Israel Medical Association Journal最新文献_第8页

Extreme Eosinophilia and Dyspnea as Presenting Signs of a Metastatic Tumor. 极端嗜酸性粒细胞增多和呼吸困难是转移性肿瘤的表现。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Roni Levin, Howard Amital, Omer Gendelman

引用次数: 0

A Case of Lactation Ketoacidosis Followed by Striking Hyperglycemia. 哺乳期酮症酸中毒并发高血糖1例。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Lior Tolkin, Osama Muhtaseb, Bezalel Pearl

引用次数: 0

Flumazenil in the Treatment of Benzodiazepine Toxicity: The Experience of a Large Urban Tertiary Care Hospital. 氟马西尼治疗苯二氮卓类药物毒性：某大型城市三级医院的经验。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Or Segev, Alexander Yelak, Dennis Scolnik, Ayelet Rimon, Miguel M Glatstein

{"title":"Flumazenil in the Treatment of Benzodiazepine Toxicity: The Experience of a Large Urban Tertiary Care Hospital.","authors":"Or Segev, Alexander Yelak, Dennis Scolnik, Ayelet Rimon, Miguel M Glatstein","doi":"","DOIUrl":"","url":null,"abstract":"Background: Flumazenil has been available since 1991 for the treatment of acute benzodiazepine overdose, yet many physicians remain reluctant to use it.Objectives: To evaluate the frequency of flumazenil use for benzodiazepine overdose at a large, urban, tertiary care center. To assess its effectiveness and associated adverse events.Methods: The study was conducted in an emergency department with approximately 220,000 annual visits. Medical records of patients who received a medical toxicology consultation and were treated with flumazenil between 1 January 2019, and 31 December 2023 were reviewed. Data collected included patient demographics, medical history, substances involved, presence of seizures, indications for flumazenil use, clinical response, and adverse effects.Results: Of 263 patients evaluated for suspected benzodiazepine overdose and referred to medical toxicology, 79 received flumazenil and comprised the study cohort. Among them, 64 cases involved intentional overdose. Indications for flumazenil administration included severe overdose with impaired consciousness and ventilatory failure (37 patients) or without ventilatory failure (42 patients). Co-ingestion of tricyclic antidepressants was documented in 4 patients and other antidepressants or antipsychotics in 35. Clinical improvement, including enhanced consciousness and/or reduced need for mechanical ventilation, was observed in all 79 patients. No adverse effects, including seizures, were reported.Conclusions: In this retrospective cohort, flumazenil was administered without serious adverse events and was associated with improved alertness and ventilation. While caution is required, particularly in mixed overdoses, flumazenil may have a role in managing benzodiazepine-induced respiratory depression when guided by toxicology consultation.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"28 1","pages":"40-44"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Transcatheter Aortic Valve Implantation Still Effective in Nonagenarians? 经导管主动脉瓣置入术对耄耋老人仍然有效吗？

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Oded Ayzenberg, Tomer Shlezinger, Noam Orvieto, Itzhak Katzir, Sigalit Bloch, Daniel Landsberger, Naomi Sigal, Eran Rotman, Zvi Vered

{"title":"Is Transcatheter Aortic Valve Implantation Still Effective in Nonagenarians?","authors":"Oded Ayzenberg, Tomer Shlezinger, Noam Orvieto, Itzhak Katzir, Sigalit Bloch, Daniel Landsberger, Naomi Sigal, Eran Rotman, Zvi Vered","doi":"","DOIUrl":"","url":null,"abstract":"Background: Transcatheter aortic valve implantation (TAVI) has become the preferred therapeutic method for elderly patients presenting with severe symptomatic aortic stenosis (AS). Most TAVI procedures are performed in patients between 75-85 years of age. A few publications exist on TAVI in patients over 90 years, yet the outcome and complication rates are inconsistent.Objectives: To identify all patients with AS who underwent TAVI between 2019 and 2020, specifically those age > 90 years at the time of the TAVI.Methods: We reviewed the Maccabi Healthcare Services database for all severe/critical AS patients who underwent TAVI between 2019 and 2020, specifically those age > 90 years at the time of TAVI. These patients were compared to all patients aged 80-89 years who underwent TAVI during the same time. Follow-up ended on 31 December 2022. We compared mortality and complications rates in nonagenarians vs. those 80-89 years and evaluated the change in left ventricular ejection fraction before and after the procedure.Results: We identified 36 nonagenarians who underwent TAVI during the study period, mean age 92.3 years, male:female ratio 15:21. During a mean follow-up period of 3 years, 44% of nonagenarians died, 26% of the control patients died (P < 0.01).Conclusions: TAVI in nonagenarians is feasible. Total mortality during follow-up was significantly higher in nonagenarians. Overall complication rates were also higher in nonagenarians, mostly due to vascular complications. Left ventricular dysfunction appeared to improve after TAVI, even in nonagenarians.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"28 1","pages":"24-27"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Spinal Stenosis the Cause of Exercise-Induced Dyspnea? 椎管狭窄是运动性呼吸困难的原因吗？

