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Nail-patella Syndrome and Bilateral Nephrolithiasis: Rare Case Study of a 17-year-old Israeli Male. 指甲-髌骨综合征和双侧肾结石：一名17岁以色列男性的罕见病例研究。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-04-01
Majd Said, Yossy Machluf, Vladimir Banchenko, Eduardo Cohen, Yoram Chaiter
{"title":"Nail-patella Syndrome and Bilateral Nephrolithiasis: Rare Case Study of a 17-year-old Israeli Male.","authors":"Majd Said, Yossy Machluf, Vladimir Banchenko, Eduardo Cohen, Yoram Chaiter","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 4","pages":"258-261"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of the COVID-19 Pandemic on Seasonal Enteroviral Meningitis in Hospitalized Children. COVID-19大流行对住院儿童季节性肠病毒性脑膜炎的影响
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-04-01
Evgenia Gurevich, Mahdi Seh, Yaser Nabari, Vered Shkalim Zemer
{"title":"The Impact of the COVID-19 Pandemic on Seasonal Enteroviral Meningitis in Hospitalized Children.","authors":"Evgenia Gurevich, Mahdi Seh, Yaser Nabari, Vered Shkalim Zemer","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Enterovirus meningitis (EM) is a common central nervous system (CNS) infection with a seasonal peak in summer and fall.</p><p><strong>Objectives: </strong>To describe the epidemiologic and clinical patterns of EM in children before (2017-2019 years) and during the coronavirus disease 2019 (COVID-19) pandemic (2020-2022).</p><p><strong>Methods: </strong>This retrospective study included children (age 0-16 years) hospitalized in a pediatric department in Israel diagnosed with EM: January 2017-December 2019 and January 2020-December 2022. The seasonal peak for each period was defined as the maximal incidence in particular months. EM was diagnosed by reverse transcription polymerase chain reaction of cerebrospinal fluid (CSF) for enteroviruses.</p><p><strong>Results: </strong>During the study period, EM was diagnosed in 134 cases (median age 5 months [1-51], 76 [57%] males); 72 during 2017-2019 and 62 during 2020-2022. The most common presentation was fever. C-reactive protein (CRP) was elevated in 57 cases (43%). CSF profile showed pleocytosis in 130 cases (97%) and elevated protein in 80 (60%). In the 2020-2022 group, fewer patients were febrile, CRP was higher, and CSF profile showed a higher glucose level compared to the 2017-2019 group. Seasonal peaks in 2017-2019 occurred June-August, and in 2020-2022 February-April.</p><p><strong>Conclusions: </strong>The COVID-19 pandemic altered the clinical characteristics of EM and its seasonal peak. Clinicians should be aware of changes in epidemiological patterns of EM to make appropriate diagnoses in viral infection in order to avoid unnecessary antibiotic treatment.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 4","pages":"224-228"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyponatremia in Pediatric Community-acquired Pneumonia is Associated with Bacterial Etiology and Severity Markers. 儿童社区获得性肺炎低钠血症与细菌病因学和严重程度标志物相关
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-04-01
Adey Matani, Nechama Sharon, Niv Reiss, Moshe Yana, Roxana Cleper, Achiya Z Amir
{"title":"Hyponatremia in Pediatric Community-acquired Pneumonia is Associated with Bacterial Etiology and Severity Markers.","authors":"Adey Matani, Nechama Sharon, Niv Reiss, Moshe Yana, Roxana Cleper, Achiya Z Amir","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Hyponatremia is common among hospitalized children, including those with community acquired pneumonia. The prevalence and severity of hyponatremia were reported to correlate with disease. However, data regarding the association between hyponatremia and causative infectious pathogens are limited and results are inconsistent.</p><p><strong>Objectives: </strong>To investigate the associations between sodium levels, severity and causative pathogen in children with pneumonia.</p><p><strong>Methods: </strong>A retrospective study of all children (< 18 years) hospitalized with pneumonia from 1 January 2018 to 31 December 2020. Admission sodium levels were compared to the presumed etiological pathogens, clinical parameters, and inflammatory markers.</p><p><strong>Results: </strong>Among 751 (52% males) children, 10 (1%) had sodium levels < 130 mEq/L, 187 (25%) had mildly decreased levels 130-134 mEq/L, and the remaining 554 (74%) had normal levels 135-145 mEq/L. Sodium levels < 130 mEq/L were found in 7/236 (3%) of the patients with presumed bacterial pneumonia, in 0/20 of patients with presumed atypical-bacterial, and in only 3/495 (0.6%) of the patients with a presumed viral infection, P < 0.001. Sodium levels < 135 mEq/L conferred an odds ratio of 3.1 (95% confidence interval [95%CI] 2.1-4.3) and levels < 130 mEq/L an odds ratio of 6.8 (95%CI 1.8-33.0) for bacterial infection, P < 0.001 for both. Hyponatremia was also inversely associated with high white blood cell counts, absolute neutrophil cell counts, and C-reactive protein levels.</p><p><strong>Conclusions: </strong>Hyponatremia was common among children hospitalized with pneumonia and was associated with elevated inflammatory markers and presumed bacterial pneumonia.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 4","pages":"231-237"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Cause of Respiratory Distress in a 1-month-old Infant. 1个月婴儿呼吸窘迫的罕见原因。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-03-01
