after drug-eluting ballon dilation, is very rare.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"79 7-8","pages":"274-278"},"PeriodicalIF":0.6,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Adult presentation of glutaric aciduria type I.","authors":"Levente Hadady, Lívia Dézsi, Tibor Kalmár, László Szpisjak, Dénes Zádori, Péter Klivényi, András Salamon","doi":"10.18071/isz.79.0279","DOIUrl":"https://doi.org/10.18071/isz.79.0279","url":null,"abstract":"<p><p>Introduction - Glutaric aciduria (or glutaric acidemia) type 1 (GA1) is a rare autosomal recessive neurometabolic disorder caused by mutations in the GCDH gene that results in a deficiency of the glutaryl-CoA dehydrogenase enzyme. It plays a vital role in the degradation of L-lysine, L-hydroxylysine, and L-tryptophan. Accumulating toxic metabolites (namely glutaric acid/GA and 3-hydroxyglutaric acid/3-OH-GA) leads to progressive neurological deterioration. GA1 is one of the limited neurometabolic disorders, where we can stop the progression of the disease with a diet and aggressive emergency treatment during excessive catabolism. If undiagnosed through newborn screening, symptoms start to present in childhood between 3-36 months, with neurological symptoms related to sepsis or fever. However, 10-20% of cases start insidiously.Case report - We report the case of a 53-year-old male with GA1, who presented progressive spastic tetraparesis, dysarthria, and focal seizures. His initial symptoms, misattributed to cerebral palsy and previous ischemic strokes, had gradually worsened in recent years, leaving him bedridden. Specific metabolic laboratory testing and radiological evaluations revealed the characteristic features of the disease. Genetic testing identified a known pathogenic homozygous mutation in the GCDH gene, which confirms the diagnosis of GA1. Low-lysine diet and supplementation with carnitine and riboflavin were started. After the initiation of treatment, no further progression was observable.Conclusion - This case underscores the importance of considering hereditary neurometabolic disorders like GA1 - taking into account the available metabolic screening - not only in pediatric patients but also in adult patients with progressive neurological decline. This case contributes to the limited literature available on GA1 cases in adults and highlights the need for early detection strategies to avoid irreversible neurological damage.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"79 7-8","pages":"279-283"},"PeriodicalIF":0.6,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}