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Development and Validation of a Clinical Protocol in COVID-19 Patients to Assess Disease Severity and Outcomes. 评估COVID-19患者疾病严重程度和预后的临床方案的制定和验证。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-01-01
Milena Tocut, Yousef Abuleil, Mona Boaz, Amos Gilad, Gisele Zandman-Goddard
{"title":"Development and Validation of a Clinical Protocol in COVID-19 Patients to Assess Disease Severity and Outcomes.","authors":"Milena Tocut, Yousef Abuleil, Mona Boaz, Amos Gilad, Gisele Zandman-Goddard","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) pandemic showed the need to evaluate disease severity promptly at the time of hospital admission.</p><p><strong>Objectives: </strong>To establish an admission protocol, which included clinical and laboratory findings.</p><p><strong>Methods: </strong>We conducted a retrospective study at Wolfson Medical Center, Israel, for a period of 19 months (2020-2021). We established a protocol for patients who were admitted with COVID-19 infection. The protocol parameters included demographic data, co-morbidities, immune status, oxygen level at room air on admission, oxygen demand, lymphopenia, C-reactive protein (CRP) level, lactate dehydrogenase, D-DIMER, creatinine, aspartate transferase, alanine aminotransferase, and ferritin. Based on this protocol, we defined the severity of COVID-19 at the beginning of hospitalization and started treatment without delay. This protocol included ferritin levels as a guide to severity and outcome of patients. A database was established for all the parameters of the patients included in the study.</p><p><strong>Results: </strong>The study included 407 patients; 207 males (50.9%), 200 females (49.1%). The age range was 18-101 years. Hyperferritinemia (> 1000 ng/dl) was one of the strongest and most significant predictors for severe disease in these patients (P < 0.001). Lymphopenia, high levels of CRP, alanine aminotransferase, aspartate transferase, lactate dehydrogenase, and creatinine also correlated with severe disease, complications, and death.</p><p><strong>Conclusions: </strong>Abnormal ferritin levels were a very significant and clear indicator of the development of severe COVID-19. The addition of ferritin levels to our protocol aided in finding which patients were at increased risk for morbidity and mortality.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 1","pages":"28-33"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Embolism in Peripartum Cardiomyopathy: An Unusual Complication. 围生期心肌病的肺栓塞：一种不寻常的并发症。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-01-01
Gassan Moady, Tameemi Abdallah Moady, Alexander Shturman, Shaul Atar
{"title":"Pulmonary Embolism in Peripartum Cardiomyopathy: An Unusual Complication.","authors":"Gassan Moady, Tameemi Abdallah Moady, Alexander Shturman, Shaul Atar","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 1","pages":"54-56"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgery in Mauthausen Concentration Camp: Therapy or Practice? 毛特豪森集中营的外科手术：治疗还是实践？
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-01-01
George M Weisz
{"title":"Surgery in Mauthausen Concentration Camp: Therapy or Practice?","authors":"George M Weisz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 1","pages":"11-16"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Educating the Physicians of the Future: The Dina Recanati School of Medicine at Reichman University. 培养未来的医生：赖曼大学迪娜·雷卡纳蒂医学院。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-01-01
Arnon Afek
{"title":"Educating the Physicians of the Future: The Dina Recanati School of Medicine at Reichman University.","authors":"Arnon Afek","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 1","pages":"5-6"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent Cardiovascular Events Despite Optimal LDL-Cholesterol Reduction: Therapeutic Challenges. 尽管降低了低密度脂蛋白胆固醇，心血管事件仍反复发生：治疗挑战。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2024-12-01
Avishay Elis, Ela Giladi
{"title":"Recurrent Cardiovascular Events Despite Optimal LDL-Cholesterol Reduction: Therapeutic Challenges.","authors":"Avishay Elis, Ela Giladi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 11","pages":"724-728"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Use and Abuse of Mohs Micrographic Surgery. 莫氏显微外科手术的使用与滥用。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2024-12-01
Joseph Alcalay
{"title":"The Use and Abuse of Mohs Micrographic Surgery.","authors":"Joseph Alcalay","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 11","pages":"712-714"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3 Letters to Editor. 3给编辑的信。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2024-12-01
Moti Ravid, Zvi Ackerman, Samuel N Heyman, George M Weisz
{"title":"3 Letters to Editor.","authors":"Moti Ravid, Zvi Ackerman, Samuel N Heyman, George M Weisz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 11","pages":"729-730"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Audiovestibular Involvement in Patients with Psoriasis. 银屑病患者听觉前庭受累的评价。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2024-12-01
Kfir Siag, Miki Paker, Salim Mazzawi, Yoni Evgeni Gutkovich, Moran Barcan, Shani Fisher, Michael Ziv
{"title":"Evaluation of Audiovestibular Involvement in Patients with Psoriasis.","authors":"Kfir Siag, Miki Paker, Salim Mazzawi, Yoni Evgeni Gutkovich, Moran Barcan, Shani Fisher, Michael Ziv","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Little is known about audiovestibular function in psoriasis, a chronic systemic inflammatory disease that affects 2% of the world's population.</p><p><strong>Objectives: </strong>To investigate audiovestibular function in patients with psoriasis.</p><p><strong>Methods: </strong>In this prospective case-control trial, we enrolled 33 patients with psoriasis and 30 healthy controls. Audiologic testing included audiometry, tympanometry, and otoacoustic emissions recording. The vestibular investigation consisted of a dizziness handicap inventory questionnaire, a complete clinical vestibular examination, and video head impulse testing.