Israel Medical Association Journal最新文献_第3页

Artificial Intelligence: Large Language Models in Pediatrics. What Do We Know So Far? 人工智能：儿科中的大型语言模型。到目前为止我们知道什么？

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-03-01

Maayan Mandelbaum, Daniella Levy-Erez, Shelly Soffer, Eyal Klang, Sarina Levy-Mendelovich

引用次数: 0

The Effect of Consanguineous Marriage on the Epidemiology of Wilson Disease among Children: A Report from Southern Israel. 近亲婚姻对儿童Wilson病流行病学的影响：一份来自以色列南部的报告。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-03-01

Raouf Nassar, Nour Ealiwa, Lior Hassan, Gadi Howard, Rotem Shalev Shamay, Slava Kogan, Nadine Abboud, Baruch Yerushalmi, Galina Ling

{"title":"The Effect of Consanguineous Marriage on the Epidemiology of Wilson Disease among Children: A Report from Southern Israel.","authors":"Raouf Nassar, Nour Ealiwa, Lior Hassan, Gadi Howard, Rotem Shalev Shamay, Slava Kogan, Nadine Abboud, Baruch Yerushalmi, Galina Ling","doi":"","DOIUrl":"","url":null,"abstract":"Background: Wilson disease (WD) is an autosomal recessive disease characterized by a defect in hepatocellular copper transport with a wide spectrum of clinical manifestations and reported prevalence.Objectives: To study the epidemiology and clinical manifestations of WD between two ethnic groups, Jewish and Bedouins, with different marriage patterns, in southern Israel.Methods: We conducted a retrospective study investigating the clinical course and laboratory characteristics of children diagnosed with WD who were treated at Soroka University Medical Center.Results: Sixteen patients were diagnosed between 2000 and 2021 (8 males, 50%), 14 were of Bedouins origin. The total cohort prevalence was 1:19,258 while the prevalence of the disease was significantly higher among Bedouins compared to Jews (1:10,828 vs.1:78,270, P-value = 0.004). The median age at diagnosis was 10.2 years, without a significant difference between the groups. The most common presenting symptom was hepatic manifestations: 81.2% had elevated transaminases, 12.5% had jaundice, 25% had neurological symptoms, one had a Kayser-Fleischer ring, and one had psychosis. The mean ceruloplasmin level was 3.0 mg/dl. During follow-up, nine patients normalized transaminases with treatment, while three required liver transplantation. There was no significant difference in the clinical presentation and disease course between the two ethnic groups.Conclusions: Our cohort showed a high prevalence of WD compared to previous studies, especially among the Bedouin population, which has a high consanguinity rate. The prognosis of WD in our population is similar to other studies and depends mainly on treatment compliance.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 3","pages":"159-164"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Pediatric Medicine: Bridging Research and Practice. 推进儿科医学：衔接研究与实践。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-03-01

Nechama Sharon

引用次数: 0

C-Reactive Protein Is Associated with Severity in Hospitalized Children with Respiratory Syncytial Virus Bronchiolitis. c反应蛋白与呼吸道合胞病毒毛细支气管炎住院患儿的严重程度相关

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-03-01

Assaf Adar, Aviv D Goldbart, Nitzan Burrack, Neta Geva, Bracha Cohen, Inbal Golan-Tripto

{"title":"C-Reactive Protein Is Associated with Severity in Hospitalized Children with Respiratory Syncytial Virus Bronchiolitis.","authors":"Assaf Adar, Aviv D Goldbart, Nitzan Burrack, Neta Geva, Bracha Cohen, Inbal Golan-Tripto","doi":"","DOIUrl":"","url":null,"abstract":"Background: Acute bronchiolitis, primarily caused by respiratory syncytial virus (RSV), is the leading cause of hospitalization in young children. Despite international guidelines supporting clinical diagnosis, laboratory evaluations are often conducted with limited validity.Objectives: To evaluate the association between C-reactive protein (CRP) serum levels on admission and disease severity in children hospitalized due to RSV bronchiolitis.Methods: This retrospective cohort study included children (0-24 months old) who were hospitalized due to RSV bronchiolitis (2018-2022), CRP levels taken at admission.Results: We included 1874 children (mean age of 6.7 months, 59% males); median CRP level 1.92 mg/dl. Children with elevated CRP (> 1.92 mg/dl) were significantly older (5.1 vs. 3.8 months, P < 0.001) and had higher rates of pneumonia (9.4% vs. 4.3%, P < 0.001), urinary tract infection (UTI), (2.2% vs. 0.2%, P < 0.001), acute otitis media (AOM) (1.7% vs. 0.2%, P < 0.001), admissions to the pediatric intensive care unit (PICU) (7.4% vs. 3.7%, P < 0.001), antibiotic treatment (49.8% vs. 37.2%, P < 0.001), and longer hospitalizations (3.83 vs. 3.31 days, P < 0.001). Multivariable analysis predicted increased risk for UTI, PICU admission, pneumonia, and longer hospitalization (relative risk 11.6, 2.25, 1.98, 1.44, respectively, P < 0.001). CRP thresholds of 3.51, 1.9, and 2.81 mg/dl for PICU admission, UTI, and pneumonia, were calculated using Youden's index with AUC 0.72, 0.62, and 0.61, respectively.Conclusions: Elevated CRP levels at admission are associated with increased disease severity and higher complication rates in children hospitalized with RSV bronchiolitis.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 3","pages":"165-171"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Lung Ultrasound in the Follow-up of Pediatric Patients with Community-acquired Pneumonia. 肺部超声在儿童社区获得性肺炎随访中的应用。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-03-01

