Israel Medical Association Journal最新文献_第2页

Mohs Micrographic Surgery: Indications for Non-head and Neck Tumors. 莫氏显微外科：非头颈部肿瘤的指征。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-06-01

Baruch Kaplan, Yehonatan Kaplan

引用次数: 0

Topical Tranexamic Acid-mediated with Non-insulated Microneedling Radiofrequency for the Treatment of Melasma. 局部氨甲环酸介导非绝缘微针射频治疗黄褐斑。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-06-01

Lehavit Akerman, Baruch Kaplan, Daniel Mimouni, Adi Nosrati, Efrat Solomon-Cohen

{"title":"Topical Tranexamic Acid-mediated with Non-insulated Microneedling Radiofrequency for the Treatment of Melasma.","authors":"Lehavit Akerman, Baruch Kaplan, Daniel Mimouni, Adi Nosrati, Efrat Solomon-Cohen","doi":"","DOIUrl":"","url":null,"abstract":"Background: Radiofrequency-skin interaction is considered self-limited for treating acquired pigmentation such as melasma. Alternatively, skin perforation with microneedling radiofrequency (MNRF) may increase skin bioavailability for depigmenting-mediated ingredients or drugs for the treatment of melasma.Objectives: To examine the clinical feasibility of topical tranexamic acid (TA) mediated with MNRF-assisted transepidermal delivery in patients with mixed melasma.Methods: The study protocol included 14 women with centrofacial or malar pattern of distribution of melasma (skin types II-VI; age 35-48 years). Patients underwent four treatments at 3-week intervals between treatments. Treatment protocol included non-insulated MNFR (Intensif, EndyMed Ltd, Caesarea, Israel) followed by TA (hexakapron 4%) solution application. The improvement was evaluated based on clinical photographs (Quantificare, Biot, France) and modified Melasma Area and Severity Index (mMASI) scores. Baseline Photographs were analyzed 3 months after the last treatment.Results: In 13 patients (93%), mMASI scores were significantly lower after 3 months (mean 3.6) than at baseline (5.22). In one patient, mMASI was higher at 3 months compared to baseline. Overall, mMASI improved by 31% (P < 0.01). Physician and patient satisfaction was high. Minimal adverse reactions were recorded.Conclusions: MNRF-assisted transepidermal delivery with topical TA is a safe and effective modality for the treatment of melasma.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 6","pages":"358-362"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Potential of ChatGPT in Identifying Drug-Drug Interactions in Dermatology. 探索ChatGPT在识别皮肤病学药物-药物相互作用中的潜力。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-06-01

Jonathan Shapiro, Tamar Freud, Baruch Kaplan, Yuval Ramot

引用次数: 0

Seasonal Trends in Patch Testing: A Large Single-Center Retrospective Cohort Study. 斑贴检测的季节性趋势：一项大型单中心回顾性队列研究。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-06-01

Zvi Segal, Sharon Baum, Aviv Barzilai, Yaron Lavi, Michal Solomon

{"title":"Seasonal Trends in Patch Testing: A Large Single-Center Retrospective Cohort Study.","authors":"Zvi Segal, Sharon Baum, Aviv Barzilai, Yaron Lavi, Michal Solomon","doi":"","DOIUrl":"","url":null,"abstract":"Background: Allergic contact dermatitis (ACD), a prevalent skin disorder marked by delayed hypersensitivity reactions to specific allergens, is commonly diagnosed through patch testing. Previous studies have indicated lower rates of positive patch tests in summer months compared to winter months.Objectives: To investigate whether there is a difference in the proportion of positive patch test results between summer and winter months.Methods: A retrospective study was performed on 1128 patients, with 14 individuals undergoing two tests each, resulting in a total of 1142 patch tests. The tests were conducted at a major tertiary referral center between 2016 and 2020. The data set encompassed patient demographics and comprehensive patch test results.Results: Of the 1142 tests conducted, 808 (70.8%) yielded a positive response. The most frequently administered test series was the European standard series, conducted for 1135 (99.3%) of the tests, with 559/1135 (49.2%) showing positive results, followed by the cosmetics series (394/1120, 35.1%) and fragrances series (61/118, 51.7%). No statistically significant difference was observed in the proportion of positive patch tests between summer and winter months (313/419, 74.7% vs. 175/245, 71.4%, respectively; P-value = 0.35). There was no statistically significant difference in the rate of testing each specific series between the summer and winter months, except for the fragrances series.Conclusions: We found no significant difference in the positive patch test rates between the summer and winter months. Therefore, patch testing can be reliably conducted during the summer without an increased risk of false-negative results.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 6","pages":"363-366"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in the Seasonality of Bronchiolitis Caused by Respiratory Syncytial Virus During and After the COVID-19 Pandemic. COVID-19大流行期间和之后呼吸道合胞病毒引起的毛细支气管炎的季节性变化

