Sharon Slomovich, Visala Natarajan, Gal Rubinstein, Pavel Gozenput, Benhoor Shamian
{"title":"A Rare and Severe Case of Hepatitis E.","authors":"Sharon Slomovich, Visala Natarajan, Gal Rubinstein, Pavel Gozenput, Benhoor Shamian","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 8","pages":"520-521"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Perinatal Outcomes Following the October 7th Hamas-led Attack on Israel.","authors":"Matan Mor, Nadav Kugler, Moshe Betser, Miki Moskovich, Yifat Wiener, Ron Maymon","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>On 7 October 2023, Hamas lunched a massive terror attack against Israel. The first weeks after were characterized with great uncertainty, insecurity, and fear.</p><p><strong>Objectives: </strong>To evaluate the effect of the first 2 months of the Iron Swords war on obstetrical emergency attendance and the corresponding perinatal outcomes.</p><p><strong>Methods: </strong>We conducted a single center retrospective cohort study of all singleton births between 7 October and 7 December 2023. Prenatal emergency labor ward admission numbers and obstetric outcomes during the first 2 months of the war were compared to the combined corresponding periods for the years 2018-2022.</p><p><strong>Results: </strong>During the initial 2 months of the conflict 1379 births were documented. The control group consisted of 7304 deliveries between 2018 and 2022. There was a decrease in daily emergency admissions to the labor ward during the first 5 weeks of the conflict compared to the corresponding periods in the preceding years (51.8 ± 15.0 vs. 57.0 ± 13.0, P = 0.0458). A notable increase in stillbirth rates was observed in the study group compared to the control group (5/1379 [0.36%] vs. 7/7304 [0.1%]; P = 0.014). Both groups exhibited similar gestational ages at birth, rates of preterm and post-term delivery, neonatal birthweights, mode of delivery, and induction of labor rates.</p><p><strong>Conclusions: </strong>In the initial weeks following Hamas's attack on Israel, there was a notable decrease in admissions to the prenatal emergency labor ward. This decline coincided with an increase in the rate of stillbirths among a population not directly involved in the conflict.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 8","pages":"475-479"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raneen Abu Shqara, Maya Frank Wolf, Jawad Karram, Inshirah Sgayer, Ala Aiob, Lior Lowenstein, Susana Mustafa Mikhae
{"title":"A Multidisciplinary Approach for Treating Women with Pelvic Organ Prolapse in Pregnancy: A Series of Eight Women.","authors":"Raneen Abu Shqara, Maya Frank Wolf, Jawad Karram, Inshirah Sgayer, Ala Aiob, Lior Lowenstein, Susana Mustafa Mikhae","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pelvic organ prolapse in pregnancy is rare. Consequent complications include cervical infection, spontaneous abortion, and premature birth. Conservative management by means of a pessary have been described as improving maternal symptomatology and minimizing gestational risk. The delivery mode is controversial.</p><p><strong>Objectives: </strong>To describe the clinical courses of patients diagnosed with pelvic organ prolapse during pregnancy, and to present our multidisciplinary approach.</p><p><strong>Methods: </strong>In this retrospective case series, we summarized the obstetrical outcomes of women diagnosed with pelvic organ prolapse during pregnancy in a single university-affiliated hospital.</p><p><strong>Results: </strong>We identified eight women with advanced uterine prolapse at a mean age of 30.3 years. Seven were diagnosed with advanced uterine prolapse (Pelvic Organ Prolapse Quantification [POPQ] stage ≥ 3). All were treated by pessary placement, which was tolerable and provided symptomatic relief. The pessary type was chosen according to the prolapse stage. In women with cervical prolapse POPQ stage > 2 and cervical edema, a support pessary was less beneficial. However, the prolapse was well-controlled with a space-filling Gellhorn pessary. Low complication rates were associated with vaginal deliveries. The few complications that were reported included minor cervical laceration, postpartum hemorrhage, and retained placenta.</p><p><strong>Conclusions: </strong>Treatment of pelvic organ prolapse during pregnancy must be individualized and requires a multidisciplinary approach of urogynecologists, obstetricians, dietitians, pelvic floor physiotherapists, and social workers. Conservative management, consisting of insertion of a vaginal pessary when prolapse symptoms appeared, provided adequate support for the pelvic floor, improved symptomatology, and minimized pregnancy complications. Vaginal delivery was feasible for most of the women.