Current Cancer Therapy Reviews最新文献

{"title":"Borderline Brenner Tumor of the Ovary in a Postmenopausal Woman: A\u0000Rare Case with Concomitant Endometrial Hyperplasia and Endocervical\u0000Polyp","authors":"Naina Kumar, I. Pradeep, Annapurna Srirambhatla, K. Poojitha, M. Mangla","doi":"10.2174/0115733947256172231128064128","DOIUrl":"https://doi.org/10.2174/0115733947256172231128064128","url":null,"abstract":"\u0000\u0000Bordeline Brenner tumors of the ovary are rare tumors accounting for 2% of\u0000all ovarian tumors and are characterized by the presence of papillary structures covered with transitional\u0000epithelium without or minimal stromal invasion.\u0000\u0000\u0000\u0000In the present case report a 60-year-old postmenopausal woman presented with\u0000complaints of lower abdominal pain and a right ovarian mass of 4x5cm, which was diagnosed on histopathological\u0000examination as borderline Brenner tumor of the ovary. There were coexisting nonatypical\u0000endometrial hyperplasia and endocervical polyps of 1.2x0.9x0.6cm, indicating endometrial\u0000hyperstimulation as a result of estrogen secreted by the tumor. The patient was managed successfully\u0000with staging laparotomy and was diagnosed with stage I borderline Brenner tumor with non-atypical\u0000endometrial hyperplasia and benign endocervical polyp.\u0000\u0000\u0000\u0000Borderline Brenner tumors are rare tumors of ovaries with uncertain malignant potential.\u0000They have no precise predictive markers but are known to produce estrogen. Surgery remains the\u0000mainstay of treatment for these tumors.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139881655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advancement in Nanotechnological Approaches for Increasing\u0000the Effectiveness of Herbal Drugs in the Treatment of Colorectal Cancer","authors":"Archana, Rohitas Deshmukh","doi":"10.2174/0115733947279599231208095726","DOIUrl":"https://doi.org/10.2174/0115733947279599231208095726","url":null,"abstract":"\u0000\u0000Colorectal cancer (CRC) ranks as the third most prevalent cancer type and the second leading\u0000cause of cancer-related deaths globally. The mortality rate from colon cancer has seen a significant\u0000increase, correlating with the widespread adoption of Western dietary habits and lifestyles. Medicinal\u0000plants, notably those containing functional phytochemicals like polysaccharides, exhibit antitumor\u0000and anti-apoptotic properties, offering potential for CRC prevention and treatment. Enhancing\u0000the efficacy of herbal medicines and addressing problems related to them could eventually become\u0000possible with the help of nanoscale drug delivery systems. Improved solubility and bioavailability,\u0000protection from toxicity, resistance to physical and chemical degradation, increased pharmacological\u0000activity, better distribution to tissue macrophages, and more stable are merely some of the benefits of\u0000developing nano dosage forms for herbal drugs in phyto-formulation research. The article has been\u0000drafted by gathering recent information available inScopus, ScienceDirect, Pubmed, Medline and\u0000Web of Science databases. The inclusion criterion was an English language article showing the effective\u0000use of whole plant or herbal products in CRC. Original articles and short communications on in\u0000vivo and in vitro experiments were included. Exclusion criteria included irrelevant studies, insufficient\u0000data, and mushroom or algae investigations. Case reports/case series, and letters to editors were\u0000not included but used to discover applicable primary material. This review suggests medicinal plants\u0000can produce anti-CRC chemicals. Herbs and spices with antiproliferative and angiogenesis-inhibiting\u0000properties may be useful as chemopreventive or chemotherapeutic therapies for colorectal cancer.\u0000This narrative review explores the usefulness of medicinal plants in the treatment of CRC using a\u0000novel drug delivery system. Nanotechnology is highlighted as a driving force behind the recent\u0000breakthroughs in CRC screening, diagnosis, and therapy. This review seeks to inform researchers on\u0000nanotechnology in CRC and inspire innovative nanotechnology-based therapies.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140494274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Potential and Therapeutic Effectiveness of a Polyethylene Alkyne Class Phytochemical ‘Atractylodin’ in Medicine for the Treatment\u0000of Cancer and other Human Complications","authors":"D. Patel, K. Patel","doi":"10.2174/0115733947265189231129105327","DOIUrl":"https://doi.org/10.2174/0115733947265189231129105327","url":null,"abstract":"\u0000\u0000Atractylodes lancea Thunb. (Asteraceae) is a commonly used medicinal\u0000plant for gastric and appetite-associated complications in traditional Chinese medicine. The rhizome\u0000of Atractylodes lancea has been widely used for the treatment of human complications. Atractylodin\u0000has anti-angiogenic, anti-cancer, anti-inflammatory, anti-microbial, anti-pyretic and anti-hypertensive\u0000potential in medicine. Nano-formulations of atractylodin were also prepared in the scientific field\u0000to enhance its water solubility and efficacy in cholangiocarcinoma.