Vered Nir, Guy Katsenelenbogen, Rima Karabitski, Vered Schichter-Konfino, Adi Klein

{"title":"The Use of Lung Ultrasound in the Follow-up of Pediatric Patients with Community-acquired Pneumonia.","authors":"Vered Nir, Guy Katsenelenbogen, Rima Karabitski, Vered Schichter-Konfino, Adi Klein","doi":"","DOIUrl":"","url":null,"abstract":"Background: Community-acquired pneumonia (CAP) is a prevalent bacterial infection in children. Lung ultrasound (LUS) is gaining popularity as a diagnostic tool for pneumonia, with the added potential for monitoring disease progression. However, research on the benefits of this modality for monitoring disease progression remains limited.Objectives: To categorize the follow-up sonographic findings of lung inflammation in pediatric patients performed 10-14 days after being diagnosed with CAP.Methods: We conducted a prospective observational study of children aged 0-18 years, diagnosed with CAP between 2020 and 2022. LUS findings at the time of diagnosis and 10-14 days later were recorded and documented.Results: In total, 47 children were recruited, and 22 were included in the analysis. At the time of diagnosis, 20 patients (90%) had B-lines. Air bronchograms were found in all patients, and consolidation findings were observed in seven of the examined patients (32%). At the follow-up LUS 10-14 days later, B-lines were observed in six patients (27%). Air bronchograms were observed in eight patients, and consolidation findings were observed in six (27%). In 13 patients (59%), the follow-up LUS was completely normal. These patients were younger and had lower body weights. Pathological findings persisted in 41% of the patients.Conclusions: For most patients, LUS demonstrated a resolution. Further large-scale studies are needed to validate the findings and determine the role of LUS in pediatric CAP.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 3","pages":"172-176"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Red Blood Cell Distribution Width at Admission and Early Mortality in Acute Pancreatitis. 入院时红细胞分布宽度与急性胰腺炎早期死亡率的关系。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Shafiq Z Azzam, Itai Ghersin, Maya Fischman, Adi Elias, Zaher S Azzam, Wisam H Abboud

{"title":"The Association Between Red Blood Cell Distribution Width at Admission and Early Mortality in Acute Pancreatitis.","authors":"Shafiq Z Azzam, Itai Ghersin, Maya Fischman, Adi Elias, Zaher S Azzam, Wisam H Abboud","doi":"","DOIUrl":"","url":null,"abstract":"Background: Several studies have shown an association between increased red blood cell distribution width (RDW) and adverse outcomes in various acute diseases. Small studies have suggested that RDW is a useful predictor of acute pancreatitis severity.Objectives: To determine the association between RDW at admission and early mortality in acute pancreatitis. To assess whether RDW adds to the predictive ability of the Glasgow Imrie Score.Methods: In this observational study, we included all adult patients admitted with a primary diagnosis of acute pancreatitis between January 2008 and June 2021. Patients were divided into two groups according to RDW: normal RDW (RDW ≤ 14.5%) and elevated RDW (RDW > 14.5%).Results: Within 30 days of admission, 29/438 patients (6.6%) with increased RDW and 20/1250 patients (1.6%) with normal RDW had died: univariate analysis (odds ratio 4.6, 95% confidence interval 2.45-7.9, P < 0.001), fully adjusted model (odds ratio 3.29, 95% confidence interval 1.75-6.26, P < 0.001). We calculated receiver operating characteristic curve (ROC) for RDW alone, Glasgow Imrie Score alone, and a combination of Glasgow Imrie Score with RDW. We assessed their ability to predict 30-day mortality. Area under the ROC curve (AUC) of RDW alone was 0.671 and Glasgow Imrie Score AUC was 0.682; Glasgow Imrie Score plus RDW had an AUC of 0.769.Conclusions: In patients with acute pancreatitis, elevated RDW at admission was independently associated with increased 30-day mortality. The addition of RDW to a pancreatitis prognostic tool such as the Glasgow Imrie Score improves its predictive ability.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 2","pages":"87-91"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol and Its Effects on Patients with COVID-19 Infection. 大麻二酚及其对COVID-19感染患者的影响

