Israel Medical Association Journal最新文献_第5页

Cannabidiol and Its Effects on Patients with COVID-19 Infection. 大麻二酚及其对COVID-19感染患者的影响

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Yuval Kuntzman, Gilad Halpert, Howard Amital

引用次数: 0

Linking Clinical Activity with Medical Research: The Steady Journey of Internal Medicine in Israel. 将临床活动与医学研究联系起来：以色列内科医学的稳步发展。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Howard Amital, Avishay Elis

引用次数: 0

Genetic Links Between Depression and Heart Disease in Women. 女性抑郁症和心脏病之间的基因联系

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Shira Peretz, Marina Kurtz, Aviad Sivan, Arnon Blum

{"title":"Genetic Links Between Depression and Heart Disease in Women.","authors":"Shira Peretz, Marina Kurtz, Aviad Sivan, Arnon Blum","doi":"","DOIUrl":"","url":null,"abstract":"Background: Cardiovascular disease (CVD) events are rare in premenopausal women. Nevertheless, women with depression have a higher prevalence of CVD. Patients with depression present with endothelial dysfunction and impaired ability to regenerate endothelial progenitor cells (EPCs).Objectives: To understand the association between depression and CVD, especially in young women.Methods: We collected peripheral blood samples from 30 premenopausal women diagnosed with major depression and 28 aged-matched healthy women. From these blood samples, we extracted RNA and conducted RNA sequencing to obtain comprehensive gene expression profiles. Gene expression analysis was performed to identify differences between the two groups.Results: We detected 6540 differentially expressed genes between the two groups, of which 5577 were downregulated and 963 up regulated. Of these genes, we detected a significant decrease of CD144 (VE-Cadherin) (P = 0.0001), CD146 (MCAM) (P = 0.0001) and CD133 (PROM1) (P = 0.00009), all known to enhance EPCs and regeneration of damaged blood vessels. A significant increase was found in the expression of CD31 (PECAM1) (P = 0.0003) and CD45 (PTPRC) (P = 0.00001), both known to promote atherogenesis and thrombogenesis with platelet and T lymphocyte activation.Conclusions: Young premenopausal women with depression had an impaired ability to grow colony forming units of endothelial progenitor cells (CFU-EPCs). Young women with depression are more vulnerable genetically to develop CVD because of the downregulated genes of the stem cells endothelial vascular regeneration and upregulation of genes coding for platelet and T lymphocyte activation, thus accelerating the atherosclerotic and atherothrombotic pathway.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 2","pages":"110-113"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low Serum IgG4 in Systemic Sclerosis: Lessons from an Israeli Cohort. 低血清IgG4在系统性硬化症：来自以色列队列的教训。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Anat Ben Ari, Noa Rabinowicz, Haim Paran, Or Carmi, Yair Levy

{"title":"Low Serum IgG4 in Systemic Sclerosis: Lessons from an Israeli Cohort.","authors":"Anat Ben Ari, Noa Rabinowicz, Haim Paran, Or Carmi, Yair Levy","doi":"","DOIUrl":"","url":null,"abstract":"Background: Immunoglobulin 4 (IgG4) is the least abundant immunoglobulin in the sera of healthy individuals; however, its levels can vary in different diseases such as IgG4-related disease (high) or Sjögren's syndrome (low). While previous studies have suggested the importance of IgG4 in autoimmune diseases, the clinical and biological significance of high or low levels remains unclear.Objectives: To investigate the association between IgG4 antibody levels and systemic sclerosis (SSc), as well as the clinical features of the disease.Methods: We measured IgG4 levels in the sera of 74 SSc patients from the years 2000 to 2019 and compared them to IgG4 levels in 80 healthy donors from the Israeli national blood bank. We performed correlation analyses between IgG4 levels and various factors, including age, sex, disease subtype, disease duration, organs involved, and medications taken by the patients.Results: Our findings revealed significantly lower IgG4 levels in SSc patients compared to healthy participants. SSc patients receiving steroid treatment exhibited prominently lower IgG4 levels. In addition, SSc patients with Raynaud's phenomenon tended to have lower IgG4 levels compared to those without Raynaud's phenomenon.Conclusions: Our study demonstrates that IgG4 levels are lower in SSc patients. Further research is needed to elucidate whether this observation contributes to the etiology of the disease or if it represents a common manifestation among other autoimmune diseases.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 2","pages":"92-97"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes and Prognosis of Acute Decompensated Heart Failure: Not a Straightforward Relationship. 糖尿病与急性失代偿性心力衰竭的预后：不是直接的关系。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Abed Qadan, Nir Levi, Tal Hasin

