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Circulation of Mumps virus genotype G in Pakistan during 2023 outbreak 2023 年疫情爆发期间腮腺炎病毒基因 G 型在巴基斯坦的流行情况
Future Virology Pub Date : 2024-02-09 DOI: 10.2217/fvl-2023-0145
M. Umair, S. A. Haider, Z. Jamal, R. Hakim, Ammara Farooq, M. Salman
{"title":"Circulation of Mumps virus genotype G in Pakistan during 2023 outbreak","authors":"M. Umair, S. A. Haider, Z. Jamal, R. Hakim, Ammara Farooq, M. Salman","doi":"10.2217/fvl-2023-0145","DOIUrl":"https://doi.org/10.2217/fvl-2023-0145","url":null,"abstract":"Aim: Despite recurring mumps outbreaks in Pakistan, the virus's genomic diversity remains unavailable. This study explores the mumps genomic diversity in the 2023 Islamabad outbreak. Methods: During January and February 2023, 32 buccal/throat swabs were collected from suspected mumps cases. 15 tested mumps virus (MuV)-positive via RT-PCR. Positive samples underwent partial SH gene sequencing; a subset (n = 10) was whole-genome sequenced using Illumina MiSeq. Results: Phylogenetic analysis identified genotype-G, sharing 95.57–98.73% homology with Japanese/Canadian isolates. Whole-genome-sequencing (n = 2) confirmed genotype-G, 99% similar to Sheffield/Iowa strain. HN region displayed 95.01–95.36% identity with Jeryl Lynn, with genotype G-specific mutations, except T265I. Conclusion: This is the first report of partial and whole-genome sequencing of MuV from Pakistan, highlighting the necessity for genomic surveillance and vaccine integration.","PeriodicalId":503758,"journal":{"name":"Future Virology","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139788719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protocol for the Mpox Prospective Observational Cohort Study (MPOCS) among individuals with mpox in Canada 加拿大麻风病人前瞻性观察队列研究（MPOCS）议定书
Future Virology Pub Date : 2024-02-09 DOI: 10.2217/fvl-2023-0189
Darrell H S Tan, Rob Kozak, Attia Qamar, Reva Persaud, Adrienne K Chan, John Maxwell, Michael Kwag, Allison McGeer, S. Walmsley, Marina B Klein, Mark W Hull, Sharmistha Mishra
{"title":"Protocol for the Mpox Prospective Observational Cohort Study (MPOCS) among individuals with mpox in Canada","authors":"Darrell H S Tan, Rob Kozak, Attia Qamar, Reva Persaud, Adrienne K Chan, John Maxwell, Michael Kwag, Allison McGeer, S. Walmsley, Marina B Klein, Mark W Hull, Sharmistha Mishra","doi":"10.2217/fvl-2023-0189","DOIUrl":"https://doi.org/10.2217/fvl-2023-0189","url":null,"abstract":"In mid-2022, a global mpox epidemic emerged that was concentrated in gay, bisexual and other men who have sex with men, prompting the WHO to declare a public health emergency of international concern. Shortly after cases were first identified in Canada, we established the Mpox Prospective Observational Cohort Study (MPOCS) to characterize clinical, psychosocial, epidemiologic and virologic characteristics of this re-emerging infection. Community members were engaged in identifying research priorities, creating participant-facing materials, and forming a community advisory board. This article outlines the MPOCS study protocol. Although cases of mpox in Canada have rapidly declined, our research procedures may serve as a template for rapidly studying emerging infectious disease threats in the future, particularly among sexual networks.","PeriodicalId":503758,"journal":{"name":"Future Virology","volume":" 67","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Title: A computational approach to predict the possible binding site of HCV NS5A and the host cell chaperone, GRP78 标题：预测 HCV NS5A 与宿主细胞伴侣蛋白 GRP78 可能结合位点的计算方法
Future Virology Pub Date : 2024-02-09 DOI: 10.2217/fvl-2023-0151
Wael M. Elshemey, Abdo A. Elfiky, Alaa M. Elgohary
