Recent Advancement in Nanotechnological Approaches for Increasing the Effectiveness of Herbal Drugs in the Treatment of Colorectal Cancer

Archana, Rohitas Deshmukh
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Abstract

Colorectal cancer (CRC) ranks as the third most prevalent cancer type and the second leading cause of cancer-related deaths globally. The mortality rate from colon cancer has seen a significant increase, correlating with the widespread adoption of Western dietary habits and lifestyles. Medicinal plants, notably those containing functional phytochemicals like polysaccharides, exhibit antitumor and anti-apoptotic properties, offering potential for CRC prevention and treatment. Enhancing the efficacy of herbal medicines and addressing problems related to them could eventually become possible with the help of nanoscale drug delivery systems. Improved solubility and bioavailability, protection from toxicity, resistance to physical and chemical degradation, increased pharmacological activity, better distribution to tissue macrophages, and more stable are merely some of the benefits of developing nano dosage forms for herbal drugs in phyto-formulation research. The article has been drafted by gathering recent information available inScopus, ScienceDirect, Pubmed, Medline and Web of Science databases. The inclusion criterion was an English language article showing the effective use of whole plant or herbal products in CRC. Original articles and short communications on in vivo and in vitro experiments were included. Exclusion criteria included irrelevant studies, insufficient data, and mushroom or algae investigations. Case reports/case series, and letters to editors were not included but used to discover applicable primary material. This review suggests medicinal plants can produce anti-CRC chemicals. Herbs and spices with antiproliferative and angiogenesis-inhibiting properties may be useful as chemopreventive or chemotherapeutic therapies for colorectal cancer. This narrative review explores the usefulness of medicinal plants in the treatment of CRC using a novel drug delivery system. Nanotechnology is highlighted as a driving force behind the recent breakthroughs in CRC screening, diagnosis, and therapy. This review seeks to inform researchers on nanotechnology in CRC and inspire innovative nanotechnology-based therapies.
提高中草药治疗结直肠癌疗效的纳米技术方法的最新进展
结肠直肠癌(CRC)在全球癌症发病率中排名第三,在癌症相关死亡原因中排名第二。结肠癌的死亡率显著上升,这与西方饮食习惯和生活方式的广泛采用有关。药用植物,尤其是含有多糖等功能性植物化学物质的药用植物,具有抗肿瘤和抗细胞凋亡的特性,为预防和治疗结肠癌提供了潜力。在纳米级给药系统的帮助下,提高中草药的疗效并解决与之相关的问题最终将成为可能。提高溶解度和生物利用度、防止毒性、抗物理和化学降解、增加药理活性、更好地分布到组织巨噬细胞以及更稳定,这些仅仅是植物制剂研究中开发中草药纳米剂型的部分益处。本文是在收集了Scopus、ScienceDirect、Pubmed、Medline和Web of Science数据库中的最新信息后撰写的。收录标准是显示全植物或草药产品在 CRC 中有效应用的英文文章。纳入标准包括有关体内和体外实验的原创文章和简短通讯。排除标准包括无关研究、数据不足以及蘑菇或藻类研究。病例报告/系列病例以及致编辑的信未被纳入,但用于发现适用的原始资料。本综述表明,药用植物可产生抗 CRC 的化学物质。本综述探讨了药用植物利用新型给药系统治疗 CRC 的作用。纳米技术是最近在 CRC 筛查、诊断和治疗方面取得突破的推动力。本综述旨在为研究人员提供有关 CRC 中纳米技术的信息,并激发基于纳米技术的创新疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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