\u0000\u0000\u0000\u0000Health-beneficial aspects of atractylodin in medicine have been investigated in the present\u0000work through collected scientific information on atractylodin from different literature databases. Scientific\u0000data on atractylodin has been collected from Google, Science Direct, Scopus, and PubMed.\u0000Further, detailed pharmacological activities and analytical aspects of atractylodin were discussed in\u0000this paper in order to know its biological potential in medicine. Analytical techniques of atractylodin\u0000were also discussed in the present work for separation, isolation, and identification of atractylodin.\u0000\u0000\u0000\u0000Scientific data analysis signified the biological importance of Atractylodes lancea Thunb.\u0000and its active phytochemical atractylodin in medicine. Scientific data signified the presence of atractylodin\u0000in Atractylodes lancea, Atractylodes chinensis, Atractylodes japonica, Atractylodes macrocephala,\u0000Atractylodes ovate and Atractylodis Rhizoma. Atractylodin has a significant biological\u0000effect on cholangiocarcinoma, hepatocellular carcinoma, breast cancer, lung cancer, cancer anorexiacachexia\u0000syndrome, colitis, rheumatoid arthritis, respiratory complications, GIT complications, hepatic\u0000complications, atopic dermatitis, aging process, neurodegenerative disease, calcified aortic valve\u0000disease, hypertension, pulmonary fibrosis, body temperature, olfactory neurons, podocyte hypermotility\u0000and toxicity. Further, its anti-nociceptive, anti-fibrotic, anti-angiogenic, anti-virulence, antibacterial,\u0000insecticidal, lipase inhibitory potential, immunomodulatory, and positive inotropic effects\u0000were also discussed in the present paper. Analytical techniques for the separation, isolation and identification\u0000of atractylodin in different samples were also discussed in the present work.\u0000\u0000\u0000\u0000The present work's scientific data signified the biological importance of atractylodin in\u0000medicine.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"11 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140495093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations of the Gut Microbiome and Metabolome Following: A\u0000Opportunity for Early Detection of Colorectal Cancer","authors":"Mehdi Pezeshgi Modarres, Mohamad Amin Habibi, M. Pashaei, Yousef Mohammadpour, Kimia Jazi, S. Ahmadpour","doi":"10.2174/0115733947270529231116114913","DOIUrl":"https://doi.org/10.2174/0115733947270529231116114913","url":null,"abstract":"\u0000\u0000Colorectal cancer (CRC) is a commonly diagnosed cancer responsible for numerous deaths\u0000worldwide. In recent decades, technological advances implicated in considering the molecular pathways\u0000underlying CRC pathogenesis. Several investigations have identified various mechanisms involved\u0000in CRC and have paved the way for new therapeutics and early diagnosis. Gut microbiome\u0000play a crucial role in intestinal inflammation and can be associated with colitis colorectal cancer. In\u0000this review, we narrated the role of the microbiome population and their metabolome profile as a new\u0000screening method for early detection of CRC.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"37 7-8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140505605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the Mistry of Blood Cancer cause and diagnosis of management.","authors":"Raja Sharma, Satendra Kumar, Niranjan Kaushik, Bahadur Singh","doi":"10.2174/0115733947263279231114111550","DOIUrl":"https://doi.org/10.2174/0115733947263279231114111550","url":null,"abstract":"\u0000\u0000Leukaemia, lymphoma, and myeloma are among the serious and frequently fatal conditions\u0000that impact thousands of people each year. Genetics, environmental factors, and medical problems\u0000can all affect the risk of developing blood cancer, however, the precise causes are still not entirely\u0000known. Fatigue, unexpected weight loss, and frequent infections are examples of common\u0000blood cancer symptoms. In the course of the diagnosis process, blood tests, imaging tests, and bone\u0000marrow biopsies are frequently combined. Blood cancer therapies include chemotherapy, radiation\u0000therapy, stem cell transplant, targeted therapy, and immunotherapy. Supportive care is also important\u0000for managing symptoms and improving quality of life. Ongoing research is exploring new treatments\u0000and therapies for blood cancer, as well as ways to improve supportive care and personalize treatment\u0000plans. Blood cancer patients and their families have severe emotional and psychological effects that\u0000must not be ignored. For improving outcomes and raising the general standard of living for people\u0000affected by this condition, it is essential to address these needs.