Israel Medical Association Journal最新文献_第9页

Thromboangiitis Obliterans of the Colon: An Unusual Manifestation of Buerger's Disease. 结肠血栓闭塞性脉管炎：伯格氏病的一种不寻常表现。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Eden Gerszman, Isaac Sitton, Veronica Sandler, Ahmad Mahamid, Alexandra Cretu, Arie Bitterman

引用次数: 0

The Unrecognized Academic Role of the Jewish Hospitals and Their Staff during the Nazi Era. 纳粹时期犹太医院及其工作人员未被承认的学术作用。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Gideon Eshel, Eran Kozer

{"title":"The Unrecognized Academic Role of the Jewish Hospitals and Their Staff during the Nazi Era.","authors":"Gideon Eshel, Eran Kozer","doi":"","DOIUrl":"","url":null,"abstract":"Background: After the Nazi regime seized power, the only place where Jewish medical students were allowed to conduct their practicum in Germany were the Jewish hospitals.Objectives: To identify the Jewish students who, during summer 1933 and later, conducted their practicum and wrote their medical dissertations in the Jewish hospitals, and to identify their tutors.Methods: We examined the dissertations at the medical faculty of Berlin that were conducted from the summer of 1933 until the autumn 1937, identifying the students who did their practicum at Jewish hospitals and stood for the MD examination.Results: In total, 29 Jewish students finished their medical practicum and wrote their dissertations either in the Jewish hospitals of Berlin or in other Jewish hospitals outside the capital city after April 1933. Only five of those studies were presented to the MD examination signed by their Jewish tutors. The remaining 24 works were submitted and signed by an Aryan professor. In 10 of those last studies, the names of the Jewish tutors could be uncovered.Conclusions: The Jewish hospitals of Berlin continued their academic activity even after being ejected from Berlin hospital's medical faculty body in April 1933. At that time most of the studies dealt with surgery and gynecology. In most cases the studies were submitted for the MD examination by proxy and signed by an Aryan professor.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"28 1","pages":"14-17"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of the COVID-19 Pandemic on Treatment Strategies for Secondary Prevention of Hip Fragility Fractures. COVID-19大流行对髋部脆性骨折二级预防治疗策略的影响

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Orit Mazza, Muhammad Abu-Leil, Itay Cohen, Chedva S Weiss, Amir Haim

{"title":"Effect of the COVID-19 Pandemic on Treatment Strategies for Secondary Prevention of Hip Fragility Fractures.","authors":"Orit Mazza, Muhammad Abu-Leil, Itay Cohen, Chedva S Weiss, Amir Haim","doi":"","DOIUrl":"","url":null,"abstract":"Background: The coronavirus disease 2019 (COVID-19) pandemic has disrupted healthcare systems globally, affecting chronic disease management like osteoporosis and the prevention of fragility hip fractures. We hypothesized that it led to suboptimal prevention of secondary femoral neck fractures, reduced treatment frequency, and delayed treatment initiation.Objectives: To evaluate the treatment initiation rate for secondary prevention of femoral neck fractures, comparing pre-COVID-19, COVID-19, and post-COVID periods, considering patient demographics.Methods: This retrospective diagnostic cohort study used automated electronic medical records database from Clalit Health Services. Data regarding patients with hip fractures from January 2017 through September 2021 were extracted from the database. Treatment for osteoporosis included one of the following treatments: alendronate, risedronate, zoledronate, abaloparatide, denosumab, romosozumab, and teriparatide. The primary outcome variable in the study is the time taken to initiate appropriate therapy for the secondary prevention of femoral neck fractures.Results: Treatment frequency decreased over time, with rates declining from 40.4% in 2019 to 33.5% in 2021 (P-value < 0.05). However, the percentage of prompt care management (within 3 months) increased between 2020 and 2021 (47.3%-62.5%) and between 2019 and 2021 (48.7%-62.5%), P < 0.05.Conclusions: The COVID-19 pandemic reduced the rate of appropriate treatment initiation following hip fractures. However, adherence to timely treatment within 3 months of the fracture has improved. The findings highlight the effectiveness of the health system response in managing crises and ensuring the timely delivery of critical treatment.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"28 1","pages":"9-13"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Medicine: At the Forefront of Clinical Medicine, Advanced Technology, and Innovative Research. 肺医学：处于临床医学、先进技术和创新研究的前沿。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2025-12-01

