Israel Medical Association Journal最新文献_第4页

Mortality and Readmissions of Solid-Organs Transplant Recipients Hospitalized Due to COVID-19 Infection with the Omicron Variant: A Matched Cohort Study. 因COVID-19感染组粒变异而住院的实体器官移植受者的死亡率和再入院率：一项匹配队列研究

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-04-01

Daniella Vronsky, Genady Drozdinsky, Irit Ayalon-Dangur, Ya'ara Leibovici Weissman, Noa Eliakim-Raz

{"title":"Mortality and Readmissions of Solid-Organs Transplant Recipients Hospitalized Due to COVID-19 Infection with the Omicron Variant: A Matched Cohort Study.","authors":"Daniella Vronsky, Genady Drozdinsky, Irit Ayalon-Dangur, Ya'ara Leibovici Weissman, Noa Eliakim-Raz","doi":"","DOIUrl":"","url":null,"abstract":"Background: Solid organ transplant (SOT) recipients represent a particularly vulnerable group due to their reliance on immunosuppressive therapies. Previous studies indicated a mortality rate of 20%-30% among SOT recipients with coronavirus disease 2019 (COVID-19). With the advent of the Omicron variant in November 2021, characterized by milder symptoms and lower mortality rates in the general population, safety measures relaxed, potentially impacting vulnerable populations like SOT recipients.Objectives: To investigate mortality and morbidity among hospitalized SOT recipients with COVID-19 infection during the Omicron wave.Methods: A retrospective, propensity-matched cohort study conducted at the Rabin Medical Center, Israel, spanned from November 2021 to June 2023. Adult SOT recipients hospitalized with COVID-19 were compared to matched controls.Results: Among 139 hospitalized SOT recipients and 209 controls, SOT recipients hospitalized with COVID-19 displayed higher in-hospital mortality (19% vs. 11%) and 90-day all-cause mortality (30% vs. 17%). In addition, the 90-day readmission rate was significantly higher among SOT recipients (43% vs. 31%). Multivariable analysis confirmed these trends, with SOT recipients exhibiting increased risk for mortality, readmission, invasive ventilation, and intensive care unit admission.Conclusions: The heightened vulnerability of hospitalized SOT recipients during the Omicron wave was characterized by higher mortality and readmission rates compared to matched controls. Despite the perceived milder nature of the Omicron variant, SOT recipients remain disproportionately affected. Continued vigilance and targeted interventions are necessary for this population including vaccinations and adherence to preventive measures. Investigating this population's outcomes through the changing COVID-19 variants is still warranted.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 4","pages":"216-220"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil-to-Lymphocyte Ratio, C-Reactive Protein, and Mean Platelet Volume in Differentiation of Ascites Causes. 中性粒细胞与淋巴细胞比值、c反应蛋白和平均血小板体积在腹水病因鉴别中的作用。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-04-01

Raymond Farah, Tammy Jacoby, Rola Khamisy-Farah

{"title":"Neutrophil-to-Lymphocyte Ratio, C-Reactive Protein, and Mean Platelet Volume in Differentiation of Ascites Causes.","authors":"Raymond Farah, Tammy Jacoby, Rola Khamisy-Farah","doi":"","DOIUrl":"","url":null,"abstract":"Background: Ascites is a product of fluid accumulation within the peritoneal cavity. Underlying etiologies include cirrhosis, congestive heart failure (CHF), nephrotic syndrome, and malignancies. Patients with cirrhotic ascites are at increased risk for infections, especially spontaneous bacterial peritonitis (SBP), which is associated with high rates of morbidity and mortality. Ascites is diagnosed both clinically and sonographically. SBP is diagnosed via abdominal paracentesis, a relatively safe and effective procedure. However, abdominal paracentesis carries risks such as bleeding, bowel perforation, and infection.Objectives: To identify new inflammatory markers as alternative or replacement methods for accurately evaluating patients before and after abdominal paracentesis and how these new inflammatory markers can be evaluated from a simple, inexpensive, and routinely performed blood sample.Methods: A total of 106 patients admitted with ascites were classified into three groups based on the underlying etiology of their condition: malignant ascites (30 patients), ascites secondary to CHF (30 patients), and ascites secondary to cirrhosis (46 patients). Levels of neutrophil-lymphocyte ratio (NLR), mean platelet volume, and C-reactive protein among the study groups were examined through blood samples and subsequently compared.Results: NLR values within malignant ascites and CHF ascites were significantly higher than cirrhotic ascites (P = 0.002). In addition, among risk factors for developing ascites, significant correlations were found among the three groups in hypertension (P < 0.001), diabetes mellitus (P = 0.003), hyperlipidemia (P = 0.002), CHF (P < 0.001), and ischemic heart disease (P < 0.001) variables.Conclusions: NLR may be a prognostic tool in patient evaluation of ascites.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 4","pages":"211-215"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison in Therapeutic Outcome of Ultrasound-guided Botulinum Injections for Limb Spasticity Versus Dystonia. 超声引导下肉毒杆菌注射治疗肢体痉挛与肌张力障碍的疗效比较。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-04-01

