Israel Medical Association Journal最新文献_第7页

Merkel cell carcinoma in Israel: Beilinson's experience. 以色列的默克尔细胞癌：Beilinson的经验。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-02-01

Eyal Fenig, Aaron Sulkes

引用次数: 0

Comparison of Autistic and Nonautistic Transgender Youth Attending Psychiatric Clinics Who Request Hormonal Therapy: A Retrospective Pilot Study. 在精神病诊所接受激素治疗的自闭症和非自闭症跨性别青年的比较：一项回顾性试点研究。

IF 0.8 4区医学

Israel Medical Association Journal Pub Date : 2026-02-01

Livia Balan-Moshe, Moran Shemesh-Iron, Daniel Assaf, Shira Goldman, Maya Schwartz-Lifshitz, Shlomit Tsafrir, Doron Gothelf

{"title":"Comparison of Autistic and Nonautistic Transgender Youth Attending Psychiatric Clinics Who Request Hormonal Therapy: A Retrospective Pilot Study.","authors":"Livia Balan-Moshe, Moran Shemesh-Iron, Daniel Assaf, Shira Goldman, Maya Schwartz-Lifshitz, Shlomit Tsafrir, Doron Gothelf","doi":"","DOIUrl":"","url":null,"abstract":"Background: Transgender and gender diverse (TGD) adolescents often experience higher rates of psychiatric co-morbidities, autism spectrum disorder (ASD), and autistic traits. A few studies have described TGD adolescents who were referred to psychiatric clinics. To the best of our knowledge, no study has yet compared clinical characteristics of autistic vs. nonautistic TGD adolescents.Objectives: To describe the demographic and clinical characteristics of TGD adolescents referred to a tertiary child and adolescent psychiatric clinic, and to compare the characteristics of autistic and nonautistic TGD adolescents.Methods: We conducted a retrospective study of 28 TDG adolescents who were consecutively referred for psychiatric evaluation in a child and adolescent psychiatric clinic at a tertiary children's hospital between December 2020 and February 2023. Data were collected from electronic medical files.Results: Of the sample, 67.9% first questioned their gender identity after the onset of secondary sex characteristics (pubertal onset) and 35.7% were identified as gifted. The gifted group had a higher rate of pubertal onset compared to the nongifted group. Our cohort exhibited a higher rate of ASD (39.3%) than the general population. Autistic compared to nonautistic TGD adolescents had a higher rate of giftedness and a lower rate of social transition.Conclusions: TGD adolescents referred for psychiatric evaluation display distinct features, including high rates of ASD, giftedness, and pubertal onset. Autistic compared to nonautistic TGD are more likely to be gifted and less likely to have undergone social transition.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"28 2","pages":"82-87"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should Gangrenous Appendicitis Be Labeled as Complicated? An 8-year Single-Center Retrospective Review. 坏疽性阑尾炎应该被标记为复杂的吗？一项为期8年的单中心回顾性研究。

IF 0.8 4区医学

Israel Medical Association Journal Pub Date : 2026-02-01

Eric Scheier, Osher Cohen, Pavel Peslin, Stav Amir

{"title":"Should Gangrenous Appendicitis Be Labeled as Complicated? An 8-year Single-Center Retrospective Review.","authors":"Eric Scheier, Osher Cohen, Pavel Peslin, Stav Amir","doi":"","DOIUrl":"","url":null,"abstract":"Background: Gangrenous appendicitis falls to the midpoint of the continuum between uncomplicated and complicated appendicitis. We present an eight-year single-center retrospective review of uncomplicated, complicated and gangrenous appendicitis.Objectives: To analyze the presentation of gangrenous appendicitis in our population.Methods: We reviewed the presentation, as well as the laboratory, surgical, and pathological findings for complicated, uncomplicated, and gangrenous appendicitis. Logistic regression analysis was conducted to identify predictors of gangrenous and of complicated appendicitis.Results: During the study period, 865 children had uncomplicated appendicitis and 134 had complicated appendicitis. Younger age, duration of illness as well as vomiting, diarrhea, and fever were more common in complicated than uncomplicated appendicitis. White blood cell count, neutrophil count and C-reactive protein were higher in complicated appendicitis. Logistic regression showed that vomiting and presence of fever occurred more frequently in children with non-perforated gangrenous appendicitis than with other uncomplicated appendicitis. Laboratory results for non-perforated gangrenous appendicitis were comparable to those of complicated appendicitis, as was usage of radiography and computed tomography.Conclusions: Gangrenous appendicitis shares similar historical elements with complicated appendicitis and has a similar laboratory. These children, like those with complicated appendicitis, may not be optimal candidates for non-operative management.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"28 2","pages":"93-98"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurofilament Light Chain Measurements by Centaur and Simoa Systems in Human and Murine Samples. 半人马和Simoa系统在人类和小鼠样本中的神经丝轻链测量。