Zvi G Fridlender

引用次数: 0

Community Neutrophil-to-Lymphocyte Ratio Can Predict Future Cardiovascular and Cardiac-related Mortality after the First Hospitalized COPD Exacerbation. 社区中性粒细胞与淋巴细胞比值可预测首次住院COPD加重后心血管和心脏相关死亡率

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2025-12-01

Michael Kassirer, Nitzan Sagie, Evyatar Bar-Haim, Liora Boehm-Cohen, Mati Shavit, Moataz Abu-Rabid, Yael Raviv

{"title":"Community Neutrophil-to-Lymphocyte Ratio Can Predict Future Cardiovascular and Cardiac-related Mortality after the First Hospitalized COPD Exacerbation.","authors":"Michael Kassirer, Nitzan Sagie, Evyatar Bar-Haim, Liora Boehm-Cohen, Mati Shavit, Moataz Abu-Rabid, Yael Raviv","doi":"","DOIUrl":"","url":null,"abstract":"Background: Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of cardiovascular events, especially following acute exacerbation (AECOPD). However, there is insufficient data to identify high-risk subjects.Objectives: To evaluate the association between neutrophil-to-lymphocyte ratio (NLR), a marker of inflammation, and the risk of cardiovascular events following exacerbation.Methods: This retrospective cohort included patients with COPD who were hospitalized with AECOPD between January 2016 and December 2022. We took the reference NLR before index admission and evaluated the incidence of major adverse cardiovascular events (MACE) or cardiovascular death over the following year. Multivariate analysis and competing risk regression were used to assess hazard ratio (HR) and NLR threshold for increased cardiovascular risk.Results: In total, 15,224 patients with AECOPD completed one 1-year follow-up session. The majority were male (54%) with a mean age of 69 ± 3 years. The risk for MACE of patients in the highest NLR quartile was higher over the first year following AECOPD; however, the magnitude of effect decreased over time. After adjustment to other confounders that may increase NLR, a value > 3.5 was found with the strongest predictive power.Conclusions: Community NLR can be used to identify patients at increased risk of cardiovascular events following AECOPD, together with other risk factors. Every effort should be made to reduce exacerbation risk, and target intervention to those patients at highest risk.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 12","pages":"759-765"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using the FEV1/FVC < 0.7 as Criterion for Obstruction in the Geriatric Population: Is There a Risk of Overdiagnosis? 以FEV1/FVC < 0.7作为老年人群梗阻的诊断标准：是否存在过度诊断的风险？

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2025-12-01

Assaf Berg, Ariel Rokach, Abraham Bohadana, Yossi Freier-Dror, Hava Azulai, Gabriel Izbicki

{"title":"Using the FEV1/FVC < 0.7 as Criterion for Obstruction in the Geriatric Population: Is There a Risk of Overdiagnosis?","authors":"Assaf Berg, Ariel Rokach, Abraham Bohadana, Yossi Freier-Dror, Hava Azulai, Gabriel Izbicki","doi":"","DOIUrl":"","url":null,"abstract":"Background: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends a ratio of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) of less than 70% (FEV1/FVC < 0.7) after bronchodilators as the criteria for obstruction. However, because the FEV1/FVC ratio decreases with age, using a fixed ratio may lead to overdiagnosis of obstruction in the geriatric population. Using the lower limit of normal (LLN) as threshold for obstruction has been suggested.Objectives: To determine the rate of overdiagnosis using the GOLD criteria compared to LLN in patients aged 60 and older. To find a better threshold with a minimal rate of over- and underdiagnosis.Methods: The study population included adults aged 60 years and older who performed pulmonary function test (PFT) at Shaare Zedek Medical Center between 2014 and 2019 with results of FEV1/FVC < 0.7.Results: We included 430 patients aged 60 years and older, 273 males (63.5%) and 157 females (36.5%). Mean age was 72 ± 8 years. Overdiagnosis was found in 35.6% of patients (95% confidence interval 31.1-40.3%) by using the GOLD criteria compared to the LLN. Overdiagnosis was reduced to 6.4% with the 0.65 threshold. The ideal point of the FEV1/FVC ratio where overdiagnosis and underdiagnosis were at their lowest rates was 0.638.Conclusions: Use of the GOLD criteria for airflow obstruction may be associated with an overdiagnosis of more than 35% in patients older than 60 years. Lowering the FEV1/FVC ratio to < 0.65 might be more accurate in this population.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 12","pages":"754-758"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Disparities in Mortality Outcomes Among COPD Patients Awaiting Lung Transplantation: A Comprehensive Analysis. 等待肺移植的COPD患者死亡率结局的性别差异：一项综合分析