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-05-01

Kfir Lavi, Vered Nir, Erez Nadir, Adi Klein, Eias Kassem

{"title":"Changes in the Seasonality of Bronchiolitis Caused by Respiratory Syncytial Virus During and After the COVID-19 Pandemic.","authors":"Kfir Lavi, Vered Nir, Erez Nadir, Adi Klein, Eias Kassem","doi":"","DOIUrl":"","url":null,"abstract":"Background: Prior to the coronavirus disease 2019 (COVID-19) pandemic, bronchiolitis caused by respiratory syncytial virus (RSV) was primarily observed during the winter months. Recently, however, an increase in incidence during the warmer months has been noted. This trend suggests an interaction between RSV and coronavirus, as well as the impact of public health measures, such as hand hygiene, mask-wearing, and social distancing.Objectives: To characterize bronchiolitis cases in children under 2 years old caused by RSV during the COVID-19 pandemic in Israel from 2018 to 2022.Methods: We conducted retrospective study by analyzing medical records of children hospitalized with bronchiolitis from January 2018 to December 2022. A comparison was made between cases before and after the first COVID-19 lockdown.Results: A total of 922 children with bronchiolitis were studied: 276 cases occurred before the lockdown and 646 cases afterward. We found an increase in bronchiolitis frequency during the summer following the lockdown and a decrease during the winter (P < 0.0001). In addition, there was a shift in the pathogenic profile, with a notable rise in mixed infections after the lockdown (P < 0.0001). No significant differences in clinical presentation were observed between pre- and post-lockdown periods.Conclusions: There was a change in bronchiolitis seasonality after the lockdown, with a significant increase in cases during the summer and a rise in mixed infections. Further studies are needed to assess whether this shift is a lasting consequence of the pandemic or a temporary change.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 5","pages":"278-282"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pheochromocytoma Presenting with Myalgia: A Case Report. 以肌痛为表现的嗜铬细胞瘤1例报告。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-05-01

Fadwa Sharabati, Elchanan Parnasa, Nur Magadle, Maor Vanunu, Iddo Z Ben-Dov

引用次数: 0

Baboon Syndrome after Percutaneous Coronary Intervention. 经皮冠状动脉介入治疗后的狒狒综合征。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-05-01

Osnat Jarchowsky Dolberg, Shani Ben Dori, Martin H Ellis, Boaz Amichai

引用次数: 0

Implanting Cardiac Electronic Devices with Uninterrupted Antithrombotic Therapy: A Novel Approach to Reduce Pocket Hematoma. 植入心脏电子设备不间断抗血栓治疗：一种减少口袋血肿的新方法。

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-05-01

Avishag Laish-Farkash, Ella Yahud, Michael Rahkovich, Yonatan Kogan, Lubov Vasilenko, Emanuel Harari, Gergana Marincheva, Emma Shvets, Eli I Lev, Uri Farkash

{"title":"Implanting Cardiac Electronic Devices with Uninterrupted Antithrombotic Therapy: A Novel Approach to Reduce Pocket Hematoma.","authors":"Avishag Laish-Farkash, Ella Yahud, Michael Rahkovich, Yonatan Kogan, Lubov Vasilenko, Emanuel Harari, Gergana Marincheva, Emma Shvets, Eli I Lev, Uri Farkash","doi":"","DOIUrl":"","url":null,"abstract":"Background: Uninterrupted antithrombotic treatment (ATT) during cardiac implantable electronic device (CIED) implantation increases bleeding and device-related infections (DRI) risk. The wide-awake-local-anesthesia-no-tourniquet (WALANT) technique, using large-volume local anesthesia and adrenaline, is successful in hand surgeries but its potential to mitigate bleeding risk in CIED implantations remains unknown.Objectives: To investigate whether WALANT protocol for CIED implantations reduces clinically significant pocket hematoma in patients with a high bleeding risk or is a contraindication for interrupting ATT.Methods: We conducted a prospective, double-blind, randomized controlled trial with CIED surgery patients on uninterrupted ATT. They received WALANT protocol (lidocaine 1% with adrenaline 1:100,000) or standard protocol (lidocaine 1%). Following implantation, patients were blindly monitored in the ward and pacemaker clinic. Patients were monitored for bleeding outcomes post-implantation.Results: Forty-six consecutive patients (73.6 ± 9 years, 72% male) were enrolled. In the WALANT group (n=24) no intra-pocket pro-hemostatic agents were needed, compared to 45% in the control group (P = 0.0002). Postoperative pressure dressings were used in 12.5% vs. 68% (P = 0.0002). WALANT patients had smaller hematoma areas (median 3.7 cm2 IQR [1-39] vs. 46 cm2 [IQR 24-76], P = 0.0004) 1-day postoperative. ATT interruption occurred in 12.5% vs. 18% (P = 0.7). Superficial skin infection rates were 4% vs. 9% (P = 0.6). No DRI occurred. No WALANT-related side effects were observed.Conclusions: WALANT protocol in CIED implantation with uninterrupted ATT reduced pro-hemostatic agents, pressure-dressing need, and hematoma size. Larger studies are needed to assess its impact on infection rates.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 5","pages":"307-313"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal Window Settings for Detection and Characterization of Ground-Glass Opacities on Computed Tomography in COVID-19 Patients Using a Simplex Algorithm-Based Approach. 基于单纯形算法的COVID-19患者计算机断层扫描毛玻璃混浊检测和表征的最佳窗口设置