Gilad Yahalom, Mikhal E Cohen, Ilana Israel, Roni Eichel, Yosef Shechter

{"title":"Comparison in Therapeutic Outcome of Ultrasound-guided Botulinum Injections for Limb Spasticity Versus Dystonia.","authors":"Gilad Yahalom, Mikhal E Cohen, Ilana Israel, Roni Eichel, Yosef Shechter","doi":"","DOIUrl":"","url":null,"abstract":"Background: Botulinum toxin (BT) can alleviate limb dystonia, but limited insurance coverage hinders its utilization.Objectives: To compare the therapeutic efficacy of BT injections for spasticity and dystonia of the limbs.Methods: BT injections of hypertonic limbs were administered under ultrasound guidance between 2019 and 2024 for either limb dystonia or limb spasticity.Results: Of 74 patients included, 57 were diagnosed with spasticity and 17 with dystonia. In total, 276 therapeutic cycles were administered. The dropout rates were 45.6% in the spasticity group and 41.2% in the dystonia group (P = 0.48). There was no significant difference in subjective motor improvement between dystonia and spasticity (P = 0.16). Dystonia patients reported significantly better pain relief (98.5 ± 4.9% vs. 72.4 ± 35.6% respectively, P < 0.001). Notably, 74.3% of dystonia treatments reported moderate or marked improvement, whereas only 54.0% of spasticity treatments did (P > 0.05), based on patient the global impression of change (PGI-C) scale. Side effects were infrequent.Conclusions: BT injections for limb spasticity and dystonia are partially effective. Nonetheless, the dropout rate is high. While BT injections are more effective in relieving pain for dystonia compared to spasticity, disease severity gradually improves over time in treated patients with spasticity but not with dystonia.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 4","pages":"238-243"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of 498 Pedestrian Injuries Involving Bicycles, E-bicycles, and E-scooters: Characteristics and Factors Influencing Injury Severity. 498例涉及自行车、电动自行车和电动滑板车的行人伤害分析：特征及影响伤害严重程度的因素

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-04-01

Ron Gurel, Rashad Seh, Mohamed Abadi, Shai Factor, Adnan Abdellatif, Addy S Brandstetter, Yair Neuman, Amal Khoury

{"title":"Analysis of 498 Pedestrian Injuries Involving Bicycles, E-bicycles, and E-scooters: Characteristics and Factors Influencing Injury Severity.","authors":"Ron Gurel, Rashad Seh, Mohamed Abadi, Shai Factor, Adnan Abdellatif, Addy S Brandstetter, Yair Neuman, Amal Khoury","doi":"","DOIUrl":"","url":null,"abstract":"Background: The increasing use of micromobility solutions (MMS), including electric scooters, electric, and non-motorized bicycles, has revolutionized urban transportation. We addressed the rising incidence of injuries related to pedestrian-MMS accidents, with a specific focus on pedestrian injuries.Objectives: To improve clinician comprehension of patient characteristics and injuries associated with pedestrian-MMS accidents and to provide insights for injury prevention, policy making, and urban planning.Methods: We conducted a retrospective analysis, June 2017 to January 2023, of pedestrians who were admitted to the emergency department post-MMS accidents. Data included patient characteristics, type of MMS, time of the accident, and outcome variables including type of injury, hospitalization, and surgical treatment.Results: The study cohort included 498 pedestrians (57.7% women), with a mean age of 42.3 ± 21.8 years. Nighttime accidents were 53.2% of cases. Fractures were the dominant type of injury (18.3% of the total cohort). Age, particularly those ≥ 60 years, significantly (P < 0.05) influenced fracture, hospitalization, and surgery rates (30.6%, 22.4%, and 12.6%, respectively). The odds ratio of having a fracture for pedestrians ≥ 60 years was 5.35 (P = 0.008). Interestingly, the type of MMS did not significantly affect outcomes.Conclusions: Age emerged as a critical factor in injury severity, emphasizing the need for age-specific safety measures in urban environments. The type of MMS did not show a significant influence on outcomes, emphasizing the importance of a comprehensive regulation of all MMS types. The high rate of accidents during nighttime calls for focused interventions during this period to prevent accidents.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 4","pages":"244-248"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgery in Auschwitz: Therapy or Experience? 奥斯维辛的外科手术：治疗还是经验？

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-04-01

George M Weisz

引用次数: 0

Minocycline-induced Polyarteritis Nodosa Manifesting as Tenosynovitis, Edema, and Rash: A Case Report. 二甲胺四环素致结节性多动脉炎1例，表现为腱鞘炎、水肿和皮疹。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-04-01

Roni Meidan, Dror Lahav, Iris Eshed, Katya Meridor, Ori Elkayam, Ofir Elalouf

引用次数: 0

Infant Botulism in Israel: A Rare Disease That Still Exist. 以色列婴儿肉毒杆菌中毒：一种仍然存在的罕见疾病。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-04-01