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2025-12-01

Shimon Izhakian, Osnat Shtraichman, Dorit Shitenberg, Dror Rosengarten, Eviatar Naamany, Alon Gorenshtein, Mordechai Reuven Kramer

{"title":"Sex Disparities in Mortality Outcomes Among COPD Patients Awaiting Lung Transplantation: A Comprehensive Analysis.","authors":"Shimon Izhakian, Osnat Shtraichman, Dorit Shitenberg, Dror Rosengarten, Eviatar Naamany, Alon Gorenshtein, Mordechai Reuven Kramer","doi":"","DOIUrl":"","url":null,"abstract":"Background: Lung transplantation (LT) is a viable option for end-stage chronic obstructive pulmonary disease (COPD) patients when conventional treatments fail. However, sex disparities in mortality outcomes among COPD patients awaiting LT remain understudied. LT waiting lists are generally shorter in Western countries compared to Israel.Objectives: To evaluate sex-specific differences in mortality and co-morbidities among COPD patients awaiting lung transplantation, to identify key risk factors influencing survival.Methods: We assessed associations between sex, co-morbidities, exacerbations, and mortality using Cox regression models, adjusting for confounders. Survival curves for lung transplant candidates were stratified by sex using Fine and Gray models.Results: We identified 385 COPD patients listed for LT at Rabin Medical Center. Females exhibited higher rates of asthma (P = 0.008), anxiety (P = 0.005), and depression (P = 0.002); males were more frequently diagnosed with ischemic heart disease (26.5% vs. 10.83%, P = 0.001) and had a higher lung transplant rate (24.9% vs. 15%, P = 0.029). Multivariate analysis revealed that female sex (hazard ratio [HR] 1.55, 95% confidence interval [95%CI] 1.06-2.29, P = 0.025), older age (HR 1.02, 95%CI 1.002-1.054, P = 0.035), ischemic heart disease (HR 1.69, 95%CI 1.12-2.48, P = 0.011), and depression (HR 1.81, 95%CI 1.15-2.83, P < 0.01) were significantly associated with increased mortality. Females showed higher 1-year mortality rates than males (40.3% vs. 29.8%, P < 0.001).Conclusions: Female sex is a significant risk factor for increased mortality among COPD patients awaiting LT, likely due to a higher burden of co-morbidities.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 12","pages":"771-777"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between RT-PCR Cycle Threshold and Outcomes of Individuals Hospitalized for COVID-19. RT-PCR周期阈值与COVID-19住院患者预后的关系

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2025-12-01

Ori Wand, Nikita Mukaseev, Keren Cohen-Hagai, Anna Breslavsky, Anat Tzurel Ferber, Amir Bar-Shai, Natalya Bilenko