Gavriel Hain, Micha Aviram, Aviva Levitas, Hana Krymko, Aviv Goldbart, Inbal Golan-Tripto
{"title":"A Rare Cause of Respiratory Distress in a 1-month-old Infant.","authors":"Gavriel Hain, Micha Aviram, Aviva Levitas, Hana Krymko, Aviv Goldbart, Inbal Golan-Tripto","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 3","pages":"177-179"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An 11-Year-Old Patient with Anorexia Nervosa Presenting with Severe Clinical and Laboratory Deterioration: A Case Report. 11岁神经性厌食症患者临床及实验室表现严重恶化1例。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-03-01
Mai Shiber, Nadav Shalev, Maor Leibzon, Nechama Sharon
{"title":"An 11-Year-Old Patient with Anorexia Nervosa Presenting with Severe Clinical and Laboratory Deterioration: A Case Report.","authors":"Mai Shiber, Nadav Shalev, Maor Leibzon, Nechama Sharon","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 3","pages":"180-182"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short Stature as a Diagnostic Indicator for Children with Gaucher Disease. 矮小作为儿童戈谢病的诊断指标。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-03-01
Shoshana Revel-Vilk, Ari Zimran, Aya Abramov, David Strich
{"title":"Short Stature as a Diagnostic Indicator for Children with Gaucher Disease.","authors":"Shoshana Revel-Vilk, Ari Zimran, Aya Abramov, David Strich","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 3","pages":"196-200"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molybdenum Cofactor Deficiency Type A disease in Northern Israel. 以色列北部缺钼辅助因子A型疾病
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-03-01
Eliyahu Fund, Hanna Mandel, Yoav Zehavi, Ronen Spiegel
{"title":"Molybdenum Cofactor Deficiency Type A disease in Northern Israel.","authors":"Eliyahu Fund, Hanna Mandel, Yoav Zehavi, Ronen Spiegel","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Molybdenum cofactor deficiency (MoCD) is a group of three autosomal recessive disorders caused by deficiency of the de novo metabolic synthesis of molybdenum cofactor. Most patients present within the first weeks of life with intractable seizures and progressive encephalopathy. Type A is the most common form caused by pathogenic variants in MOCS1 gene that result in deficiency of the first enzyme, cyclic pyranopterin monophosphate synthase.</p><p><strong>Objectives: </strong>To characterize MoCD type A clinical features, disease course, neuroradiology, and genetic features in Northern Israel.</p><p><strong>Methods: </strong>In this retrospective study, we collected the clinical, brain imaging, and genetic data of confirmed MoCD type A patients in Northern Israel.</p><p><strong>Results: </strong>The study included 10 confirmed MoCD type A patients (6 males, 4 females), all deceased. The patients were of consanguineous families. Nine patients were of Arab Muslim ethnicity and one was of Druze origin. A total of four different homozygous genotypes were identified. All patients presented initially between 1-4 days of life. Three died within the first month of life, five within the first year of life, and only two died after the age of 7 years. All patients who survived beyond the first month developed profound global developmental delays, had poorly controlled epilepsy, and developed severe microcephaly.</p><p><strong>Conclusions: </strong>Although MoCD type A is an ultra-rare disease worldwide, it is relatively common in northern Israel due to several founder mutations and high consanguinity. All the patients presented the severe neonatal form of the disease with significant neurological deterioration and early lethality within infancy and childhood.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 3","pages":"142-146"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interobserver Agreement in Assessment of Chest Radiographs for the Diagnosis of Pneumonia between Residents and Radiologists in a Pediatric Emergency Department: The Role of patient and Resident Characteristics. 儿科急诊科住院医师和放射科医师在评估胸片诊断肺炎的一致性：患者和住院医师特征的作用
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-03-01
Tali Pelts-Shlayer, Michael Benacon, Yair Glick, Daniel Yakubovich, Nechama Sharon