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Yoram Epstein, Erik Baltaxe, Yehuda Shoenfeld

引用次数: 0

Improved Pelvic Support and Urinary Symptoms Following Apical Mesh Reinforcement with a Partially Absorbable Lightweight Polypropylene Mini Mesh for Advanced Pelvic Organ Prolapse. 用部分可吸收的轻质聚丙烯迷你网片顶端补强治疗晚期盆腔器官脱垂后改善盆腔支持和泌尿系统症状

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Alla Saban, Jonatan Neuman, Reka Fabian-Kovacs, Menahem Neuman, Adi Y Weintraub

{"title":"Improved Pelvic Support and Urinary Symptoms Following Apical Mesh Reinforcement with a Partially Absorbable Lightweight Polypropylene Mini Mesh for Advanced Pelvic Organ Prolapse.","authors":"Alla Saban, Jonatan Neuman, Reka Fabian-Kovacs, Menahem Neuman, Adi Y Weintraub","doi":"","DOIUrl":"","url":null,"abstract":"Background: Studies have shown that approximately half of the female population may experience some degree of pelvic organ prolapse (POP) during their lifetime, although only 3-6% report symptomatic prolapse.Objectives: To evaluate the clinical and adverse outcomes associated with transvaginal repair using partially absorbable lightweight polypropylene Seratom PA MR MN® mini mesh for enhanced apical support in the treatment of advanced POP.Methods: A retrospective study was conducted on 114 patients who underwent transvaginal repair with the Seratom partially absorbable lightweight polypropylene mini mesh between August 2013 and January 2016. Data collected included demographic, surgical, adverse symptoms, and anatomical characteristics assessed via the modified Pelvic Organ Prolapse Quantification system (POP-Q). Postoperative pain was assessed using the Visual Analog Scale.Results: Significant improvements were observed in POP-Q measurements (P-value < 0.001). Subjective outcomes demonstrated significant pre- to 4-month postoperative reductions in urinary stress incontinence and overactive bladder (P < 0.001). No cases of mesh erosion were reported. Immediate complications included bleeding (3.5%), fever (1.7%), and urinary obstruction (0.9%). The recurrence rate was 12.3%. Patient satisfaction scores were consistently high, with an average of 95.96% at 1 month, 94.73% at 4 months, and 91.33% at the most recent follow-up.Conclusions: Transvaginal repair with the Seratom PA MR MN® partially absorbable mini mesh demonstrated significant improvements in anatomical and subjective outcomes, with few complications, and low recurrence rates. Further studies are necessary to validate these outcomes and optimize patient selection.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"28 1","pages":"34-39"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individualized Carbohydrate Counting: A Simple Tool for Improvement of Glycemic Control. 个体化碳水化合物计数：改善血糖控制的简单工具。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Judith Ben Dror, Idit F Liberty, Shulamit Witkow, Rachel Golan