{"title":"Association Between RT-PCR Cycle Threshold and Outcomes of Individuals Hospitalized for COVID-19.","authors":"Ori Wand, Nikita Mukaseev, Keren Cohen-Hagai, Anna Breslavsky, Anat Tzurel Ferber, Amir Bar-Shai, Natalya Bilenko","doi":"","DOIUrl":"","url":null,"abstract":"Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to a wide spectrum of clinical severity. The gold standard diagnosis of infection is reverse transcription polymerase chain reaction of nasopharyngeal swabs, which also provides a semiquantitative assessment of viral loads by measuring cycle threshold (CT) values.Objectives: To assess whether CT values at admission can predict mortality and oxygen needs among individuals hospitalized for coronavirus disease 2019 (COVID-19).Methods: The retrospective study included adults hospitalized for COVID-19 between 1 August 2020 and 30 April 2021 at Barzilai University Medical Center. Patients were categorized according to initial CT values as high (≥ 25) or low (< 25) values. The primary outcome was the association between CT values during admission and overall mortality.Results: The study group included 636 patients, with a mean age of 67.2 years, 54.4% males. Overall mortality of patients with CT values < 25 was significantly higher (odds ratio for mortality 1.78 vs. patients with CT ≥ 25, P = 0.002). Significantly more patients in the low CT group required oxygen support than in the high CT group, 50% vs. 31.9% (P < 0.001). An inverse association between CT values and mortality rates remained significant in multivariate regression analysis, such that a 1-unit decrease in CT was associated with a 6% increased mortality.Conclusions: Lower CT values at admission were associated with increased mortality among patients hospitalized for COVID-19. CT values can be used to predict outcomes among such patients.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 12","pages":"795-799"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood Gas Analysis: Establishing the Normal Range for Elderly Patients. A Single Center Cohort Study. 血气分析：建立老年患者正常范围。单中心队列研究。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2025-12-01

Ksenya Epshtein, Shay Baron, Maly Keler, Alexander Sivokha, Eran Kalmanovich, Benjamin D Fox

{"title":"Blood Gas Analysis: Establishing the Normal Range for Elderly Patients. A Single Center Cohort Study.","authors":"Ksenya Epshtein, Shay Baron, Maly Keler, Alexander Sivokha, Eran Kalmanovich, Benjamin D Fox","doi":"","DOIUrl":"","url":null,"abstract":"Background: Interpretation of blood gases is essential for the correct practice of medicine. Normal ranges for arterial blood gases (ABG) have not been extensively studied in the older population. Also, venous blood gases and venous-arterial pCO2 gradient have not been studied in this population, even though they signify the majority of hospitalized patients.Objectives: To determine the normal range for ABG and the bias limits of agreement for arterial-venous difference in the elderly population.Methods: We recruited 130 elderly patients (> 70 years) and obtained blood gas measurements from venous and arterial blood. Patients were divided into four categories: healthy patients, patients with stable chronic pulmonary disease, hospitalized patients with acute respiratory illness, and hospitalized patients without respiratory disease. Samples were analyzed in a point of care analyzer.Results: Mean PaCO2 was 36.9 ± 4.2 mmHg for the healthy control group, 37.0 ± 4.8 mmHg in the stable chronic respiratory group, 37.0 ± 5.0 mmHg in the non-respiratory hospitalization group, and 42.3 ± 11.4 mmHg for the respiratory hospitalization group, Kruskall-Wallis, P <0.0025. Mean bias between venous and arterial CO2 was +10.0 mmHg with 95% limits of agreement between 2.7 mmHg and -22.8 mmHg.Conclusions: In elderly patients, the range of PaCO2 measurements was similar to the accepted normal range in clinical practice. Venous-arterial PCO2 gradient had high bias and wide limits of agreement, similar to previously published studies.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 12","pages":"766-770"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperbaric Oxygen Therapy for Cerebral Arterial Air Embolism Secondary to Transbronchial Lung Biopsies: More Air than Substance? 高压氧治疗经支气管肺活检继发的脑动脉空气栓塞：空气多于物质？

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2025-12-01

Moshe Heching, Shimon Izhakian, Orly Efros, Maor Mermelstein, Avigail Rockland, Moshe Shai Amor, Lev Freidkin, Dror Rosengarten, Dorit Shitenberg, Yael Shostak, Osnat Shtraichman, Mordechai Reuven Kramer

引用次数: 0