{"title":"Title: A computational approach to predict the possible binding site of HCV NS5A and the host cell chaperone, GRP78","authors":"Wael M. Elshemey, Abdo A. Elfiky, Alaa M. Elgohary","doi":"10.2217/fvl-2023-0151","DOIUrl":"https://doi.org/10.2217/fvl-2023-0151","url":null,"abstract":"Aim: Glucose-regulated protein 78 (GRP78) is an endoplasmic reticulum located chaperone that plays a vital role during cellular stress. NS5A is one of the hepatitis C virus (HCV) non-structural proteins essential for replication. Materials & methods: Protein–protein docking was used to test the binding mode between GRP78 and HCV NS5A. Molecular dynamics simulations (MDSs) are performed on HCV NS5A, GRP78 and the HCV NS5A–GRP78 complex. Results: Docking and MDS reveal the ability of the GRP78 substrate-binding domain β to associate tightly with the HCV NS5A C142-C165 region. Conclusion: MDS reveals the potential of the C142-C165 region of the HCV NS5A to be used as a seed to develop a recognition inhibitor that counterparts the viral protein recognition by GRP78.","PeriodicalId":503758,"journal":{"name":"Future Virology","volume":"57 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139850091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulation of Mumps virus genotype G in Pakistan during 2023 outbreak 2023 年疫情爆发期间腮腺炎病毒基因 G 型在巴基斯坦的流行情况
Future Virology Pub Date : 2024-02-09 DOI: 10.2217/fvl-2023-0145
M. Umair, S. A. Haider, Z. Jamal, R. Hakim, Ammara Farooq, M. Salman
{"title":"Circulation of Mumps virus genotype G in Pakistan during 2023 outbreak","authors":"M. Umair, S. A. Haider, Z. Jamal, R. Hakim, Ammara Farooq, M. Salman","doi":"10.2217/fvl-2023-0145","DOIUrl":"https://doi.org/10.2217/fvl-2023-0145","url":null,"abstract":"Aim: Despite recurring mumps outbreaks in Pakistan, the virus's genomic diversity remains unavailable. This study explores the mumps genomic diversity in the 2023 Islamabad outbreak. Methods: During January and February 2023, 32 buccal/throat swabs were collected from suspected mumps cases. 15 tested mumps virus (MuV)-positive via RT-PCR. Positive samples underwent partial SH gene sequencing; a subset (n = 10) was whole-genome sequenced using Illumina MiSeq. Results: Phylogenetic analysis identified genotype-G, sharing 95.57–98.73% homology with Japanese/Canadian isolates. Whole-genome-sequencing (n = 2) confirmed genotype-G, 99% similar to Sheffield/Iowa strain. HN region displayed 95.01–95.36% identity with Jeryl Lynn, with genotype G-specific mutations, except T265I. Conclusion: This is the first report of partial and whole-genome sequencing of MuV from Pakistan, highlighting the necessity for genomic surveillance and vaccine integration.","PeriodicalId":503758,"journal":{"name":"Future Virology","volume":"281 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139848491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protocol for the Mpox Prospective Observational Cohort Study (MPOCS) among individuals with mpox in Canada 加拿大麻风病人前瞻性观察队列研究（MPOCS）议定书
Future Virology Pub Date : 2024-02-09 DOI: 10.2217/fvl-2023-0189
Darrell H S Tan, Rob Kozak, Attia Qamar, Reva Persaud, Adrienne K Chan, John Maxwell, Michael Kwag, Allison McGeer, S. Walmsley, Marina B Klein, Mark W Hull, Sharmistha Mishra
{"title":"Protocol for the Mpox Prospective Observational Cohort Study (MPOCS) among individuals with mpox in Canada","authors":"Darrell H S Tan, Rob Kozak, Attia Qamar, Reva Persaud, Adrienne K Chan, John Maxwell, Michael Kwag, Allison McGeer, S. Walmsley, Marina B Klein, Mark W Hull, Sharmistha Mishra","doi":"10.2217/fvl-2023-0189","DOIUrl":"https://doi.org/10.2217/fvl-2023-0189","url":null,"abstract":"In mid-2022, a global mpox epidemic emerged that was concentrated in gay, bisexual and other men who have sex with men, prompting the WHO to declare a public health emergency of international concern. Shortly after