引用次数: 0

From Fat to Muscle. 从脂肪到肌肉

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Milena Tocut, Ron Dabby, Arie Soroksky, Gisele Zandman-Goddard

引用次数: 0

Osteoporosis Among Glucocorticoid-treated Patients with Giant-cell Arteritis: A Population-based Cohort Analysis. 糖皮质激素治疗的巨细胞动脉炎患者骨质疏松：基于人群的队列分析。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Batsheva Varda, Arielle D Zur, Yuval Kuntzman, Yonatan Shneor Patt, Howard Amital, Arnon D Cohen, Omer Gendelman

{"title":"Osteoporosis Among Glucocorticoid-treated Patients with Giant-cell Arteritis: A Population-based Cohort Analysis.","authors":"Batsheva Varda, Arielle D Zur, Yuval Kuntzman, Yonatan Shneor Patt, Howard Amital, Arnon D Cohen, Omer Gendelman","doi":"","DOIUrl":"","url":null,"abstract":"Background: Giant cell arteritis (GCA) is a large vessel vasculitis predominantly affecting patients over 50 years, typically managed with glucocorticoids, with treatment varying on individual patient needs. While effective for GCA, long-term glucocorticoids use poses significant risks, including the development of osteoporosis, a metabolic bone disease common in older individuals. This overlap poses a significant clinical challenge, as the treatment for GCA inadvertently raises the risk of osteoporosis and necessitates careful balance to manage both conditions effectively.Objectives: To investigate the occurrence of osteoporosis and other co-morbid conditions in patients with GCA treated with glucocorticoids.Methods: A retrospective cross-sectional analysis of GCA patients examined the correlation between GCA and osteoporosis by searching the Clalit Health Service database for patients over 50 years of age from January 2002 to January 2018. In addition, we conducted a logistic regression analysis stratifying for other co-morbidities to evaluate the independent association between GCA and osteoporosis.Results: In total, 6607 GCA patients were compared with 36,066 age- and sex-matched controls. The study revealed a higher prevalence of osteoporosis in the GCA group (43%) compared to controls (27%) (odds ratio [OR] 2.06, 95% confidence interval [95%CI] 1.95-2.17). In addition, hypertension, hyperlipidemia, diabetes mellitus, and ischemic heart disease were more prevalent among GCA patients. After stratifying for cardiovascular co-morbidities, GCA remained independently associated with osteoporosis (OR 2.1, 95%CI 1.96-2.26, P < 0.001).Conclusions: Glucocorticoid-treated GCA is independently associated with osteoporosis. Healthcare providers must consider this added aspect of GCA for the treatment and management of patients.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 2","pages":"98-102"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemophagocytic Lymphohistiocytosis Secondary to Murine Typhus: A Case Report. 鼠斑疹伤寒继发的噬血细胞性淋巴组织细胞增多症1例。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Talia Mandell, Shimrit Hershcovitz, Muhammad Awwad, Yaara Leibovici-Weisman, Noa Eliakim-Raz, Nassem Ghantous

引用次数: 0

Diabetes and Acute Decompensated Heart Failure: A Comprehensive Analysis of In-Hospital Outcomes. 糖尿病与急性失代偿性心力衰竭：住院结果综合分析》。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Alena Kirzhner, Hefziba Green, Ronit Koren, Haitham Abu Khadija, Danielle Sapojnik, Tal Schiller