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-05-01

Marron Daud, S Nahum Goldberg, Dotan Cohen, Gili Dar, Shiran Levy, Adam Nevo, Jacob Sosna, Naama Lev-Cohain

{"title":"Optimal Window Settings for Detection and Characterization of Ground-Glass Opacities on Computed Tomography in COVID-19 Patients Using a Simplex Algorithm-Based Approach.","authors":"Marron Daud, S Nahum Goldberg, Dotan Cohen, Gili Dar, Shiran Levy, Adam Nevo, Jacob Sosna, Naama Lev-Cohain","doi":"","DOIUrl":"","url":null,"abstract":"Background: Coronavirus disease-2019 (COVID-19) chest computed tomography (CT) involves ground-glass opacity (GGO) and denser consolidations, which are crucial for diagnosis.Objectives: To determine optimal window settings for characterization and detection of GGO and dense consolidation on CT imaging in COVID-19 patients using a Simplex-based approach.Methods: The study included 54 conventional CTs of COVID patients in two phases. First, CT images of 14 patients with GGO and 4 with dense consolidation were included. Seven radiologists evaluated representative images in different windows of varied width and center. They were graded for adequacy of characterization and detection. A Simplex algorithm was used to iteratively determine the optimal window settings. Surface response maps expressing the relationship between window settings and overall reader grades were constructed. Next, the reviewers compared manufacturer recommendations to the new optimal windows found on CT images of 40 patients.Results: Overall, 12 different window settings were evaluated over a total of 1176 reads. Optimal characterization and detection of pure GGO was seen with a center of 630 HU and width 1460 HU, producing higher grades for both detection and characterization than the manufacturer window settings (P = 0.005). Optimal windowing for dense consolidation was like manufacturer measures (-585 HU and 1800 HU). In phase 2, an overwhelming preference of 78% favoring the optimal window compared to conventional settings was found.Conclusions: GGO lung opacities characteristic for COVID-19 can be best seen using a lower CT windowing width than the manufacturer's recommendations, unlike denser consolidations, possibly due to differences in underlying pathophysiology.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 5","pages":"283-289"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CA125 Serum Levels in BRCA1/BRCA2 Pathogenic Sequence Variant Carriers as an Ovarian Cancer Screening Tool: A Longitudinal Study. BRCA1/BRCA2致病序列变异携带者血清CA125水平作为卵巢癌筛查工具：一项纵向研究

IF 1.8 4区医学

Israel Medical Association Journal Pub Date : 2025-05-01

Dana Madorsky Feldman, Yael Laitman, Dana Albagli, Jacob Korach, Eitan Friedman

{"title":"CA125 Serum Levels in BRCA1/BRCA2 Pathogenic Sequence Variant Carriers as an Ovarian Cancer Screening Tool: A Longitudinal Study.","authors":"Dana Madorsky Feldman, Yael Laitman, Dana Albagli, Jacob Korach, Eitan Friedman","doi":"","DOIUrl":"","url":null,"abstract":"Background: BRCA1/BRCA2 female pathogenic sequence variant (PSV) carriers in Israel are offered semiannual cancer antigen 125 (CA125) serum level determination and transvaginal ultrasound until performing risk reducing salpingo-oophorectomy (RRSO), even with the lack of proven efficacy of these procedures in providing adequate early detection of ovarian cancer.Objectives: To report the results of longitudinal CA125 measurements in BRCA1/BRCA2 carriers as a tool for ovarian cancer detection in a single medical center in Israel.Methods: Asymptomatic BRCA1/BRCA2 PSV carriers attending the Meirav High Risk Clinic at Sheba Medical Center for more than 3 years were eligible. Data on specific PSV, risk reducing surgeries, and cancer diagnoses were obtained from participant records. We used chi-square and Wilcoxon-Rank tests for statistical analyses.Results: Overall, 739 (399 BRCA1, 336 BRCA2, 4 BRCA1 + BRCA2) PSV carriers were included. Mean age at the start of follow-up was 38.96 ± 11.13 years, mean follow-up time was 7.93 ± 2.34 years, (5860.80 women/years). Most participants (490/739 [66.3%]) had stable CA125 levels (± 5 U/µl). Of participants, 61 had CA125 levels > 35 U/µl at least twice (n=42) or at least doubling of marker levels to a minimum of 20 U/µl (n=19), results that have led to further cancer defining investigations. Of these, 14 and 4 were diagnosed with breast and ovarian cancer, respectively.Conclusions: Longitudinally stable CA125 levels were noted in most BRCA1/BRCA2 PSV carriers and elevated levels were a poor marker for ovarian cancer development.","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"27 5","pages":"297-300"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0