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"14 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140506268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of Compound Kushen Injection in the Treatment of Acute Myeloid Leukemia from the Analysis Perspectives","authors":"Jia Zeng, Huiqun Tian, Le Kang, Qian Wu, Shiwen Liu, Yugang Xiao, Hongwei Shao, Guangrui Huang, Song Liu","doi":"10.2174/0115733947271076231204181500","DOIUrl":"https://doi.org/10.2174/0115733947271076231204181500","url":null,"abstract":"\u0000\u0000Chemotherapy resistance often occurs in the conventional treatment with\u0000AML and results in poor cure rates. CKI was found to have a good therapeutic effect when it was\u0000combined with other chemotherapy drugs in the clinical treatment of AML. However, the underlying\u0000mechanism is unclear. Therefore, this study aims to preliminarily describe the pharmacological activity\u0000and mechanism of CKI through comprehensive network pharmacology methods.\u0000\u0000\u0000\u0000This study aimed to explore the possible mechanism of Compound Kushen Injection\u0000(CKI) in the treatment of acute myeloid leukemia (AML) by using network pharmacology, molecular\u0000docking, and molecular dynamics techniques.\u0000\u0000\u0000\u0000Active compounds of CKI were identified based on the Traditional Chinese Medicine Systems\u0000Pharmacy (TCMSP) database, and the related targets of the active compounds were predicted using\u0000Swiss Target Prediction; AML-related targets from Gene Cards and Online Mendelian Inheritance in\u0000Man (OMIM) were collected. Protein-protein interaction (PPI) network was constructed, and its mechanism\u0000was predicted through Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes\u0000(KEGG) enrichment. The protein-protein interaction (PPI) network construction, module partitioning,\u0000and hub node screening were visualized by using the Cytoscape software and its plugins. These\u0000module partitionings were also verified by using molecular docking and molecular dynamics.\u0000\u0000\u0000\u0000Fifty-six active ingredients corresponding to 223 potential targets were identified. Biological\u0000function analysis showed that 731, 70, and 137 GO entries were associated with biological processes,\u0000cellular components, and molecular functions, respectively. A total of 163 KEGG pathways were\u0000identified. Network analysis showed that the key anti-AML targets of CKI are MAPK3, EGFR, SRC,\u0000PIK3CA, and PIK3R1 targets, which are involved in the PI3K/Akt and Ras/MAPK signaling pathways\u0000or related crosstalk pathways.\u0000\u0000\u0000\u0000Our results suggested that the key anti-AML targets of CKI, such as MAPK3, EGFR,\u0000SRC, PIK3CA and PIK3R1, are involved in the PI3K/Akt and Ras/MAPK signaling pathways or related\u0000crosstalk pathways. Concentrating on the dynamic and complex crosstalk regulation between\u0000PI3K/Akt and Ras/MAPK signal pathways and related signal pathways may be a new direction in\u0000anti-AML therapy in the future.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"62 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and Awareness of Emerging Cancer Therapies and their Regulations among Budding Scientists in India: A Survey","authors":"Pinky Sharma, V. Jhawat, Jatinder Singh, Rohit Dutt","doi":"10.2174/0115733947268695231116100736","DOIUrl":"https://doi.org/10.2174/0115733947268695231116100736","url":null,"abstract":"\u0000\u0000Academic clinical research is considered the most important for cancer research\u0000because it frequently tests novel drug combinations, investigates rarer diseases, and lowers the\u0000risk for future commercial investments. However, due to the potential risks to the cancer patient, clinical\u0000research is governed by strict regulations. In high-income countries, comprehensive cancer centers\u0000(CCCs) have been established to align academic clinical cancer research with the regulatory\u0000framework. In comparison, academic clinical cancer research is considered ineffective in low-income\u0000countries.\u0000\u0000\u0000\u0000A cross-sectional, online survey was conducted to evaluate the knowledge of Indian health\u0000science students regarding cutting-edge cancer therapeutics and their underlying regulatory requirements.\u0000\u0000\u0000\u0000The survey found that 163 out of the 265 respondents were aware of the challenges of developing\u0000safe and effective anticancer therapeutics. 43 respondents found no challenges, while 59\u0000respondents were unaware of any. Out of 163, 44 respondents identified technical challenges, 31\u0000identified regulatory issues, and 88 identified both challenges in developing novel anticancer therapeutics.\u0000Interestingly, only 83 students out of 265, study cancer therapy regulations in their curriculum.\u0000This clearly indicates that most of India's health science students have a significant lack of understanding\u0000about the regulations for new cancer treatments.\u0000\u0000\u0000\u0000Academic clinical cancer research in India is just recognized as a prerequisite for degree\u0000completion due to a lack of regulatory foundation. An emphasis should be placed on restructuring the\u0000coursework offered to health science students to improve their ability to translate theoretical cancer\u0000research to real-world clinical care.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"31 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139389340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}