{"title":"Individualized Carbohydrate Counting: A Simple Tool for Improvement of Glycemic Control.","authors":"Judith Ben Dror, Idit F Liberty, Shulamit Witkow, Rachel Golan","doi":"","DOIUrl":"","url":null,"abstract":"Background: Carbohydrate counting (CC), a recommended method for managing insulin bolus in patients with Type 1 diabetes mellitus (T1DM), depends on patient cognitive ability and motivation, and often does not account for ethnic foods. We have developed a simplified, accessible, patient-specific carbohydrate counting tool (SCC) to serve our very diverse population.Objectives: To retrospectively evaluate the long-term efficacy of the SCC with an emphasis on patients with moderate to poor glycemic control.Methods: The SCC tool is tailored to each patient's insulin:carbohydrate ratio (I:C), insulin sensitivity (IS), and dietary pattern. It includes two tables written in the patient's preferred language. The first lists the units of insulin needed to correct pre-meal blood glucose to target glucose. The second contains a list of food items derived from participant's personal eating habits, carbohydrate content, and the number of insulin units needed. At a median follow-up period of 6 months, we examined the change in hemoglobin A1c (HbA1c) in 212 patients with T1DM who utilized the SCC.Results: At follow-up, HbA1c in the study population decreased by 1.07% (22.43 mmol/mol) (95% confidence interval 0.8-1.3, P < 0.001). The variables sex and diabetes duration were nearly statistically significant in relation to the change in HbA1c levels (P = 0.059, P = 0.056).Conclusions: While not influenced by age, sex, ethnicity, socioeconomic status, education, insulin delivery method, duration of diabetes, or residence, the SCC tool is designed to help adult patients with T1DM with moderate to poor glycemic control.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"28 1","pages":"28-33"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genitourinary Syndrome of Menopause: A Bibliometric Analysis of the Top 100 Cited Articles. 绝经期泌尿生殖系统综合征：前100篇被引文章的文献计量学分析。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Elena Korytnikova, Adi Y Weintraub, Aparna Hegde, Reut Rotem, Salvatore Andrea Mastrolia, Tamar Eshkoli

引用次数: 0

Successful Non-operative Management of Tracheal Injury after Blunt Trauma in a Child: A Case Report. 儿童钝性创伤后气管损伤的非手术治疗成功一例报告。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Sofyan Abu Freih, Dor Halpern, Sergei Tsaregorodtsev, Gadi Shaked

引用次数: 0

Low Disease Burden in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Is Associated with Improved Outcomes: A Single Center Experience. 细胞减少手术和腹腔内高温化疗的低疾病负担与改善预后相关：单中心经验

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Yossi Maman, Jawad Tome, Rina Neeman, Dan Mirelman, Danit Dayan, Guy Lahat, Ravit Geva, Eran Nizri

{"title":"Low Disease Burden in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Is Associated with Improved Outcomes: A Single Center Experience.","authors":"Yossi Maman, Jawad Tome, Rina Neeman, Dan Mirelman, Danit Dayan, Guy Lahat, Ravit Geva, Eran Nizri","doi":"","DOIUrl":"","url":null,"abstract":"Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are established treatments for peritoneal metastasis from colorectal cancer (PM-CRC). The peritoneal carcinomatosis index (PCI) measures disease burden.Objectives: To evaluate the effect of PCI on short- and long-term outcomes of patients with PM-CRC who underwent CRS-HIPEC.Methods: We retrospectively analyzed 120 PM-CRC patients who underwent CRS-HIPEC, categorizing them into four PCI groups (PCI ≤ 3, PCI 4-6, PCI 7-11, PCI >11). We evaluated perioperative outcomes and long-term survival.Results: Higher PCI scores were associated with increased surgical complexity, longer operative times, more organ resections, and higher blood transfusion requirements. Complete cytoreduction was achieved in 100% of the PCI ≤ 3 group, but only in 70.8% of the PCI > 11 group (P = 0.001). Postoperative outcomes showed a trend toward less major morbidity in low PCI patients (16.7% vs. 28%) and significantly shorter hospital stays (10-13 days vs. 19 days, P = 0.006). The 90-day mortality rate was 0% in the PCI ≤ 3 group compared to 11.5% in the PCI > 11 group. Long-term outcomes revealed significantly better disease-free survival (DFS) and overall survival (OS) for the PCI ≤ 3 group (DFS: 22 months vs. 4-6 months; OS: 79.6 months vs. 21-40 months, P < 0.001).Conclusions: Patients with low PCI scores experience reduced morbidity and improved long-term survival, supporting the use of CRS-HIPEC in this subgroup. Further research is needed to enhance treatment strategies for patients with high PCI scores.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"28 1","pages":"18-23"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0