cases were first identified in Canada, we established the Mpox Prospective Observational Cohort Study (MPOCS) to characterize clinical, psychosocial, epidemiologic and virologic characteristics of this re-emerging infection. Community members were engaged in identifying research priorities, creating participant-facing materials, and forming a community advisory board. This article outlines the MPOCS study protocol. Although cases of mpox in Canada have rapidly declined, our research procedures may serve as a template for rapidly studying emerging infectious disease threats in the future, particularly among sexual networks.","PeriodicalId":503758,"journal":{"name":"Future Virology","volume":"168 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139849183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Title: A computational approach to predict the possible binding site of HCV NS5A and the host cell chaperone, GRP78 标题：预测 HCV NS5A 与宿主细胞伴侣蛋白 GRP78 可能结合位点的计算方法
Future Virology Pub Date : 2024-02-09 DOI: 10.2217/fvl-2023-0151
Wael M. Elshemey, Abdo A. Elfiky, Alaa M. Elgohary
{"title":"Title: A computational approach to predict the possible binding site of HCV NS5A and the host cell chaperone, GRP78","authors":"Wael M. Elshemey, Abdo A. Elfiky, Alaa M. Elgohary","doi":"10.2217/fvl-2023-0151","DOIUrl":"https://doi.org/10.2217/fvl-2023-0151","url":null,"abstract":"Aim: Glucose-regulated protein 78 (GRP78) is an endoplasmic reticulum located chaperone that plays a vital role during cellular stress. NS5A is one of the hepatitis C virus (HCV) non-structural proteins essential for replication. Materials & methods: Protein–protein docking was used to test the binding mode between GRP78 and HCV NS5A. Molecular dynamics simulations (MDSs) are performed on HCV NS5A, GRP78 and the HCV NS5A–GRP78 complex. Results: Docking and MDS reveal the ability of the GRP78 substrate-binding domain β to associate tightly with the HCV NS5A C142-C165 region. Conclusion: MDS reveals the potential of the C142-C165 region of the HCV NS5A to be used as a seed to develop a recognition inhibitor that counterparts the viral protein recognition by GRP78.","PeriodicalId":503758,"journal":{"name":"Future Virology","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139790345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing a risk prediction model for COVID-19 infection in heart transplant recipients using artificial intelligence 利用人工智能开发心脏移植受者感染 COVID-19 的风险预测模型
Future Virology Pub Date : 2024-02-09 DOI: 10.2217/fvl-2023-0162
Shriya Sharma, Nora Menon, Jose Ruiz, Caitlyn Luce, Lisa Brumble, Anirban Bhattacharya, Rohan Goswami
{"title":"Developing a risk prediction model for COVID-19 infection in heart transplant recipients using artificial intelligence","authors":"Shriya Sharma, Nora Menon, Jose Ruiz, Caitlyn Luce, Lisa Brumble, Anirban Bhattacharya, Rohan Goswami","doi":"10.2217/fvl-2023-0162","DOIUrl":"https://doi.org/10.2217/fvl-2023-0162","url":null,"abstract":"Aim: Describe the utility of an inverse reinforcement learning pathway to develop a novel model to predict and manage the spread of COVID-19. Materials & methods: Convolutional neural network (CNN) with multilayer perceptron (MLP) modeling functions utilized inverse reinforcement learning to predict COVID-19 outcomes based on a comprehensive array of factors. Results: Our model demonstrates a sensitivity of 0.67 in the receiver operating characteristic curve and can correctly identify approximately 67% of the positive cases. Conclusion: We demonstrate the ability to augment clinical decision-making with a novel artificial intelligence (AI) solution that accurately predicted the susceptibility of transplant patients to COVID-19. This enables physicians to administer treatment and take appropriate preventative measures based on patients' risk factors.","PeriodicalId":503758,"journal":{"name":"Future Virology","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139788510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary application of a coronavirus pseudovirus system 冠状病毒伪病毒系统的初步应用