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 8","pages":"493-499"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The White Blood Cell Count in Laboring Women at Term Is Associated with Neonatal Macrosomia.","authors":"Naama Srebnik, Jennia Michaeli, Rosa Ruchlemer, Rivka Farkash, Keren Rotshenker-Olshinka, Sorina Grisaru-Granovsk","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Fetal weight estimation at term is a challenging clinical task.</p><p><strong>Objectives: </strong>To evaluate the association between peripheral white blood cell (WBC) count of the laboring women and neonatal birth weight (BW) for term uncomplicated pregnancies.</p><p><strong>Methods: </strong>We conducted a single-center, retrospective cohort study (2006-2021) of women admitted in the first stage of labor or planned cesarean delivery. Complete blood counts were collected at admission. BW groups were categorized by weight (grams): < 2500 (group A), 2500-3499 (group B), 3500-4000 (group C), and > 4000 (group D). Two study periods were used to evaluate the association between WBC count and neonatal BW.</p><p><strong>Results: </strong>There were a total of 98,632 deliveries. The dataset analyses showed a lower WBC count that was significantly and linearly associated with a higher BW; P for trend < 0.001 for women in labor. The most significant association was noted for the > 4000-gram newborns; adjusted odds ratio 0.97, 95% confidence interval 0.96-0.98; P < 0.001; adjusted for hemoglobin level, gestational age, and fetal sex. The 2018-2021 dataset analyses revealed WBC as an independent predictor of macrosomia with a significant incremental predictive value (P < 0.0001). The negative predictive value of the WBC count for macrosomia was significantly high, 93.85% for a threshold of WBC < 10.25 × 103/µl.</p><p><strong>Conclusions: </strong>WBC count should be considered to support the in-labor fetal weight estimation, especially valuable for the macrosomic fetus.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 8","pages":"486-492"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Future Hybrid Hospital and Telehealth as a Significant Part of a General Medical Center.","authors":"Yaron Niv, Juliet Dreyer, Dora Niv","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 8","pages":"529-532"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ohad Gabay, Alexander Zhuravlov, Yakov Perlov, Chun Ho Szeto, Yoav Bichovsky, Dana Braiman, Leonid Koyfman, Asaf Honig, Mohamed Eldada, Evgeni Brotfain
{"title":"Preeclampsia and Severe Metabolic Alkalosis as Co-morbid Factors in Reversible Cerebral Vasoconstriction Syndrome: A Case Report.","authors":"Ohad Gabay, Alexander Zhuravlov, Yakov Perlov, Chun Ho Szeto, Yoav Bichovsky, Dana Braiman, Leonid Koyfman, Asaf Honig, Mohamed Eldada, Evgeni Brotfain","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 8","pages":"517-519"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can Blood Inflammatory Markers Identify Pregnant Women with Preeclampsia? Still a Controversial Issue.","authors":"Andrei Braester, Artyom Bilyk, Celia Suriu, Luiza Akria, Najib Dally, Masad Barhoum","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia is a unique vascular disease during pregnancy that generally appears after 20 of weeks gestation or until 6 weeks after delivery. Left undiagnosed, preeclampsia can lead rapidly to death of both mother and fetus.</p><p><strong>Objectives: </strong>To verify the efficacy of peripheral blood inflammatory markers (BIMs)in diagnosing preeclampsia and compare them with results from other studies.</p><p><strong>Methods: </strong>Our retrospective case-control study comprised two patient groups. Pregnant women with preeclampsia and pregnant women without preeclampsia were compared for BIMs: neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV). The primary endpoint of our research was to assess the predictive power of BIMs for preeclampsia diagnosis.</p><p><strong>Results: </strong>The sample size was calculated based on expected differences of BIMs between the control and study groups. Comparison of quantitative variables was conducted with independent sample t-test or alternatively by Wilcoxon rank sum test. The MPV values were slightly higher in the preeclampsia group, but not statistically significant. NLR and PLR did differentiate between study and control groups.