IF 0.8 4区医学

Israel Medical Association Journal Pub Date : 2026-02-01

Tali Drori, Amir Dori, Zehavit Goldberg, Valery Golderman, Polina Sonis, Michael Gurevich, Rina Zilkha-Falb, Joab Chapman, Efrat Shavit-Stein

{"title":"Neurofilament Light Chain Measurements by Centaur and Simoa Systems in Human and Murine Samples.","authors":"Tali Drori, Amir Dori, Zehavit Goldberg, Valery Golderman, Polina Sonis, Michael Gurevich, Rina Zilkha-Falb, Joab Chapman, Efrat Shavit-Stein","doi":"","DOIUrl":"","url":null,"abstract":"Background: Neurofilament light chain (NfL) is an established biomarker for detecting axonal injury in various neurological disorders. The Quanterix Single Molecule Array (Simoa) is the current standard; however, automated immunoassays, such as the Siemens Atellica and Centaur, may serve as alternatives.Objectives: To compare NfL measurements obtained with the Centaur system to those from the Simoa-SR-X. To assess their agreement and applicability in clinical practice, research, and animal studies.Methods: NfL levels were measured in 27 human serum, 8 plasma, and 16 cerebrospinal fluid (CSF) samples, and 9 murine serum samples, by Centaur and Simoa systems. NfL levels in concomitantly drawn serum and plasma were compared in 8 humans. The agreement between platforms was evaluated.Results: NfL levels measured by Centaur and Simoa systems demonstrated a strong correlation in serum (Spearman r=0.97, P < 0.0001) and plasma (Pearson R²=0.95, P < 0.0001). Centaur measurements were higher (P = 0.01) than Simoa. Most importantly, system-specific Z-scores corrected these differences. Serum and plasma levels measured by the Centaur system correlated strongly (R²=0.98, P < 0.0001) and showed similar results. CSF levels measured by the Centaur system were lower (52% bias) than those measured by Simoa, with poor correlation at concentrations within the normal range (R2=0.32, P = 0.11). Mouse serum results showed a strong correlation between systems (R²=0.86, P < 0.001) with similar values.Conclusions: The Centaur system offers an alternative to Simoa for measuring NfL in human serum, plasma, and murine serum. System-specific age-adjusted Z-scores are essential for interpretation. CSF evaluation requires further assessment.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"28 2","pages":"77-81"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative Management of Ossifying Fibroma of the Facial Bones Using Denosumab. 应用Denosumab创新治疗面部骨骨化性纤维瘤。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-02-01

Michael Pesis, Anna Pikovsky, Navot Givol

引用次数: 0

Right Atrial Mimicry: A Unique Case of Cardiac Tamponade Caused by a Loculated Right Pleural Effusion Following Coronary Artery Bypass Graft Surgery. 右心房模仿：冠状动脉搭桥术后由局部胸腔积液引起的心脏填塞的独特病例。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-02-01

Amir Aker, Yuval Avidan, Ibrahim Naoum, Hussein Sliman, Salim Bashir, Salim Adawi

引用次数: 0

Polymicrobial Endocarditis with Enterococcus faecalis and Proteus mirabilis: A Case Report. 多微生物性心内膜炎伴粪肠球菌和变形杆菌1例。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-02-01

Rotem Chaimoff, Michal Michaelis, Yaara Leibovici Weissman, Noa Eliakim-Raz

引用次数: 0

Unraveling the Genetics of Sexual Orientation: A Historical and Contemporary Perspective. 解开性取向的遗传学：一个历史和当代的观点。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-02-01

Nicola Luigi Bragazzi, Raymond Farah, Rola Khamisy-Farah

引用次数: 0

Clinical Outcomes of Renal Denervation for Resistant Hypertension: The Tel Aviv Renal Denervation Prospective Registry. 肾去神经治疗顽固性高血压的临床结果：特拉维夫肾去神经前瞻性登记。