Future Virology Pub Date : 2024-02-05 DOI: 10.2217/fvl-2023-0131
X. Tao, Tengfei Li, Baojun He, Wei Zhao, Siman Hu, Zhuping Ma, Lvyin Sun, Runlin Li, Like Luo, Yonggang Li
{"title":"Preliminary application of a coronavirus pseudovirus system","authors":"X. Tao, Tengfei Li, Baojun He, Wei Zhao, Siman Hu, Zhuping Ma, Lvyin Sun, Runlin Li, Like Luo, Yonggang Li","doi":"10.2217/fvl-2023-0131","DOIUrl":"https://doi.org/10.2217/fvl-2023-0131","url":null,"abstract":"Aim: The preparation of a VSVΔG*-S pseudovirus carrying the spike (S) protein of SARS-CoV-2 and its preliminary application. Materials & methods: 293T cells were transfected with pCAGGS-SARS-2-S and infected with VSVΔG viruses. The VSVΔG*-S pseudovirus was collected by centrifugation. The pseudovirus was used to investigate the neutralization ability of serum from SARS-CoV-2 patients and the ability of peptides to inhibit the virus. Results: A VSVΔG*-S pseudovirus was successfully prepared. Patient serum and peptides could neutralize the pseudovirus infection as determined by measuring the expression of GFP. Conclusion: This pseudovirus system can be used to screen polypeptides and fusion inhibitors and measure neutralizing activity, which will benefit the study of SARS-CoV-2.","PeriodicalId":503758,"journal":{"name":"Future Virology","volume":"5 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139803017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary application of a coronavirus pseudovirus system 冠状病毒伪病毒系统的初步应用
Future Virology Pub Date : 2024-02-05 DOI: 10.2217/fvl-2023-0131
X. Tao, Tengfei Li, Baojun He, Wei Zhao, Siman Hu, Zhuping Ma, Lvyin Sun, Runlin Li, Like Luo, Yonggang Li
{"title":"Preliminary application of a coronavirus pseudovirus system","authors":"X. Tao, Tengfei Li, Baojun He, Wei Zhao, Siman Hu, Zhuping Ma, Lvyin Sun, Runlin Li, Like Luo, Yonggang Li","doi":"10.2217/fvl-2023-0131","DOIUrl":"https://doi.org/10.2217/fvl-2023-0131","url":null,"abstract":"Aim: The preparation of a VSVΔG*-S pseudovirus carrying the spike (S) protein of SARS-CoV-2 and its preliminary application. Materials & methods: 293T cells were transfected with pCAGGS-SARS-2-S and infected with VSVΔG viruses. The VSVΔG*-S pseudovirus was collected by centrifugation. The pseudovirus was used to investigate the neutralization ability of serum from SARS-CoV-2 patients and the ability of peptides to inhibit the virus. Results: A VSVΔG*-S pseudovirus was successfully prepared. Patient serum and peptides could neutralize the pseudovirus infection as determined by measuring the expression of GFP. Conclusion: This pseudovirus system can be used to screen polypeptides and fusion inhibitors and measure neutralizing activity, which will benefit the study of SARS-CoV-2.","PeriodicalId":503758,"journal":{"name":"Future Virology","volume":"138 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139862644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of viral infections: vaccines or antivirals 病毒感染管理：疫苗或抗病毒药物
Future Virology Pub Date : 2024-01-25 DOI: 10.2217/fvl-2023-0196
E. D. Clercq
{"title":"Management of viral infections: vaccines or antivirals","authors":"E. D. Clercq","doi":"10.2217/fvl-2023-0196","DOIUrl":"https://doi.org/10.2217/fvl-2023-0196","url":null,"abstract":"","PeriodicalId":503758,"journal":{"name":"Future Virology","volume":"14 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139597509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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