{"title":"Diabetes and Acute Decompensated Heart Failure: A Comprehensive Analysis of In-Hospital Outcomes.","authors":"Alena Kirzhner, Hefziba Green, Ronit Koren, Haitham Abu Khadija, Danielle Sapojnik, Tal Schiller","doi":"","DOIUrl":"","url":null,"abstract":"Background: The prognostic significance of diabetes mellitus (DM) on hospitalization outcomes of patients with acute decompensated heart failure (ADHF) remains inconclusive.Objectives: To comprehensively assess the clinical outcomes of patients with and without DM hospitalized for ADHF.Methods: This single center retrospective cohort study included consecutive hospitalized patients with a principal diagnosis of ADHF between 1 January 2010 and 31 December 2019. Patients were categorized into diabetic and non-diabetic groups. The primary outcomes assessed were in-hospital mortality, 1-year overall mortality, and readmission rate within a year of follow-up.Results: The final analysis involved 787 ADHF patients, with 62% having a pre-existing diagnosis of DM. Despite a higher burden of co-morbidities in diabetic patients, there were no differences in clinical outcomes when compared to non-diabetic counterparts. Specifically, there were no differences in overall hospital mortality (10% vs. 10%, P = 0.675), 1-year mortality (22% vs. 25%, P = 0.389), and re-admissions (51% vs. 56%, P = 0.154). Notably, the 1-year mortality among diabetic patients was not influenced by HbA1c levels documented before or during admission.Conclusions: The clinical outcomes of patients hospitalized with ADHF did not differ by the presence of diabetes. Instead, our findings emphasize the importance of early heart failure prevention and subsequent hospitalization. Considering the evolving landscape of disease-modifying therapies for heart failure, achieving this goal becomes increasingly feasible.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 2","pages":"103-109"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complementary Medicine for Treating Emotional Exhaustion and Burnout of Frontline Healthcare Providers during the COVID-19 Pandemic. COVID-19大流行期间一线医护人员情绪衰竭和倦怠的补充医学治疗

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Noa Bigman-Peer, Genady Drozdinsky, Irit Heruti, Eran Rotman, Irit Ayalon-Dangur, Anat Dagan, Noa Eliakim-Raz

{"title":"Complementary Medicine for Treating Emotional Exhaustion and Burnout of Frontline Healthcare Providers during the COVID-19 Pandemic.","authors":"Noa Bigman-Peer, Genady Drozdinsky, Irit Heruti, Eran Rotman, Irit Ayalon-Dangur, Anat Dagan, Noa Eliakim-Raz","doi":"","DOIUrl":"","url":null,"abstract":"Background: Burnout is prevalent among healthcare providers and characterized by emotional exhaustion, depersonalization, and reduced personal accomplishment. The coronavirus disease 2019 (COVID-19) pandemic exacerbated burnout due to increased workloads, emotional strain, and heightened risk. Complementary medicine (CAM) interventions like shiatsu massage and reflexology have been explored as potential to mitigate burnout, particularly pandemic-related stress.Objectives: To assess the efficacy of CAM interventions for alleviating burnout in healthcare providers treating COVID-19 patients during 2022, when the Delta variant was prevalent.Methods: This prospective observational study included 86 healthcare providers at Rabin Medical Center, Beilinson Campus. Workers were divided into two groups: an intervention group participating in CAM activities and a control group. Participant burnout and post-traumatic stress disorder (PTSD) symptoms were evaluated using the Maslach Burnout Inventory and General Anxiety Disorder 7 at baseline and at one day and one week post-intervention.Results: The CAM group demonstrated significant reduction in burnout scores, primarily due to an enhanced sense of accomplishment (P = 0.023), with enduring effects observed after one week, although not reaching statistical significance (P = 0.078). There was no observed difference in PTSD scores between the groups (P = 0.28).Conclusions: The study reveals potential benefits of CAM interventions in reducing burnout symptoms among healthcare providers during the COVID-19 pandemic. The findings underscore the importance of integrating such interventions to address the mental well-being of healthcare providers, especially in high-stress environments. Further randomized controlled trials with diverse samples and extended follow-up are recommended to validate and explore these initial findings.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 2","pages":"82-86"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0