{"title":"Interobserver Agreement in Assessment of Chest Radiographs for the Diagnosis of Pneumonia between Residents and Radiologists in a Pediatric Emergency Department: The Role of patient and Resident Characteristics.","authors":"Tali Pelts-Shlayer, Michael Benacon, Yair Glick, Daniel Yakubovich, Nechama Sharon","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Chest radiograph is a standard procedure for diagnosis of pneumonia; however, interpretation shows considerable variability among observers.</p><p><strong>Objectives: </strong>To assess the extent of agreement between pediatric residents and board-certified radiologists in interpretation of chest radiography for detection of pneumonia. To evaluate the impact of resident experience, patient age, and signs of infection on this phenomenon.</p><p><strong>Methods: </strong>The cohort included 935 patients with suspected pneumonia admitted to the pediatric emergency department at a non-tertiary medical center in Israel 2019-2021. All patients had chest radiographs interpreted by a resident and a radiologist. Interobserver agreement was assessed using Κ and prevalence-adjusted bias-adjusted κ (PABAK) with 95% confidence intervals (95%CI). Results were stratified by resident experience (junior or senior), patient age (≤ 3 vs. > 3 years), white blood cells (≤ 15,000 vs. > 15,000 cells/ml), C-reactive protein (≤ 5 vs. > 5.0 mg/dl), and temperature (< 38.0°C vs. ≥ 38.0°C).</p><p><strong>Results: </strong>Moderate agreement between pediatric residents and radiologists was demonstrated for diagnosis of pneumonia (κ= 0.45). After adjustment for disease prevalence, the extent of agreement increased to near-substantial (PABAK= 0.59, 95% confidence interval 0.54-0.64). The extent of agreement was higher for children over 3 years of age and in patients without clinical or biochemical features of pneumonia, especially when diagnosis of pneumonia was ruled out.</p><p><strong>Conclusions: </strong>A second reading of chest radiographs by an experienced radiologist should be considered, particularly for patients younger than 3 years of age and in those with signs of infection and an initial diagnosis of pneumonia.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 3","pages":"147-152"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inborn Errors of Immunity: A Fascinating and Ever-Evolving Field Advancing Medicine. 先天免疫错误：一个引人入胜且不断发展的医学领域。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-03-01
Ido Somekh, Ilan Dalal, Raz Somech
{"title":"Inborn Errors of Immunity: A Fascinating and Ever-Evolving Field Advancing Medicine.","authors":"Ido Somekh, Ilan Dalal, Raz Somech","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 3","pages":"189-195"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Graphic Organizers for Parental Education on Pediatric Medical Guidelines: Spacer Use for Asthma Inhalers and Rectal Diazepam for Seizures. 使用图形组织者对儿童医学指南的家长教育：间隔剂用于哮喘吸入器和直肠安定用于癫痫发作。
IF 1.8 4区 医学
Israel Medical Association Journal Pub Date : 2025-03-01
Inbal Golan-Tripto, Naama Apian-Amichai, Yotam Dizitzer-Hillel, Sameera Zoubi, Ely Kozminsky, Aviv Goldbart
{"title":"Using Graphic Organizers for Parental Education on Pediatric Medical Guidelines: Spacer Use for Asthma Inhalers and Rectal Diazepam for Seizures.","authors":"Inbal Golan-Tripto, Naama Apian-Amichai, Yotam Dizitzer-Hillel, Sameera Zoubi, Ely Kozminsky, Aviv Goldbart","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Understanding medical guidelines can be challenging for patients and their families, leading to incorrect use or dosages due to inadequate or unclear explanations. Graphic organizers are tools that can help improve comprehension of medical guidelines.</p><p><strong>Objectives: </strong>To assess the effectiveness of using designed graphic organizers to enhance comprehension of medical guidelines.</p><p><strong>Methods: </strong>A prospective randomized controlled study was conducted at Soroka University Medical Center between 2015 and 2017. Parents of children aged 1-7 years, admitted for asthma exacerbation requiring the use of an inhaler with a spacer or for febrile convulsion requiring rectal diazepam, were enrolled. Participants were randomly assigned to receive instructions through a graphic organizer (intervention group) or plain text (control group). An assessment form was administered to evaluate the understanding of the correct steps for using the inhaler with a spacer or administering rectal diazepam. A follow-up telephone assessment was conducted after 30-60 days to evaluate recollection.</p><p><strong>Results: </strong>Seventy-four parents with similar demographic characteristics were enrolled (intervention group [38], control group [36]). There was no significant difference in comprehension between the two groups when using medical guidelines for the two interventions. However, there was a correlation between maternal education level and long-term recollection, with an average score of 24%, 42%, and 48% among mothers with less than 8 years, 8-12 years, and over 12 years of education, respectively (P = 0.004).</p><p><strong>Conclusions: </strong>The use of graphic organizers did not improve parent comprehension of pediatric medical guidelines. However, long-term recollection was positively correlated with maternal education level.</p>","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 3","pages":"153-158"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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