</p><p><strong>Conclusions: </strong>The diagnostic accuracy of BIMs is unsatisfactory for preeclampsia diagnosis. Discrepancies concerning these values need to be clarified. Further large prospective studies are necessary to validate the potential factor accuracy in preeclampsia diagnosis.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 8","pages":"500-503"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current Perspectives on Maintaining Medical Education and Medical Communication Skills during War Times.","authors":"Moshe Salai, Yoram Sandhaus, Eitan Lunenfeld, Naomi Levine-Rahimi, Shai Ashkenazi, Avinoam Tzabari, Ahuva Golik, Zachi Grossman, Talma Kushnir","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 8","pages":"480-482"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilan Rozenberg, Sydney Benchetrit, Tali Zitman-Gal, Moanis Ajaj, Maysam Shehab, Naomi Nacasch, Keren Cohen-Hagai
{"title":"Prevalence and Predictors of Tunneled Dialysis Catheter Dysfunction.","authors":"Ilan Rozenberg, Sydney Benchetrit, Tali Zitman-Gal, Moanis Ajaj, Maysam Shehab, Naomi Nacasch, Keren Cohen-Hagai","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Hemodialysis requires reliable, recurrent access to the circulatory system. Central venous tunneled dialysis catheters (TDC) are frequently used for patients receiving hemodialysis as a bridge to permanent vascular access or as a final option. TDC are prone to complications such as infection and dysfunction.</p><p><strong>Objectives: </strong>To assess the prevalence and predictors of TDC dysfunction in a cohort of chronic hemodialysis patients.</p><p><strong>Methods: </strong>This single-center, retrospective study was based on data from an electronic database of chronic hemodialysis patients during 5 years of follow-up.</p><p><strong>Results: </strong>A total of 625 TDC were inserted in 361 patients, of which 234 (37.4%) were replaced due to dysfunction. The main insertion site was the right internal jugular vein. Diabetes mellitus was an important predictor of TDC dysfunction and was significantly correlated with TDC extraction. Chronic anticoagulation and antiplatelet treatment did not affect the rate of TDC dysfunction or replacement.</p><p><strong>Conclusions: </strong>TDC use for chronic dialysis patients is increasing and dysfunction is a major problem. In our study, we highlighted the high prevalence of TDC dysfunction and the need for further research to improve hemodialysis access as well as TDC patency and function.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 8","pages":"508-513"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gassan Moady, Michal De Picciotto, Naila Aslan, Shaul Atar
{"title":"The Impact of a Heart Failure Clinic on Clinical Outcomes: Our Experience.","authors":"Gassan Moady, Michal De Picciotto, Naila Aslan, Shaul Atar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) is an emerging pandemic associated with increased mortality, recurrent hospitalizations, and reduced quality of life. Guideline-directed medical therapy has been shown to improve outcomes, particularly in patients with HF with reduced ejection fraction (HFrEF). The main goal of HF clinics is optimizing medical therapy.</p><p><strong>Objectives: </strong>To assess the impact of our HF clinic on medical therapy and clinical outcomes.</p><p><strong>Methods: </strong>We obtained demographic, echocardiographic, and clinical data of patients listed in our HF clinic during a 4-year period. Medical therapy was evaluated based on patient reports and documented data. Recurrent admissions for HF were documented.</p><p><strong>Results: </strong>A total of 317 patients (74.1% male, median age 66 years, IQR 55-74) were listed in the clinic with a total of 1140 visits. Of these patients, 62.5% had HFrEF, 20.5% presented with mildly reduced ejection fraction, and 17% showed preserved ejection fraction at the time of the first visit. The use of sodium glucose co-transporter 2 inhibitors and mineralocorticoid receptor antagonists was optimized in 92% and 91% of the patients, respectively. In the subgroup of patients with HFrEF, the use of angiotensin-receptor antagonist/neprilysin inhibitor increased from 22.6% to 87.9% (P < 0.001) and SGLT2 inhibitor use increased from 49.2% to 92% (P < 0.001). During the follow-up period (2.2 years, IQR 1.1-3.1), 203 patients (64%) were readmitted to the hospital for HF at least once. The rate of readmissions decreased over time.</p><p><strong>Conclusions: </strong>An HF clinic plays an important role in optimizing medical therapy and reducing readmissions.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 8","pages":"504-507"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}