</p><p><strong>Results: </strong>The psoriasis group showed significantly higher average hearing thresholds in both ears at all frequencies. Otoacoustic measurements differed significantly at 3000 Hz in the right (P = 0.026) and left ear (P = 0.034). The average dizziness handicap score was considerably higher in the psoriasis group, with a mean difference of 7.70 (P = 0.025). The number of patients with abnormal right anterior semicircular canal gain values was significantly higher in the psoriasis group (P = 0.047). Saccade analysis in the psoriasis group showed significantly higher number of patients with covert corrective saccades of the left posterior canal (P = 0.037) and significantly higher number of patients with abnormal interaural difference of corrective saccades in the plane of the right anterior-left posterior canals (P = 0.035).</p><p><strong>Conclusions: </strong>The study demonstrates an association between psoriasis and audiovestibular impairment, which can affect quality of life. These results suggest that patients with psoriasis may be evaluated with audiometry for possible hearing loss. Vestibular testing may be pursued as clinically indicated.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 11","pages":"675-681"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Influencing Refractive Surgery Rejection in Israeli Patients. 影响以色列患者屈光手术排斥反应的因素。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2024-12-01
Nadav Shemesh, Nadav Levinger, Shmuel Levinger, Ami Hirsch, Asaf Achiron, Eliya Levinger
{"title":"Factors Influencing Refractive Surgery Rejection in Israeli Patients.","authors":"Nadav Shemesh, Nadav Levinger, Shmuel Levinger, Ami Hirsch, Asaf Achiron, Eliya Levinger","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>One of the major causes of reversible visual impairment is a refractive error, which can be corrected through refractive surgery. Data regarding the outcomes and complications of these procedures exist; however, there is a notable gap in understanding the factors leading to patient rejection, particularly in diverse populations like Israel.</p><p><strong>Objectives: </strong>To detect clinical risk factors of patients who intend to undergo LASIK procedure and to improve the conversion rates of LASIK procedure in this population.</p><p><strong>Methods: </strong>The study included a retrospective analysis of patients who were rejected from having refractive surgery in two Enaim Refractive Surgery Centers: Jerusalem and Tel Aviv. Comparisons between centers were conducted using the t-test for continuous variables and Fisher's exact test for categorical data.</p><p><strong>Results: </strong>Our study included 337 patients who were rejected from having refractive surgery, including 152 (45.1%) who were rejected permanently and 185 (54.9%) rejected temporarily. The most common reasons for permanent rejection were corneal irregularity (n=81, 53.3%), keratoconus (n=27, 17.8%), thin corneas (n=13, 8.6%), and amblyopia (n=10, 6.6%). The most common temporary reasons were unstable refraction (n=96, 51.9%), prolonged use of contact lenses (n=54, 29.2%), and corneal irregularity (n=16, 8.6%).</p><p><strong>Conclusions: </strong>The leading permanent cause of rejection for refractive surgery was a corneal irregularity, whereas the primary temporary cause was unstable refraction. In a time of rapid technological advancements and growing demand for freedom from glasses, there is an increasing need for more informed and patient-focused refractive correction approaches.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 11","pages":"688-693"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shortened Survival of Chronic Hemodialysis Patients during Quarantine Periods of COVID-19. A Retrospective Analysis of 344 Patients. COVID-19隔离期慢性血液透析患者生存期缩短。对 344 例患者的回顾性分析。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2024-12-01
Amit Oppenheim, Nabil Abu-Amer, Itai Gueta, Ramy Haj, Pazit Beckerman, David J Ozeri
{"title":"Shortened Survival of Chronic Hemodialysis Patients during Quarantine Periods of COVID-19. A Retrospective Analysis of 344 Patients.","authors":"Amit Oppenheim, Nabil Abu-Amer, Itai Gueta, Ramy Haj, Pazit Beckerman, David J Ozeri","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The impact of the coronavirus disease 2019 (COVID-19) pandemic on patient populations can be divided to direct consequences of the disease and indirect implications of changes imposed on the national healthcare systems. The impact of the later survival of chronic hemodialysis patients is still unknown.</p><p><strong>Objectives: </strong>To examine the impact of quarantine on health outcomes of dialysis patients.</p><p><strong>Methods: </strong>In a retrospective case-controlled study, we compared chronic hemodialysis patients from two separate timeframes: during a quarantine period and a parallel time without quarantine.</p><p><strong>Results: </strong>The study included 344 hemodialysis patients. Baseline characteristics were compared between those enrolled in 2015 and those enrolled in 2020. Despite comparable clinical parameters, a statistically significant increase in the 6-month mortality rate was observed in 2020 (1.2% vs. 6.7%, P = 0.01), primarily attributed to sepsis. Notably, no deaths were attributed to COVID-19 in 2020. Interdialytic weight gain and dialysis quality remained similar between the two groups, with a mild trend toward excessive weight gain in 2020. Secondary outcomes after 6 months did not significantly differ, except for lower sodium values in 2015 compared to 2020.</p><p><strong>Conclusions: </strong>Dialysis patients experienced disproportionate effects from the COVID-19 pandemic, even with continuous care and no direct virus-related fatalities. The findings showed unintended consequences of quarantine measures, highlighting adverse impact on both physical and mental health. Recognizing and addressing these consequences are imperative for minimizing their impact in future pandemics, emphasizing the importance of proactive measures in healthcare planning.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 11","pages":"669-674"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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