Uri Rubinstein, Nechama Sharon, Ahmad Masarwa, Michael Benacon, Elka Bella Kosinovski

引用次数: 0

Outcomes of Percutaneous Cholecystostomy in Older Adults with Acute Cholecystitis. 经皮胆囊造瘘术治疗老年急性胆囊炎的疗效。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-04-01

Edden Slomowitz, Lisa Cooper, Hadas Tsivion-Visbord, Tzippy Shochat, Hanoch Kashtan, Ilan Schrier

{"title":"Outcomes of Percutaneous Cholecystostomy in Older Adults with Acute Cholecystitis.","authors":"Edden Slomowitz, Lisa Cooper, Hadas Tsivion-Visbord, Tzippy Shochat, Hanoch Kashtan, Ilan Schrier","doi":"","DOIUrl":"","url":null,"abstract":"Background: Acute cholecystitis (ACC) is one of the most common diagnoses encountered in surgical wards. A number of treatment modalities are available, and various guidelines have been developed to help decision making. Many factors influence treatment strategies, including patient age and frailty. Due to the increasing proportion of older patients, consideration into the best treatment modalities for this population are warranted.Objectives: To determine outcomes of elderly patients with ACC according to different treatment strategies.Methods: A retrospective analysis of consecutive patients aged ≥ 80 years who were admitted with a diagnosis of ACC between 2015 and 2019 to a single academic center. Patients were divided into three groups according to treatment: percutaneous cholecystostomy tube placement, cholecystectomy, intravenous antibiotic treatment only.Results: Overall, 466 patients were included in the cohort. The majority (approximately 75%) were treated with antibiotics only, 17% underwent percutaneous cholecystostomy, and 8% underwent laparoscopic cholecystectomy. One-year mortality was 28.1%. The highest mortality rate was 41.6% in the cholecystostomy group (P = 0.002). In multivariable analysis age, functional status, C-reactive protein, and albumin levels were found to be independent risk factors for 1-year mortality (hazard ratio [HR] 1.08, 0.56, 0.98, 0.4, respectively). Cholecystostomy increased risk of one-year mortality compared to cholecystectomy and antibiotics alone (HR 0.61, 0.23, respectively).Conclusions: The use of cholecystostomy for ACC in older adults is an independent risk factor for 1-year mortality. Its use in older adults should be reserved for carefully selected cases.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 4","pages":"249-254"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nail-patella Syndrome and Bilateral Nephrolithiasis: Rare Case Study of a 17-year-old Israeli Male. 指甲-髌骨综合征和双侧肾结石：一名17岁以色列男性的罕见病例研究。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-04-01

Majd Said, Yossy Machluf, Vladimir Banchenko, Eduardo Cohen, Yoram Chaiter

引用次数: 0

The Impact of the COVID-19 Pandemic on Seasonal Enteroviral Meningitis in Hospitalized Children. COVID-19大流行对住院儿童季节性肠病毒性脑膜炎的影响

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-04-01

Evgenia Gurevich, Mahdi Seh, Yaser Nabari, Vered Shkalim Zemer

{"title":"The Impact of the COVID-19 Pandemic on Seasonal Enteroviral Meningitis in Hospitalized Children.","authors":"Evgenia Gurevich, Mahdi Seh, Yaser Nabari, Vered Shkalim Zemer","doi":"","DOIUrl":"","url":null,"abstract":"Background: Enterovirus meningitis (EM) is a common central nervous system (CNS) infection with a seasonal peak in summer and fall.Objectives: To describe the epidemiologic and clinical patterns of EM in children before (2017-2019 years) and during the coronavirus disease 2019 (COVID-19) pandemic (2020-2022).Methods: This retrospective study included children (age 0-16 years) hospitalized in a pediatric department in Israel diagnosed with EM: January 2017-December 2019 and January 2020-December 2022. The seasonal peak for each period was defined as the maximal incidence in particular months. EM was diagnosed by reverse transcription polymerase chain reaction of cerebrospinal fluid (CSF) for enteroviruses.Results: During the study period, EM was diagnosed in 134 cases (median age 5 months [1-51], 76 [57%] males); 72 during 2017-2019 and 62 during 2020-2022. The most common presentation was fever. C-reactive protein (CRP) was elevated in 57 cases (43%). CSF profile showed pleocytosis in 130 cases (97%) and elevated protein in 80 (60%). In the 2020-2022 group, fewer patients were febrile, CRP was higher, and CSF profile showed a higher glucose level compared to the 2017-2019 group. Seasonal peaks in 2017-2019 occurred June-August, and in 2020-2022 February-April.Conclusions: The COVID-19 pandemic altered the clinical characteristics of EM and its seasonal peak. Clinicians should be aware of changes in epidemiological patterns of EM to make appropriate diagnoses in viral infection in order to avoid unnecessary antibiotic treatment.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 4","pages":"224-228"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0