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Yuval Kuntzman, Gilad Halpert, Howard Amital

引用次数: 0

Genetic Links Between Depression and Heart Disease in Women. 女性抑郁症和心脏病之间的基因联系

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Shira Peretz, Marina Kurtz, Aviad Sivan, Arnon Blum

{"title":"Genetic Links Between Depression and Heart Disease in Women.","authors":"Shira Peretz, Marina Kurtz, Aviad Sivan, Arnon Blum","doi":"","DOIUrl":"","url":null,"abstract":"Background: Cardiovascular disease (CVD) events are rare in premenopausal women. Nevertheless, women with depression have a higher prevalence of CVD. Patients with depression present with endothelial dysfunction and impaired ability to regenerate endothelial progenitor cells (EPCs).Objectives: To understand the association between depression and CVD, especially in young women.Methods: We collected peripheral blood samples from 30 premenopausal women diagnosed with major depression and 28 aged-matched healthy women. From these blood samples, we extracted RNA and conducted RNA sequencing to obtain comprehensive gene expression profiles. Gene expression analysis was performed to identify differences between the two groups.Results: We detected 6540 differentially expressed genes between the two groups, of which 5577 were downregulated and 963 up regulated. Of these genes, we detected a significant decrease of CD144 (VE-Cadherin) (P = 0.0001), CD146 (MCAM) (P = 0.0001) and CD133 (PROM1) (P = 0.00009), all known to enhance EPCs and regeneration of damaged blood vessels. A significant increase was found in the expression of CD31 (PECAM1) (P = 0.0003) and CD45 (PTPRC) (P = 0.00001), both known to promote atherogenesis and thrombogenesis with platelet and T lymphocyte activation.Conclusions: Young premenopausal women with depression had an impaired ability to grow colony forming units of endothelial progenitor cells (CFU-EPCs). Young women with depression are more vulnerable genetically to develop CVD because of the downregulated genes of the stem cells endothelial vascular regeneration and upregulation of genes coding for platelet and T lymphocyte activation, thus accelerating the atherosclerotic and atherothrombotic pathway.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 2","pages":"110-113"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking Clinical Activity with Medical Research: The Steady Journey of Internal Medicine in Israel. 将临床活动与医学研究联系起来：以色列内科医学的稳步发展。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Howard Amital, Avishay Elis

引用次数: 0

Low Serum IgG4 in Systemic Sclerosis: Lessons from an Israeli Cohort. 低血清IgG4在系统性硬化症：来自以色列队列的教训。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-02-01

Anat Ben Ari, Noa Rabinowicz, Haim Paran, Or Carmi, Yair Levy

{"title":"Low Serum IgG4 in Systemic Sclerosis: Lessons from an Israeli Cohort.","authors":"Anat Ben Ari, Noa Rabinowicz, Haim Paran, Or Carmi, Yair Levy","doi":"","DOIUrl":"","url":null,"abstract":"Background: Immunoglobulin 4 (IgG4) is the least abundant immunoglobulin in the sera of healthy individuals; however, its levels can vary in different diseases such as IgG4-related disease (high) or Sjögren's syndrome (low). While previous studies have suggested the importance of IgG4 in autoimmune diseases, the clinical and biological significance of high or low levels remains unclear.Objectives: To investigate the association between IgG4 antibody levels and systemic sclerosis (SSc), as well as the clinical features of the disease.Methods: We measured IgG4 levels in the sera of 74 SSc patients from the years 2000 to 2019 and compared them to IgG4 levels in 80 healthy donors from the Israeli national blood bank. We performed correlation analyses between IgG4 levels and various factors, including age, sex, disease subtype, disease duration, organs involved, and medications taken by the patients.Results: Our findings revealed significantly lower IgG4 levels in SSc patients compared to healthy participants. SSc patients receiving steroid treatment exhibited prominently lower IgG4 levels. In addition, SSc patients with Raynaud's phenomenon tended to have lower IgG4 levels compared to those without Raynaud's phenomenon.Conclusions: Our study demonstrates that IgG4 levels are lower in SSc patients. Further research is needed to elucidate whether this observation contributes to the etiology of the disease or if it represents a common manifestation among other autoimmune diseases.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 2","pages":"92-97"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0