IF 0.8 4区医学

Israel Medical Association Journal Pub Date : 2026-02-01

Netanel Golan, Ophir Freund, Yael Horwitz, Yaron Arbel

{"title":"Clinical Outcomes of Renal Denervation for Resistant Hypertension: The Tel Aviv Renal Denervation Prospective Registry.","authors":"Netanel Golan, Ophir Freund, Yael Horwitz, Yaron Arbel","doi":"","DOIUrl":"","url":null,"abstract":"Background: Apparent treatment-resistant hypertension (aTRH) is a high-risk phenotype associated with increased cardiovascular and renal morbidity. Renal denervation (RDN) has emerged as a promising intervention for patients with refractory blood pressure (BP) despite maximal medical therapy.Objectives: To present the first Israeli prospective cohort evaluating RDN outcomes in aTRH patients.Methods: The Tel Aviv Renal Denervation registry is a single-center, prospective cohort of 19 patients with aTRH who underwent RDN between 2021 and 2024. Baseline data included demographics, co-morbidities, medication burden, ambulatory BP monitoring (ABPM), and renal function. Outcomes were assessed at 3 and 12 months post-procedure, with repeated measures analyses used to evaluate longitudinal trends.Results: The cohort (median age 62 years, 42% female) exhibited a high burden of co-morbidities including ischemic heart disease (37%), diabetes (26%), and chronic kidney disease (21%). Baseline ABPM showed a median 24-hour systolic BP of 152 mmHg. Following RDN, mean systolic BP decreased to 143 mmHg at 3 months and 138 mmHg at 12 months (P = 0.097), with a significant reduction in nighttime systolic BP (P = 0.033). Pill burden decreased from a median of 7 to 4 pills daily (P = 0.037). The number of antihypertensive drug classes declined from 6 to 4 (P = 0.052). Renal function remained stable throughout follow-up.Conclusions: In this Israeli RDN cohort, patients with aTRH experienced clinically meaningful reductions in BP and medication burden, with preserved renal function and minimal complications. These findings support further expansion of national RDN registries to better guide patient selection and optimize long-term outcomes.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"28 2","pages":"110-115"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity Screening in Hospitalized Pediatric Patients: Rates of Diagnosis, Intervention, and Risk Factors for Overlooked Obesity. 住院儿科患者的肥胖筛查：被忽视肥胖的诊断率、干预和危险因素。

IF 1.3 4区医学

Israel Medical Association Journal Pub Date : 2026-01-01

Shir Libman, Michal Vinker-Shuster, Zvi Perry, Yonatan Yeshayahu

{"title":"Obesity Screening in Hospitalized Pediatric Patients: Rates of Diagnosis, Intervention, and Risk Factors for Overlooked Obesity.","authors":"Shir Libman, Michal Vinker-Shuster, Zvi Perry, Yonatan Yeshayahu","doi":"","DOIUrl":"","url":null,"abstract":"Background: Recent guidelines have emphasized the importance of the diagnosis and treatment of obesity in all healthcare settings. However, obesity rarely appears as a chronic diagnosis during hospitalization, and there are few reports of targeted interventions.Objectives: To assess obesity-related diagnoses and interventions during pediatric acute hospitalization.Methods: A retrospective cohort study was conducted in a pediatric ward. Hospitalization records of all patients aged 2-18 years were retrieved during a 30-month period. Weight percentile for patient age was calculated using the U.S. Centers for Disease Control and Prevention (CDC) age- and sex-adjusted charts. Patients with a weight-percentile-for-age of ≥ 95% were classified as suspected obesity. The characteristics of obesity-diagnosed patients were compared to obesity-overlooked patients.Results: Of the hospitalized patients, 245/2827 (8.6%) had weight-percentile-for-age of ≥ 95%. Of these, 91/245 (37.4%) had obesity-related references in their medical record; 65/245 (26.5%) had a mean body mass index of 97.66% ± 2.6. Only 38/245 (15.5%) were diagnosed with obesity; weight-related recommendations only appeared in the discharge letter for 44/245 (17.9%). Multivariate analysis indicated that obesity was significantly more overlooked in preschoolers than in adolescents (adjusted odds ratio [OR] 11.78, 95% confidence interval [95%CI] 4.71-29.42), P < 0.001) and in patients, regardless of age, whose chief complaint was not abdominal (OR 7.7, 95%CI 1.92-30.8, P = 0.004).Conclusions: Low rates of obesity-related diagnoses during pediatric acute hospitalization, especially in younger patients, are frequent. Pediatric staff should note obesity in patients and be trained in non-stigmatizing intervention during hospitalization.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"28 1","pages":"45-49"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0